{"id":8558,"date":"2021-03-15T07:43:09","date_gmt":"2021-03-15T07:43:09","guid":{"rendered":"https:\/\/zeepedia.com\/?p=8558"},"modified":"2021-04-12T15:23:55","modified_gmt":"2021-04-12T15:23:55","slug":"exemestane-accord","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/exemestane-accord\/","title":{"rendered":"Exemestane Accord &#8211; Exemestane uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n25 mg&nbsp;film-coated tablets&nbsp;<br>exemestane<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Exemestane Accord is and what it is used for<\/h2>\n\n\n\n<p>Exemestane belongs to a group of medicines called&nbsp;aromatase&nbsp;inhibitors.&nbsp;These drugs affect a substance called&nbsp;aromatase&nbsp;, which is necessary for the production of female sex hormones,&nbsp;estrogens&nbsp;, especially in women who have passed menopause.&nbsp;Reducing estrogen levels in the body is one way to treat hormone-dependent breast cancer.<br><\/p>\n\n\n\n<p>Exemestane Accord is used to treat early hormone-dependent breast cancer in women who have passed menopause, after completing 2-3 years of treatment with tamoxifen.<\/p>\n\n\n\n<p>Exemestane Accord is also used to treat advanced breast cancer in women who have passed menopause, when other hormone replacement therapy has not worked satisfactorily.<br><\/p>\n\n\n\n<p>Exemestane contained in the Exemestane Accord may also be approved for the treatment of other conditions not mentioned in this product information.&nbsp;Ask your doctor, pharmacist or other healthcare professional if you have any further questions and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before using Exemestane Accord<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Exemestane Accord<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to or have previously had an&nbsp;allergic reaction&nbsp;to exemestane or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you have not passed the menopause, ie.&nbsp;if you are still menstruating.<\/li><li>if you are pregnant or planning to become pregnant or breast-feeding.<\/li><\/ul>\n\n\n\n<p>Talk to your doctor, pharmacist or nurse before using Exemestane Accord<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Your doctor may want to take a blood test to make sure you are past menopause before you are treated with Exemestane Accord.<\/li><li>Routine monitoring of vitamin D levels will also be done before treatment as the level can be very low in the early stages of breast cancer.&nbsp;You get a supplement of&nbsp;vitamin D&nbsp;if the level is below normal.<\/li><li>Before using the Exemestane Accord, tell your doctor if you have liver or kidney problems.<\/li><li>Tell your doctor if you are in or have previously been in a condition that affects the strength of the bone structure.&nbsp;Your doctor may want to measure your bone density before and during treatment with Exemestane Accord.&nbsp;This is because drugs of this type lower the levels of female&nbsp;hormones&nbsp;that can cause a decrease in the mineral content of the bone structure, which in turn can lead to poorer bone strength.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Exemestane Accord<\/h2>\n\n\n\n<p>Tell your doctor if you are taking, have recently taken or might take any other medicines, including medicines obtained without a prescription.<\/p>\n\n\n\n<p>Exemestane Accord should not be given at the same time as hormone replacement therapy (&nbsp;HRT&nbsp;).<br><\/p>\n\n\n\n<p>The following medicines must be used with caution in conjunction with Exemestane Accord.<\/p>\n\n\n\n<p>Tell your doctor if you are taking:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>rifampicin (&nbsp;antibiotic&nbsp;)<\/li><li>carbamazepine or&nbsp;phenytoin&nbsp;(&nbsp;anticonvulsant&nbsp;drug used to treat&nbsp;epilepsy&nbsp;)<\/li><li>the herbal medicine&nbsp;St. John&#8217;s wort&nbsp;(Hypericum perforatum) or agents containing it.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Exemestane Accord with food, drink and alcohol<\/h2>\n\n\n\n<p>Exemestane Accord should be taken after a meal at approximately the same time each day<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding and fertility<\/h2>\n\n\n\n<p>You should not use Exemestane Accord if you are pregnant or breast-feeding.