{"id":8915,"date":"2021-03-20T11:37:03","date_gmt":"2021-03-20T11:37:03","guid":{"rendered":"https:\/\/zeepedia.com\/?p=8915"},"modified":"2021-04-12T15:02:44","modified_gmt":"2021-04-12T15:02:44","slug":"fluorescite","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/fluorescite\/","title":{"rendered":"Fluorescite &#8211; Fluorescein uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n100 mg \/ ml&nbsp;injection&nbsp;solution<br>fluorescein<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Fluorescite 100 mg\/ml solution for injection is and what it is used for<\/h2>\n\n\n\n<p>Fluorescite 100 mg\/ml solution for injection is a solution of a dye that makes the blood vessels in the back of the eye visible during an eye examination (this procedure is called&nbsp;fluorescein angiography&nbsp;).&nbsp;The drug is for diagnostic use only.&nbsp;It is not used to treat any disease.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you are given Fluorescite 100 mg\/ml solution for injection<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">You should NOT be given Fluorescite 100 mg\/ml solution for injection<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic (hypersensitive) to&nbsp;fluorescein&nbsp;or any of the other ingredients of this medicine (listed in section 6).&nbsp;Tell your doctor if you think you are allergic or hypersensitive to&nbsp;fluorescein&nbsp;or any of the other ingredients of Fluorescite 100 mg\/ml&nbsp;solution for injection.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p><strong>Talk to your doctor before giving Fluorescite 100 mg\/ml&nbsp;solution for injection<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>if you have any other illness, e.g.&nbsp;cardiovascular disease or diabetes (&nbsp;diabetes mellitus&nbsp;)<\/strong><\/li><li><strong>if you have impaired kidney function.&nbsp;<\/strong>Then your doctor may&nbsp;normally&nbsp;give you a lower&nbsp;dose of&nbsp;Fluorescite 100 mg\/ml solution for injection.<\/li><li><strong>if you are taking&nbsp;beta-blocker&nbsp;medicines<\/strong>.&nbsp;Beta-blockers&nbsp;are used to treat high&nbsp;blood pressure&nbsp;and certain heart diseases and are also used as&nbsp;eye drops&nbsp;for the treatment of&nbsp;glaucoma&nbsp;(&nbsp;glaucoma&nbsp;).&nbsp;An&nbsp;allergic reaction&nbsp;to Fluorescite 100 mg\/ml solution for injection may cause a rapid drop in blood pressure.&nbsp;Blood pressure&nbsp;may be lower in patients treated with&nbsp;beta-blockers&nbsp;(eg atenolol, sotalol, propranolol,&nbsp;metoprolol, bisoprolol).<\/li><li><strong>if you have reacted to&nbsp;fluorescein&nbsp;before<\/strong>.&nbsp;You may need to get another medicine to reduce nausea.<\/li><li><strong>if you are on a low sodium diet<\/strong>.&nbsp;Fluorescite 100 mg \/ ml solution for injection contains up to 3.15 mmol (72.45 mg)&nbsp;sodium&nbsp;per&nbsp;dose&nbsp;.<\/li><\/ul>\n\n\n\n<p>If any of the above apply to you or you are not sure, tell your doctor before giving Fluorescite 100 mg\/ml&nbsp;solution for injection.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Fluorescite 100 mg\/ml solution for injection<\/h2>\n\n\n\n<p>Tell your doctor if you are taking, have recently taken, or might take any other medicines, including medicines obtained without a prescription.&nbsp;This medicine must not be used with other medicines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p><strong>Pregnancy and&nbsp;fertility<\/strong><\/p>\n\n\n\n<p>If you are pregnant, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine.&nbsp;If you are pregnant, Fluorescite 100 mg\/ml&nbsp;solution for injection&nbsp;should only be used after your doctor has prescribed it.&nbsp;Due to limited experience with this medicine, the use of Fluorescite 100 mg\/ml&nbsp;solution&nbsp;for&nbsp;injection&nbsp;should be used with caution&nbsp;during pregnancy.<br><\/p>\n\n\n\n<p><strong>Breast-feeding<\/strong><\/p>\n\n\n\n<p>Tell your doctor if you are breast-feeding.&nbsp;Fluorescein, the active substance in Fluorescite 100 mg\/ml&nbsp;solution for injection, passes into breast milk and is slowly excreted therefrom.&nbsp;Therefore, you should not breast-feed for 7 days after administration of Fluorescite 100 mg\/ml&nbsp;solution for injection.&nbsp;During these days, breast milk should be pumped out and discarded.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>As part of your eye examination, you may be given&nbsp;eye drops&nbsp;that dilate the&nbsp;pupil.&nbsp;This can temporarily affect your vision and your ability to drive and use machines.&nbsp;Do not drive or use any tools or machines until your vision has returned to normal.