During menopause, the estrogen content that the female body produces decreases. This can cause symptoms such as heat over the face, neck, and chest (“hot flashes”). Estrogel relieves these symptoms after menopause. Estrogel will only be prescribed to you if your symptoms are a serious limitation of your daily life.
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Prevention of osteoporosis<\/strong><\/p>\n\n\n\n After menopause, some women develop osteoporosis ( osteoporosis ). You should discuss all available options with your doctor.<\/p>\n\n\n\n If you are at increased risk of fracture due to osteoporosis and other medicines are not suitable for you, you can use Estrogel to prevent post-menopausal osteoporosis. Estradiol contained in Estrogel may also be approved for the treatment of other conditions not mentioned in this product information. Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions. Medical history and regular check-ups<\/strong><\/p>\n\n\n\n The use of HRT entails risks that must be taken into account when deciding to start treatment or continue an ongoing treatment. Experience in treating women with a premature menopause (due to ovarian failure or surgery) is limited. If you have premature menopause, the risks of HRT may be different. Talk to your doctor. Before you start (or resume) HRT, your doctor will ask you about your own and your family’s medical history. Your doctor may decide to perform an examination. This examination may include an examination of the breasts and\/or a gynecological examination, if necessary. Once you have started using Estrogel, go to your doctor for regular check-ups (at least once a year). Discuss the benefits and risks of continuing to use Estrogel with your doctor during these check-ups. Get regular breast screening according to your doctor’s or nurse’s recommendations. Do not use Estrogel:<\/strong><\/p>\n\n\n\n If any of the following applies to you. If you are not sure about any of the things below, talk to your doctor<\/strong> before using Estrogel.<\/p>\n\n\n\n If any of the conditions occur for the first time when you use Estrogel, stop using it immediately and see your doctor immediately. When to take special care with Estrogel<\/strong><\/p>\n\n\n\n Tell your doctor if you have, or have had, any of the following problems before starting treatment, as these may recur or worsen with treatment with Estrogel. You should see your doctor more often at check-ups if any of these situations apply to you:<\/p>\n\n\n\n Stop using Estrogel and contact a doctor immediately<\/strong><\/p>\n\n\n\n If you notice any of the following during treatment with HRT:<\/p>\n\n\n\n For more information, see “Blood clots in a vein ( thrombosis )” Note! Estrogel is not a contraceptive. If it is less than 12 months since your last menstrual period or if you are under 50, you may need additional contraception to prevent pregnancy. Talk to your doctor if you need advice. HRT and cancer<\/strong> Severe thickening of the uterine lining ( endometrial hyperplasia ) and cancer of the uterine lining (endometrial cancer)<\/strong><\/p>\n\n\n\n The use of estrogen-only HRT increases the risk of severe thickening of the uterine lining( endometrial hyperplasia ) and uterine lining cancer (endometrial cancer). Using a corpus luteum hormone ( progestin ) in addition to estrogen for at least 12 days in each 28-day cycle protects you from this extra risk. Your doctor will prescribe a corpus luteum hormone ( progestin ) separately if you have the uterus left. If your uterus has undergone surgery ( hysterectomy ), you should consult your doctor about the safety of the product when used without corpus luteum hormone ( progestogen ). In women who have the uterus left and do not use HRT, on average,<\/p>\n\n\n\n 5 out of 1,000 are diagnosed with endometrial cancer between the ages of 50 and 65. For women aged 50 to 65 who have the uterus left and who take HRT with estrogen alone, between 10 and 60 out of 1,000 women are diagnosed with endometrial cancer (ie between 5 and 55 extra cases), depending on dose one and for how long it tas. Estrogel contains a higher dose of estrogen than other estrogen-only HRT products. The risk of endometrial cancer when using Estrogel with a corpus luteum hormone ( progestin ) is not known. Irregular bleeding<\/strong><\/p>\n\n\n\n You may experience irregular bleeding or spotting during the first 3 to 6 months of treatment with Estrogel. About irregular bleeding:<\/p>\n\n\n\n Unexpected bleeding<\/strong><\/p>\n\n\n\n If you use Estrogel with a progestogen (ie progesterone ) you will have bleeding once a month (so-called dropout bleeding). But if you get unexpected small spotting ( spotting ) in addition to your monthly bleeding such as:<\/p>\n\n\n\n See your doctor as soon as possible.<\/strong> Breast cancer<\/strong><\/p>\n\n\n\n Data show that hormone replacement therapy ( HRT ) with a combination of estrogen-progestogen or with estrogen alone increases the risk of breast cancer. The increased risk depends on how long you use HRT. The increased risk is seen within 3 years. When treatment is stopped, the increased risk decreases over time, but it can persist for 10 years or more if you have used HRT for more than 5 years. Comparison<\/p>\n\n\n\n Of 1,000 women aged 50 to 54 who do not take HRT, an average of 13 to 17 will be diagnosed with breast cancer over a 5-year period. In women who are 50 years old and start taking HRT with estrogen-progestogen for 5 years, there will be 21 cases per 1,000 users (ie 4-8 extra cases).<\/p>\n\n\n\n Among women aged 50-59 who do not use HRT, an average of 27 out of 1,000 will be diagnosed with breast cancer over a 10-year period.<\/p>\n\n\n\n In women who are 50 years old and start taking HRT with estrogen alone for 10 years, 34 cases per 1,000 users (ie 7 extra cases will occur).