{"id":8520,"date":"2021-03-13T09:21:30","date_gmt":"2021-03-13T09:21:30","guid":{"rendered":"https:\/\/zeepedia.com\/?p=8520"},"modified":"2021-04-12T16:16:59","modified_gmt":"2021-04-12T16:16:59","slug":"eviplera","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/eviplera\/","title":{"rendered":"Eviplera &#8211; Tenofovir Disoproxil \/ Rilpivirine \/ Emtricitabine uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n200 mg \/ 25 mg \/ 245 mg&nbsp;film-coated tablets&nbsp;<br>emtricitabine \/ rilpivirine \/ tenofovir disoproxil<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Eviplera is and what it is used for<\/h2>\n\n\n\n<p><strong>Eviplera contains three active substances<\/strong>&nbsp;used to treat&nbsp;human immunodeficiency virus (&nbsp;HIV&nbsp;)&nbsp;infection&nbsp;:<br><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Emtricitabine, a&nbsp;nucleoside&nbsp;reverse transcriptase inhibitor (NRTI).<\/li><li>Rilpivirine, a non-&nbsp;nucleoside&nbsp;reverse transcriptase inhibitor (NNRTI).<\/li><li>Tenofovir disoproxil, a&nbsp;nucleotide&nbsp;reverse transcriptase inhibitor (NRTI).<\/li><\/ul>\n\n\n\n<p>Each of these active substances, also called antiretroviral drugs, acts by disrupting an&nbsp;enzyme&nbsp;(a&nbsp;protein&nbsp;called &#8220;reverse transcriptase&#8221;) that is necessary for the&nbsp;virus&nbsp;to multiply.<br><\/p>\n\n\n\n<p>Eviplera reduces the amount of&nbsp;HIV&nbsp;in the body.&nbsp;This strengthens the immune system and the risk of developing illnesses associated with&nbsp;HIV&nbsp;&#8211;&nbsp;infection&nbsp;decreases.<br><\/p>\n\n\n\n<p><strong>Eviplera is a treatment for&nbsp;human&nbsp;immunodeficiency virus (&nbsp;HIV&nbsp;)<\/strong>&nbsp;infection in adults aged 18 years and older.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before taking Eviplera<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Eviplera<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>If you are allergic<\/strong>&nbsp;to emtricitabine, rilpivirine, tenofovir disoproxil, or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<p>\u2192&nbsp;<strong>If this applies to you, tell your doctor immediately.<\/strong><br><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>If you are currently taking any of the following medicines<\/strong><ul><li><strong>carbamazepine, oxcarbazepine, phenobarbital, and&nbsp;phenytoin<\/strong>&nbsp;(medicines to treat&nbsp;epilepsy&nbsp;and to prevent seizures)<\/li><li><strong>rifampicin and rifapentine<\/strong>&nbsp;(used to treat certain bacterial&nbsp;infections&nbsp;like&nbsp;tuberculosis&nbsp;)<\/li><li><strong>omeprazole, lansoprazole, rabeprazole, pantoprazole, and esomeprazole<\/strong>&nbsp;(&nbsp;proton pump inhibitors&nbsp;which are medicines used to prevent and treat&nbsp;stomach ulcers, heartburn, acid reflux)<\/li><li><strong><a href=\"https:\/\/zeepedia.com\/medical\/medicines\/toflacort\/\">dexamethasone<\/a><\/strong>&nbsp;(a&nbsp;corticosteroid&nbsp;used to treat&nbsp;inflammation&nbsp;and to&nbsp;suppress the&nbsp;immune system) when taken by mouth or given as an&nbsp;injection&nbsp;(except when treated with a single dose)<\/li><li><strong>products containing&nbsp;St. John&#8217;s wort&nbsp;<\/strong><em>(Hypericum perforatum)<\/em>&nbsp;(a traditional herbal medicine used for mild depression and mild anxiety)<\/li><\/ul><\/li><\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Warnings and cautions<\/h3>\n\n\n\n<p>Your treatment with Eviplera must be constantly monitored by a doctor.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>You can still transmit&nbsp;HIV&nbsp;infection<\/strong>&nbsp;when you take this medicine, even though the risk of effective&nbsp;antiviral&nbsp;therapy is&nbsp;reduced.&nbsp;Discuss with your doctor the necessary steps to avoid infecting others.&nbsp;This medicine does not cure&nbsp;HIV&nbsp;&#8211;&nbsp;infection.