{"id":8524,"date":"2021-03-13T09:28:03","date_gmt":"2021-03-13T09:28:03","guid":{"rendered":"https:\/\/zeepedia.com\/?p=8524"},"modified":"2021-04-12T15:35:56","modified_gmt":"2021-04-12T15:35:56","slug":"evotaz","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/evotaz\/","title":{"rendered":"Evotaz &#8211; Cobicistat \/ Atazanavir uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n300 mg \/ 150 mg&nbsp;film-coated tablets&nbsp;<br>atazanavir \/ cobicistat<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What EVOTAZ is and what it is used for<\/h2>\n\n\n\n<p>EVOTAZ contains two active substances:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>atazanavir, an antiviral (or antiretroviral) medicine.&nbsp;<\/strong>It belongs to a group called&nbsp;<em>protease inhibitors<\/em>.&nbsp;This drug controls the Human Immunodeficiency Virus (&nbsp;HIV&nbsp;) &#8211;&nbsp;infection,&nbsp;by stopping the production of a&nbsp;protein&nbsp;that&nbsp;HIV&nbsp;&#8211;&nbsp;the virus&nbsp;et needs to multiply.&nbsp;It works by reducing the number of&nbsp;HIV&nbsp;&#8211;&nbsp;the virus&nbsp;in the blood and this, in turn, strengthens your immune system.&nbsp;This reduces EVOTAZ&#8217;s risk of diseases associated with&nbsp;HIV, which will be developed.<\/li><li><strong>cobicistat, an enhancer (&nbsp;pharmacokinetic&nbsp;enhancer) that helps to improve the effects of atazanavir.&nbsp;<\/strong>Cobicistat, do not treat your&nbsp;HIV&nbsp;&#8211;&nbsp;infection, but enhances the levels of atazanavir in the blood, by atazanavir is broken down more slowly and therefore stays in the body longer.<\/li><\/ul>\n\n\n\n<p>EVOTAZ can be used by adults over 18 who are infected with&nbsp;HIV&nbsp;&#8211;&nbsp;the virus&nbsp;that can cause acquired immunodeficiency syndrome (&nbsp;AIDS&nbsp;).&nbsp;It is used in combination with other anti-&nbsp;HIV&nbsp;medicines to help control your&nbsp;HIV&nbsp;infection.&nbsp;Your doctor will discuss with you which combinations of these medicines together with EVOTAZ are best for you.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before taking EVOTAZ<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take EVOTAZ:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>if you are allergic to<\/strong>&nbsp;atazanavir, cobicistat, or any of the other ingredients of this medicine (listed in section 6).<\/li><li><strong>if you have moderate to severe liver problems<\/strong><\/li><li><strong>if you are taking any of these medicines:<\/strong>&nbsp;see also&nbsp;<em>Using other medicines with EVOTAZ<\/em><ul><li>rifampicin (an&nbsp;antibiotic&nbsp;used to treat&nbsp;tuberculosis&nbsp;)<\/li><li>carbamazepine, phenobarbital, and&nbsp;phenytoin&nbsp;(&nbsp;antiepileptic drugs&nbsp;used to prevent seizures)<\/li><li>astemizole or terfenadine (often used to treat allergic symptoms, these medications may be over-the-counter);&nbsp;cisapride (used to treat acid reflux (heartburn));&nbsp;pimozide (used to treat schizophrenia);&nbsp;amiodarone, dronedarone,&nbsp;quinidine,&nbsp;lidocaine&nbsp;(for&nbsp;injection&nbsp;), or bepridil (used to correct heart rhythm);&nbsp;ergotamine, dihydroergotamine, ergonovine, ergometrine and methylergonovine (used to treat headaches) and alfuzosin (used to treat prostate enlargement).<\/li><li>quetiapine (used to treat schizophrenia,&nbsp;bipolar disorder,&nbsp;and major depression);&nbsp;lurasidone (used to treat schizophrenia).<\/li><li>medicines containing&nbsp;St. John&#8217;s wort&nbsp;(&nbsp;<em>Hypericum perforatum<\/em>, a herbal medicine).