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Important information about some of the ingredients of Fluorescite<\/h2>\n\n\n\n<p>This medicine contains up to 3.15 mmol (72.45 mg)&nbsp;sodium&nbsp;per&nbsp;dose&nbsp;&nbsp;This should be considered by patients on a low-salt diet.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to give Fluorescite 100 mg\/ml solution for injection<\/h2>\n\n\n\n<p>Fluorescite 100 mg\/ml&nbsp;solution for injection&nbsp;is given by your doctor.&nbsp;Depending on your condition, the&nbsp;dose&nbsp;may need to be adjusted.&nbsp;As this is a product that has not been studied in children, there is no information on the appropriate&nbsp;dose&nbsp;for children.&nbsp;Fluorescite 100 mg\/ml&nbsp;solution for injection&nbsp;should therefore not be used in patients below 18 years of age as efficacy and safety have not been established in this group.<br><\/p>\n\n\n\n<p><strong>Injection<\/strong><\/p>\n\n\n\n<p>A bottle of Fluorescite 100 mg\/ml&nbsp;solution for injection is&nbsp;usually given&nbsp;into a vein in the arm.&nbsp;Fluorescite 100 mg\/ml&nbsp;solution for injection&nbsp;should not be injected intrathecally (into the spinal canal) or intraarterially (into&nbsp;arteries&nbsp;).<br><\/p>\n\n\n\n<p>If you have any further questions on the use of Fluorescite 100 mg\/ml&nbsp;solution for injection, contact your doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, Fluorescite 100 mg\/ml&nbsp;solution for injection&nbsp;can cause&nbsp;side effects, although not everybody gets them.&nbsp;The following&nbsp;side effects&nbsp;have been reported:<br><\/p>\n\n\n\n<p><strong>Very common&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p><em>May affect more than 1 user in 10<\/em><\/p>\n\n\n\n<p>Nausea.<br><\/p>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p><em>May affect up to 1 in 10 users<\/em><\/p>\n\n\n\n<p>Vomiting, stomach problems, fainting,&nbsp;itching, fluid, or blood leaks from the vein.<br><\/p>\n\n\n\n<p><strong>Uncommon&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p><em>May affect up to 1 in 100 users<\/em><\/p>\n\n\n\n<p>Headache, dizziness, tingling in the skin, cough, feeling of a tight throat, abdominal pain, rash, impaired speech, pain, feeling hot, hypersensitivity,&nbsp;inflammation&nbsp;of the veins.<br><\/p>\n\n\n\n<p><strong>Rare&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p><em>May affect up to 1 in 1,000 users<\/em><\/p>\n\n\n\n<p>Severe&nbsp;allergic reaction, cardiac arrest, low&nbsp;blood pressure,&nbsp;shock, breathing problems, or wheezing (&nbsp;bronchospasm&nbsp;).<br><\/p>\n\n\n\n<p><strong>Very rare&nbsp;side effect&nbsp;s<\/strong><\/p>\n\n\n\n<p><em>May affect up to 1 in 10,000 users<\/em><\/p>\n\n\n\n<p>Anaphylactic&nbsp;shock, seizures,&nbsp;angina pectoris, low heart rate, fast heart rate, high&nbsp;blood pressure, vascular spasm, calf muscle spasms, poor circulation, reddening of the skin, pallor, hot flashes, respiratory arrest, fluid in the lungs,&nbsp;asthma, impaired respiratory function, swelling, swelling, swelling, sneezing.<br><\/p>\n\n\n\n<p><strong>Has been reported<\/strong><\/p>\n\n\n\n<p><em>Occurs in an unknown number of users<\/em><\/p>\n\n\n\n<p>Stroke, chest pain, unconsciousness, tremors, abnormal or decreased sensitivity of the skin, rash, cold sweats, dermatitis, sweating,&nbsp;edema&nbsp;(swelling), general weakness, heart attack, throat irritation, skin discoloration, abnormal taste sensation, and chills.<br><\/p>\n\n\n\n<p>After administration of Fluorescite 100 mg\/ml&nbsp;solution for injection, you may experience a change in taste.&nbsp;Your skin may turn yellow;&nbsp;this color usually disappears after 6-12 hours.&nbsp;Your urine may also turn bright yellow;&nbsp;it may take 24-36 hours before the color returns to normal.<br><\/p>\n\n\n\n<p>After&nbsp;injection,&nbsp;inflammation&nbsp;of the vein and blood clots in the vein may occur.&nbsp;If the solution leaks from the vein during&nbsp;injection, the skin may be damaged and the vein, nerves, and&nbsp;tissue&nbsp;near the injection site may become inflamed.&nbsp;This can lead to severe pain.&nbsp;If you experience pain or other problems at the injection site, contact your doctor.&nbsp;You may need to get painkillers or other treatment to alleviate the problems.<br><\/p>\n\n\n\n<p>As mentioned earlier,&nbsp;fluorescein&nbsp;can cause unexpected serious&nbsp;side effects.&nbsp;They occur more often if you have had similar reactions to&nbsp;fluorescein&nbsp;before or if you suffer from&nbsp;allergies&nbsp;(caused by food or medicine),&nbsp;eczema,&nbsp;asthma,&nbsp;or hay fever.<br><\/p>\n\n\n\n<p>If you experience any of the&nbsp;side effects&nbsp;are, or if you notice&nbsp;adverse&nbsp;effects not listed in this leaflet, contact your doctor.<br><\/p>\n\n\n\n<p><strong>Blood and urine tests<\/strong><\/p>\n\n\n\n<p>Fluorescein&nbsp;may affect some blood and urine tests for 3-4 days after you receive it.