&nbsp;While taking Eviplera you may still develop&nbsp;infections&nbsp;you or other illnesses associated with&nbsp;HIV&nbsp;&#8211;&nbsp;infection.<br><\/li><li><strong>Tell your doctor if you have&nbsp;had kidney disease<\/strong>&nbsp;or if tests have shown that you have kidney problems.&nbsp;Eviplera can affect your kidneys.&nbsp;Before starting treatment and during treatment, your doctor may&nbsp;prescribe&nbsp;some blood tests to check if your kidneys are functioning normally.&nbsp;Eviplera is not recommended if you have moderate or severe kidney disease.<br>Eviplera is not usually taken with other medicines that can damage the kidneys (see&nbsp;<em>Other medicines and Eviplera<\/em>&nbsp;).&nbsp;If this is unavoidable, your doctor will check your kidney function once a week.<br><\/li><li><strong>Tell your doctor if you have&nbsp;or have had liver disease, including&nbsp;hepatitis.&nbsp;<\/strong>HIV&nbsp;patients with liver disease (including&nbsp;chronic&nbsp;hepatitis&nbsp;B or C) treated with antiretroviral drugs are at increased risk for severe and life-threatening liver problems.&nbsp;If you have&nbsp;hepatitis&nbsp;B, your doctor will carefully consider the best treatment for you.&nbsp;Two of the active substances in Eviplera (tenofovir disoproxil and emtricitabine) show some activity against&nbsp;the hepatitis&nbsp;B&nbsp;virus.&nbsp;If you have or have had liver disease or&nbsp;chronic&nbsp;hepatitis&nbsp;B&nbsp;infection, your doctor may take blood samples to check your liver function.<br>If you have&nbsp;a hepatitis&nbsp;B&nbsp;infection, liver problems may worsen after you stop taking Eviplera.&nbsp;It is important that you do not stop taking Eviplera without talking to your doctor: see section 3,&nbsp;<em>Do not stop taking Eviplera.<\/em><br><\/li><li><strong>Tell your doctor immediately and stop taking Eviplera if you develop a rash with the following symptoms: fever, blisters, red eyes, and swelling of the face, mouth,h, or body.&nbsp;<\/strong>This can be serious or potentially life-threatening.<br><\/li><li><strong>Talk to your doctor if you are over 65 years old<\/strong>.&nbsp;Not enough patients over the age of 65 have been studied.&nbsp;If you are over 65 years of age and have been prescribed Eviplera, your doctor will monitor you closely.<\/li><\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">While taking Eviplera<\/h3>\n\n\n\n<p>Once you have started taking Eviplera, you should be observant of:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>any signs of&nbsp;inflammation&nbsp;or&nbsp;infection<\/li><li>leg problem<\/li><\/ul>\n\n\n\n<p>\u2192&nbsp;<strong>Contact a doctor immediately if you get any of these symptoms.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p><strong>Do not give this medicine to children<\/strong>&nbsp;and teenagers under 18 years of age.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Eviplera<\/h2>\n\n\n\n<p><strong>Tell<\/strong>&nbsp;your&nbsp;<strong>doctor<\/strong>&nbsp;or pharmacist if you are taking, have recently taken, or might take any other medicines.&nbsp;This includes over-the-counter medicines, herbal remedies, or other natural products.<br><\/p>\n\n\n\n<p><strong>Tell your doctor<\/strong>&nbsp;if you are taking any of the following:<\/p>\n\n\n\n<p><strong>Other medicines that contain<\/strong>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>emtricitabine<\/li><li>rilpivirine<\/li><li>tenofovir disoproxil<\/li><li>tenofoviralafenamide<\/li><li>other antiviral medicines containing <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/triumeq\/\">lamivudine<\/a> or adefovir dipivoxil<\/li><\/ul>\n\n\n\n<p>Eviplera may&nbsp;interact&nbsp;with other medicines.&nbsp;This may affect the amount of Eviplera or other medicines in the blood.&nbsp;The medicines may then not work properly or any&nbsp;side effects&nbsp;may be&nbsp;exacerbated.