60 micrograms, 120 micrograms, and 240 micrograms lyophilized desmopressin tablets
What Minirin is and what it is used for
The active substance in Minirin acts like the natural hormone et vasopressin and regulates the kidneys’ ability to concentrate urine.
Minirin is used to treat:
- Central diabetes insipidus (pituitary disorder leading to severe thirst and large amounts of urine).
- Bed wetting in children from 6 years of age with normal ability to concentrate urine.
- Nocturnal urination in adults.
What you need to know before you use Minirin
Do not use Minirin
- if you are allergic to desmopressin or any of the other ingredients of this medicine (listed in section 6)
- if you suffer from polydipsia (abnormally high fluid intake), heart failure and other conditions that require treatment with diuretics
- if you have impaired kidney function
- if you have low sodium in your blood
- if you have disturbed hormone secretion (so-called SIADH)
Warnings and cautions
Talk to your doctor before using Minirin:
- if you are 65 years of age or older, have low blood sodium or high daily urine levels
- if you are at risk of increased pressure in the skull.
When treating bedwetting and nocturnal urination, fluid intake should be limited to the minimum possible to quench thirst during the period 1 hour before to 8 hours after taking Minirin.
Minirin should be used with caution when disturbing the fluid balance. Consult a doctor if, in connection with an acute illness, you have a disturbed fluid and/or electrolyte balance.
Other medicines and Minirin
Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines, including medicines obtained without a prescription.
The effect of Minirin can be enhanced with an increased risk of an abnormal amount of fluid remaining in the body if taken at the same time as certain medicines for:
- depression ( tricyclic antidepressants , selective serotonin reuptake inhibitors)
- psychosis (chlorpromazine)
- epilepsy (carbamazepine)
- diabetes (so-called sulphonylureas eg chloropropramide)
- diarrhea (loperamide)
- pain and inflammation (so-called NSAIDs )
The effect of Minirin may be reduced if taken at the same time as certain medicines for:
- gas in the stomach (dimethicone)
Minirin with food and drink
The effect of Minirin may be worse if the tablet is taken with a meal.
Pregnancy and breastfeeding
If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
Limited experience of use during pregnancy.
Minirin passes into breast milk but is unlikely to affect breastfed infants.
Driving and using machines
Minirin has no or negligible effect on the ability to drive and use a machine
How to use Minirin
Always use this medicine exactly as your doctor has told you. Ask your doctor or pharmacist if you are unsure.
Dose one is determined by the doctor, who adjusts it individually for you.
Minirin should always be taken at the same time as food intake.
The freeze-dried tablet is placed under the tongue.
Diabetes insipidus: The usual dose for adults and children is 1-2 tablets under the tongue (60 micrograms tablet) 3 times daily.
Bedwetting: The usual dose is 1-2 tablets (120 micrograms tablet) under the tongue at night. The medication should be given at bedtime. Fluid intake should be limited.
Nocturnal urination in adults: The usual dose is 1 tablet (60 micrograms tablet) under the tongue at night. Fluid intake should be limited.
Instructions for use
The tablets are brittle and can not be pushed through the foil as they then risk breaking. The tablets are removed from the blister cards by pulling off the aluminum cover.
Use for children
Minirin is used for treating diabetes insipidus and nocturnal bedwetting (see dosage for different treatment conditions above). Dosage is the same for children and adults.
If you forget to take Minirin
Do not take a double dose to make up for a forgotten tablet.
If you have any further questions on the use of this product, ask your doctor or pharmacist.
Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them.
If fluid intake is not limited according to the instructions above, abnormal amounts of fluid can accumulate in the body, which can lead to headaches, stomach pain, nausea/vomiting, weight gain, dizziness, confusion, malaise, dizziness, and in severe cases seizures and coma.
Adults
Very common (may affect more than 1 user in 10)
Headache
Common (may affect up to 1 in 10 people)
Hyponatremia (low sodium in the blood), dizziness, high blood pressure, stomach pain, nausea, diarrhea, constipation, vomiting, symptoms of bladder and urethra, swelling of the hands, arms, feet, or legs, fatigue
Uncommon (may affect up to 1 in 100 people)
Insomnia, drowsiness, and crawling, visual disturbances, dizziness, palpitations, low blood pressure when getting up, shortness of breath, indigestion, flatulence, bloating and tension in the stomach, sweating, itching, rash, hives, muscle spasms, muscle spasms, muscle soreness, muscle pain, weight gain, increase in liver enzymes, low potassium content in the blood.
Rare (may affect up to 1 in 1,000 people)
Confusion, allergic skin inflammation.
Has been reported (occurs in an unknown number of users)
Anaphylactic reaction (severe allergic reaction ), dehydration, hypernatremia (high sodium content in the blood), convulsions, weakness, coma.
Children
Common (may affect up to 1 in 10 people)
Headache
Uncommon (may affect up to 1 in 100 people)
Rapidly changing emotions, aggression, nausea, stomach pain, vomiting, diarrhea, symptoms of bladder and urethra, swollen hands and feet, fatigue.
Rare (may affect up to 1 in 1,000 people)
Anxiety symptoms, nightmares, mood swings, drowsiness, high blood pressure, irritation.
Has been reported (occurs in an unknown number of users)
Anaphylactic reaction (severe allergic reaction ), hyponatremia (low sodium content in the blood), abnormal behavior, emotional disturbances, depression, hallucination, insomnia, attention deficit, increased muscle movements, cramps, nosebleeds, rash, allergic dermatitis, sweating, nosebleeds.
How to store Minirin
Keep this medicine out of the sight and reach of children.
Store in the original package (sensitive to moisture, light-sensitive).
Do not use this medicine after the expiry date which is stated on the carton. The expiration date is the last day of the specified month.
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.
Contents of the package and other information
Content declaration
- The active substance is desmopressin.
- The other ingredients are gelatin (from fish), mannitol (E421) and citric acid (E330).
What the medicine looks like and contents of the pack
60 micrograms tablets: White, round tablet debossed with a drop on one side.
120 microgram tablets: White, round tablet debossed with two drops on one side.
240 micrograms tablets: White, round tablet debossed with three drops on one side.
Pack sizes:
10, 30, and 100 tablets
Not all pack sizes may be marketed.
Marketing Authorization Holder and Manufacturer
Marketing Authorisation Holder
Ferring Läkemedel AB
Box 4041
203 11 Malmö
040-691 69 00
Manufacturer
Ferring GmbH
Westland 11
24109 Kiel
Germany