{"id":8556,"date":"2021-03-15T07:42:11","date_gmt":"2021-03-15T07:42:11","guid":{"rendered":"https:\/\/zeepedia.com\/?p=8556"},"modified":"2022-09-01T12:12:56","modified_gmt":"2022-09-01T12:12:56","slug":"exemestan-actavis","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/exemestan-actavis\/","title":{"rendered":"Exemestan Actavis &#8211; Exemestane uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n25 mg&nbsp;film-coated tablets&nbsp;<br>exemestane<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Exemestan Actavis is and what it is used for<\/h2>\n\n\n\n<p>Exemestane Actavis belongs to a group of medicines called aromatase inhibitors.&nbsp;These drugs affect a substance called&nbsp;aromatase, which is necessary for the production of the female sex hormone&nbsp;estrogen, especially in menopausal women.&nbsp;Reducing estrogen levels in the body is one way to treat hormone-dependent breast cancer.<br><\/p>\n\n\n\n<p>Exemestane Actavis is used to treat early hormone-dependent breast cancer in postmenopausal women, after completing 2 to 3 years of treatment with tamoxifen.<br><\/p>\n\n\n\n<p>Exemestane Actavis is also used to treat hormone-dependent advanced breast cancer in women who have passed menopause when another hormone replacement therapy has not worked satisfactorily.<br><\/p>\n\n\n\n<p>Exemestane contained in Exemestane Actavis may also be approved for the treatment of other conditions not mentioned in this leaflet.&nbsp;Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Exemestan Actavis<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Exemestan Actavis<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to or have previously had an&nbsp;allergic reaction&nbsp;to exemestane (the active substance in Exemestane Actavis) or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you have&nbsp;<strong>not<\/strong>&nbsp;passed menopause, ie if you are still menstruating.<\/li><li>if you are pregnant, planning to become pregnant, or breastfeeding.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before taking Exemestan Actavis.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Before treatment with Exemestane Actavis, your doctor may want to take a blood test to determine that you have reached menopause.<\/li><li>Routine monitoring of vitamin D levels will also be done before treatment as the level can be very low in the early stages of breast cancer.&nbsp;You get a supplement of&nbsp;vitamin D&nbsp;if the level is below normal.<\/li><li>Before using the Exemestane Actavis, tell your doctor if you have liver or kidney problems.<\/li><li>Tell your doctor if you have or have had a condition that affects the strength of the bone structure.&nbsp;Your doctor may want to make bone density measurements before and during treatment with Exemestan Actavis.&nbsp;This is because drugs of this type lower the levels of female&nbsp;hormones&nbsp;and can cause reduced mineral content in the bone structure, which in turn can lead to poorer bone strength.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Exemestan Actavis<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines, including medicines obtained without a prescription.<br><\/p>\n\n\n\n<p>Exemestane Actavis should not be given at the same time as hormone replacement therapy.&nbsp;The following medicines must be used with caution with Exemestan Actavis.&nbsp;Tell your doctor if you are taking:<\/p>\n\n\n\n<p>&#8211; rifampicin (&nbsp;antibiotic&nbsp;)<\/p>\n\n\n\n<p>&#8211; carbamazepine or&nbsp;phenytoin&nbsp;(an&nbsp;anticonvulsant&nbsp;drug used to treat&nbsp;epilepsy&nbsp;)<\/p>\n\n\n\n<p>&#8211; herbal medicine containing&nbsp;St. John&#8217;s wort&nbsp;<em>(Hypericum perforatum)<\/em>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>Do not use Exemestane Actavis if you are pregnant or breast-feeding.<\/p>\n\n\n\n<p>Tell your doctor if you are or think you may be pregnant.<\/p>\n\n\n\n<p>Discuss the use of appropriate contraception with your doctor if you may become pregnant.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>If you feel drowsy, dizzy, or weak while taking Exemestan Actavis, do not drive or use machines.<br><\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased vigilance.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Exemestane Actavis contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;sodium&nbsp;per tablet, ie it is essentially &#8216;sodium-free&#8217;.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Exemestan Actavis<\/h2>\n\n\n\n<p><em>Adults and the elderly<\/em><\/p>\n\n\n\n<p>Exemestane Actavis tablets should be taken orally (orally) after a meal at approximately the same time each day.&nbsp;Your doctor will tell you how to take Exemestane Actavis and for how long.&nbsp;The usual&nbsp;dose&nbsp;is one 25 mg tablet daily.<\/p>\n\n\n\n<p>If you have to go to the hospital while taking Exemestan Actavis, tell your healthcare professional what medicines you are taking.<br><\/p>\n\n\n\n<p><em>Children<\/em><\/p>\n\n\n\n<p>Exemestane Actavis is not suitable for use in children.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Exemestan Actavis then you should<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if, for example, a child has accidentally ingested the medicine, contact a doctor, hospital, or the Poison Information Center for risk assessment and advice.&nbsp;Take the pack of Exemestan Actavis film-coated tablets with you to the hospital.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Exemestan Actavis<\/h2>\n\n\n\n<p>Do not take a double&nbsp;dose&nbsp;to make up for a forgotten&nbsp;dose&nbsp;.<\/p>\n\n\n\n<p>If you forget to take your tablet, take it as soon as you remember.&nbsp;If it is soon time to take the next tablet, take it at the usual time.