&nbsp;In some cases, your doctor may need to change your&nbsp;dose&nbsp;or check the amount of medicine in your blood.<br><\/p>\n\n\n\n<p><strong>Drugs that can damage the kidneys<\/strong>, for example:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>aminoglycosides&nbsp;(eg streptomycin,&nbsp;neomycin,&nbsp;and gentamicin), vancomycin (against bacterial&nbsp;infections&nbsp;)<\/li><li>foscarnet, ganciclovir, cidofovir (for viral infections)<\/li><li>amphotericin B, pentamidine (against fungal infections)<\/li><li>interleukin&nbsp;-2, also called aldesleukin (for the treatment of cancer)<\/li><li>non-steroidal anti-inflammatory drugs (&nbsp;NSAIDs&nbsp; to relieve skeletal or muscle pain)<\/li><\/ul>\n\n\n\n<p><strong>Medicines containing didanosine (for&nbsp;HIV&nbsp;&#8211;&nbsp;infection&nbsp;):<\/strong>&nbsp;If you take Eviplera with other antiviral medicines that contain didanosine, blood levels of didanosine increase, and CD4 + cell counts drop.&nbsp;Rare cases of pancreatitis and lactic acidosis (excess&nbsp;lactic acid&nbsp;in the blood), in some cases fatal, have been reported during concomitant treatment with drugs containing tenofovir disoproxil and didanosine.&nbsp;Your doctor will carefully consider whether to treat you with other medicines used to treat&nbsp;HIV&nbsp;&#8211;&nbsp;infection&nbsp;(&nbsp;<em>see Other medicines used to treat&nbsp;HIV&nbsp;&#8211;&nbsp;infection<\/em>&nbsp;).<br><\/p>\n\n\n\n<p><strong>Other medicines used to&nbsp;treat&nbsp;HIV&nbsp;infection:<\/strong>&nbsp;Non-nucleoside reverse transcriptase inhibitors (NNRTIs).&nbsp;Eviplera contains an NNRTI (rilpivirine) and therefore Eviplera should not be combined with other medicines of this type.&nbsp;If necessary, your doctor will discuss another medicine.<br><\/p>\n\n\n\n<p><strong>Rifabutin,<\/strong>&nbsp;a drug used to treat certain bacterial&nbsp;infections.&nbsp;This medicine may reduce the amount of rilpivirine (an ingredient in Eviplera) in the blood.&nbsp;The doctor may need to give you another&nbsp;dose of&nbsp;rilpivirine to treat your&nbsp;HIV&nbsp;&#8211;&nbsp;infection&nbsp;<em>(see section 3. How to take Eviplera)<\/em>.<br><\/p>\n\n\n\n<p><strong>Antibiotics&nbsp;used to treat bacterial&nbsp;infection&nbsp;s<\/strong>, including tuberculosis:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>clarithromycin<\/li><li>erythromycin<\/li><\/ul>\n\n\n\n<p>These medicines can increase the amount of rilpivirine (a component of Eviplera) in the blood.&nbsp;Your doctor may need to change the&nbsp;dose of&nbsp;one of the&nbsp;antibiotics&nbsp;or give you another&nbsp;antibiotic.<br><\/p>\n\n\n\n<p><strong>Medicines for&nbsp;stomach ulcers, heartburn, or acid reflux<\/strong>&nbsp;such as:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>antacids (aluminum\/magnesium hydroxide or&nbsp;calcium carbonate&nbsp;)<\/li><li>H&nbsp;<sub>2<\/sub>&nbsp;&#8211;&nbsp;antagonist&nbsp;is (famotidine, cimetidine, nizatidine, or ranitidine)<\/li><\/ul>\n\n\n\n<p>These medicines can reduce the amount of rilpivirine (an ingredient in Eviplera) in your blood.&nbsp;If you take any of these medicines, your doctor will either give you another medicine for&nbsp;stomach ulcers, heartburn, or acid reflux or recommend how and when to take it.<br><\/p>\n\n\n\n<p><strong>If you are taking an antacid<\/strong>&nbsp;(eg medicines containing&nbsp;magnesium&nbsp;or&nbsp;potassium&nbsp;), take it at least 2 hours before or at least 4 hours after Eviplera&nbsp;<em>(see section 3 How to take Eviplera)<\/em>.<br><\/p>\n\n\n\n<p><strong>If you take an H&nbsp;<sub>2<\/sub>&nbsp;&#8211;&nbsp;antagonists&nbsp;<\/strong>(used to treat&nbsp;stomach ulcers, heartburn, or acid reflux), take it at least 12 hours before or at least 4 hours after Eviplera.&nbsp;The H2&nbsp;antagonist&nbsp;can only be taken once a day if you are taking Eviplera.