{"id":9058,"date":"2021-03-24T07:58:59","date_gmt":"2021-03-24T07:58:59","guid":{"rendered":"https:\/\/zeepedia.com\/?p=9058"},"modified":"2021-04-12T14:07:25","modified_gmt":"2021-04-12T14:07:25","slug":"fragmin","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/fragmin\/","title":{"rendered":"Fragmin &#8211; Dalteparinnatrium uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n2500 IU, 5000 IU, 7500 IU, 10000 IU, 12500 IU, 15000 IU, 18000 IU solution for injection, pre-filled syringe.&nbsp;2500 IU \/ ml, 10000 IU \/ ml solution for injection.&nbsp;10000 IU \/ ml, 25000 IU \/ ml solution for injection (with preservative).<br>dalteparinnatrium<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Fragmin is and what it is used for<\/h2>\n\n\n\n<p>Fragmin is an antithrombotic agent (anticoagulant).<br><\/p>\n\n\n\n<p>Fragmin is used:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>For the treatment of blood clots in deep veins (blood vessels) and lungs.<\/li><li>For the treatment and prevention of blood clots in deep veins (blood vessels) and lungs in cancer patients.<\/li><li>Prevention of&nbsp;coagulation&nbsp;in&nbsp;dialysis&nbsp;or blood filtration in renal impairment.<\/li><li>Prevention of blood clots during surgical procedures and in case of temporarily reduced mobility due to&nbsp;acute&nbsp;illness such as&nbsp;heart failure&nbsp;or severe&nbsp;infection.<\/li><li>Treatment of unstable coronary heart disease.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before using Fragmin<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Fragmin<\/h2>\n\n\n\n<p><em>Fragmin should not be used if you have or have had any of the following conditions:<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are allergic to dalteparin,&nbsp;heparin,&nbsp;or any of the other ingredients of this medicine (listed in section 6).<\/li><li>Thrombocytopenia&nbsp;(decreased number of&nbsp;platelets&nbsp;in the blood).&nbsp;Your doctor has told you if you suffer from this.<\/li><li>Gastrointestinal or duodenal ulcer.<\/li><li>Cerebral hemorrhage or another active hemorrhage.<\/li><li>Increased tendency for bleeding<\/li><li>Bacterial&nbsp;infection&nbsp;of the heart (&nbsp;septic&nbsp;endocarditis&nbsp;).<\/li><li>Injury or surgery in the&nbsp;central nervous system, eyes, or ears.<\/li><li>Spinal anesthesia should be avoided during treatment with Fragmin in&nbsp;acute&nbsp;deep&nbsp;vein thrombosis,&nbsp;pulmonary embolism,&nbsp;or unstable coronary heart disease.<\/li><\/ul>\n\n\n\n<p>Fragmin 10000 IU \/ ml,&nbsp;solution for injection&nbsp;(with&nbsp;preservative&nbsp;), and Fragmin 25000 IU \/ ml,&nbsp;solution for injection&nbsp;(with&nbsp;preservative&nbsp;) contain benzyl alcohol as a&nbsp;preservative.&nbsp;These should not be given to children under 3 years of age, as benzyl alcohol may cause poisoning or allergic reactions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p><em>You must tell your doctor if you have or have had any of the following conditions as they may affect the effect of Fragmin treatment:<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Thrombocytopenia&nbsp;and platelet dysfunction.<\/li><li>Severe hepatic or renal impairment.<\/li><li>Uncontrolled high&nbsp;blood pressure.<\/li><li>Changes in the retina of the eye, due to&nbsp;diabetes&nbsp;or high&nbsp;blood pressure.<\/li><li>Diabetes<\/li><li>Elevated potassium levels<\/li><li>Acute&nbsp;myocardial infarction.<\/li><li>If you are going to have an operation, you must inform your doctor about this.<\/li><li>If you are older.&nbsp;There may be an increased risk of bleeding.<\/li><li>If you are allergic or suspect that you are allergic to latex (natural rubber) or if the needle guard on Fragmin pre-filled syringes will be handled by someone with a known or suspected&nbsp;allergy&nbsp;to latex (natural rubber).&nbsp;The needle guard on Fragmin pre-filled syringes may contain latex (natural rubber) which may cause severe allergic reactions in individuals who are allergic to latex (natural rubber).