&nbsp;If you are going to have blood or urine tests or further x-rays during this period, tell your doctor that you have been&nbsp;given fluorescein.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Fluorescite 100 mg\/ml solution for injection<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Keep this medicine out of the sight and reach of children.<\/li><li>Do not use this medicine after the expiry date which is stated on the label and carton (EXP).&nbsp;The expiration date is the last day of the specified month.<\/li><li>A&nbsp;vial&nbsp;should be used immediately after opening.<\/li><li>Your doctor or nurse knows how to store Fluorescite 100 mg\/ml&nbsp;solution for injection.<\/li><li>Do not store above 25 \u00b0 C.&nbsp;Do not freeze.&nbsp;Keep the vial in the outer carton.&nbsp;Sensitive to light.<\/li><li>Do not use Fluorescite 100 mg\/ml&nbsp;solution for injection&nbsp;if the vial is cracked or damaged in any way.<\/li><li>The solution should be inspected to see if it contains particles or discoloration before use.&nbsp;The solution may only be used if it is clear and free of particles.<br>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<br><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>The active substance is&nbsp;fluorescein.<\/p>\n\n\n\n<p>1 ml solution contains 100 mg&nbsp;fluorescein&nbsp;(as 113.2 mg fluorescein sodium).<\/p>\n\n\n\n<p>One&nbsp;vial&nbsp;of 5 ml solution contains 500 mg&nbsp;fluorescein&nbsp;(as 566 mg fluorescein sodium).<br><\/p>\n\n\n\n<p>The other ingredients are sodium hydroxide and\/or&nbsp;hydrochloric acid&nbsp;(to adjust the acidity) and water for injections.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Fluorescite 100 mg\/ml&nbsp;solution for injection&nbsp;is a clear red-orange&nbsp;solution for injection.<\/p>\n\n\n\n<p>Fluorescite 100 mg\/ml&nbsp;solution for injection is&nbsp;supplied in packs of 12 vials of 5 ml&nbsp;solution for injection.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Alcon Nordic A \/ S<\/p>\n\n\n\n<p>Edvard Thomsens Vej 14<\/p>\n\n\n\n<p>2300 Copenhagen S<\/p>\n\n\n\n<p>Denmark<br><\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>SA Alcon-Couvreur NV<\/p>\n\n\n\n<p>Rijksweg 14<\/p>\n\n\n\n<p>2870 Puurs<\/p>\n\n\n\n<p>Belgium<br><\/p>\n\n\n\n<p><strong>This medicinal product is authorized under the European Economic Area under the names: <\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><th scope=\"col\">Name of Member State<\/th><th scope=\"col\">Name of the medicine<\/th><\/tr><\/thead><tbody><tr><td>The Czech Republic<\/td><td>Fluorescite 100mg \/ ml injectable drug<\/td><\/tr><tr><td>Denmark<\/td><td>Anantara 100 mg \/ ml solution for&nbsp;injection<\/td><\/tr><tr><td>Estonia<\/td><td>Fluorescite 100 mg \/ ml solution for&nbsp;injection<\/td><\/tr><tr><td>Finland<\/td><td>Fluorescite 100 mg \/ ml solution for&nbsp;injection<\/td><\/tr><tr><td>Germany<\/td><td>Fluorescein&nbsp;Alcon 10%<\/td><\/tr><tr><td>Iceland<\/td><td>Anatera 100 mg \/ ml solution for&nbsp;injection<\/td><\/tr><tr><td>Latvia<\/td><td>Fluorescite 100 mg \/ ml solution for&nbsp;injection<\/td><\/tr><tr><td>Lithuania<\/td><td>Fluorescite 100 mg \/ ml solution for&nbsp;injection<\/td><\/tr><tr><td>Netherlands<\/td><td>Fluorescite 100mg \/ ml solution for injection<\/td><\/tr><tr><td>Norway<\/td><td>Anatera 100 mg \/ ml solution for&nbsp;injection<\/td><\/tr><tr><td>Poland<\/td><td>Fluorescite<\/td><\/tr><tr><td>Slovakia<\/td><td>Fluorescite<\/td><\/tr><tr><td>UK<\/td><td>Anatera 100mg \/ ml solution for&nbsp;injection<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p> 100 mg \/ ml injection solution<br \/>\nfluorescein<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2206,2200],"tags":[2651,2653,2654,2652,2655,2657,2656,2658,2215,2212],"class_list":["post-8915","post","type-post","status-publish","format-standard","hentry","category-f","category-medicines","tag-fluorescein","tag-fluorescein-dose","tag-fluorescein-side-effects","tag-fluorescein-uses","tag-fluorescite","tag-fluorescite-dose","tag-fluorescite-uses","tag-fluoresciteside-effects","tag-injection","tag-medicine"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8915","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=8915"}],"version-history":[{"count":6,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8915\/revisions"}],"predecessor-version":[{"id":10004,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8915\/revisions\/10004"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=8915"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=8915"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=8915"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}