&nbsp;H2&nbsp;antagonist,&nbsp;you should not be taken with&nbsp;dosage&nbsp;twice a day.&nbsp;Talk to your doctor about an alternative treatment regimen (&nbsp;<em>see section 3 How to take Eviplera)<\/em>.<br><\/p>\n\n\n\n<p><strong>Methadone<\/strong>, a drug used to treat opiate addiction, as your doctor may need to change your methadone dose.<br><\/p>\n\n\n\n<p><strong>Dabigatran etexilate<\/strong>, a medicine used to treat heart conditions, as your doctor may need to check the levels of this medicine in your blood.<br><\/p>\n\n\n\n<p>\u2192&nbsp;<strong>Tell your doctor if you are taking any of these medicines<\/strong>.&nbsp;You should not stop treatment without talking to your doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<br><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Use an effective method of contraception<\/strong>&nbsp;while taking Eviplera.<\/li><li><strong>Tell your doctor immediately if you become pregnant&nbsp;or are planning to become pregnant.&nbsp;<\/strong>Pregnant women should discuss the use of Eviplera with their doctor.&nbsp;Your doctor will discuss the benefits and risks of taking Eviplera for you and your baby.<\/li><li><strong>If you have taken Eviplera<\/strong>&nbsp;during your pregnancy, your doctor may ask you to have regular blood tests and other tests to check your baby&#8217;s development.&nbsp;For children whose&nbsp;mothers&nbsp;took NRTIs during pregnancy, the benefit of&nbsp;HIV protection outweighs the&nbsp;risk of&nbsp;side effects.<\/li><\/ul>\n\n\n\n<p><strong>Do not breast-feed during treatment with Eviplera:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>This is because the active substances in this medicine are excreted in human breast milk.<\/li><li>If you are an&nbsp;HIV-&nbsp;infected woman, it is recommended that you do not breast-feed your baby to avoid transmitting&nbsp;HIV&nbsp;to&nbsp;your&nbsp;baby through breast milk.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Do not drive or use any tools or machines if you feel tired, drowsy, or dizzy while taking this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Eviplera contains lactose, para-orange aluminum lacquer (E110), and sodium<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine<\/li><li><strong>Tell your doctor if you are allergic to para-orange aluminum paint (E110).&nbsp;<\/strong>Eviplera contains para-orange aluminum lacquer, also called &#8220;E110&#8221; which can cause allergic reactions.<\/li><li>This medicine contains less than 1 mmol&nbsp;sodium&nbsp;(23 mg) per tablet, ie essentially &#8216;sodium-free&#8217;.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to take Eviplera<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<br><\/p>\n\n\n\n<p><strong>The usual&nbsp;dose&nbsp;is one tablet taken daily by mouth.&nbsp;The tablet must be taken with food<\/strong>.&nbsp;This is important for you to get the right levels of the active substance in your body.&nbsp;A nutritional drink alone does not replace food.<br><\/p>\n\n\n\n<p>Swallow the tablet whole with water.<br><\/p>\n\n\n\n<p><strong>Do not chew, crush or split the tablet<\/strong>&nbsp;&#8211; if you do, it may affect the&nbsp;release of&nbsp;one of the drugs in the body.<br><\/p>\n\n\n\n<p>If your doctor decides to stop one of the components of Eviplera or change the&nbsp;dose of Eviplera, you may be given emtricitabine, rilpivirine, and\/or tenofovir disoproxil separately or with other medicines to treat&nbsp;HIV&nbsp;&#8211;&nbsp;infection.<br><\/p>\n\n\n\n<p><strong>If you are taking an antacid<\/strong>&nbsp;such as&nbsp;medicines containing&nbsp;magnesium&nbsp;or&nbsp;potassium.&nbsp;Take it at least 2 hours before or at least 4 hours after Eviplera.<br><\/p>\n\n\n\n<p><strong>If you take an H&nbsp;<sub>2<\/sub>&nbsp;&#8211;&nbsp;antagonist<\/strong>&nbsp;that as famotidine, cimetidine, nizatidine, or ranitidine.