<\/li><li>triazolam and orally (taken by mouth) midazolam (used as a sleeping pill and\/or to reduce anxiety).<\/li><li>simvastatin, lovastatin, and lomitapide (used to lower blood cholesterol).<\/li><li>avanafil (used to treat&nbsp;erectile dysfunction&nbsp;)<\/li><li>colchicine (used to treat&nbsp;gout&nbsp;), if you have kidney and\/or liver problems<\/li><li>dabigatran and ticagrelor (used to prevent and prevent blood clots)<\/li><li>grazoprevir-containing products, including fixed-dose combinations of elbasvir and grazoprevir, as well as fixed-dose combinations of glekaprevir and pibrentasvir (used to treat&nbsp;chronic&nbsp;hepatitis&nbsp;C&nbsp;infection&nbsp;)<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>Do not take sildenafil with EVOTAZ when sildenafil is used to treat&nbsp;pulmonary&nbsp;arterialhypertension.&nbsp;Sildenafil is also used to treat&nbsp;erectile dysfunction.&nbsp;Tell your doctor if you are using sildenafil to treat&nbsp;erectile dysfunction.<br><\/p>\n\n\n\n<p>Tell your doctor immediately if this applies to you.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>For some people, special consideration may need to be given before or when taking EVOTAZ.&nbsp;Talk to your doctor or pharmacist before taking EVOTAZ.<br><\/p>\n\n\n\n<p><strong>EVOTAZ is not a cure for&nbsp;HIV&nbsp;&#8211;&nbsp;infection.&nbsp;<\/strong>You can continue to develop&nbsp;infections&nbsp;or diseases associated with&nbsp;HIV.&nbsp;You can still transmit&nbsp;HIV&nbsp;to other people when you take this medicine, even though the risk of effective&nbsp;antiviral&nbsp;treatment is&nbsp;reduced.&nbsp;Discuss with your doctor the necessary steps to avoid infecting others.<br><\/p>\n\n\n\n<p>Make sure your doctor knows the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have liver problems<\/li><li>if you develop signs or symptoms of&nbsp;gallstones&nbsp;(pain in the right side).&nbsp;Gallstones have been reported in patients taking atazanavir, one of the substances in EVOTAZ.<\/li><li>if you have&nbsp;hemophilia&nbsp;A or B. You may notice increased bleeding.<\/li><li>if you have kidney problems or need&nbsp;hemodialysis.&nbsp;Kidney stones&nbsp;have been reported in patients taking atazanavir, a substance in EVOTAZ.&nbsp;Tell your doctor immediately if you develop signs and symptoms of&nbsp;kidney stones&nbsp;(pain in the side, blood in the urine, pain when urinating).<\/li><li>if you are taking contraceptives (&nbsp;<strong>birth control pills<\/strong>&nbsp;) to prevent pregnancy.&nbsp;If you are currently using&nbsp;birth control pills&nbsp;or hormone patches to prevent pregnancy, you should use another type of contraceptive (such as a condom).<\/li><\/ul>\n\n\n\n<p>In some patients with advanced&nbsp;HIV&nbsp;&#8211;&nbsp;infection&nbsp;(&nbsp;AIDS&nbsp;) and a history of opportunistic&nbsp;infection,&nbsp;you (&nbsp;the infection&nbsp;that occurs due to the immune system is impaired), signs and symptoms of&nbsp;inflammation&nbsp;from previous&nbsp;infections&nbsp;may occur soon after anti-&nbsp;HIV&nbsp;started.&nbsp;These symptoms are probably due to an improvement in the body&#8217;s&nbsp;immune response, which enables the body to fight&nbsp;infections&nbsp;that may have been present without any obvious symptoms.&nbsp;Tell your doctor immediately if you notice any symptoms of&nbsp;infection.