Probecid – Probenecid uses, dose and side effects


500 mg probenecid tablets

What Probecid is and what it is used for

Probecid contains the active substance probenecid and is used in gout to relieve gout problems. Probecid accelerates the excretion of uric acid by preventing it from re-entering the kidneys. As a result, the blood’s content of uric acid decreases, and this leads to reduced gout problems. Probecid should be administered continuously. When treatment is stopped, the level of uric acid in the blood rises. Probecid has no immediate analgesic effect. In acute gout attacks, painkillers must therefore be used.

Probecid also inhibits the excretion of penicillin via the kidneys and can in some special cases be used to enhance the effect of penicillin. If Probecid is given together with penicillin, a higher level of penicillin is therefore obtained in the body for a longer period. The penicillin doses can then be given at longer intervals.

What you need to know before you take Probecid

Do not take Probecid:

  • if you are allergic to probenecid or any of the other ingredients of this medicine (listed in section 6).
  • if you have severe kidney damage.

Other medicines and Probecid

Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.

Probecid may affect or be affected by certain medicines such as:

  • methotrexate (medicines for tumors and disorders of the immune system)
  • naproxen, indomethacin, ketorolac (medicines for inflammation and rheumatism)
  • zidovudine (antiviral drug)
  • paracetamol (medicine for pain and fever).

Pregnancy and breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

Pregnancy: Limited experience of use during pregnancy. Therefore, consult a physician if more than temporary use of Probecid during pregnancy.

Lactation: It is unknown whether Probecid is excreted in human milk. Therefore, consult a physician before regular use during breastfeeding.

Driving and using machines

Probecid has no or negligible effect on the ability to drive and use machines.

How to take Probecid

Always take this medicine exactly as your doctor or pharmacist has told you. Ask your doctor or pharmacist if you are unsure.

Dose one should be determined by a doctor who adapts it individually for you.

The usual dose for adults with gout is 1 tablet twice daily (the first week, however, 1/2 tablet twice daily).

You should drink a lot when using Probecid for gout treatment.

The usual dose for adults when combined with penicillin is 2 tablets twice daily.

If you take more Probecid than you should

If you have ingested too much medicine or if e.g. a child ingested the medicine accidentally contact a doctor or hospital for risk assessment and advice.

Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Common (may affect more than 1 in 100 people ): Nausea

Rare ( may affect up to 1 in 1,000 people ): Skin rash

Has been reported  (occurs in an unknown number of users): Coombs positive hemolytic anemia (a special type of anemia )

How to store Probecid

Keep this medicine out of the sight and reach of children.

Do not store above 25 ° C.

Do not use this medicine after the expiry date which is stated on the carton after EXP.

The expiration date is the last day of the specified month.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

Contents of the pack and other information

Content declaration

  • The active substance is probenecid 500 mg.
  • The other ingredients are gelatin, potato starch, colloidal silica, stearic acid, talc, and magnesium stearate.

What the medicine looks like and the contents of the pack

Pack size: Plastic jar, 50 tablets.

Marketing Authorisation Holder


Recipharm Stockholm AB, Jordbro

allphamed PHARBIL Arzneimittel GmbH

Hildebrandstr. 10-12

37081 Göttingen


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