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Exemestan Actavis<\/h2>\n\n\n\n<p>Do not stop taking the tablets even if you feel well, unless your doctor tells you to.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor, pharmacist or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, Exemestan Actavis can cause&nbsp;side effects,&nbsp;although not everybody gets them.<br><\/p>\n\n\n\n<p>Hypersensitivity, liver inflammation (&nbsp;hepatitis&nbsp;) and&nbsp;inflammation&nbsp;of the bile ducts in the liver leading to yellowing of the skin (cholestatic&nbsp;hepatitis&nbsp;) can occur.&nbsp;Symptoms include general malaise, nausea, jaundice (yellowing of the skin and eyes),&nbsp;itching&nbsp;, pain in the right abdomen and loss of appetite.&nbsp;Contact a doctor immediately for advice if you think you have any of these symptoms.<br><\/p>\n\n\n\n<p>Exemestane Actavis is generally well tolerated and the&nbsp;side effects&nbsp;observed in patients treated with Exemestane Actavis are mainly mild or less severe.&nbsp;Most&nbsp;side effects&nbsp;are related to estrogen deficiency (eg hot flashes).<br><\/p>\n\n\n\n<p><em>Very common (may affect more than 1 user in 10):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Depression<\/li><li>insomnia<\/li><li>headache<\/li><li>hot flashes<\/li><li>dizziness<\/li><li>nausea<\/li><li>increased sweating<\/li><li>muscle and joint pain (including&nbsp;osteoarthritis&nbsp;, back pain and&nbsp;inflammation&nbsp;and stiffness in the joints)<\/li><li>fatigue<\/li><li>decreased&nbsp;white blood cell count<\/li><li>abdominal pain<\/li><li>elevated liver enzymes<\/li><li>increased degradation of&nbsp;hemoglobin&nbsp;in the blood<\/li><li>elevated levels of an&nbsp;enzyme&nbsp;in the blood due to liver damage<\/li><li>pain<\/li><\/ul>\n\n\n\n<p><em>Common (may affect up to 1 in 10 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>loss of appetite<\/li><li>carpal tunnel syndrome&nbsp;(tingling, numbness and pain in the whole hand except the little finger) or tingling in the skin<\/li><li>vomiting, constipation, indigestion, diarrhea<\/li><li>hair loss<\/li><li>skin rash,&nbsp;hives&nbsp;and&nbsp;itching<\/li><li>impaired skeletal strength (osteoporosis), which can sometimes lead to&nbsp;fractures(fractures or cracks)<\/li><li>swollen hands and feet<\/li><li>decreased&nbsp;platelet count<\/li><li>muscle weakness<\/li><\/ul>\n\n\n\n<p><em>Uncommon (may affect up to 1 in 100 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>hypersensitivity<\/li><\/ul>\n\n\n\n<p><em>Rare (may affect up to 1 in 1,000 people)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>rash of small blisters on a skin area with rash<\/li><li>drowsiness<\/li><li>hepatitis<\/li><li>inflammation&nbsp;of the bile ducts of the liver leading to yellowing of the skin<\/li><\/ul>\n\n\n\n<p><em>Has been reported (occurs in an unknown number of users)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>low levels of certain&nbsp;white blood cells<\/li><li>Changes in the number of certain&nbsp;blood cells&nbsp;(&nbsp;lymphocytes&nbsp;) and&nbsp;plateletscirculating in the blood, especially in patients with pre-existing lymphopenia (decreased number of&nbsp;lymphocytes&nbsp;in the blood) can also be seen.<\/li><\/ul>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Exemestan Actavis<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>Do not store above 25 \u00b0 C.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton and blister after EXP.&nbsp;dat.&nbsp;or EXP.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is exemestane.&nbsp;Each film-coated tablet contains 25 mg of exemestane.<\/li><li>The other ingredients are:&nbsp;<em>Tablet core:<\/em>&nbsp;povidone K30, corn starch (bleached), pregelatinized (partial)&nbsp;starch&nbsp;, sodium&nbsp;starch&nbsp;glycolate type A, microcrystalline cellulose type 101, talc,&nbsp;colloidal&nbsp;anhydrous silica, magnesium stearate and polysorbate 80;&nbsp;<em>Film coating<\/em>&nbsp;: partially hydrolyzed polyvinyl alcohol, talc, macrogol 3350, titanium dioxide (E171).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Exemestane Actavis 25 mg film-coated tablets are white, round, cupped and smooth tablets with smooth edges.<br><\/p>\n\n\n\n<p><em>Pack sizes<\/em><\/p>\n\n\n\n<p>Blister packs: 10, 30, 40, 60, 84, 90 and 100 film-coated tablets.<br><\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Actavis Group PTC ehf.<\/p>\n\n\n\n<p>Reykjavikurvegur 76-78<\/p>\n\n\n\n<p>220 Hafnarfjordur<\/p>\n\n\n\n<p>Iceland<br><\/p>\n\n\n\n<p><em>Manufacturer<\/em><\/p>\n\n\n\n<p>SC Sindan-Pharma SRL<\/p>\n\n\n\n<p>11, Ion Mihalache Blvd.<\/p>\n\n\n\n<p>011171 Bucharest<\/p>\n\n\n\n<p>Romania<br><\/p>\n","protected":false},"excerpt":{"rendered":"<p> 25 mg film-coated tablets<br \/>\nexemestane<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2205,2200],"tags":[3350,3352,3353,3351,3326,3328,3329,3327,2212,2210],"class_list":["post-8556","post","type-post","status-publish","format-standard","hentry","category-e","category-medicines","tag-exemestan-actavis","tag-exemestan-actavis-dose","tag-exemestan-actavis-side-effects","tag-exemestan-actavis-uses","tag-exemestane","tag-exemestane-dose","tag-exemestane-side-effects","tag-exemestane-uses","tag-medicine","tag-tablet"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8556","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=8556"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8556\/revisions"}],"predecessor-version":[{"id":24831,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8556\/revisions\/24831"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=8556"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=8556"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=8556"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}