{"id":8685,"date":"2021-03-17T07:25:06","date_gmt":"2021-03-17T07:25:06","guid":{"rendered":"https:\/\/zeepedia.com\/?p=8685"},"modified":"2021-04-12T15:18:43","modified_gmt":"2021-04-12T15:18:43","slug":"fenemal-meda","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/fenemal-meda\/","title":{"rendered":"Fenemal Meda &#8211; Phenobarbital uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n200 mg \/ ml&nbsp;injection&nbsp;solution&nbsp;<br>phenobarbital<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Fenemal Meda is and what it is used for<\/h2>\n\n\n\n<p>Fenemal Meda contains phenobarbital which counteracts seizures and shortens seizures that occur by limiting the spread of irritation in the brain.<br><\/p>\n\n\n\n<p>Fenemal Meda is used for&nbsp;epilepsy, in so-called generalized tonic-clonic epileptic seizures (&nbsp;grand mal&nbsp;), and for seizures where only parts of the brain are affected (&nbsp;partial seizures&nbsp;).&nbsp;Fenemal Meda is an alternative medicine to&nbsp;diazepam&nbsp;for&nbsp;status epilepticus&nbsp;.<br><\/p>\n\n\n\n<p>Fenemal Meda is used for seizures during the neonatal period.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before using Fenemal Meda<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Fenemal Meda<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have a disease that involves the formation of porphyrins in the liver (&nbsp;acute intermittent&nbsp;porphyria&nbsp;)<\/li><li>if you are hypersensitive to certain sedatives and sleeping pills (&nbsp;barbiturates&nbsp;)<\/li><li>if you have severe liver damage<\/li><li>if you are allergic to phenobarbital or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before using Fenemal Meda.<\/p>\n\n\n\n<p>Skin reactions, which may be life-threatening (&nbsp;Stevens-Johnson syndrome&nbsp;and&nbsp;toxic epidermal necrolysis&nbsp;), have been reported with the use of phenobarbital.&nbsp;It can start as red-violet target-like or round spots with blistering in the middle, often symmetrically spread, on the torso.<\/p>\n\n\n\n<p>Additional signs to be aware of are sores in the mouth, throat, nose, genitals, or eye inflammation (red and swollen eyes).<\/p>\n\n\n\n<p>The skin reactions, which can be life-threatening, are often followed by&nbsp;flu-like symptoms.&nbsp;The rash can develop into blisters over large areas of skin detachment.<\/p>\n\n\n\n<p>The risk of serious skin reactions is greatest during the first weeks of treatment.<\/p>\n\n\n\n<p>If you have had&nbsp;Stevens-Johnson&nbsp;syndrome or&nbsp;toxic epidermal necrolysis&nbsp;while using phenobarbital contained in Fenemal Meda, you should never use medicines containing phenobarbital again.<\/p>\n\n\n\n<p>If you get a rash or signs of these skin reactions, stop taking Fenemal Meda immediately, and contact your doctor immediately and tell them that you are taking this medicine.<br><\/p>\n\n\n\n<p>If you have impaired liver or kidney function, you should consult a doctor before starting treatment with Fenemal Meda.<br><\/p>\n\n\n\n<p>To avoid tooth damage due to&nbsp;dry mouth, it is important to brush your teeth with fluoride toothpaste twice daily.<br><\/p>\n\n\n\n<p>If a rash occurs, the treating physician should be consulted.<\/p>\n\n\n\n<p>If you stop taking Fenemal Meda too quickly, there is a risk of an increased number, and possibly more severe, seizures.&nbsp;If the medical treatment is to be terminated, it is therefore very important that the phasing out takes place slowly, often over the course of 3-12 months.&nbsp;However, never change your treatment yourself without consulting a doctor.<br><\/p>\n\n\n\n<p>If you get a rash, fever, joint pain, jaundice (whites of the eyes and skin turn yellow), enlarged&nbsp;lymph nodes, you should contact a doctor as soon as possible.&nbsp;This may be a sign of hypersensitivity syndrome.