&nbsp;Tell your doctor if you are or think you may be pregnant.<br><\/p>\n\n\n\n<p>Discuss the use of appropriate contraception with your doctor if it is possible that you may become pregnant.<br><\/p>\n\n\n\n<p>Ask your doctor or pharmacist for advice before taking any medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and \/ or&nbsp;side effects&nbsp;.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<br><\/p>\n\n\n\n<p>If you feel drowsy, dizzy or weak while taking Exemestane Accord, do not drive or use machines.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use Exemestane Accord<\/h2>\n\n\n\n<p><strong>Adults and the elderly<\/strong><\/p>\n\n\n\n<p>Always take this medicine exactly as your doctor has told you.&nbsp;Consult a doctor if you are unsure.<br><\/p>\n\n\n\n<p>Exemestane Accord tablets should be taken orally after a meal at about the same time each day.<\/p>\n\n\n\n<p>Your doctor will tell you how to take Exemestane Accord and for how long.<br><\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;is one 25 mg tablet daily.<br><\/p>\n\n\n\n<p>If you need hospitalization while taking Exemestane Accord, tell your healthcare provider what medicines you are taking.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Use for children and adolescents<\/h2>\n\n\n\n<p>Exemestane Accord should not be given to children.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Exemestane Accord than you should<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if e.g.&nbsp;If a child has accidentally ingested the medicine, contact a doctor, hospital or the Poison Information Center for risk assessment and advice.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Exemestane Accord<\/h2>\n\n\n\n<p>Do not take a double&nbsp;dose&nbsp;to make up for a forgotten&nbsp;dose&nbsp;.<\/p>\n\n\n\n<p>If you forget to take your tablet, take it as soon as you remember.&nbsp;If it is soon time to take the next tablet, take it at the usual time.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Exemestane Accord<\/h2>\n\n\n\n<p>Do not stop taking the tablets even if you feel well, unless your doctor tells you to.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor, pharmacist or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects&nbsp;, although not everybody gets them.<br><\/p>\n\n\n\n<p>Exemestane Accord is well tolerated and the&nbsp;side effects&nbsp;observed in patients treated with Exemestane Accord are mainly mild or less severe.&nbsp;Most&nbsp;side effects&nbsp;are related to estrogen deficiency (eg hot flashes).<br><\/p>\n\n\n\n<p>Hypersensitivity, liver inflammation (&nbsp;hepatitis&nbsp;) and&nbsp;inflammation&nbsp;of the bile ducts in the liver leading to yellowing of the skin (cholestatic&nbsp;hepatitis&nbsp;) can occur.&nbsp;Symptoms include general malaise, nausea, jaundice (yellowing of the skin and eyes),&nbsp;itching&nbsp;, pain in the right abdomen and loss of appetite.&nbsp;Contact a doctor immediately for advice if you think you have any of these symptoms.<br><\/p>\n\n\n\n<p><em>Very common (may affect more than 1 user in 10):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Depression<\/li><li>Difficulty sleeping<\/li><li>Headache<\/li><li>Hemorrhoids<\/li><li>Dizziness<\/li><li>Nausea<\/li><li>Increased sweating<\/li><li>Muscle and joint pain (including&nbsp;osteoarthritis&nbsp;, back pain,&nbsp;arthritis&nbsp;and joint stiffness)<\/li><li>Fatigue<\/li><li>Decreased&nbsp;white blood cell count<\/li><li>Abdominal pain<\/li><li>Elevated liver enzymes<\/li><li>Increased breakdown of&nbsp;hemoglobin&nbsp;in the blood<\/li><li>Elevated levels of an&nbsp;enzyme&nbsp;in the blood due to liver damage<\/li><li>Pain<\/li><\/ul>\n\n\n\n<p>Common (may affect up to 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Loss of appetite<\/li><li>Carpal tunnel syndrome&nbsp;(tingling and numbness in the whole hand except the little finger) or tingling in the skin<\/li><li>Stomach pain, vomiting, constipation, digestive problems, diarrhea<\/li><li>Hair loss<\/li><li>Skin rash,&nbsp;hives&nbsp;and&nbsp;itching<\/li><li>Impaired skeletal strength (osteoporosis), which can sometimes lead