<\/li><\/ul>\n\n\n\n<p>It is very important that you carefully follow the instructions given to you by your doctor or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children<\/h2>\n\n\n\n<p>The dosage recommendations for children are based on clinical experience, there are limited data from&nbsp;clinical trials&nbsp;that will help your doctor calculate the&nbsp;dose&nbsp;of Fragmin.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Fragmin<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.<\/p>\n\n\n\n<p>The treatment effect may be affected if this medicine is taken at the same time as other medicines.<\/p>\n\n\n\n<p>Some medicines that affect blood and&nbsp;coagulation&nbsp;may increase the risk of bleeding during Fragmin treatment, e.g.&nbsp;acetylsalicylic acid&nbsp;and other painkillers and anti-inflammatory drugs called&nbsp;NSAIDs.&nbsp;If you are being treated for unstable coronary heart disease, your doctor may&nbsp;prescribe&nbsp;concomitant treatment with&nbsp;acetylsalicylic acid.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>There are no known risks of using Fragmin during pregnancy.<br><\/p>\n\n\n\n<p>Fragmin 10000 IU \/ ml and Fragmin 25000 IU \/ ml,&nbsp;solution for injection, contains benzyl alcohol as a&nbsp;preservative.&nbsp;Benzyl alcohol may pass through the placenta.&nbsp;<em>Fragmin without&nbsp;preservatives&nbsp;should therefore be used during pregnancy.<\/em><br><\/p>\n\n\n\n<p>Fragmin passes into breast milk.<\/p>\n\n\n\n<p>Therefore consult a doctor before use during breast-feeding.<br><\/p>\n\n\n\n<p>Data from&nbsp;clinical trials&nbsp;do not indicate that Fragmin affects&nbsp;fertility.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Fragmin does not affect the ability to drive.&nbsp;You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use Fragmin<\/h2>\n\n\n\n<p>Always use this medicine exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.&nbsp;Dose&nbsp;one is determined by your doctor who adjusts it individually for you.<\/p>\n\n\n\n<p>Fragmin is usually injected by a doctor or nurse.&nbsp;In some cases, you may need to be treated with Fragmin for a longer period after leaving the hospital.&nbsp;In this case, your doctor or nurse will teach you to inject Fragmin yourself before you leave the hospital.<br><\/p>\n\n\n\n<p>Fragmin should be injected at the same time each day.<br><\/p>\n\n\n\n<p><strong>Use for children<\/strong><\/p>\n\n\n\n<p>Dose&nbsp;one will be based on both the child&#8217;s age and weight.&nbsp;Younger children may need a little more Fragmin per kg than adults.&nbsp;Your doctor will determine the right&nbsp;dose&nbsp;for you.&nbsp;Healthcare professionals can take blood samples during your treatment to check the effects of Fragmin.<br><\/p>\n\n\n\n<p>Instructions for use for&nbsp;injecting&nbsp;Fragmin into pre-filled syringes<\/p>\n\n\n\n<p>Fragmin is injected under the skin.&nbsp;You can inject yourself in the abdomen or the thickest part of the upper part of the buttocks.&nbsp;Your doctor or nurse will tell you where it is most suitable for you to inject.&nbsp;In order not to get sore at the injection site, you should vary the injection site.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>&nbsp;<\/td><td>1.Before&nbsp;injection,&nbsp;clean the injection site with disinfectant or soap and water.&nbsp;Wipe clean with a towel.&nbsp;On the abdomen, the fat layer can be so thin that you have to lift a fold of skin to be able to inject.&nbsp;You do not have to pinch so hard, but keep a firm grip throughout the&nbsp;injection.&nbsp;If you inject into the buttocks, the fat layer is so thick that you do not need to lift a skin fold.<\/td><\/tr><tr><td>&nbsp;<\/td><td>2.Remove the entire protective paper on the syringe package.&nbsp;Turn the plastic package over so that you have the syringe in your hand, without pressing the plunger.