&nbsp;In addition to opportunistic&nbsp;infection,&nbsp;you can autoimmune disorders (a condition in which the immune system attacks healthy body tissue) may also occur after you start taking medicines to treat your&nbsp;HIV&nbsp;&#8211;&nbsp;infection.&nbsp;Autoimmune disorders can occur several months after starting treatment.&nbsp;If you notice any symptoms of&nbsp;infection&nbsp;or other symptoms such as muscle weakness, a weakness that starts in the hands or feet and moves to the torso, palpitations, tremors, or hyperactivity, inform your doctor immediately for the necessary treatment.<br><\/p>\n\n\n\n<p>Some patients receiving&nbsp;combination&nbsp;antiretroviral&nbsp;therapy may develop a bone disease called&nbsp;osteonecrosis&nbsp;(bone tissue dies due to lost blood supply to the bone).&nbsp;Some of the many risk factors for developing the disease are long-term&nbsp;antiretroviral combination therapy, use of&nbsp;corticosteroids, alcohol consumption, a severe weakening of the immune system, and higher body mass index.&nbsp;Signs of&nbsp;osteonecrosis&nbsp;are stiffness in the joints and pain (especially in the hip, knee, and shoulders) and difficulty moving.&nbsp;Tell your doctor if you experience any of these symptoms.<br><\/p>\n\n\n\n<p>Increased levels of bile dye in the blood (hyperbilirubinemia) have occurred in patients receiving EVOTAZ.&nbsp;Signs of this may be a mild yellowing of the skin or eyes.&nbsp;Tell your doctor if you experience any of these symptoms.<br><\/p>\n\n\n\n<p>Severe rash including&nbsp;Stevens-Johnson&nbsp;syndrome has been reported in patients taking EVOTAZ.&nbsp;Tell your doctor immediately if you develop a skin rash.<br><\/p>\n\n\n\n<p>EVOTAZ can affect how well your kidneys work.<br><\/p>\n\n\n\n<p>If you find that your heart beats differently (changes in your heart rhythm), tell your doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p><strong>Do not give this medicine to children and adolescents under 18 years of age.&nbsp;<\/strong>The use of EVOTAZ has not been studied in children and adolescents.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and EVOTAZ<\/h2>\n\n\n\n<p><strong>You must not take EVOTAZ with certain medicines.&nbsp;<\/strong>These are listed under Do not take EVOTAZ, at the beginning of section 2.<br><\/p>\n\n\n\n<p>Other medicines may not be taken together or may require a change in their route of administration when taken with EVOTAZ.&nbsp;Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.&nbsp;It is especially important to mention these:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>medicines containing ritonavir or cobicistat (enhancer)<\/li><li>other medications for treating&nbsp;HIV&nbsp;&#8211;&nbsp;infection&nbsp;(for example, indinavir, didanosine, tenofovir disoproxil, tenofoviralafenamid, efavirenz, etravirine, nevirapine, and maraviroc)<\/li><li>sofosbuvir \/ velpatasvir \/ voxilaprevir (used to treat&nbsp;hepatitis&nbsp;C)<\/li><li>sildenafil, vardenafil, and tadalafil (used by men to treat&nbsp;impotence&nbsp;[erectile dysfunction])<\/li><li>if you are taking contraceptives (&nbsp;birth control pills&nbsp;).&nbsp;You should also use another type of contraceptive (such as a condom).