to&nbsp;fractures(fractures and cracks)<\/li><li>Pain, swollen hands and feet<\/li><li>Reduced&nbsp;platelet count<\/li><li>Muscle weakness<\/li><\/ul>\n\n\n\n<p>Uncommon (may affect up to 1 in 100 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Hypersensitivity<\/li><\/ul>\n\n\n\n<p>Rare (may affect up to 1 in 1,000 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Outbreak of small blisters on a skin area with rash<\/li><li>Drowsiness<\/li><li>Liver inflammation<\/li><li>Inflammation&nbsp;of the bile ducts of the liver leading to yellow skin<\/li><\/ul>\n\n\n\n<p>Has been reported (occurs in an unknown number of users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Low levels of certain&nbsp;white blood cells<\/li><\/ul>\n\n\n\n<p>Changes in the number of certain&nbsp;blood cells&nbsp;(&nbsp;lymphocytes&nbsp;) and&nbsp;platelets&nbsp;circulating in the blood, especially in patients with pre-existing lymphopenia (decreased number of&nbsp;lymphocytes&nbsp;in the blood) can also be seen.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Exemestane Accord<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton and the blister after EXP.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>No special storage instructions.<br><\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>The active substance is exemestane.&nbsp;One film-coated tablet contains 25 mg of exemestane.<br><\/p>\n\n\n\n<p>Other ingredients are:<\/p>\n\n\n\n<p><em>Core<\/em>&nbsp;: Mannitol, microcrystalline cellulose, crospovidone, sodium starch glycolate (type A), hypromellose E5, polysorbate 80,&nbsp;colloidal&nbsp;anhydrous silica, magnesium stearate<\/p>\n\n\n\n<p><em>Film coating<\/em>&nbsp;: Hypromellose 6 cp (E464), titanium dioxide (E171), macrogol 400<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Exemestane Accord is a white to off-white, round, cupped film-coated tablet marked with E25 on one side and unmarked on the other.<\/p>\n\n\n\n<p>Exemestane Accord is available in white opaque blister packs (PVC \/ PVdC-aluminum) on 15, 20, 28, 30, 90, 98, 100 and 120 tablets.<br><\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder:<\/strong><\/p>\n\n\n\n<p>Accord Healthcare BV<\/p>\n\n\n\n<p>Winthontlaan 200<\/p>\n\n\n\n<p>3526 KV Utrecht<\/p>\n\n\n\n<p>Netherlands<br><\/p>\n\n\n\n<p><strong>Manufacturer:<\/strong><\/p>\n\n\n\n<p>Accord Healthcare Limited<\/p>\n\n\n\n<p>Sage House, 319, Pinner Road,<\/p>\n\n\n\n<p>North Harrow,<\/p>\n\n\n\n<p>Middlesex, HA1 4HF,<\/p>\n\n\n\n<p>UK<br><\/p>\n\n\n\n<p>Laboratori Fundaci\u00f3 DAU<\/p>\n\n\n\n<p>C \/ C, 12-14 Pol.&nbsp;Ind.&nbsp;Zone, France, Barcelona 08040 (Barcelona) Spain<\/p>\n\n\n\n<p>Spain<br><\/p>\n\n\n\n<p>European Pharma Hub Kft.,<\/p>\n\n\n\n<p>7000\/9 hrsz, Gorcsev Iv\u00e1n u. 5., warehouse 15., 16., H-2360 Gy\u00e1l<\/p>\n\n\n\n<p>Hungary<br><\/p>\n\n\n\n<p>Accord Healthcare Polska Sp.z oo,<\/p>\n\n\n\n<p>ul.&nbsp;Lutomierska 50,95-200 Pabianice, Poland<br><\/p>\n\n\n\n<p>Accord Healthcare BV<\/p>\n\n\n\n<p>Winthontlaan 200<\/p>\n\n\n\n<p>3526 KV Utrecht<\/p>\n\n\n\n<p>Netherlands<br><\/p>\n","protected":false},"excerpt":{"rendered":"<p>25 mg film-coated tablets<br \/>\nexemestane<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2205,2200],"tags":[3326,3342,3344,3345,3343,3328,3329,3327,2212,2211],"class_list":["post-8558","post","type-post","status-publish","format-standard","hentry","category-e","category-medicines","tag-exemestane","tag-exemestane-accord","tag-exemestane-accord-dose","tag-exemestane-accord-side-effects","tag-exemestane-accord-uses","tag-exemestane-dose","tag-exemestane-side-effects","tag-exemestane-uses","tag-medicine","tag-tablets"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8558","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=8558"}],"version-history":[{"count":6,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8558\/revisions"}],"predecessor-version":[{"id":10046,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8558\/revisions\/10046"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=8558"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=8558"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=8558"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}