<\/td><\/tr><tr><td>&nbsp;<\/td><td>3.Grasp the tip of the colored puncture guard and bend it away from the syringe (see picture below).&nbsp;Remove the gray needle cover by pulling it straight out.&nbsp;The syringe contains a small air bubble that you do not need to take into account.&nbsp;Most of it remains in the top of the syringe and the small amount of air that can get into the adipose tissue is harmless.<\/td><\/tr><tr><td>&nbsp;<\/td><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=19880318000040#\" rel=\"noopener\"><\/a><br><\/td><\/tr><tr><td>&nbsp;<\/td><td>4.Lift the skin on the abdomen so that you get a skin fold between the fingers.&nbsp;Then hold the grip throughout the&nbsp;injection.&nbsp;Insert the needle at a 45 \u00b0 -90 \u00b0 angle in the middle of the skin fold as far as it will go (see picture below).<\/td><\/tr><tr><td>&nbsp;<\/td><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=19880318000040#\" rel=\"noopener\"><\/a><br><\/td><\/tr><tr><td>&nbsp;<\/td><td>5.Press the plunger and&nbsp;slowly&nbsp;inject&nbsp;all the Fragmin that is in the syringe.&nbsp;Before pulling out the needle completely, pull it out in half and count to five.&nbsp;Then pull out the entire needle. D o does not rub the skin after&nbsp;injection&nbsp;one.<\/td><\/tr><tr><td>6. Place the colored needle guard against a hard, stable surface, turn the syringe with one hand upwards so that the needle is forced into the needle guard where it locks in place (see picture below).&nbsp;Then bend the needle further until the syringe exceeds a 45 \u00b0 angle to the flat surface.<\/td><\/tr><tr><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=19880318000040#\" rel=\"noopener\"><\/a><br><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>The syringe can now be taken to a hospital or pharmacy for destruction.<br><\/p>\n\n\n\n<p>Ask your doctor or nurse if you have any questions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Fragmin than you should<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if e.g.&nbsp;If a child has inadvertently ingested the medicine, contact a doctor, hospital, or the Poison Information Center for risk assessment and advice.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Fragmin<\/h2>\n\n\n\n<p>If you forget to take a&nbsp;dose, take it as soon as possible.&nbsp;However, if it is soon time to take the next&nbsp;dose, skip the missed&nbsp;dose&nbsp;and take the next&nbsp;dose&nbsp;at the usual time.&nbsp;Do not take a double&nbsp;dose&nbsp;to make up for a forgotten&nbsp;dose.&nbsp;Tell your doctor if you forget, or think you may have forgotten, to take your&nbsp;dose<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects,&nbsp;although not everybody gets them.<\/p>\n\n\n\n<p>About 3 out of 100 of the patients treated for prevention are at risk of&nbsp;side effects.<br><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>Common (affects more than 1 user in 100)<\/td><td>Bruising at the injection site, pain at the injection site. Decreased&nbsp;platelet count&nbsp;(&nbsp;thrombocytopenia&nbsp;) which is usually mild and recurs during treatment.BleedingTransient increase in liver enzymes<\/td><\/tr><tr><td>Uncommon (affects less than 1 user in 100)<\/td><td>Hypersensitivity<\/td><\/tr><tr><td>Rare (affects less than 1 user in 1,000)<\/td><td>Local tissue death, transient hair loss<\/td><\/tr><tr><td>No known frequency (cannot be calculated from the available data)<\/td><td>Severe&nbsp;hypersensitivity reaction&nbsp;with symptoms such as&nbsp;itching, rash, swelling (&nbsp;edema&nbsp;), and shortness of breathRashBleeding behind the abdominal cavity, in some cases life-threatening bleeding in or around the brain, in some cases life-threatening bleeding in or around the spinal cord<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>The risk of bleeding is dose-dependent.