&nbsp;Take it at least 12 hours before or at least 4 hours after Eviplera.&nbsp;H&nbsp;<sub>2<\/sub>&nbsp;&#8211;&nbsp;antagonist,&nbsp;you can only be taken once a day if you take Eviplera.&nbsp;H2 antagonists should not be taken twice a day.&nbsp;Talk to your doctor about an alternative treatment regimen.<br><\/p>\n\n\n\n<p><strong>If you are taking rifabutin.&nbsp;<\/strong>Your doctor may need to give you another&nbsp;dose of rilpivirine.&nbsp;Take the rilpivirine tablet while you are taking Eviplera.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Eviplera then you should<\/h2>\n\n\n\n<p>If you accidentally take more than the prescribed&nbsp;dose&nbsp;of Eviplera, the risk of&nbsp;side effects&nbsp;is with this medicine may increase (see&nbsp;<em>section 4, Possible&nbsp;side effects&nbsp;s<\/em>&nbsp;).<br><\/p>\n\n\n\n<p>Contact your doctor or nearest emergency department immediately for advice.&nbsp;Save the jar so you can easily describe what you have taken.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Eviplera<\/h2>\n\n\n\n<p>You mustn&#8217;t miss a&nbsp;dose of&nbsp;Eviplera.<br><\/p>\n\n\n\n<p>If you miss a dose:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>If you notice it within 12 hours<\/strong>&nbsp;after the time you usually take Eviplera, you must take the tablet as soon as possible.&nbsp;The tablet must always be taken with food.&nbsp;Then take the next&nbsp;dose&nbsp;as usual.<\/li><li><strong>If you notice it 12 hours or more<\/strong>&nbsp;after the time you usually take Eviplera, do not take the missed&nbsp;dose.&nbsp;Wait and take the next&nbsp;dose&nbsp;of food at its regular time.<\/li><\/ul>\n\n\n\n<p><strong>If you vomit within less than 4 hours after a&nbsp;dose of&nbsp;Eviplera<\/strong>, take a new tablet of food.&nbsp;<strong>If you vomit more than 4 hours after taking Eviplera<\/strong>, you do not need to take a new tablet until it is time to take your next&nbsp;dose&nbsp;at the usual time.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Do not stop taking Eviplera<\/h2>\n\n\n\n<p><strong>Do not stop taking Eviplera without talking to your doctor.&nbsp;<\/strong>If you stop taking Eviplera, it may seriously affect your response to future treatment.&nbsp;If for any reason you stop taking Eviplera talk to your doctor before taking Eviplera tablets again.&nbsp;Your doctor may consider giving you the components of Eviplera individually if you have any problems or need a dose adjustment.<br><\/p>\n\n\n\n<p><strong>When your Eviplera supply starts to run low<\/strong>, get more from&nbsp;<strong>your<\/strong>&nbsp;doctor or pharmacist.&nbsp;This is very important because the amount of&nbsp;virus&nbsp;can start to increase even if you only stop taking the medicine for a short time.&nbsp;The virus&nbsp;can then become more difficult to treat.<br><\/p>\n\n\n\n<p><strong>If you have&nbsp;HIV&nbsp;&#8211;&nbsp;infection&nbsp;and&nbsp;hepatitis&nbsp;B&nbsp;infection<\/strong>, it is especially important not to stop your Eviplera treatment without first talking to your doctor.&nbsp;Some patients&#8217; blood tests or symptoms have shown that their&nbsp;hepatitis&nbsp;has worsened when treatment with emtricitabine or tenofovir disoproxil (two of the three active substances in Eviplera) is stopped.&nbsp;If you stop taking Eviplera, your doctor may recommend that you resume treatment for&nbsp;hepatitis&nbsp;B. You may need to provide blood tests to check how your liver is working for 4 months after stopping treatment.&nbsp;In some patients with advanced liver disease or&nbsp;cirrhosis, it is not recommended that treatment be discontinued as this may lead to&nbsp;worsening of&nbsp;hepatitis&nbsp;A, which may be life-threatening.<br><\/p>\n\n\n\n<p><strong>\u2192 Tell your doctor immediately<\/strong>&nbsp;about any new and unexpected symptoms that occur after stopping treatment, especially symptoms that you usually associate with your&nbsp;hepatitis&nbsp;B&nbsp;infection.