Tiplo Citrus – Acetylsalicylic acid/caffeine  uses, dose and side effects


500 mg/50 mg effervescent tablet
acetylsalicylic acid/caffeine 

What Tiplo Citrus is and what it is used for

Tiplo Citrus contains the combination of acetylsalicylic acid and caffeine.

Tiplo Citrus has an analgesic, antipyretic and anti- inflammatory effect.

Acetylsalicylic acid relieves pain by counteracting the formation of special substances, prostaglandins . The antipyretic effect is due to acetylsalicylic acid increasing the body’s heat output.

Caffeine enhances the pain-relieving effect of acetylsalicylic acid . Caffeine also has an analgesic effect through its constricting effect on dilated blood vessels in the brain, e.g. in case of migraine.

Caffeine also has an invigorating effect.

Tiplo Citrus gives a clear solution with water that is gentler on the stomach than regular solid tablets with acetylsalicylic acid . Tiplo Citrus starts working within 30 minutes. The effect is greatest after 1-2 hours.

This medicine is used for temporary mild to moderate pain conditions, e.g. headaches, including migraine headaches, toothaches, muscle and joint pains, menstrual pains and in case of fever in cold diseases.

You must speak to a doctor if you do not feel better or if you feel worse after 3 days for fever and migraine and 5 days for pain.

The combination of acetylsalicylic acid and caffeine found in Tiplo Citrus may also be approved to treat other conditions not mentioned in this product information. Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.

What you need to know before using Tiplo Citrus

Do not use Tiplo Citrus

  • if you are allergic to acetylsalicylic acid , caffeine or any other ingredient in this medicine (listed in section 6).
  • if you have had any hypersensitivity reaction such as asthma , breathing difficulties, hay fever or hives when taking aspirin or certain other anti- inflammatory medicines
  • if you have a stomach ulcer
  • if you have hemophilia or a reduced number of blood platelets ( thrombocytopenia )
  • if you have cirrhosis of the liver ( liver cirrhosis )
  • if you have severe heart failure
  • if you have severe kidney disease
  • if you are pregnant in the last three months of pregnancy (see “Pregnancy, breastfeeding and fertility”).

Warnings and precautions

Higher doses than those recommended may entail serious risks. Do not use different types of pain relievers at the same time without a doctor’s prescription.

Talk to your doctor, pharmacist or nurse before using Tiplo Citrus:

  • if you have asthma
  • if you have mild to moderate heart failure
  • if you have kidney disease or liver disease, especially during concomitant treatment with diuretics
  • if you take medicines that thin the blood to prevent blood clots ( anticoagulants )
  • if you have had a stomach ulcer
  • if you are hypersensitive to acetylsalicylic acid , ibuprofen or other anti-inflammatory agents
  • if you are trying to get pregnant.

Due to the caffeine content, Tiplo Citrus can make it difficult to fall asleep if taken close to bedtime.

Long-term use of painkillers for headaches can worsen the headache. If you have or think you have such a headache, you should seek medical advice and stop treatment.

Children and young people

Templo Citrus should not be used by children under 14 years of age.

Medicines containing acetylsalicylic acid should not be given to people under the age of 18 with a fever without consulting a doctor due to the risk of developing Reye’s syndrome, a rare but serious medical condition.

Other medicines and Tiplo Citrus

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.

Treatment with Tiplo Citrus can affect or be affected by certain medicinal substances against:

  • Anticoagulants (drugs against blood clots, e.g. warfarin )
  • Cyclosporine and tacrolimus (anti-rejection medicines for transplanted organs)
  • Diuretics and medicines for high blood pressure
  • Corticosteroids (medicines against inflammation , e.g. cortisone or prednisolone ) and other NSAIDs (medicines against pain and inflammation , e.g. ibuprofen )
  • Probenecid (for gout )
  • Methotrexate (against cancer and rheumatism)
  • Acetazolamide (medication for glaucoma , also called glaucoma )
  • Digoxin and adenosine (medicines for heart rhythm disorders)
  • Fluvoxamine (medicine against depression called SSRIs , selective serotonin reuptake inhibitors)
  • Clozapine (anti-schizophrenia)
  • Lithium (for manic depression)
  • Phenytoin , valproic acid , carbamazepine (for epilepsy )
  • Sulfonureides (drugs for type II diabetes )
  • Nicotinic acid (against high blood fats)
  • Ciprofloxacin, Norfloxacin ( antibiotics against infection )
  • Phenylpropanolamine (anti- allergy medicine )

Tiplo Citrus with food and drink

Tiplo Citrus in combination with alcohol may increase the risk of bleeding in the gastrointestinal tract.

Pregnancy, breastfeeding, and fertility

If you are pregnant or breast-feeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.


Pregnant women should not use Tiplo Citrus during the last three months of pregnancy. Ingestion of Tiplo Citrus should be avoided by women planning pregnancy or who are pregnant. Treatment during any part of the pregnancy must only take place after a doctor’s prescription .


Acetylsalicylic acid and caffeine pass into breast milk but probably do not affect the breastfed baby. However, talk to your doctor if you use Tiplo Citrus more than occasionally during breastfeeding.


Tiplo Citrus can, like many anti-inflammatory drugs (so-called NSAIDs ), make it difficult to get pregnant and is therefore not recommended for women trying to get pregnant. The effect is temporary, i.e. it stops when you stop using these types of drugs.

