100% Medical gas, compressed
oxygen
1. What Conoxia is and what it is used for
What Conoxia is
Conoxia contains oxygen that is used for inhalation. It is colorless, odorless, and tasteless and is supplied in a gas bottle that has a pressure regulator to reduce the gas pressure. The gas cylinder contains only pure oxygen.
Conoxia increases the level of oxygen in the blood (increased oxygen saturation). Conoxia means that more oxygen is transported to all tissues in the body.
What Conoxia is used for
Under normal pressure, Conoxia is used:
- for the treatment of acute or chronic hypoxia (low levels of oxygen in the blood).
- as part of the gas flow under general anesthesia, and intensive care.
- to operate a nebulizer while inhaling inhaled drugs.
- as first aid treatment with 100% oxygen in connection with diving accidents.
- for the treatment of an acute attack of Horton’s headache.
Conoxia under normal pressure can be used in all age groups except in children who should not be treated with Conoxia in an acute attack of Horton’s headache.
Under high pressure, Conoxia can be used in so-called pressure chambers to:
- Increase the content of oxygen in the blood and other tissues to reduce the risk of injury caused by:
- diving sickness, gas or air bubbles in blood vessels.
- Treat carbon monoxide poisoning
- Treat infection in tissues ( clostridium myonecrosis, gas gangrene )
Conoxia in pressure chambers can be used in all age groups (see also section 2).
2. What you need to know before using Conoxia
Inform your doctor so that he/she is aware of any medical conditions you have or may have before using Conoxia.
Conoxia should not be used in pressure chambers if you have:
- an untreated injury to the alveoli, so-called pneumothorax.
- have undergone surgery or have injuries to the body, as these events can form gas bubbles in the body.
Warnings and cautions
- Talk to a doctor if you suffer from chronic lung diseases such as asthma or chronic obstructive pulmonary disease (COPD).
- Newborns, especially premature babies, are more sensitive to oxygen than adults. Only supply the amount of oxygen that you have been instructed by your healthcare professional.
- If you have been prescribed treatment in a pressure chamber (hyperbaric oxygen therapy), the risk associated with damage to the alveoli (so-called pneumothorax) must be considered.
Children and young people
Conoxia should not be used to treat an acute attack of Horton’s headache in children and adolescents.
Experience with Conoxia under high pressure in newborns, children, and adolescents is limited.
The benefit/risk balance should be evaluated for each patient.
Other medicines and Conoxia
Tell your doctor if you are taking, have recently taken, or might take any other medicines.
If you use or have been prescribed:
bleomycin, cisplatin or doxorubicin (a medicine used to treat cancer), amiodarone(a medicine used to treat heart disease), quarantine ( nitrofurantoin ) or similar antibiotics (a medicine used to treat infection ), disulfiram (a medicine used to treat alcohol abuse), and chemicals such as paraquat, Inform your doctor before taking these medicines, as there is a risk that the treatment may increase the risk of lung damage.
Pregnancy, breastfeeding, and fertility
Conoxia under normal pressure
Conoxia can be used during pregnancy and breast-feeding. Treatment with Conoxia has no known adverse effects on fertility.
Conoxia under high pressure
If you have been prescribed Conoxia in a pressure chamber, tell your doctor if you are pregnant or think you may be pregnant, as there is a possible risk of harm to the fetus caused by oxygen stress.
There are no known side effects during breast-feeding as Conoxia is used in pressure chambers. However, breastfeeding should be avoided during the treatment itself as there is a risk that the newborn baby will be exposed to the pressure and compression in the pressure chamber. It is safe to breastfeed before and after treatment in a pressure chamber.
The effect on fertility when Conoxia is used in pressure chambers has not been studied.
Driving and using machines
You can drive after using Conoxia provided your doctor thinks you are capable of it.
3. How to use Conoxia
Always use this medicine exactly as described in this leaflet or as your doctor advised. Consult a doctor if you are unsure. Do not change the dose without first consulting a doctor. If you use this medicine at home, you will receive instructions at the first delivery, on how to use Conoxia and the equipment.
Conoxia is used for inhalation. You usually breathe through a nasal mask or mask. Either you breathe yourself – you “spontaneously breathe” or you get help to breathe from a respirator/ventilator.
Carefully read the instructions for use / patient instructions for current breathing equipment!
- The recommended dose is determined individually for you, based on your medical condition.
The usual dose for adults to treat or prevent acute hypoxia under normal pressure is 2-6 liters per minute when using a nasal mask, or 5-10 liters per minute with a face mask and 10-15 liters per minute with a reservoir mask.
- For dosing in other cases consult a doctor.
Use in children and adolescents
Conoxia under normal pressure
Children of all ages can be treated with Conoxia, but special consideration must be given to newborns. See also section 2.
Conoxia under high pressure
Children of all ages can be treated with Conoxia in a pressure chamber. The duration of treatment and how often your child should take Conoxia is determined by your doctor.
If you use more Conoxia than you should
You may experience symptoms of overdose if you use more Conoxia than you were prescribed. Too much of this medicine can:
- cause pain, dry cough, and shortness of breath
- affect lung function and in rare cases (eg in some patients suffering from chronic lung disease) cause respiratory depression and unconsciousness.
If you notice these signs of Conoxia overdose, always consult a doctor. If you experience severe symptoms, consult a doctor or hospital immediately.
If you have any further questions on the use of this product, ask your doctor.
