{"id":8590,"date":"2021-03-15T08:25:12","date_gmt":"2021-03-15T08:25:12","guid":{"rendered":"https:\/\/zeepedia.com\/?p=8590"},"modified":"2021-04-10T07:58:09","modified_gmt":"2021-04-10T07:58:09","slug":"ezetimibe-sandoz","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/ezetimibe-sandoz\/","title":{"rendered":"Ezetimibe Sandoz &#8211; Ezetimibe uses, dose, and side effects"},"content":{"rendered":"\n<p>\n\n10 mg&nbsp;tablets&nbsp;<br>ezetimibe<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Ezetimibe Sandoz is and what it is used for<\/h2>\n\n\n\n<p>Ezetimibe Sandoz is a drug used to lower elevated blood&nbsp;cholesterol levels.<br><\/p>\n\n\n\n<p>Sandoz Ezetimibe reduces blood levels of total cholesterol, the &#8220;bad&#8221;&nbsp;cholesterol&nbsp;et (&nbsp;LDL&nbsp;&#8211;&nbsp;cholesterol&nbsp;), and one type of blood lipids called&nbsp;triglycerides&nbsp;s.&nbsp;Ezetimibe Sandoz also increases the levels of &#8220;good&#8221;&nbsp;cholesterol&nbsp;(&nbsp;HDL&nbsp;&#8211;&nbsp;cholesterol&nbsp;).<\/p>\n\n\n\n<p>Ezetimibe, the active substance in Ezetimibe Sandoz, works by reducing the cholesterol uptake into the gastrointestinal tract.&nbsp;<br><\/p>\n\n\n\n<p>Ezetimibe Sandoz enhances the cholesterol-lowering effect of statins, a group of drugs that reduce the amount of&nbsp;cholesterol&nbsp;your body produces.<br><\/p>\n\n\n\n<p>Cholesterol&nbsp;is one of several fats found in your blood.&nbsp;Your total cholesterol is made up mainly of&nbsp;LDL&nbsp;and&nbsp;HDL&nbsp;&#8211;&nbsp;cholesterol.<br><\/p>\n\n\n\n<p>LDL&nbsp;&#8211;&nbsp;cholesterol&nbsp;is often called &#8220;bad&#8221;&nbsp;cholesterol&nbsp;et because it can build up in the walls of your arteries and form&nbsp;plaque.&nbsp;This&nbsp;plaque&nbsp;storage can eventually lead to a narrowing of your&nbsp;vessels.&nbsp;This narrowing can reduce or block blood flow to important organs such as the heart and brain.&nbsp;Blockage of blood flow can result in a heart attack or&nbsp;stroke.<\/p>\n\n\n\n<p><br>HDL&nbsp;&#8211;&nbsp;cholesterol&nbsp;is often called &#8220;good&#8221;&nbsp;cholesterol&nbsp;et because it helps prevent the &#8220;bad&#8221;&nbsp;cholesterol&nbsp;et from building up in container&nbsp;one and protects against heart disease.<\/p>\n\n\n\n<p><br>Triglycerides&nbsp;are another type of fat in the blood that can increase the risk of heart disease.<\/p>\n\n\n\n<p>This medicine is used for patients whose cholesterol levels can not be kept down by a cholesterol-lowering diet alone.&nbsp;You should continue with a cholesterol-lowering diet while you are taking this medicine.&nbsp;<br><br>Ezetimibe Sandoz is used as a supplement to your cholesterol-lowering diet if you have:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>elevated blood cholesterol levels (primary&nbsp;hypercholesterolemia&nbsp;[heterozygous familial and non-familial])<ul><li>along with a statin, when a statin alone does not provide adequate control of your cholesterol levels<\/li><li>alone, when treatment with statins is considered inappropriate or if you do not tolerate statins.<\/li><\/ul><\/li><li>an inherited disease (&nbsp;homozygous&nbsp;familial&nbsp;hypercholesterolemia&nbsp;) that causes elevated cholesterol levels in the blood.&nbsp;You will also be prescribed treatment with a statin and may also receive other treatment.<\/li><\/ul>\n\n\n\n<p>If you have heart disease, Ezetimibe Sandoz in combination with cholesterol-lowering medicines called statins may reduce the risk of heart attack,&nbsp;stroke, surgery to increase blood flow to the heart, or hospitalization for chest pain.<br><\/p>\n\n\n\n<p>Ezetimibe Sandoz does not help you lose weight.<br><\/p>\n\n\n\n<p>Ezetimibe contained in Ezetimibe Sandoz may also be approved for the treatment of other conditions not mentioned in this product information.&nbsp;Ask your doctor, pharmacist, or other healthcare professional if you have any further questions, and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take Ezetimibe Sandoz<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Ezetimibe Sandoz<\/h2>\n\n\n\n<p>If you are taking Ezetimibe Sandoz with a statin, also read the package leaflet for that medicine.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are&nbsp;<strong>allergic<\/strong>&nbsp;to ezetimibe or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<p><strong><br>Do not take Ezetimibe Sandoz with a statin<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you have&nbsp;<strong>liver problems<\/strong><\/li><li>you are&nbsp;<strong>pregnant<\/strong>&nbsp;or&nbsp;<strong>breastfeeding.