{"id":8610,"date":"2021-03-16T10:30:26","date_gmt":"2021-03-16T10:30:26","guid":{"rendered":"https:\/\/zeepedia.com\/?p=8610"},"modified":"2021-04-09T18:28:44","modified_gmt":"2021-04-09T18:28:44","slug":"faslodex","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/faslodex\/","title":{"rendered":"Faslodex &#8211; Fulvestrant uses, dose, and side effects"},"content":{"rendered":"\n<p> 250 mg&nbsp;injection, solution&nbsp;<br>fulvestrant<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Faslodex is and what it is used for<\/h2>\n\n\n\n<p>Faslodex contains the active substance fulvestrant, which belongs to the group of estrogen blockers.&nbsp;Estrogen&nbsp;er, a type of female sex hormone may in some cases be involved in the growth of breast cancer.<br><\/p>\n\n\n\n<p>Faslodex is used either:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>alone to treat postmenopausal women with a type of breast cancer called estrogen receptor-positive breast cancer that is locally advanced or has spread to other parts of the body (metastatic), or<\/li><li>in combination with palbociclib for the treatment of women with a type of breast cancer called hormone receptor-positive,&nbsp;human&nbsp;epidermal&nbsp;growth&nbsp;factor receptor 2 \u2011 negative breast cancer, which is locally advanced or has spread to other parts of the body (metastatic).&nbsp;Women who have not reached menopause will also be treated with a drug called luteinizing hormone-releasing&nbsp;hormone(LHRH)&nbsp;agonist.<\/li><\/ul>\n\n\n\n<p>When Faslodex is given in combination with palbociclib, it is important that you also read the package leaflet for palbociclib.&nbsp;Ask your doctor if you have any questions about palbociclib.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before using Faslodex<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Faslodex<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to fulvestrant or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you are pregnant or breastfeeding<\/li><li>if you have severe liver problems<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before using Faslodex if any of the following apply to you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>kidney or liver problems<\/li><li>low&nbsp;platelet count, (contributes to blood clotting), bleeding disorder<\/li><li>previous problems with blood clots<\/li><li>problems with bone mineral loss (&nbsp;osteoporosis&nbsp;)<\/li><li>alcohol problem<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Faslodex is not intended for children and adolescents under 18 years of age.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Faslodex<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.&nbsp;You must tell your doctor if you are&nbsp;taking anticoagulants&nbsp;(medicines that prevent blood clots).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>You must not use Faslodex if you are pregnant.&nbsp;If you can get pregnant, you should use an effective contraceptive when you are treated with Faslodex and for 2 years after your last&nbsp;dose.<br><\/p>\n\n\n\n<p>You must not breast-feed while being treated with Faslodex.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Faslodex is unlikely to affect your ability to drive or use machines, but if you feel tired after the treatment, avoid driving or using machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Faslodex contains 10% w \/ v ethanol (alcohol),<\/h2>\n\n\n\n<p>corresponding to about 500 mg per&nbsp;injection, to be equated with 10 ml of beer or 4 ml of wine.<\/p>\n\n\n\n<p>Harmful to those who suffer from alcoholism.<\/p>\n\n\n\n<p>To be considered for high-risk groups such as patients with liver disease, or&nbsp;epilepsy.<br><\/p>\n\n\n\n<p><strong>Faslodex contains 500 mg of benzyl alcohol per&nbsp;injection<\/strong>, equivalent to 100 mg\/ml.<\/p>\n\n\n\n<p>Benzyl alcohol can cause allergic reactions.<br><\/p>\n\n\n\n<p><strong>Faslodex contains 750 mg benzyl benzoate per&nbsp;injection<\/strong>, equivalent to 150 mg\/ml.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use Faslodex<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor, pharmacist or nurse has told you.&nbsp;If you are not sure, talk to your doctor, pharmacist, or nurse.<br><\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;is 500 mg fulvestrant (two 250 mg \/ 5 ml&nbsp;injections&nbsp;) once a month, with an additional&nbsp;dose&nbsp;of 500 mg two weeks after the initial&nbsp;dose.