Safety instructions
- Smoking and open flames must not occur in rooms where Conoxia is used, as this increases the risk of fire.
- Conoxia is for medical use only.
- Only connect the bottle to the connection intended for medical oxygen.
- The oxygen (containers and bottles) should only be used in areas with good ventilation.
- The pressure regulator should be opened slowly and carefully to avoid ignition.
- Never use grease, oil, or the like to lubricate threaded threads as there is a risk of self-ignition in contact with Conoxia under high pressure.
- Handle valves and equipment with clean and grease-free hands (ie no use of hand cream, etc.).
- Do not use a toaster, hairdryer, or similar electrical appliances during treatment with Conoxia.
- Never apply an oxygen mask or nasal mask directly to textiles during treatment – textiles that have become oxygen-saturated can become very flammable/flammable. If this should nevertheless occur, shake and ventilate such textiles properly.
- In case of fire – switch off the equipment.
- Gas cylinders must be carried safely in the event of a fire hazard.
- Switch off the equipment when not in use.
4. Possible side effects
Like all medicines, Conoxia can cause side effects, although not everybody gets them. Side effects are usually seen at high concentrations (above 70%) and after prolonged treatment (at least 6 – 12 hours).
Conoxia treatment under normal pressure
The most serious side effect that can occur is difficulty breathing, so-called acute pulmonary failure / respiratory distress syndrome (which can lead to pulmonary fibrosis ). If you have difficulty breathing, stop taking the medicine and seek medical attention immediately.
Uncommon (may affect up to 1 in 100 people)
Dry mucous membranes in the nose and mouth due to the gas being dry. Pain when breathing, dry cough, and shortness of breath.
Rare (may affect up to 1 in 1,000 people)
In newborns exposed to high oxygen concentrations: Damage to the eye which may lead to impaired vision.
Respiratory depression
Very rare (may affect up to 1 in 10,000 people)
Difficulty breathing Acute pulmonary failure / respiratory distress syndrome. Burn
If you get any of these side effects, stop taking the treatment and consult a doctor.
Conoxia treatment under high pressure
The most serious side effects are confusion and seizures ( epilepsy ). Medical personnel is always present when you are being treated with Conoxia under high pressure. Your doctor will take action if you notice any of these side effects.
Uncommon (may affect up to 1 in 100 people)
Feeling of pressure in the middle ear, cracked eardrum
Rare (may affect up to 1 in 1,000 people)
Feeling of pressure or pain in the nose
Very rare (may affect up to 1 in 10,000 people)
Anxiety, impaired vision, barotrauma (tissue damage due to the pressure effect), confusion, unconsciousness, and seizures ( epilepsy ).
Additional side effects are in children
Conoxia treatment under normal pressure
Special consideration must be given when treating newborns as they are more sensitive to certain side effects than other patient groups.
The most serious adverse reactions were of the newborn is damage to the eye (retrolental fibroplasia ) that can cause vision loss and lung damage (called bronchial pulmonary dysplasia).
If you suspect that your child has any of these side effects, stop the treatment and contact your doctor immediately.
Apart from these serious side effects just described, there are no other known side effects in children other than those reported in adults.
Conoxia treatment under high pressure
There are no other known side effects caused by Conoxia in pressure chambers than those reported in adults.
Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist, or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly to the Medical Products Agency, www.lakemedelsverket.se. By reporting side effects, you can help increase drug safety information. Postal address
5. How to store Conoxia
Keep this medicine out of the sight and reach of children.
- Store the bottle in a well-ventilated place where it is not exposed to strong heat.
- Keep the bottle clean and dry.
- Make sure that the gas cylinders are not exposed to shocks and falls.
- Store away from flammable substances.
- Do not use this medicine after the expiry date which is stated on the label after EXP. The expiration date is the last day of the specified month.
- Do not use this medicine if the gas bottle does not have an intact seal when it is delivered to you.
- Must be stored and transported with the valve closed and the protective plug and cover fitted where such occurs.
- The bottle must be returned to the supplier.
6. Contents of the packaging and other information
Content declaration
- The active substance is 100% oxygen. (Chemical name: O 2 ).
- No other ingredients are included in Conoxia.
What the medicine looks like and the contents of the pack
The shoulder of the gas cylinder is marked with white color for oxygen. The body of the gas bottle is white (medical gas).
Bottles/packages filled to 200 bar, 153 bar * and 138 bar **, respectively, contain about X liters of gas at atmospheric pressure and 15 ° C according to the table below: Show larger
| Bottle size in liters | 1 | 1.1 | 1.2 | 2 | 2.5 | 3 | 4 | 4.7 | 5 |
| Liter gas | 210 | 230 | 260 | 430 | 530 | 630 | 850 | 1000 | 1060 |
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| Bottle size in liters | 6 | 10 | 15 | 20 | 21.3 * | 21.3 ** | 50 |
| Liter gas | 1260 | 2120 | 3180 | 4200 | 3450 | 2900 | 10 600 |
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| Package size in liters | 2 x 21.3 * | 10×50 | 12×50 |
| Liter gas | 6900 | 106 000 | 128 000 |
Not all pack sizes may be marketed.
Manufacturer
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This medicinal product is authorized under the European Economic Area under the names: Show larger
| Denmark | Conoxia |
| Estonia | CONOXIA |
| Finland | CONOXIA |
| Iceland | CONOXIA |
| Latvia | CONOXIA |
| Lithuania | CONOXIA |
| Norway | Conoxia |