{"id":8438,"date":"2021-03-12T09:34:42","date_gmt":"2021-03-12T09:34:42","guid":{"rendered":"https:\/\/zeepedia.com\/?p=8438"},"modified":"2021-04-13T18:22:06","modified_gmt":"2021-04-13T18:22:06","slug":"estradot","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/estradot\/","title":{"rendered":"Estradot &#8211; Estradiol uses, dose and side effects"},"content":{"rendered":"\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Estradot 25 micrograms \/ 24 hours&nbsp;transdermal patch<\/strong><\/td><\/tr><tr><td><strong>Estradot 37.5 microg \/ 24 hours&nbsp;transdermal patch<\/strong><\/td><\/tr><tr><td><strong>Estradot 50 micrograms \/ 24 hours&nbsp;transdermal patch<\/strong><\/td><\/tr><tr><td><strong>Estradot 75 microg \/ 24 hours&nbsp;transdermal patch<\/strong><\/td><\/tr><tr><td><strong>Estradot 100 micrograms \/ 24 hours&nbsp;transdermal patch<\/strong><\/td><\/tr><tr><td><strong>estradiol (as hemihydrate)<\/strong><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Estradot is and what it is used for<\/h2>\n\n\n\n<p>Estradot is a preparation used for hormonal&nbsp;substitution therapy&nbsp;(&nbsp;HormoneReplacement&nbsp;Therapy,&nbsp;HRT&nbsp;).&nbsp;It contains the female sex hormone&nbsp;estrogen.&nbsp;Estradot is used in women whose period has stopped (&nbsp;menopause&nbsp;), at least 12 months after their last natural menstrual period.&nbsp;Estradot is a&nbsp;patch&nbsp;that is applied to the skin.<br><\/p>\n\n\n\n<p><strong>Estradot is used to:<\/strong><br><\/p>\n\n\n\n<p><strong>Relieve symptoms during and after menopause<\/strong><\/p>\n\n\n\n<p>When menstruation ceases (&nbsp;menopause&nbsp;), a woman&#8217;s&nbsp;estrogen&nbsp;drops.&nbsp;It can cause problems such as sweating and hot flashes.&nbsp;Estradot relieves these symptoms after&nbsp;menopause.&nbsp;Estradot should only be used if the problems cause problems in daily life.<br><\/p>\n\n\n\n<p><strong>Prevent osteoporosis<\/strong>&nbsp;(only applies to Estradot 50, 75, and 100 micrograms \/ 24 hours)<\/p>\n\n\n\n<p>After&nbsp;menopause,&nbsp;some women suffer from osteoporosis.&nbsp;Discuss all possible options with your doctor.<\/p>\n\n\n\n<p>If you have an increased risk of&nbsp;fractures&nbsp;(bone fractures) and other medicines that are not suitable for you, you can use Estradot to prevent osteoporosis after&nbsp;menopause.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Estradot<\/h2>\n\n\n\n<p><strong>Medical background and regular check-ups<\/strong><\/p>\n\n\n\n<p>The use of&nbsp;HRT&nbsp;involves risks that must be taken into account when deciding to start treatment or continue an ongoing treatment.<br><\/p>\n\n\n\n<p>Experience is limited for the treatment of women whose menstruation has stopped prematurely (when the ovaries have stopped working or the uterus has been removed).&nbsp;If you belong to that group, the risks of&nbsp;HRT&nbsp;may be different.&nbsp;Talk to your doctor.<br><\/p>\n\n\n\n<p>Before starting treatment (or resuming treatment), your doctor will ask about your own, and your family&#8217;s, medical background.&nbsp;Your doctor may do a general medical and gynecological examination, which also includes an examination of your breasts.<br><\/p>\n\n\n\n<p>Once you have started treatment, you should go for regular medical check-ups, at least once a year.&nbsp;During these check-ups, you should discuss with your doctor the benefits and risks of continued treatment.<br><\/p>\n\n\n\n<p>Perform regular breast examinations according to your doctor&#8217;s recommendations.<br><\/p>\n\n\n\n<p><strong>Do not use Estradot<\/strong><\/p>\n\n\n\n<p>if any of the following apply to you.&nbsp;If you are not sure,&nbsp;<strong>talk to your doctor<\/strong>&nbsp;before using Estradot.