<\/strong><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Ezetimibe Sandoz.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Inform your doctor about all your medical ailments, including&nbsp;allergies.<\/li><li>Your doctor should take a blood sample before you start taking this medicine with a statin.&nbsp;This blood test is taken to check your liver function.<\/li><li>Your doctor may also need to take a blood test to check your liver function after you start taking this medicine with a statin.<\/li><\/ul>\n\n\n\n<p><br>Ezetimibe Sandoz is not recommended if you have&nbsp;<strong>moderate to severe hepatic impairment<\/strong>.<\/p>\n\n\n\n<p><br>The safety and efficacy of concomitant use of Ezetimibe Sandoz and&nbsp;<strong>fibrates<\/strong>(cholesterol-lowering drugs) have not been established.&nbsp;Concomitant use should be avoided.<\/p>\n\n\n\n<p><br><strong>Contact a doctor immediately if you get it<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>unexplained muscle aches, soreness, or weakness.<\/li><\/ul>\n\n\n\n<p>The reason for this is that in rare cases, muscle problems, including the breakdown of muscles with kidney damage, as a result,&nbsp;<strong>can be serious and become life-threatening.<\/strong><\/p>\n\n\n\n<p><br>The risk of muscle breakdown is greater in some patients taking Ezetimibe Sandoz with cholesterol-lowering medicines, such as statins.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Do not give this medicine to children and adolescents (aged 6 to 17 years) unless it has been prescribed by a specialist as there are limited data on safety and efficacy.&nbsp;<br>Do not give this medicine to children under 6 years of age as there is no information for this age group.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Ezetimibe Sandoz<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.&nbsp;<br>Tell your doctor in particular if you are taking any of the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>ciclosporin (a medicine often used by organ transplant patients)<\/li><li>anticoagulants&nbsp;such as&nbsp;warfarin&nbsp;, phenprocoumon, acenocoumarol, or fluindione<\/li><li>cholestyramine (a cholesterol-lowering drug), as it affects the effect of ezetimibe (see also section 3)<\/li><li>fibrates (cholesterol-lowering drugs) (see also section 2: Warnings and precautions).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.&nbsp;<br><br><strong>Pregnancy<br><\/strong>Do not take Ezetimibe Sandoz with a statin if you are pregnant, trying to conceive, or think you may be pregnant.&nbsp;If you become pregnant while taking Ezetimibe Sandoz with a statin, discontinue treatment with both medicines immediately and tell your doctor.&nbsp;Experience with the use of Ezetimibe Sandoz<\/p>\n\n\n\n<p>without a statin during pregnancy is missing.<\/p>\n\n\n\n<p><br><strong>Breast-feeding<\/strong><\/p>\n\n\n\n<p>Do not take Ezetimibe Sandoz with a statin if you are breast-feeding as it is unknown if the medicines pass into breast milk.&nbsp;<br>Ezetimibe Sandoz without a statin should not be used if you are breast-feeding.&nbsp;Consult your doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Ezetimibe Sandoz is not expected to affect your ability to drive or use machines.&nbsp;However, some people may get dizzy when they take Ezetimibe Sandoz.&nbsp;If this happens to you, do not drive or use machines until you feel better.<br><\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Ezetimibe Sandoz contains lactose<\/h2>\n\n\n\n<p>If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Ezetimibe Sandoz<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor has told you.&nbsp;Continue to take your other cholesterol-lowering medications, unless your doctor tells you to stop.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Before you start taking Ezetimibe Sandoz you should follow a cholesterol-lowering diet.<\/li><li>You should continue with this cholesterol-lowering diet while you are taking Ezetimibe Sandoz.<\/li><\/ul>\n\n\n\n<p>The recommended dose is one tablet once a day by mouth.<\/p>\n\n\n\n<p><br>Ezetimibe Sandoz can be taken at any time of the day and can be taken with or without food.