<br><\/p>\n\n\n\n<p><strong>Children<\/strong><\/p>\n\n\n\n<p>The side effects&nbsp;in children are expected to be similar to those in adults, but there is little information on possible&nbsp;side effects&nbsp;with long-term use in children.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Fragmin<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>Store below 25&nbsp;<sup>\u00b0<\/sup>&nbsp;C.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton.<br><\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>&#8211; The active substance is dalteparin sodium.&nbsp;1 ml contains 2,500, 10,000, 12,500 and 25,000 IU anti-Xa, respectively.&nbsp;A pre-filled&nbsp;syringe&nbsp;contains 2,500, 5,000, 7,500, 10,000, 12,500, 15,000 and 18,000 IU anti-Xa, respectively.<\/p>\n\n\n\n<p>&#8211; The other ingredients are:<\/p>\n\n\n\n<p><em>Pre-filled syringe:<\/em>&nbsp;Water for injections.&nbsp;The pre-filled&nbsp;syringe&nbsp;2500 IU also contains sodium chloride.<\/p>\n\n\n\n<p><em>Preservative-free<\/em>&nbsp;solution for injection<em>:<\/em>&nbsp;Sodium chloride, water for injections<\/p>\n\n\n\n<p><em>Liquid for injection&nbsp;with preservative:<\/em>&nbsp;Benzyl alcohol, water for injections<\/p>\n\n\n\n<p>Do not give to children under 3 years, as benzyl alcohol may cause poisoning or allergic reactions.&nbsp;Other formulations without benzyl alcohol are available.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Fragmin is a clear colorless liquid.<br><\/p>\n\n\n\n<p><em>Packaging sizes<\/em><\/p>\n\n\n\n<p><em>Pre-filled&nbsp;syringe<\/em><\/p>\n\n\n\n<p>2500 IU (0.2 ml at 12500 IU \/ ml): 2&#215;1, 10&#215;1, 100&#215;1 pcs<\/p>\n\n\n\n<p>5000 IU (0.2 ml at 25000 IU \/ ml): 2&#215;1, 5&#215;1, 10&#215;1, 25&#215;1, 100&#215;1 pcs<\/p>\n\n\n\n<p>7500 IU (0.3 ml at 25000 IU \/ ml): 5&#215;1, 10&#215;1 st<\/p>\n\n\n\n<p>10000 IU (0.4 ml at 25000 IU \/ ml): 2&#215;1, 5&#215;1, 6x5x1 pcs<\/p>\n\n\n\n<p>12500 IU (0.5 ml at 25000 IU \/ ml): 2&#215;1, 5&#215;1, 6x5x1 pcs<\/p>\n\n\n\n<p>15000 IU (0.6 ml at 25000 IU \/ ml): 2&#215;1, 5&#215;1, 6x5x1 pcs<\/p>\n\n\n\n<p>18000 IU (0.72 ml at 25000 IU \/ ml): 2&#215;1, 5&#215;1, 6x5x1 pcs<br><\/p>\n\n\n\n<p><em>Solution for injection&nbsp;without&nbsp;preservatives<\/em><\/p>\n\n\n\n<p>2500 IU \/ ml, solution for injection: 10&#215;4 ml vials<\/p>\n\n\n\n<p>10000 IU \/ mL, injection: 10&#215;1 ml&nbsp;ampoule&nbsp;s<br><\/p>\n\n\n\n<p><em>Solution for injection&nbsp;with&nbsp;preservatives<\/em><\/p>\n\n\n\n<p>10000 IU \/ ml solution for injection: 1&#215;10 ml&nbsp;vial<\/p>\n\n\n\n<p>25000 IU \/ ml solution for injection: 1&#215;4 ml&nbsp;vial<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Pfizer AB<\/p>\n\n\n\n<p>191 90 Sollentuna<\/p>\n\n\n\n<p>Phone: 08-550 520 00<\/p>\n\n\n\n<p>Email: eumedinfo@pfizer.com<\/p>\n","protected":false},"excerpt":{"rendered":"<p> 2500 IU, 5000 IU, 7500 IU, 10000 IU, 12500 IU, 15000 IU, 18000 IU solution for injection, pre-filled syringe. 2500 IU \/ ml, 10000 IU \/ ml solution for injection. 10000 IU \/ ml, 25000 IU \/ ml solution for injection (with preservative).<br \/>\ndalteparinnatrium<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2206,2200],"tags":[2431,2305,2306,2215,2216,2212,2213,2307],"class_list":["post-9058","post","type-post","status-publish","format-standard","hentry","category-f","category-medicines","tag-dalteparinnatrium","tag-fragmin","tag-how-to-use-fragmin","tag-injection","tag-injections","tag-medicine","tag-medicines","tag-side-effects-of-fragmin"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/9058","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=9058"}],"version-history":[{"count":6,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/9058\/revisions"}],"predecessor-version":[{"id":9929,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/9058\/revisions\/9929"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=9058"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=9058"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=9058"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}