<\/p>\n\n\n\n In women who are 50 years old and start taking HRT with estrogen-progestogen for 10 years, 48 \u200b\u200bcases per 1,000 users (ie 21 extra cases) will occur. It is also recommended that you participate in screening programs with mammography when they are offered to you. During mammography screening, you must inform the nurse\/healthcare professional performing the X-ray examination that you are using HRT as this medicine may increase the density (density) of the breasts and this may affect the results of the mammogram. If the density of your breasts increases, it is possible that mammography will not detect all the lumps. Ovarian cancer<\/strong><\/p>\n\n\n\n Ovarian cancer (cancer of the ovaries) is rare – much less common than breast cancer. Use of HRT with only estrogen or HRT with combined estrogen-progestin has been associated with a slightly increased risk of ovarian cancer. The risk of ovarian cancer varies with age. Of, for example, women aged 50 to 54 who do not take HRT, approximately 2 women out of 2,000 will be diagnosed with ovarian cancer over a 5-year period. For women who have used HRT for 5 years, 3 cases per 2,000 users have been reported (ie approximately 1 extra case). How HRT affects the heart and blood circulation<\/strong><\/p>\n\n\n\n Blood clots in a vein ( thrombosis )<\/strong><\/p>\n\n\n\n The risk of blood clots in the veins<\/strong> is about 1.3 to 3 times greater for those who use HRT than for those who do not use it, especially during the first year of treatment. Blood clots can be serious and if a blood clot ends up in the lungs, it can cause chest pain, shortness of breath, lead to fainting or even death. You are more likely to get a blood clot if you are older and if any of the following apply to you. Tell your doctor if any of these situations apply to you:<\/p>\n\n\n\n For signs of a blood clot, see “Stop using Estrogel and contact a doctor immediately”<\/strong> For women in their 50s who do not use HRT, an average of 4 to 7 per 1,000 people are expected to have a blood clot in a vein over a 5-year period. For women in their 50s who have used HRT with estrogen-progestogen for more than 5 years, there will be 9 to 12 cases per 1,000 users (ie 5 extra cases). For women in their 50s who have had their uterus operated on and have used HRT with estrogen alone for more than 5 years, there will be 5 to 8 cases per 1,000 users (ie 1 extra case). Heart disease (heart attack\/heart attack)<\/strong><\/p>\n\n\n\n There is no evidence that HRT can prevent a heart attack. For women over the age of 60 who take HRT with estrogen-progestogen, the probability of developing heart disease is slightly greater than for those who do not take HRT. For women who have had their uterus operated on and who use estrogen-only treatment, there is no increased risk of heart disease. Stroke<\/strong><\/p>\n\n\n\n The risk of stroke is about 1.5 times higher for those who use HRT than for those who do not use it. The number of extra cases of stroke due to the use of HRT increases with age.<\/p>\n\n\n\n If you look at women in their 50s who do not take HRT, an average of 8 women out of 1,000 are expected to have a stroke during a 5-year period.<\/p>\n\n\n\n For women in their 50s who take HRT, there will be 11 cases per 1,000 users during a 5-year period (ie 3 extra cases). Other conditions<\/strong><\/p>\n\n\n\n Some medicines may affect the effect of Estrogel. This can lead to irregular bleeding. This applies to the following medicines:<\/p>\n\n\n\n Tell your doctor or pharmacist if you are taking or using, or have recently taken or used, or might take or take any other medicines, including medicines obtained without a prescription, (traditional) herbal and herbal medicines, other natural products, or medical skincare products containing alcohol or skin cleanser.<\/p>\n\n\n\n If you need to take blood samples, tell your doctor or laboratory staff that you are taking Estrogel,<\/strong> as this medicine may affect the results of some tests.<\/p>\n\n\n\n Estrogel is for use in postmenopausal women only. If you become pregnant, stop using Estrogel and contact your doctor.<\/p>\n\n\n\n You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention. One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or side effects. Descriptions of these effects and side effects can be found in other sections. Read all the information in this leaflet for guidance. If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n Each dose of 1.25 g of this medicine contains 500 mg of alcohol ( ethanol ), equivalent to 400 mg \/ g (40% (w \/ w)). It can cause a burning sensation on damaged skin. Always use this medicine exactly as your doctor or pharmacist has told you. Ask your doctor or pharmacist if you are unsure. Your doctor will strive to prescribe the lowest dose to treat your symptoms in as short a time as possible. Talk to your doctor if you think your dose is too high or too low. Estrogel is a gel that contains the female sex hormone estradiol. When you apply a gel to the skin, it dries within 5 minutes and the hormone is quickly absorbed and absorbed by the bloodstream. Apply as thin a layer of gel as possible over the entire surface of the inside and outside of the arm from the wrist to the shoulder, and\/or the inside of the thighs. Spread it out as much as possible.
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<\/p>\n\n\n\n2. What you need to know before you use Estrogel<\/h2>\n\n\n\n
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your doctor as soon as possible.<\/strong><\/li><\/ul>\n\n\n\n
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In women who are 50 years old and start taking HRT with estrogen alone for 5 years, 16-17 cases per 1,000 users (ie 0-3 extra cases) will occur.<\/p>\n\n\n\n
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<\/p>\n\n\n\nOther medicines and Estrogel<\/h2>\n\n\n\n
Laboratory tests<\/h2>\n\n\n\n
Pregnancy and breastfeeding<\/h2>\n\n\n\n
<\/p>\n\n\n\nDriving and using machines<\/h2>\n\n\n\n
Estrogel contains ethanol<\/h2>\n\n\n\n
<\/p>\n\n\n\n3. How to use Estrogel<\/h2>\n\n\n\n
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