<br><\/p>\n\n\n\n<p>A small number of people who are treated with antiepileptic&nbsp;drugs&nbsp;such as phenobarbital have also had thoughts of harming themselves or committing suicide.&nbsp;If you ever get these thoughts, contact your doctor immediately.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Fenemal Meda<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Medicines containing so-called&nbsp;beta-blocker blockers&nbsp;are often used to&nbsp;treat&nbsp;high&nbsp;blood pressure, angina, and&nbsp;migraine&nbsp;prevention, medicines used after myocardial infarction or unstable angina (ticagrelor), medicines for&nbsp;epilepsy&nbsp;(midazolam),&nbsp;birth control pills, certain strong painkillers, so-called&nbsp;opioids,&nbsp;and also some other drugs.&nbsp;may affect or be affected by treatment with Fenemal Meda.&nbsp;The treating physician, therefore, needs to know about other concomitant medications.<\/p>\n\n\n\n<p>Herbal remedies containing&nbsp;St. John&#8217;s wort&nbsp;(&nbsp;<em>Hypericum perforatum<\/em>&nbsp;) should not be used during medication with Fenemal Meda.&nbsp;If you are already taking a&nbsp;St. John&#8217;s wort&nbsp;preparation, consult a doctor before stopping this preparation.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<br><\/p>\n\n\n\n<p>There is a risk of fetal harm effects.&nbsp;Do not use phenobarbitone Meda during pregnancy except on certain&nbsp;prescriptions&nbsp;from the doctor.&nbsp;A breastfed baby may be affected.&nbsp;Therefore, do not use Fenemal Meda while breast-feeding, as otherwise&nbsp;prescribed&nbsp;by a doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>During treatment with Fenemal Meda, the ability to react may be reduced.&nbsp;This should be taken into account when sharper attention is required, e.g.&nbsp;while driving.<br><\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Fenemal Meda contains propylene glycol, ethanol, and sodium<\/h2>\n\n\n\n<p>This medicine contains 400 mg of propylene glycol per ml.<\/p>\n\n\n\n<p>If your child is younger than 4 weeks, consult a doctor or pharmacist before using the medicine, especially if the child is taking other medicines that contain propylene glycol or alcohol.<br><\/p>\n\n\n\n<p>This medicine contains 140 mg of alcohol (&nbsp;ethanol&nbsp;) per ml.&nbsp;The amount in ml of this medicine corresponds to less than 4 ml of beer or 2 ml of wine.<br><\/p>\n\n\n\n<p>The low amount of alcohol in this medicine does not produce any noticeable effects.<br><\/p>\n\n\n\n<p>This medicine contains 14.4 mg&nbsp;sodium&nbsp;(the main ingredient in table salt\/table salt) per ml.&nbsp;This corresponds to 0.72% of the highest recommended daily intake of&nbsp;sodium&nbsp;for adults.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use Fenemal Meda<\/h2>\n\n\n\n<p>Always use this medicine exactly as your doctor or pharmacist has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<br><\/p>\n\n\n\n<p>Dose&nbsp;one is determined by the doctor, who adjusts it individually for you.<\/p>\n\n\n\n<p>Dosage&nbsp;one of Fenemal Meda varies greatly from person to person.<\/p>\n\n\n\n<p>The doctor adjusts the size of the dose concerning the level of Fenemal Meda in the blood, how the medicine affects the disease, and how you as a patient feel.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Fenemal Meda then you should<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if e.g.&nbsp;a child inadvertently ingested the medicine immediately contact a doctor, hospital, or the Poison Information Center for risk assessment and advice.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects,&nbsp;although not everybody gets them.<br><\/p>\n\n\n\n<p><em>Common (&nbsp;may&nbsp;affect up to 1&nbsp;in&nbsp;10<\/em>&nbsp;people&nbsp;<em>):<\/em>&nbsp;Drowsiness, which may be postpartum, and difficulty concentrating.&nbsp;Rash.&nbsp;Inability to coordinate muscle movements and involuntary eye movements.