<\/li><li>medicines used to treat diseases related to stomach acid (&#8220;heartburn&#8221;) (eg antacids, H&nbsp;<sub>2<\/sub>&nbsp;blockers like famotidine, and&nbsp;proton pump inhibitors&nbsp;like omeprazole)<\/li><li>disopyramide,&nbsp;flecainide, mexiletine,&nbsp;propafenone,&nbsp;digoxin,&nbsp;bosentan, amlodipine, felodipine, nicardipine, nifedipine, verapamil,&nbsp;diltiazem,&nbsp;metoprolol, and&nbsp;timolol&nbsp;(medicines that lower&nbsp;blood pressure, lower or correct heart rhythm)<\/li><li>atorvastatin, pravastatin, fluvastatin, pitavastatin and rosuvastatin (used to lower blood cholesterol)<\/li><li>salmeterol&nbsp;(used to treat&nbsp;asthma&nbsp;)<\/li><li>ciclosporin, tacrolimus, and sirolimus (medicines that reduce the effects of the body&#8217;s immune system)<\/li><li>certain&nbsp;antibiotics&nbsp;(rifabutin, clarithromycin)<\/li><li>ketoconazole&nbsp;, itraconazole, voriconazole and&nbsp;fluconazole&nbsp;(antifungals)<\/li><li>metformin&nbsp;(used to treat&nbsp;type 2&nbsp;diabetes&nbsp;)<\/li><li>warfarin&nbsp;, apixaban, edoxaban and rivaroxaban (used to prevent blood clots)<\/li><li>irinotecan, dasatinib, nilotinib, vinblastine and vincristine (used to treat cancer)<\/li><li>trazodone (used to treat depression)<\/li><li>perphenazine,&nbsp;risperidone, thioridazine, midazolam (given as an&nbsp;injection&nbsp;), buspirone, clorazepate,&nbsp;diazepam, estazolam, flurazepam, and zolpidem (used to treat diseases of the nervous system)<\/li><li>buprenorphine (used to treat opioid dependence and as an analgesic)<\/li><\/ul>\n\n\n\n<p>It is important to tell your doctor if you are taking:&nbsp;Corticosteroids&nbsp;including betamethasone, budesonide,&nbsp;fluticasone, mometasone, prednisone, triamcinolone.&nbsp;These medicines are used to treat&nbsp;allergies,&nbsp;asthma, inflammatory bowel diseases,&nbsp;inflammation&nbsp;of the eyes, joints, and muscles, and other inflammatory diseases.&nbsp;If there are no alternatives, the drug should be used only after a doctor&#8217;s evaluation and under the close supervision of your doctor for&nbsp;side effects&nbsp;caused by&nbsp;corticosteroids.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>EVOTAZ should not be used during pregnancy, as the drug level in your blood may be lower during pregnancy and may not be high enough to control&nbsp;HIV.&nbsp;Your doctor may&nbsp;prescribe&nbsp;other medicines if you become pregnant while taking EVOTAZ.<br><\/p>\n\n\n\n<p>Atazanavir, an active substance in EVOTAZ, passes into breast milk.&nbsp;It is not known whether cobicistat, the other active substance in EVOTAZ, passes into breast milk, but it has been shown to pass into the milk of animals.&nbsp;Tell your doctor that you are breastfeeding if you are taking EVOTAZ.&nbsp;Patients should not breast-feed while taking EVOTAZ.&nbsp;It is recommended that women infected with&nbsp;HIV&nbsp;do not breast-feed as the&nbsp;virus&nbsp;can be transmitted through breast milk.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Some patients have reported dizziness after taking atazanavir and cobicistat, the active substances of EVOTAZ.&nbsp;Do not drive or use machines if you feel dizzy or dizzy.&nbsp;Contact your doctor immediately.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to take EVOTAZ<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor has told you.&nbsp;Consult a doctor if you are unsure.&nbsp;In this way, you can be sure that you get the full effect of your medication and reduce the risk of&nbsp;HIV&nbsp;&#8211;&nbsp;the virus&nbsp;et develop&nbsp;resistance&nbsp;to the treatment.<br><\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;for adults of EVOTAZ is one tablet daily with food, in combination with other anti-&nbsp;HIV&nbsp;medicines.&nbsp;The tablets have a bad taste, so swallow the tablet whole;&nbsp;do not crush or chew the tablets.