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects,&nbsp;although not everybody gets them.<br><\/p>\n\n\n\n<p><strong>Possible side effects: Contact a doctor immediately<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Lactic acidosis<\/strong>&nbsp;(too much&nbsp;lactic acid&nbsp;in the blood) is a rare but potentially life-threatening&nbsp;side effect&nbsp;of certain&nbsp;HIV&nbsp;medicines.&nbsp;Lactic acidosis is more common in women &#8211; especially if they are overweight, and in people with liver disease.&nbsp;The following may be signs of lactic acidosis:<ul><li>Deep, rapid breathing<\/li><li>Fatigue or drowsiness<\/li><li>Nausea, vomiting<\/li><li>Stomach pain<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>\u2192&nbsp;<strong>Contact a doctor immediately if you think you may have lactic acidosis.<\/strong><br><\/p>\n\n\n\n<p><strong>Any sign of&nbsp;inflammation&nbsp;or&nbsp;infection.&nbsp;<\/strong>In some patients with advanced&nbsp;HIV&nbsp;&#8211;&nbsp;infection&nbsp;(&nbsp;AIDS&nbsp;) who have a history of opportunistic&nbsp;infection,&nbsp;you (&nbsp;infection&nbsp;s that occur in people with weakened immune systems) may be signs and symptoms of&nbsp;inflammation&nbsp;from previous&nbsp;infections&nbsp;that occur shortly after&nbsp;HIV&nbsp;treatment is started.&nbsp;It is believed that these symptoms are because the body&#8217;s immune system has been strengthened so that the body can fight&nbsp;infections&nbsp;that may have been present without giving any clear symptoms.<br><\/p>\n\n\n\n<p>In addition to opportunistic&nbsp;infection,&nbsp;you can autoimmune disorders (a condition in which the immune system attacks healthy body tissue) may also occur after you start taking medicines to treat your&nbsp;HIV&nbsp;&#8211;&nbsp;infection.&nbsp;Autoimmune disorders can occur several months after starting treatment.&nbsp;If you notice any symptoms of&nbsp;infection&nbsp;or other symptoms such as muscle weakness, a weakness that starts in the hands or feet and moves to the torso, palpitations, tremors, or hyperactivity, inform your doctor immediately for the necessary treatment.<br><\/p>\n\n\n\n<p>\u2192&nbsp;<strong>If you notice any symptoms of&nbsp;inflammation&nbsp;or&nbsp;infection, tell your doctor immediately.<\/strong><br><\/p>\n\n\n\n<p><strong>Very common&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p><em>(may occur in more than 1 in 10 people)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Diarrhea, vomiting, nausea<\/li><li>Difficulty sleeping&nbsp;<em>(insomnia)<\/em><\/li><li>Dizziness, headache<\/li><li>Rash<\/li><li>Feeling weak<\/li><\/ul>\n\n\n\n<p><em>Samples can also show<\/em>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Lowering the phosphate level in the blood<\/li><li>Elevated levels of creatine kinase in the blood can cause muscle pain and muscle weakness<\/li><li>Elevated levels of&nbsp;cholesterol&nbsp;and\/or pancreatic amylase (&nbsp;enzyme&nbsp;from the pancreas) in the blood<\/li><li>Elevated levels of liver enzymes in the blood<\/li><\/ul>\n\n\n\n<p>\u2192&nbsp;<strong>Tell your doctor if any of these&nbsp;side effects&nbsp;become serious.<\/strong><br><\/p>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p><em>(may occur in up to 1 in 10 people)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Decreased appetite<\/li><li>Depression and lowered mood<\/li><li>Fatigue, drowsiness&nbsp;<em>(&nbsp;somnolence&nbsp;)<\/em><\/li><li>Drowsiness<\/li><li>Pain, abdominal pain or discomfort, feeling of bloating,&nbsp;dry mouth<\/li><li>Abnormal dreams, sleep disorders<\/li><li>Indigestion which results in discomfort after meals,&nbsp;<em>flatulence&nbsp;(&nbsp;flatulence&nbsp;)<\/em><\/li><li>Skin rash (including red spots or blemishes sometimes with blistering and swelling of the skin) which may be allergic