Elaprase – Idursulfase uses, dose and side effects
Elaprase is used as an enzyme replacement therapy to treat children and adults with Hunter’s syndrome (mucopolysaccharidosis II) when the level of enzyme et iduronate-2-sulphatase in the body is lower than normal and helps to improve the symptoms of the disease. If you suffer from Hunter’s syndrome, your body does not break down a carbohydrate called glycosaminoglycan, which is normally broken down in the body, but it accumulates slowly in various cells in your body. This causes these cells to function abnormally and thereby cause problems in various organs in your body, which can lead to tissue destruction, organs not functioning properly, and organ failure. Glycosaminoglycan usually accumulates in the spleen, liver, lungs, heart, and connective tissue. In some patients, glucosaminoglycan also accumulates in the brain. Elaprase contains an active substance called idursulfase which acts by acting as a replacement for the enzyme which is present at a low level, thereby breaking down this carbohydrate in the affected cells.
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