<br><\/p>\n\n\n\n<p>Your doctor or nurse will give you Faslodex as a slow&nbsp;intramuscular&nbsp;injection, one in each buttock.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<br><\/p>\n\n\n\n<p><strong>You may need immediate medical attention if you get any of the following side effects:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Allergic reactions (hypersensitivity), including swelling of the face, lips, tongue, and\/or throat which may be signs of anaphylactic reactions<\/li><li>Thromboembolism (increased risk of blood clots) *<\/li><li>Inflammation of the liver (&nbsp;hepatitis&nbsp;)<\/li><li>Liver failure<\/li><\/ul>\n\n\n\n<p><strong>Tell your doctor, pharmacist, or nurse if you get any of the following side effects:<\/strong><br><\/p>\n\n\n\n<p><strong>A very common&nbsp;side effect&nbsp;is<\/strong>&nbsp;(may affect more than one in 10)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Injection site reactions, such as pain and\/or&nbsp;inflammation<\/li><li>Changes in liver enzyme values \u200b\u200b(shown by blood tests) *<\/li><li>Nausea<\/li><li>Weakness, fatigue *<\/li><li>Joint and musculoskeletal pain<\/li><li>Hemorrhoids<\/li><li>Rash<\/li><li>Allergic (hypersensitivity) reaction, including swelling of the face, lips, tongue, and\/or throat<\/li><\/ul>\n\n\n\n<p><strong>Other side effects:<\/strong><br><\/p>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;are<\/strong>&nbsp;(may affect up to 1 in 10)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Headache<\/li><li>Vomiting, diarrhea, or decreased appetite *<\/li><li>Urinary tract infection<\/li><li>Back pain *<\/li><li>Elevation of&nbsp;bilirubin&nbsp;(a bile pigment produced by the liver)<\/li><li>Thromboembolism&nbsp;(increased risk of blood clots) *<\/li><li>Decreased&nbsp;platelet count&nbsp;(&nbsp;thrombocytopenia&nbsp;)<\/li><li>Vaginal&nbsp;bleeding<\/li><li>Pain in the lower back that radiates to the leg on one side (sciatica)<\/li><li>Sudden weakness, numbness, tingling, or loss of mobility in the leg, especially on one side of the body, sudden difficulty walking or maintaining balance (&nbsp;peripheral neuropathy&nbsp;)<\/li><\/ul>\n\n\n\n<p><strong>Less common&nbsp;side effects&nbsp;are<\/strong>&nbsp;(may affect up to 1 in 100)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Thick, whitish&nbsp;vaginal discharge&nbsp;and fungal infection<\/li><li>Bruising and bleeding at the injection site<\/li><li>Increase in gamma-GT, a liver enzyme seen in a blood test<\/li><li>Inflammation of the liver (&nbsp;hepatitis&nbsp;)<\/li><li>Liver failure<\/li><li>Numbness, tingling, and pain<\/li><li>Anaphylactic reactions<\/li><\/ul>\n\n\n\n<p>* Includes&nbsp;side effects&nbsp;for which the exact effect of Faslodex can not be assessed due to the underlying disease.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Faslodex<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton or syringe label after \u201cEXP\u201d.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>Store and transport in a refrigerator (2 -C-8\u00baC).<br><\/p>\n\n\n\n<p>Deviations outside the temperature range 2 \u00b0 C-8 \u00b0 C must be limited.&nbsp;This includes avoiding storage at temperatures exceeding 30 \u00b0 C and not exceeding a period of 28 days where the average storage temperature of the product is below 25 \u00b0 C (but above 2 \u00b0 C \u2011 8 \u00b0 C).&nbsp;After temperature deviations, the product must be returned immediately to the recommended storage conditions (stored and transported in a refrigerator, 2 \u00b0 C-8 \u00b0 C).&nbsp;Temperature deviations have a cumulative effect on product quality and the time period of 28 days must not be exceeded during the entire shelf life of 4 years for Faslodex.&nbsp;Exposure to temperatures below 2 \u00b0 C does not damage the product, provided it is not stored below -20 \u00b0 C.<br><\/p>\n\n\n\n<p>Store the prefilled syringe in the original package.&nbsp;Sensitive to light<br><\/p>\n\n\n\n<p>The healthcare staff is responsible for the correct storage, use, and disposal of Faslodex.<br><\/p>\n\n\n\n<p>This medicine may pose a risk to the aquatic environment.&nbsp;Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is fulvestrant.&nbsp;Each pre-filled&nbsp;syringe&nbsp;(5 ml) contains 250 mg fulvestrant.<\/li><li>The other ingredients (excipients) are&nbsp;ethanol&nbsp;(96 percent), benzyl alcohol, benzyl benzoate, and castor oil (refined).