Trombyl 75 mg or 160 mg tablets of Acetylsalicylic Acid
What Trombyl Is And What It Is Used For?
Thrombyl is a so-called blood thinner, which reduces the risk of blood clot formation by preventing platelets from clumping together.
Trombyl medication is used by patients who have severe angina pectoris ( unstable angina pectoris) or who have previously suffered a heart or brain infarction ( stroke ). Thrombyl helps to reduce the risk of recurrence of a new heart attack by preventing clots from forming in the blood vessels of the heart and brain.
What You Need To Know Before Using Trombyl
Do Not Use Trombyl
- If you are allergic to acetylsalicylic acid, other medicines with pain-relieving and anti-inflammatory effects (so-called non-steroidal anti-inflammatory agents), or any other ingredient in this medicine (listed in section 6).
- If you have had allergic symptoms (e.g. breathing difficulties, nasal congestion and runny nose, skin rash) when you have taken acetylsalicylic acid or similar anti-inflammatory agents.
- If you suffer from stomach ulcers.
- If you have hemophilia.
- If you have a deficiency of the platelets that help to clot the blood.
- If you have cirrhosis
- If you have severe heart failure.
The daily dose of Trombyl must not exceed 100 mg during the last three months of pregnancy (see section Pregnancy and breastfeeding).
Warnings And Precautions
Talk to your doctor or pharmacist before taking Trombyl.
Inform the doctor before starting treatment with Trombyl:
- If you are treated with medicines that prevent the formation of blood clots or are diuretics
- If you have gastrointestinal disease
- If you have heart failure
- If you have kidney or liver disease.
People with bronchial asthma, chronic lung disease, hay fever or nasal polyps have an increased risk of hypersensitivity reaction.
You must seek medical attention immediately if your symptoms worsen or if you experience severe or unexpected side effects, e.g. unusual bleeding, severe skin rash, or other signs of severe allergy (see section “Possible side effects”).
Other Medicines And Trombyl
Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.
The effect of the treatment can be affected if Trombyl medication is taken at the same time as certain other medicines against:
- Blood clots (eg warfarin)
- Rejection of organs after transplantation
- Ciclosporin
- Tacrolimus
- High blood pressure e.g.
- Diuretics
- ACE inhibitors
- Pain and inflammation e.g.
- Corticosteroids
- NSAIDs
- Gout
- Probenecid
- Cancer and rheumatoid arthritis
- Methotrexate
- Heart rhythm disturbances
- Digoxin
- Manic depressive disorder
- Lithium
- Epilepsy
- Phenytoin
- Valproic acid
- Diabetes type II
- Sulphonylureas
- High blood fats
- Nicotinic acid
- Pain and fever (metamizole). Metamizole can reduce the effect of aspirin on platelet aggregation ( blood cells that stick together and form a blood clot) when taken at the same time. Therefore, this combination should be used with caution in patients taking a low dose of aspirin for cardioprotection.
Trombyl With Food, Drink, And Alcohol
Thrombyl in combination with alcohol can increase the risk of bleeding in the gastrointestinal tract.
Pregnancy, Breastfeeding, And Fertility
If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.
Pregnant women should not take acetylsalicylic acid during pregnancy unless prescribed by a doctor. The daily dose must not exceed 100 mg during the last three months of pregnancy (see section Do not take Trombyl). Regular or high doses of this drug during late pregnancy can cause serious complications for the mother and baby.
Acetylsalicylic acid passes into breast milk but probably does not affect children who are breastfed. However, talk to your doctor if you use Trombyl more than occasionally during breastfeeding.
Trombyl, like many anti-inflammatory drugs (so-called NSAIDs ), can make it difficult to get pregnant and is therefore not recommended for women who are trying to get pregnant.
Driving Ability And Use Of Machinery
Trombyl has no known effects on the ability to drive and use machines.