&nbsp;Excessive irritability in children and confusion in the elderly.<br><\/p>\n\n\n\n<p><em>Uncommon&nbsp;(may affect up to 1 in 100 people):&nbsp;<\/em>Dry mouth, calcification of the skeleton after prolonged treatment.<br><\/p>\n\n\n\n<p><em>Rare (&nbsp;<\/em><em>may&nbsp;<\/em><em>affect&nbsp;<\/em><em>up to 1&nbsp;<\/em><em>in 1,000&nbsp;<\/em><em>people&nbsp;<\/em><em>):<\/em>&nbsp;A special form of&nbsp;anemia&nbsp;(megaloblastic&nbsp;anemia&nbsp;).&nbsp;Skin and mucous membrane changes (sometimes severe).&nbsp;Severe widespread skin damage (skin detachment).<br><\/p>\n\n\n\n<p><em>Very rare (&nbsp;<\/em><em>may occur&nbsp;<\/em><em>in&nbsp;<\/em><em>up to&nbsp;<\/em><em>1&nbsp;<\/em><em>in 10&nbsp;<\/em><em>000&nbsp;<\/em><em>users&nbsp;<\/em><em>):<\/em>&nbsp;Skin reactions, which can be life-threatening (&nbsp;Stevens-Johnson&nbsp;syndrome,&nbsp;toxic epidermal necrolysis&nbsp;) have been reported (see section 2).<br><\/p>\n\n\n\n<p>Hypersensitivity symptoms may occur, usually, within the first 2 months of treatment, see &#8220;What to think about before and when using Fenemal Meda&#8221;.<br><\/p>\n\n\n\n<p>There have been reports of bone diseases e.g.&nbsp;decreased bone density in the skeleton, osteoporosis, and bone fractures.&nbsp;Contact a doctor or pharmacist if you are being treated with epilepsy medication for a long time, if you know you have osteoporosis or if you are on medication with&nbsp;steroids.<br><\/p>\n\n\n\n<p><strong>Reporting of&nbsp;side effects&nbsp;ar<\/strong><\/p>\n\n\n\n<p>If you get&nbsp;any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This also applies to&nbsp;side effects&nbsp;that are not mentioned in this information.&nbsp;You can also report&nbsp;side effects&nbsp;directly (see details below).&nbsp;By reporting&nbsp;side effects, you can help increase the safety of medicines.<br><\/p>\n\n\n\n<p>The Medical Products Agency<\/p>\n\n\n\n<p>Box 26<\/p>\n\n\n\n<p>751 03 Uppsala<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Fenemal Meda<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Store in a refrigerator (2 \u00b0 C &#8211; 8 \u00b0 C), in the original package.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton after EXP.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>The medicine should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is phenobarbital 200 mg per milliliter.<\/li><li>The other ingredients are Propylene glycol,&nbsp;ethanol, sodium hydroxide to&nbsp;pH8.5\u20139.5, and water for injections.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>The unstained solution in 1 ml&nbsp;glass ampoule.<\/p>\n\n\n\n<p>Packaging: 10 x 1 ml.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Meda AB, Box 906, 170 09 Solna.<br><\/p>\n","protected":false},"excerpt":{"rendered":"<p> 200 mg \/ ml injection solution<br \/>\nphenobarbital<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2206,2200],"tags":[3038,3040,3041,3039,2215,2212,3035,3036,3037,3034],"class_list":["post-8685","post","type-post","status-publish","format-standard","hentry","category-f","category-medicines","tag-fenemal-meda","tag-fenemal-meda-dose","tag-fenemal-meda-side-effects","tag-fenemal-meda-uses","tag-injection","tag-medicine","tag-phenobarbital","tag-phenobarbital-dose","tag-phenobarbital-side-effects","tag-phenobarbital-uses"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8685","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=8685"}],"version-history":[{"count":6,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8685\/revisions"}],"predecessor-version":[{"id":10029,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8685\/revisions\/10029"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=8685"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=8685"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=8685"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}