&nbsp;This will help you make sure you get the full&nbsp;dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more EVOTAZ than you should<\/h2>\n\n\n\n<p>If you accidentally take more EVOTAZ than your doctor has recommended, contact your&nbsp;HIV&nbsp;doctor immediately or contact&nbsp;your&nbsp;nearest hospital for advice.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take EVOTAZ<\/h2>\n\n\n\n<p>If you forget to take a&nbsp;dose&nbsp;of EVOTAZ and discover it within 12 hours, take it with food as soon as possible and then take the next&nbsp;dose&nbsp;at the usual time.&nbsp;If you miss a&nbsp;dose&nbsp;and it is more than 12 hours since you should take EVOTAZ, do not take the missed&nbsp;dose.&nbsp;Wait and take the next&nbsp;dose&nbsp;at the usual time.&nbsp;Do not take a double&nbsp;dose&nbsp;the next time.&nbsp;It is important not to forget to take any&nbsp;dose&nbsp;of EVOTAZ or your other anti-&nbsp;HIV&nbsp;medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking EVOTAZ<\/h2>\n\n\n\n<p>Do not stop taking EVOTAZ before talking to your doctor.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.&nbsp;Tell your doctor if you notice anything unusual about your health.<br><\/p>\n\n\n\n<p>The following&nbsp;side effects&nbsp;may occur with EVOTAZ<br><\/p>\n\n\n\n<p>Very common (may affect more than 1 user in 10)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>yellowing of the skin or whites of the eyes<\/li><li>nausea<\/li><\/ul>\n\n\n\n<p>Common (may affect up to 1 in 10 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>increased levels of&nbsp;bilirubin&nbsp;in the blood<\/li><li>vomiting, diarrhea, stomach pain or discomfort, regurgitation, distended abdomen, gas (&nbsp;flatulence&nbsp;)<\/li><li>headache, dizziness<\/li><li>extreme fatigue<\/li><li>increased appetite, impaired sense of taste,&nbsp;dry mouth<\/li><li>difficulty sleeping, abnormal dreams, fatigue<\/li><li>rash<\/li><\/ul>\n\n\n\n<p>Uncommon (may affect up to 1 in 100 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>life-threatening irregular heartbeat (&nbsp;torsade de pointes&nbsp;)<\/li><li>allergic reaction&nbsp;(hypersensitivity)<\/li><li>inflammation&nbsp;of the liver<\/li><li>pancreatitis, gastritis<\/li><li>allergic reactions with rash, high fever, increased levels of liver enzymes in blood samples, increased levels of&nbsp;white blood cells&nbsp;(&nbsp;eosinophilia&nbsp;) and\/or enlarged&nbsp;lymph nodes&nbsp;) (see section 2)<\/li><li>severe swelling of the skin and other&nbsp;tissues&nbsp;usually your lips or eyes<\/li><li>fainting, high&nbsp;blood pressure<\/li><li>chest pain, malaise, fever<\/li><li>respiratory distress<\/li><li>kidney stone disease, kidney inflammation, blood in the urine, increased amount of protein in the urine, more frequent urination,&nbsp;chronic&nbsp;kidney disease (how well your kidneys are working)<\/li><li>gallstones&nbsp;ar<\/li><li>muscle wasting, joint pain, muscle pain<\/li><li>breast augmentation in men<\/li><li>depression, anxiety, sleep disturbance<\/li><li>abnormal fatigue or weakness<\/li><li>loss of appetite, weight loss, weight gain<\/li><li>disorientation, memory loss<\/li><li>numbness, weakness, tingling, or pain in the arms and legs<\/li><li>cold sores and colds<\/li><li>itchy rash, abnormal hair loss or thinning,&nbsp;itching<\/li><\/ul>\n\n\n\n<p>Rare (may affect up to 1 in 1,000 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>allergic reactions with severe skin rash, high fever, and enlarged&nbsp;lymph nodes(Stevens-Johnson syndrome, see section 2).