Driving ability and use of machinery

In some people, Tiplo Citrus can impair the ability to react, e.g. due to side effects such as dizziness and fatigue. This should be considered at times when increased attention is required, e.g. when driving.

You yourself are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention. One of the factors that can affect your ability in these respects is the use of drugs due to their effects and/or side effects . Descriptio of these effects and side effects can be found in other sections. Read all the information in this leaflet for guidance. Discuss with your doctor or pharmacist if you are unsure.

Tiplo Citrus contains sodium, sucrose and sodium benzoate

This medicine contains 345 mg of sodium (the main ingredient in common salt/table salt) per effervescent tablet . This corresponds to 17.3% of the maximum recommended daily intake of sodium for adults. Consult a doctor or pharmacist about your need for Tiplo or more effervescent tablets daily for a longer period, especially if you have been prescribed a low-salt diet.

If you have an intolerance to certain sugars, you should consult your doctor before taking this medication.

This medicine contains 0.15 mg of sodium besoate per effervescent tablet .

How to use Tiplo Citrus

Always use this medicine exactly as described in this leaflet or as directed by your doctor, pharmacist or nurse. Consult a doctor, pharmacist or nurse if you are unsure.

Tiplo effervescent tablets are intended for temporary discomfort.

Recommended dose for adults and adolescents over 14 years of age: 

1-2 effervescent tablets 1-3 times per day or according to doctor’s prescription, maximum 6 tablets per day.

More than 2 effervescent tablets at a time do not provide a better pain-relieving effect. Contact the doctor if the symptoms worsen or do not improve within 3 days for fever and migraine and within 5 days for pain.

Use for children

Tiplo Citrus should not be given to children under 14 years of age.

Warning : Should not be given to people under 18 years of age with fever without consulting a doctor due to the risk of developing Reye’s syndrome, a rare but serious medical condition.

Dissolve the fizzy tablets in half a glass of water.
As caffeine is a stimulant, it may not be appropriate to take this medicine at night.

If you have used too much Tiplo Citrus

If you have ingested too much medicine or if, for example, a child has ingested the medicine by mistake, contact a doctor or hospital for an assessment of the risk and advice.

Symptoms of overdose may include: headache, dizziness, convulsions, vomiting, ringing in the ears, palpitations ( tachycardia ), abdominal pain, irritation, restlessness and shortness of breath.

If you forget to take Tiplo Citrus

Do not take a double dose to make up for a missed tablet.

If you have any further questions about this medicine, ask your doctor, pharmacist or nurse.

Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Common side effects ( 
may affect up to 1 in 10 users):

  • stomach upset, such as acid reflux, heartburn and nausea
  • increased risk of bleeding
  • palpitations, tremors, restlessness, insomnia.

Uncommon  side effects ( may affect up to 1 in 100 users):

  • fatigue, sweating, dizziness and tinnitus
  • hypersensitivity reaction such as hives , hay fever or shortness of breath
  • stomach ulcers and stomach bleeding.

Rare side effects ( 
may affect up to 1 in 1,000 users):

  • decrease in the number of blood platelets ( thrombocytopenia )
  • dissolution of the red blood cells ( hemolysis ) in those who have a hereditary deficiency of the metabolic enzyme glucose -6-phosphate dehydrogenase
  • severe bleeding in the gastrointestinal tract
  • severe skin reactions
  • liver damage
  • kidney damage.

Smaller blood losses can in some cases lead to anemia .

Dizziness and ringing in the ears can be symptoms of overdose.

Additional side effects are in children

Acetylsalicylic acid may possibly increase the risk of Reye’s syndrome in children and adolescents in connection with diseases caused by viruses , especially chickenpox and influenza . Reye’s syndrome is very rare. The symptoms consist of signs of swelling in the brain and liver damage, sometimes with low blood sugar.

How to store Tiplo Citrus

Store at a maximum of 30 °C.

Store in the original packaging. Moisture sensitive.

Keep this medicine out of the sight and reach of children.

Use before the expiry date stated on the packaging. The expiration date is the last day of the specified month.

Medicines must not be thrown into the drain or among the household waste. Ask the pharmacist how to dispose of medicines that are no longer used. These measures will help to protect the environment.

Contents of the packaging and other information

Contents declaration

  • The active substances are acetylsalicylic acid 500 mg, caffeine 50 mg per effervescent tablet .
  • Other ingredients are sodium bicarbonate; citric acid, anhydrous; sodium benzoate, docusate sodium, lemon flavor (contains sucrose (sugar)).

Appearance and package sizes of the medicine


Tiplo Citrus effervescent tablets are 20 mm diameter, round, white to off-white, flat tablets with unevenly distributed yellow dots.

Package sizes

The effervescent tablets are in an aluminum tube with a plastic lid. In the lid there is a d,esiccant consisting of silica gel.

20 pcs in tube and outea r carton.

60 pcs (3 x 20 pcs) in tube and in outer cart

Not all pack sizes may be marketed.

Marketing authorization holder and manufacturer

Orifarm Generics A/S

Energivej 15

5260 Odense S


Local representative:

Orifarm Generics AB

BOX 56048

10217 Stockholm


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