<\/p>\n\n\n\n<p><br>If your doctor has prescribed Ezetimibe Sandoz with a statin, both medicines can be taken at the same time.&nbsp;Then also read the dosing instructions in the package leaflet for that medicine.<\/p>\n\n\n\n<p><br>If your doctor has prescribed Ezetimibe Sandoz together with cholestyramine or any other bile acid sequestrant (a cholesterol-lowering medicine), you should take Ezetimibe Sandoz at least 2 hours before or 4 hours after taking the bile acid sequestrant.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Ezetimibe Sandoz then you should<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if e.g.&nbsp;a child accidentally ingests the medicine, contact a doctor,<\/p>\n\n\n\n<p>hospital or the Poison Information Center for risk assessment and counseling.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Ezetimibe Sandoz<\/h2>\n\n\n\n<p>Do not take a double&nbsp;dose&nbsp;to make up for a forgotten tablet, just take your usual&nbsp;dose of&nbsp;Ezetimibe Sandoz at the usual time the next day.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Ezetimibe Sandoz<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist as your cholesterol levels may rise again if you stop taking this medicine.<\/p>\n\n\n\n<p><br>If you have any further questions on the use of this product, ask your doctor or pharmacist<strong>.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<br><\/p>\n\n\n\n<p><strong>Contact a doctor immediately if you get it<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>unexplained muscle aches<\/li><li>muscle soreness or weakness.<\/li><\/ul>\n\n\n\n<p>The reason for this is that in rare cases, muscle problems, including the breakdown of muscles with kidney damage, as a result,&nbsp;<strong>can be serious and become life-threatening.<\/strong><br><\/p>\n\n\n\n<p><strong>Allergic reactions<\/strong>&nbsp;including<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>swelling of the face, lips, tongue, and\/or throat which may cause breathing or swallowing difficulties<\/li><li>dizziness or fainting and unusually fast or irregular heartbeat&nbsp;<strong>requiring immediate treatment<\/strong>&nbsp;have been reported during normal use.<\/li><\/ul>\n\n\n\n<p><strong>Other&nbsp;<\/strong><strong>side effects have<\/strong><strong>&nbsp;been reported in&nbsp;<\/strong><strong>clinical trials<\/strong><strong>&nbsp;<\/strong><br><\/p>\n\n\n\n<p>When&nbsp;this medicine&nbsp;<strong>alone<\/strong>&nbsp;was used, the following side effects were reported:<\/p>\n\n\n\n<p><br><strong>Common&nbsp;<\/strong>side effects&nbsp;(may affect up to 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>abdominal pain<\/li><li>diarrhea<\/li><li>gas formation<\/li><li>fatigue.<\/li><\/ul>\n\n\n\n<p><strong>Uncommon&nbsp;<\/strong>side effects&nbsp;(may affect up to 1 in 100 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>elevations of certain blood test values \u200b\u200bshowing liver function (&nbsp;transaminases&nbsp;) and muscle function (CK)<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>cough<\/li><li>indigestion<\/li><li>heartburn<\/li><li>nausea<\/li><li>joint pain<\/li><li>muscle cramps<\/li><li>neck pain<\/li><li>decreased appetite<\/li><li>pain<\/li><li>chest pain<\/li><li>hot&nbsp;redness&nbsp;(&nbsp;flushing&nbsp;)<\/li><li>high&nbsp;blood pressure.<\/li><\/ul>\n\n\n\n<p><br>When&nbsp;<strong>this drug was used with a statin<\/strong>, the following side effects were also reported:<br><\/p>\n\n\n\n<p><strong>Common&nbsp;<\/strong>side effects&nbsp;(may affect up to 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>elevations of certain blood test values \u200b\u200bshowing liver function (&nbsp;transaminases&nbsp;)<\/li><li>headache<\/li><li>muscle aches or soreness.<\/li><\/ul>\n\n\n\n<p><strong>Uncommon&nbsp;<\/strong>side effects&nbsp;(may affect up to 1 in 100 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>stinging sensation<\/li><li>dry mouth<\/li><li>inflammation&nbsp;of the gastric mucosa<\/li><li>itching<\/li><li>rash<\/li><li>hives<\/li><li>back pain<\/li><li>muscle weakness<\/li><li>pain in arms and legs<\/li><li>unusual tiredness or weakness<\/li><li>swelling, especially in the hands and feet.<\/li><\/ul>\n\n\n\n<p><br>When this medicine&nbsp;<strong>was used with fenofibrate<\/strong>&nbsp;cholesterol-lowering medicine) the following side effects were reported:<br><\/p>\n\n\n\n<p><strong>Common&nbsp;<\/strong>side effect&nbsp;(may affect up to 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>abdominal pain.