<\/li><li>fast or irregular heartbeat (QTc prolongation)<\/li><li>enlargement of the liver and spleen<\/li><li>gallbladder inflammation<\/li><li>kidney pain<\/li><li>swelling<\/li><li>visible accumulation of fluid under the skin, rash, vasodilation<\/li><li>abnormal gait<\/li><li>muscle pain, muscle weakness not caused by exercise<br><\/li><\/ul>\n\n\n\n<p>During&nbsp;HIV&nbsp;treatment, weight gain and increased levels of fats and sugar in the blood may occur.&nbsp;This is partly related to restored health and lifestyle, but when it comes to blood fats, there can sometimes be a connection with&nbsp;HIV&nbsp;drugs.&nbsp;The doctor will perform tests to find such changes.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store EVOTAZ<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the label and carton after EXP.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>Do not store above 30 \u00b0 C.<br><\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substances are atazanavir and cobicistat.&nbsp;Each film-coated tablet contains 300 mg of atazanavir (as sulfate) and 150 mg of cobicistat.<\/li><li>Other ingredients are:<ul><li><em>Tablet core<\/em>&nbsp;&#8211; microcrystalline cellulose (E460 (i)), croscarmellose sodium (E468), sodium starch glycolate, crospovidone (E1202), stearic acid (E570), magnesium stearate (E470b), hydroxypropylcellulose (E463), silica (E463)<\/li><li><em>Film coating<\/em>&nbsp;&#8211; hypromellose (hydroxypropyl methylcellulose, E464), titanium dioxide (E171), talc (E553b), triacetin (E1518), red iron oxide (E172)<\/li><\/ul><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>EVOTAZ film-coated tablets are pink, oval, biconvex, measuring 19 mm x 10.4 mm, debossed with &#8220;3641&#8221; on one side, and flat on the other side of the tablet.<br><\/p>\n\n\n\n<p>EVOTAZ film-coated tablets are packaged in bottles of 30 tablets.&nbsp;The following pack sizes are available: an outer carton of 1 bottle of 30 film-coated tablets and an outer carton of 90 (3 bottles of 30) film-coated tablets.<br><\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Bristol-Myers Squibb Pharma EEIG<\/p>\n\n\n\n<p>Plaza 254&nbsp;<br>Blanchardstown Corporate Park 2&nbsp;<br>Dublin 15, D15 T867<\/p>\n\n\n\n<p>Ireland<br><\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>CATALENT ANAGNI SRL<\/p>\n\n\n\n<p>Loc.&nbsp;Fontana del Ceraso snc<\/p>\n\n\n\n<p>Provincial Street 12 Casilina, 41<\/p>\n\n\n\n<p>03012 Anagni (FR)<\/p>\n\n\n\n<p>Italy<br><\/p>\n\n\n\n<p>Swords Laboratories T \/ A Bristol-Myers Squibb Pharmaceutical Operations,<\/p>\n\n\n\n<p>External Manufacturing<\/p>\n\n\n\n<p>Plaza 254<\/p>\n\n\n\n<p>Blanchardstown Corporate Park 2<\/p>\n\n\n\n<p>Dublin 15, D15 T867<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>Contact the representative of the marketing authorization holder to find out more about this medicine.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgique \/ Belgi\u00eb \/ Belgien<\/strong>NV Bristol \u2011 Myers Squibb Belgium SATel: + 32 2 352 76 11<\/td><td><strong>Lithuania<\/strong>Bristol-Myers Squibb Kft.Tel: + 370 5 236 9140<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Bristol \u2011 Myers Squibb Kft.Tel: + 359 2 4942 480<\/td><td><strong>Luxembourg \/ Luxemburg<\/strong>NV Bristol \u2011 Myers Squibb Belgium SATel: + 32 2 352 76 11<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Bristol \u2011 Myers Squibb spol.