1 mg / ml solution
for injection
metoprolol tartrate
What Seloken is and what it is used for
Seloken belongs to the group of medicines beta-blockers. The active substance metoprolol reduces the effects of stress hormones in the heart. This causes the heart to slow down, preventing and treating arrhythmias and lowering blood pressure.
Seloken solution for injection is used for:
- treatment and prevention of irregular heartbeat ( arrhythmia )
- treatment of myocardial infarction
What you need to know before using Seloken
Do not use Seloken
- if you are allergic to metoprolol tartrate or any of the other ingredients of this medicine (listed in section 6) or other similar medicines ( beta-receptor blockers )
- if you have severe heart block and/or very low heart rate
- if you have very low blood pressure
- if you have severe peripheral vascular disease
Warnings and cautions
Talk to your doctor or nurse before using Seloken if you:
– have asthma or severe breathing problems for other reasons (eg COPD)
– has severe kidney disease
– has heart failure / low blood pressure
– has arrhythmias
– has spasmangina (Prinzmetal’s angina)
– has pheochromocytoma ( tumor of the adrenal medulla)
– receiving treatment for a severe allergic reaction
– prone to low blood sugar (hypoglycemia).
– has a severe acute illness with acidic substances in the body
– have window viewer disease ( peripheral vascular disease)
Other medicines and Seloken
Tell your doctor if you are taking, have recently taken, or might take any other medicines. Some medicines may affect or be affected by treatment with Seloken, for example:
• medicines for cardiovascular disease (eg amiodarone, quinidine, propafenone, diltiazem , verapamil, clonidine, disopyramide, hydralazine, digitalis/digoxin)
• antiepileptic drugs (barbituric acid derivatives)
• anti-inflammatory painkillers (eg celecoxib, indomethacin)
• medicines for acute shock and severe allergic reaction ( adrenaline )
• medicines for nasal mucosal swelling (phenylpropanolamine)
• medicines for allergies (diphenhydramine)
• medicines for fungal infections of the skin (terbinafine)
• drugs against tuberculosis (rifampicin)
• another beta-blockers, for example as eye drops
• antidepressants and Parkinson’s disease ( MAO inhibitors )
• drugs for inhalation under anesthesia (inhalation anesthetics)
• antidiabetic drugs in tablet form
• medicines for heartburn and acid reflux (cimetidine)
• antidepressants (eg paroxetine, fluoxetine, and sertraline )
Pregnancy and breastfeeding
If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before using this medicine.
Seloken is given to you during pregnancy and lactation only if necessary.
Beta-blockers including Seloken can cause harm to the fetus and premature birth. Seloken can cause slowed heart function in the fetus and the newborn baby.
Seloken is excreted in breast milk and may affect the baby.
Sloane contains sodium
This medicine contains less than 1 mmol (23 mg) sodium per ampoule, ie essentially ‘sodium-free’.
How to use Seloken
Your doctor will decide on a dose to suit you.
If you use more Seloken than you should
Your doctor will give you the dose you need, an overdose is unlikely. If you are accidentally given too high a dose of Seloken, you may experience symptoms such as nausea and vomiting, cramps, sweating, fatigue, low heart rate, blood pressure, heart failure, and shortness of breath. Unconsciousness can occur.
Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them.
Very common (more than 1 in 10 people affected): fatigue
Common (more than 1 person in 100 affected): headache, dizziness, cold hands and feet, low heart rate, palpitations, shortness of breath on exertion, abdominal pain, nausea, vomiting, diarrhea, constipation.
Uncommon (affects more than 1 in 1,000 people): chest pain, fluid retention ( edema ), weight gain, sleep disturbances, nightmares, depression, skin tingling, skin hypersensitivity, worsening tracheal problems, transient worsening of heart failure. During a heart attack, blood pressure can drop sharply.
Rare (less than 1 in 1,000 people affected): Increased sweating, hair loss, taste changes, a transient decrease in sexual function, memory disorders, confusion, nervousness, anxiety, hallucinations, psoriasis may worsen, hypersensitivity to sunlight, decreased platelet count ( thrombocytopenia ), slow heart activity, heart rhythm disorders, fainting spells, liver effects, visual disturbances, tinnitus, dry and/or irritated eyes.
No known frequency (can not be calculated from the available data): tissue death (gangrene) in patients with severe circulatory disorders, hepatitis, joint pain, muscle cramps, runny nose, dry mouth, eye inflammation, and impaired concentration.
If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or healthcare professional.
Reporting
How to store Seloken
Keep this medicine out of the sight and reach of children.
Do not store above 25 ° C.
Do not use this medicine after the expiry date which is stated on the carton. The expiration date is the last day of the specified month.
Contents of the packaging and other information
Content declaration
- The active substance is metoprolol tartrate 1 mg/ml.
- The other ingredients are sodium chloride, and water for injections.
What the medicine looks like and the contents of the pack
Clear, colorless solution.
Marketing Authorisation Holder
AstraZeneca AB, 151 85, Södertälje
tel. 08-553 260 00