reactions,&nbsp;itching, discoloration of the skin including dark spots on the skin<\/li><li>Other allergic reactions, such as wheezing\/wheezing, swelling, or intoxication<\/li><\/ul>\n\n\n\n<p><em>Samples can also show:<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Small&nbsp;white blood cell count&nbsp;(a decrease in&nbsp;white blood cell count&nbsp;may make you more likely to get an&nbsp;infection&nbsp;)<\/li><li>Small&nbsp;platelet count&nbsp;(a type of&nbsp;blood cell&nbsp;involved in&nbsp;coagulation&nbsp;)<\/li><li>Decreased level of&nbsp;hemoglobin&nbsp;in the blood (low number of&nbsp;red blood cells&nbsp;)<\/li><li>Elevated levels of fatty acids&nbsp;<em>(&nbsp;triglycerides&nbsp;)<\/em>,&nbsp;bilirubin,&nbsp;or sugar in the blood<\/li><li>Pancreatic problems<\/li><\/ul>\n\n\n\n<p>\u2192&nbsp;<strong>Tell your doctor if any of these&nbsp;side effects&nbsp;become serious.<\/strong><br><\/p>\n\n\n\n<p><strong>Uncommon&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p><em>(may occur in up to 1 in 100 people)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Anemia&nbsp;(&nbsp;Anemia, a small number of&nbsp;red blood cells&nbsp;)<\/li><li>Abdominal pain (stomach) caused by&nbsp;inflammation&nbsp;of the pancreas<\/li><li>Muscle breakdown, muscle pa, in or muscle weakness<\/li><li>Swelling of the face, lips, tongue, or throat<\/li><li>Signs or symptoms of&nbsp;inflammation&nbsp;or&nbsp;infection<\/li><li>Severe skin reactions including rash accompanied by fever, swelling, and liver problems<\/li><li>Renal injury (renal tubules)<\/li><\/ul>\n\n\n\n<p><em>Samples can also show<\/em>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Decreased potassium levels in the blood<\/li><li>Elevated creatinine content in the blood<\/li><li>Changes in urine<\/li><\/ul>\n\n\n\n<p>\u2192&nbsp;<strong>Tell your doctor if any of these&nbsp;side effects&nbsp;become serious.<\/strong><br><\/p>\n\n\n\n<p><strong>Rare&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p><em>(can occur in up to 1 in 1,000 people)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Lactic acidosis&nbsp;<em>(see Possible side effects: Contact a doctor immediately)<\/em><\/li><li>Back pain is caused by kidney damage, including&nbsp;kidney failure.&nbsp;Your doctor may take blood samples to see if your kidneys are working properly.<\/li><li>Fatty liver<\/li><li>Yellow skin or yellow eyes,&nbsp;itching, or pain in the abdomen (stomach) caused by&nbsp;inflammation&nbsp;of the liver<\/li><li>Kidney inflammation, that you urinate a lot and that you feel thirsty<\/li><li>Decreased bone hardness (which causes bone pain and sometimes leads to&nbsp;fractures&nbsp;)<\/li><\/ul>\n\n\n\n<p>Muscle breakdown decreased bone hardness (which causes bone pain and sometimes leads to&nbsp;fractures&nbsp;), muscle pain, muscle weakness, and decreased&nbsp;potassium&nbsp;or phosphate levels in the blood can occur due to damage to kidney tubules.<br><\/p>\n\n\n\n<p><strong>\u2192 Tell your doctor if any of these&nbsp;side effects&nbsp;become serious.<\/strong><br><\/p>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;are&nbsp;<\/strong><strong>liable to occur in&nbsp;HIV&nbsp;treatment<\/strong><br><\/p>\n\n\n\n<p>The frequency of the following&nbsp;side effects&nbsp;is unknown (frequency cannot be calculated from the available data).<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Leg problem.&nbsp;<\/strong>Some patients taking combination antiretroviral medicines such as Eviplera may develop a bone disease called&nbsp;<em>osteonecrosis<\/em>&nbsp;(bone tissue dies due to lost blood supply to the bone).&nbsp;Some of the many risk factors for developing this disease are long-term use of this type of drug, treatment with corticosteroids, alcohol consumption, a very weak immune system, and obesity.