You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased vigilance. One of the factors that can affect your ability in these respects is the use of drugs due to their effects and/or side effects. A description of these effects and side effects can be found in other sections. Read all the information in this leaflet for guidance. Discuss with a doctor or pharmacist if you are unsure.
How To Use Trombyl
Trombyl 75 mg uses
- Always take this medicine as directed by your doctor or pharmacist. Ask your doctor or pharmacist if you are unsure.
- The dose must be determined by a doctor who adjusts it individually for you.
- The usual dose is 1 tablet a day.
If You Have Used Too Much Trombyl
If you have ingested too much medicine or if, for example, a child has accidentally ingested the medicine, contact a doctor or hospital for an assessment of the risk and advice.
If You Forget To Use Trombyl
- Do not take a double dose to make up for a missed tablet.
If you have any further questions about this medicine, ask your doctor or pharmacist.
Possible Trombyl Side Effects
Like all medicines, this medicine can cause side effects, although not everybody gets them.
If you notice any of the serious side effects below, stop taking Trombyl and contact your doctor immediately.
Rare Trombyl side effects (occur in less than 1 patient in 1,000):
- Bleeding in the gastrointestinal tract can appear as black stools
- Brain hemorrhage, symptoms can be
- Numbness or paralysis in the face, arms, and legs, usually in one half of the body
- Speech difficulties
- Confusion
- Visual disturbances
- Dizziness
- Problems with balance
- Severe headache
- Severe skin rashes such as:
- Reddish rash that often appears first on the upper body, the rash appears as target-like or round spots, often with blisters in the center, peeling skin, and sores in the mouth, throat, nose, eyes, and around the genitals. These severe skin rashes may be preceded by fever and flu-like symptoms (Steven Johnson syndrome, toxic epidermal necrolysis )
- Widespread skin rash, fever, and enlarged lymph nodes that appear about 2-6 weeks (sometimes up to 8 weeks) after starting treatment (drug reaction with eosinophilia and systemic symptoms (DRESS syndrome))
Other side effects ar
Common Trombyl side effects (occurs in more than 1 patient in 100):
- Stomach upset
- Increased risk of bleeding
Uncommon side effects (occurs in more than 1 patient in 1,000):
- Hpersensitivity reactions such as
- Hives
- Allergic rhinitis
- Asthma
Rare side effects (occur in less than 1 patient in 1,000):
- Kidney damage
- People with known allergies or asthma are at increased risk of a hypersensitivity reaction. Smaller blood losses can in some cases lead to anemia.
- Dizziness and ringing in the ears can be symptoms of overdose.
How Trombyl Should Be Stored
- Keep this medicine out of the sight and reach of children.
- Use before the expiry date stated on the label, carton, and blister after Exp or EXP. The expiration date is the last day of the specified month.
- The cans contain desiccant which must remain in the packaging.
- Plastic cans: No special storage instructions.
- Blister packs 75 mg: Store at a maximum of 30 ºC.
- Blister packs 160 mg: No special storage instructions.
Medicines must not be thrown into the drain or among the household waste. Ask the pharmacist how to dispose of medicines that are no longer used. These measures will help to protect the environment.
Contents Of The Packaging And Other Information
Contents Declaration
- The active substance is acetylsalicylic acid 75 mg and 160 mg respectively.
- Other ingredients are
- Magnesium oxide, corn starch
- Microcrystalline cellulose (only 75 mg)
- Talc
- Gelatin
- Silicon dioxide
Appearance And Package Sizes Of The Medicine
| Trombyl 75mg: | Single dose blister containing 50×1 tablets, blister containing 98 tablets, plastic container containing 100 tablets, and plastic container for dose dispensing containing 1000 tablets. |
Trombyl 160 mg: | Single-dose blister containing 50×1 tablets, a blister containing 98 tablets, and a plastic container containing 100 tablets. |
Marketing Authorization Holder And Manufacturer
Pfizer AB
191 90 Sollentuna
Phone: 08-550 520 00
Email: eumedinfo@pfizer.com