<\/li><\/ul>\n\n\n\n<p><strong>Besides, the following&nbsp;side effects have&nbsp;been reported after the medicine has come into general use (after the medicine has been marketed):<\/strong><\/p>\n\n\n\n<p><br><strong>No known frequency<\/strong>&nbsp;(cannot be calculated from the available data):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>dizziness<\/li><li>liver problems,<\/li><li>allergic reactions including skin and&nbsp;hives, swelling of the face, tongue, or throat, and fainting<\/li><li>raised red, sometimes target-like rashes, e.g.&nbsp;light red annular rash around a pale center<\/li><li>muscle aches or soreness<\/li><li>muscle weakness: cramps, stiffness, or&nbsp;spasm<\/li><li>severe muscle pain or weakness as well as red-brown urine caused by muscle breakdown<\/li><li>gallstones&nbsp;or&nbsp;inflammation&nbsp;of the gallbladder (which can cause abdominal pain, nausea, vomiting)<\/li><li>inflammation&nbsp;of the pancreas, often with severe abdominal pain<\/li><li>constipation<\/li><li>decreased number of&nbsp;platelets&nbsp;which may cause bruising\/bleeding (&nbsp;thrombocytopenia&nbsp;)<\/li><li>stinging sensation<\/li><li>Depression<\/li><li>unusual tiredness or weakness<\/li><li>shortness of breath.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Ezetimibe Sandoz<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p><br>Do not use this medicine after the expiry date which is stated on the carton or package after EXP.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>Blister: Store in the original package.&nbsp;Moisture sensitive.<\/p>\n\n\n\n<p>Jar: Close the jar tightly.&nbsp;Moisture sensitive.<\/p>\n\n\n\n<p>After opening: Do not store above 25 \u00b0 C. Use any later than 9 months after opening.<br><\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is ezetimibe.&nbsp;<br>Each tablet contains 10 mg of ezetimibe.<\/li><li>The other ingredients are&nbsp;lactose monohydrate&nbsp;<em>(see the end of section 2 for more information)<\/em>, hypromellose, croscarmellose sodium, microcrystalline cellulose, sodium lauryl sulfate, and magnesium stearate.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Ezetimibe Sandoz tablets are white or almost white, oval (7.4 mm x 4.0 mm), and marked with \u201c10\u201d on one side and \u201cEZT\u201d on the other side.<br><\/p>\n\n\n\n<p>Al \/ Al blisters or PVC \/ PVDC \/ Al blisters: 7, 10, 14, 20, 28, 30, 50, 56, 60, 84, 90, 98, 100 and 100 (hospital packaging) tablets.<\/p>\n\n\n\n<p>HDPE cans, with polypropylene screw caps: 100 and 250 tablets (only for hospital use and dose dispensing).<br><\/p>\n\n\n\n<p>Not all packaging may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Sandoz A \/ S, Edvard Thomsens Vej 14, 2300 Copenhagen S, Denmark<br><\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Lek Pharmaceuticals dd, Verov\u0161kova 57, 1526 Ljubljana, Slovenia<\/p>\n\n\n\n<p>or<\/p>\n\n\n\n<p>LEK SA, ul.&nbsp;Domaniewska 50 C, 02-672 Warsaw, Poland<\/p>\n\n\n\n<p>or<\/p>\n\n\n\n<p>Salutas Pharma GmbH, Otto-von-Guericke-Allee 1, 39179 Barleben, Germany<\/p>\n\n\n\n<p>or<\/p>\n\n\n\n<p>SC Sandoz, SRL, Str. Livezeni no.&nbsp;7A, 540472 Targu-Mures, Romania<\/p>\n\n\n\n<p>or<\/p>\n\n\n\n<p>Lek Pharmaceuticals dd, Trimlini 2D, 9220 Lendava, Slovenia<\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p> 10 mg tablets<br \/>\nezetimibe<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2205,2200],"tags":[3224,3226,3236,3238,3239,3237,3227,3225,2212,2210],"class_list":["post-8590","post","type-post","status-publish","format-standard","hentry","category-e","category-medicines","tag-ezetimibe","tag-ezetimibe-dose","tag-ezetimibe-sandoz","tag-ezetimibe-sandoz-dose","tag-ezetimibe-sandoz-side-effects","tag-ezetimibe-sandoz-uses","tag-ezetimibe-side-effects","tag-ezetimibe-uses","tag-medicine","tag-tablet"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8590","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=8590"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8590\/revisions"}],"predecessor-version":[{"id":9852,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8590\/revisions\/9852"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=8590"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=8590"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=8590"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}