&nbsp;Signs of&nbsp;osteonecrosis&nbsp;are:<ul><li>Joint stiffness<\/li><li>Pain and pain (especially in hips, knees, and shoulders)<\/li><li>Movement difficulties<\/li><\/ul><\/li><li>\u2192&nbsp;<strong>Tell your doctor if you notice any of these symptoms.<\/strong><\/li><\/ul>\n\n\n\n<p>During&nbsp;HIV&nbsp;treatment, weight gain and increased levels of fat and&nbsp;glucose&nbsp;in the blood may occur.&nbsp;This is partly related to restored health and lifestyle, but when it comes to blood fats, there can sometimes be a connection with&nbsp;HIV&nbsp;drugs.&nbsp;The doctor will perform tests to find such changes.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Eviplera<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the jar and carton after {EXP}.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>Store in the original package.&nbsp;Moisture sensitive.&nbsp;Close the jar tightly.<br><\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>The active substances are&nbsp;<\/strong><em>emtricitabine, rilpivirine, and tenofovir disoproxil.&nbsp;<\/em>One Eviplera film-coated tablet contains 200 mg emtricitabine, 25 mg rilpivirine (as hydrochloride), and 245 mg tenofovir disoproxil (as fumarate).<\/li><li><strong>Other ingredients are <\/strong><em>Tablet core: <\/em>Microcrystalline cellulose,&nbsp;lactose monohydrate, povidone, pregelatinized maize starch, polysorbate 20, croscarmellose sodium, and magnesium stearate.<br><em>Film coating: <\/em>Hypromellose, indigo carmine aluminum&nbsp;lacquer,&nbsp;lactose monohydrate, polyethylene glycol, red iron oxide, para-orange aluminum lacquer (E110), titanium dioxide, and triacetin.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Eviplera is a purple-pink, capsule-shaped, film-coated tablet, debossed on one side with \u201cGSI\u201d and smooth on the other side.&nbsp;Eviplera is supplied in cans containing 30 tablets and in packs of 3 cans each containing 30 tablets.&nbsp;Each jar contains desiccant (silica gel) which must be present in the jar to protect the tablets.&nbsp;The desiccant (silica gel) is in a separate&nbsp;sachet&nbsp;or container and should not be swallowed.<br><\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Gilead Sciences Ireland UC<\/p>\n\n\n\n<p>Carrigtohill<\/p>\n\n\n\n<p>County Cork, T45 DP77<\/p>\n\n\n\n<p>Ireland<br><\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Gilead Sciences Ireland UC<\/p>\n\n\n\n<p>IDA Business &amp; Technology Park<\/p>\n\n\n\n<p>Carrigtohill<\/p>\n\n\n\n<p>County Cork<\/p>\n\n\n\n<p>Ireland<br><\/p>\n","protected":false},"excerpt":{"rendered":"<p> 200 mg \/ 25 mg \/ 245 mg film-coated tablets<br \/>\nemtricitabine \/ rilpivirine \/ tenofovir disoproxil<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2205,2200],"tags":[3398,3400,3401,3399,3411,3413,3414,3412,2212,3394,3396,3397,3395,2211,3389,3392,3393,3391],"class_list":["post-8520","post","type-post","status-publish","format-standard","hentry","category-e","category-medicines","tag-emtricitabine","tag-emtricitabine-dose","tag-emtricitabine-side-effects","tag-emtricitabine-uses","tag-eviplera","tag-eviplera-dose","tag-eviplera-side-effects","tag-eviplera-uses","tag-medicine","tag-rilpivirine","tag-rilpivirine-dose","tag-rilpivirine-side-effects","tag-rilpivirine-uses","tag-tablets","tag-tenofovir-disoproxil","tag-tenofovir-disoproxil-dose","tag-tenofovir-disoproxil-side-effect","tag-tenofovir-disoproxil-uses"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8520","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=8520"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8520\/revisions"}],"predecessor-version":[{"id":10086,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8520\/revisions\/10086"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=8520"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=8520"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=8520"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}