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Faslodex is a clear, colorless to yellow,&nbsp;viscous&nbsp;solution in a pre-filled&nbsp;syringe&nbsp;fitted with a safety closure containing 5 ml&nbsp;solution for injection.&nbsp;Two syringes must be administered to reach the recommended monthly&nbsp;dose of&nbsp;500 mg.<br><\/p>\n\n\n\n<p>Faslodex is available in two pack sizes, either a pack containing 1 pre-filled&nbsp;syringe&nbsp;or a pack containing 2 pre-filled syringes.&nbsp;Protected needles (BD SafetyGlide) to attach to each&nbsp;syringe&nbsp;are also included.<br><\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>AstraZeneca AB<\/p>\n\n\n\n<p>Global External Sourcing (GES)<\/p>\n\n\n\n<p>Astraall\u00e9n<\/p>\n\n\n\n<p>AstraZeneca UK Limited<\/p>\n\n\n\n<p>Silk Road Business Park<\/p>\n\n\n\n<p>Macclesfield<\/p>\n\n\n\n<p>Cheshire<\/p>\n\n\n\n<p>SK10 2NA<\/p>\n\n\n\n<p>UK<br><\/p>\n\n\n\n<p>Contact the representative of the marketing authorization holder to find out more about this medicine:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgium \/ Belgique \/ Belgien<\/strong>AstraZeneca SA \/ NVTel: +32 2 370 48 11<\/td><td><strong>Lithuania<\/strong>UAB AstraZeneca LietuvaTel .: +370 5 266055<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Astrology Bulgaria BODYTel: +359 24455000<\/td><td><strong>Luxembourg \/ Luxemburg<\/strong>AstraZeneca SA \/ NVTel: +32 2 370 48 11<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>AstraZeneca Czech Republic sroTel: +420 222 807 111<\/td><td><strong>Hungary<\/strong>AstraZeneca KftTel: +36 1 883 6500<\/td><\/tr><tr><td><strong>Denmark<\/strong>AstraZeneca A \/ STel: +45 43 66 64 62<\/td><td><strong>Malta<\/strong>Associated Drug Co.&nbsp;Ltd.Tel: +356 2277 8000<\/td><\/tr><tr><td><strong>Germany<\/strong>AstraZeneca GmbHTel: +49 41 03 7080<\/td><td><strong>The Netherlands<\/strong>AstraZeneca BVTel: +31 79 363 2222<\/td><\/tr><tr><td><strong>Eesti<\/strong>AstraZenecaTel: +372 6549 600<\/td><td><strong>Norway<\/strong>AstraZeneca ASTel: + 47 21 00 64 00<\/td><\/tr><tr><td><strong>Greece<\/strong>AstraZeneca AE:\u0397\u03bb: + 30 210 6871500<\/td><td><strong>Austria<\/strong>AstraZeneca \u00d6sterreich GmbHTel: +43 1 711 31 0<\/td><\/tr><tr><td><strong>Spain<\/strong>AstraZeneca Pharmac\u00e9utica Spain, SATel: +34 91 301 91 00<\/td><td><strong>Poland<\/strong>AstraZeneca Pharma Poland Sp.&nbsp;z ooTel .: + 48 22 245 73 00<\/td><\/tr><tr><td><strong>France<\/strong>AstraZenecaTel: + 33 1 41 29 40 00<\/td><td><strong>Portugal<\/strong>AstraZeneca Pharmaceutical Products, Lda.Tel: +351 21 434 61 00<\/td><\/tr><tr><td><strong>Croatia<\/strong>AstraZeneca dooTel: +385 1 4628 000<\/td><td><strong>Romania<\/strong>AstraZeneca Pharma SRLTel: + 40 21 317 60 41<\/td><\/tr><tr><td><strong>Ireland<\/strong>AstraZeneca Pharmaceuticals (Ireland) DACTel: + 353 1609 7100<\/td><td><strong>Slovenia<\/strong>AstraZeneca UK LimitedTel: +386 1 51 35 600<\/td><\/tr><tr><td><strong>Iceland<\/strong>Vistor hf.Phone: + 354 535 7000<\/td><td><strong>Slovak Republic<\/strong>AstraZeneca AB ozTel .: + 421 2 5737 7777<\/td><\/tr><tr><td><strong>Italy<\/strong>AstraZeneca SpATel: + 39 02 9801 1<\/td><td><strong>Finland \/ Finland<\/strong>AstraZeneca OyPuh \/ Tel: + 358 10 23 010<\/td><\/tr><tr><td><strong>Latvia<\/strong>SIA AstraZeneca Latvij\u0101Tel: +371 67377100<\/td><td><strong>United Kingdom<\/strong>AstraZeneca UK LtdTel: + 44 1582 836 836<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p> 250 mg injection, solution<br \/>\nfulvestrant<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2206,2200],"tags":[3174,3172,3173,3171,2385,2386,2384,3170,2215,2212],"class_list":["post-8610","post","type-post","status-publish","format-standard","hentry","category-f","category-medicines","tag-faslodex","tag-faslodex-dose","tag-faslodex-side-effects","tag-faslodex-uses","tag-fulvestrant-doses","tag-fulvestrant-side-effects","tag-fulvestrant-uses","tag-fulvestrant-2","tag-injection","tag-medicine"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8610","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=8610"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8610\/revisions"}],"predecessor-version":[{"id":9813,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8610\/revisions\/9813"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=8610"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=8610"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=8610"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}