&nbsp;s roTel: + 420 221 016 111<\/td><td><strong>Hungary<\/strong>Bristol-Myers Squibb Kft.Tel: + 36 1 9206 550<\/td><\/tr><tr><td><strong>Denmark<\/strong>Bristol \u2011 Myers SquibbTel: + 45 45 93 05 06<\/td><td><strong>Malta<\/strong>Bristol \u2011 Myers Squibb SrlTel: + 356 23976333<\/td><\/tr><tr><td><strong>Germany<\/strong>Bristol \u2011 Myers Squibb GmbH &amp; Co.&nbsp;KGaATel: 0800 0752002 (+49 (0) 89 121 42 350)<\/td><td><strong>The Netherlands<\/strong>Bristol \u2011 Myers Squibb BVTel: + 31 (0) 30 300 2222<\/td><\/tr><tr><td><strong>Eesti<\/strong>Bristol-Myers Squibb Kft.Tel: + 372 6401030<\/td><td><strong>Norway<\/strong>Bristol \u2011 Myers Squibb Norway LtdTel: + 47 67 55 53 50<\/td><\/tr><tr><td><strong>Greece<\/strong>Bristol \u2011 Myers Squibb AE:\u0397\u03bb: + 30 210 6074300<\/td><td><strong>Austria<\/strong>Bristol \u2011 Myers Squibb GesmbHTel: + 43 1 60 14 30<\/td><\/tr><tr><td><strong>Spain<\/strong>Bristol \u2011 Myers Squibb, SATel: + 34 91 456 53 00<\/td><td><strong>Poland<\/strong>Bristol \u2011 Myers Squibb Polska Sp.&nbsp;z ooTel .: + 48 22 2606400<\/td><\/tr><tr><td><strong>France<\/strong>Bristol \u2011 Myers Squibb SARLTel: + 33 (0) 810 410 500<\/td><td><strong>Portugal<\/strong>Bristol \u2011 Myers Squibb Pharmac\u00eautica Portuguesa, SATel: + 351 21 440 70 00<\/td><\/tr><tr><td><strong>Croatia<\/strong>Bristol \u2011 Myers Squibb spol.&nbsp;s Rotel: +385 1 2078\u2011508<\/td><td><strong>Romania<\/strong>Bristol \u2011 Myers Squibb Kft.Tel: + 40 (0) 21 272 16 00<\/td><\/tr><tr><td><strong>Ireland<\/strong>Bristol \u2011 Myers Squibb Pharmaceuticals ucTel: + 353 (0) 1 483 3625<\/td><td><strong>Slovenia<\/strong>Bristol \u2011 Myers Squibb spol.&nbsp;s roTel: + 386 1 2355 100<\/td><\/tr><tr><td><strong>Iceland<\/strong>Bristol-Myers Squibb AB at Visitor hf.Phone: + 354 535 7000<\/td><td><strong>Slovak Republic<\/strong>Bristol \u2011 Myers Squibb spol.&nbsp;s roTel: + 421 2 20833 600<\/td><\/tr><tr><td><strong>Italy<\/strong>Bristol \u2011 Myers Squibb SrlTel: + 39 06 50 39 61<\/td><td><strong>Finland \/ Finland<\/strong>Oy Bristol \u2011 Myers Squibb (Finland) AbPuh \/ Tel: + 358 9 251 21 230<\/td><\/tr><tr><td><strong>Latvia<\/strong>Bristol-Myers Squibb Kft.Tel: + 371 66164750<\/td><td><strong>United Kingdom<\/strong>Bristol \u2011 Myers Squibb Pharmaceuticals LtdTel: + 44 (0800) 731 1736<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p> 300 mg \/ 150 mg film-coated tablets<br \/>\natazanavir \/ cobicistat<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2205,2200],"tags":[3367,3369,3370,3368,3362,3365,3366,3363,3371,3373,3374,3372,2212,2211],"class_list":["post-8524","post","type-post","status-publish","format-standard","hentry","category-e","category-medicines","tag-atazanavir","tag-atazanavir-dose","tag-atazanavir-side-effects","tag-atazanavir-uses","tag-cobicistat","tag-cobicistat-dose","tag-cobicistat-side-effects","tag-cobicistat-uses","tag-evotaz","tag-evotaz-dose","tag-evotaz-side-effects","tag-evotaz-uses","tag-medicine","tag-tablets"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8524","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=8524"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8524\/revisions"}],"predecessor-version":[{"id":10055,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8524\/revisions\/10055"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=8524"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=8524"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=8524"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}