<br><\/p>\n\n\n\n<p>Do not use Estradot:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have or have had&nbsp;<strong>breast cancer<\/strong>&nbsp;or there is a suspicion that you may have it.<\/li><li>if you have or have had&nbsp;<strong>estrogen-dependent cancer<\/strong>, such as cancer of the lining of the uterus (endometrium), or if there is a suspicion of such cancer.<\/li><li>if you have&nbsp;<strong>unexpected genital bleeding<\/strong>&nbsp;that has not been investigated by a doctor.<\/li><li>if you have&nbsp;<strong>endometrial hyperplasia<\/strong>&nbsp;(severe thickening of the uterine lining) and are not being treated for it.<\/li><li>if you have or have had a&nbsp;<strong>blood clot in a vein<\/strong>&nbsp;(venous&nbsp;thromboembolism&nbsp;), in your legs (deep&nbsp;vein thrombosis&nbsp;), or your lungs (&nbsp;pulmonary embolism&nbsp;).<\/li><li>if you have a&nbsp;<strong>coagulation disorder,<\/strong>&nbsp;a condition with an increased risk of blood clots (lack of&nbsp;protein&nbsp;C,&nbsp;protein&nbsp;S, or antithrombin).<\/li><li>if you have or have had a disease caused by blood clots in the&nbsp;arteries&nbsp;are as&nbsp;<strong>heart attack,&nbsp;stroke<\/strong>&nbsp;(stroke), or&nbsp;<strong>angina.<\/strong><\/li><li>if you have or have had any&nbsp;<strong>liver disease<\/strong>&nbsp;and still have abnormal liver values.<\/li><li>if you have&nbsp;<strong>porphyria,<\/strong>&nbsp;a rare inherited blood disorder.<\/li><li>if you are&nbsp;<strong>allergic<\/strong>&nbsp;to estradiol or any of the other ingredients of this medicine (see section 6 Contents of the pack and other information).<\/li><\/ul>\n\n\n\n<p>If any of the above affects you the first time you use Estradot, stop using Estradot and contact your doctor immediately.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor if you have or have had any of the following problems before starting treatment.&nbsp;They may recur or worsen during treatment with Estradot.&nbsp;Should this occur, have more frequent check-ups with a doctor.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have any disease affecting the lining of the uterus, as well as muscle knots (&nbsp;fibroids&nbsp;),&nbsp;endometriosis,&nbsp;or have had&nbsp;endometrial hyperplasia&nbsp;(severe thickening of the uterine lining).<\/li><li>if you have an increased risk of getting a blood clot (see below &#8220;Blood clots in a vein (&nbsp;thrombosis&nbsp;)&#8221;)<\/li><li>if a close relative has had breast cancer or other estrogen-dependent cancer<\/li><li>high&nbsp;blood pressure<\/li><li>liver disease e.g.&nbsp;liver adenoma (benign&nbsp;tumor&nbsp;)<\/li><li>diabetes<\/li><li>gallstone disease<\/li><li>if you get a&nbsp;migraine&nbsp;or severe headache<\/li><li>if you have systemic lupus erythematosus (&nbsp;SLE&nbsp;) &#8211; an&nbsp;autoimmune&nbsp;disease that affects many organs in the body<\/li><li>epilepsy<\/li><li>asthma<\/li><li>otosclerosis (ossification of the middle ear leading to a hearing loss)<\/li><li>hypertriglyceridemia&nbsp;(elevated blood lipids)<\/li><li>fluid retention due to heart or kidney disease<\/li><li>Products containing&nbsp;estrogen&nbsp;can cause or worsen the symptoms of hereditary&nbsp;angioedema. Contact a doctor immediately if you experience symptoms of&nbsp;angioedema&nbsp;such as swelling of the face, tongue, and\/or throat and\/or difficulty swallowing, or&nbsp;hives and difficulty breathing.<\/li><\/ul>\n\n\n\n<p><strong>You should contact a doctor immediately and discontinue treatment if any of the following occur:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Some of what is mentioned in the section &#8216;Do not use Estradot&#8217;<\/li><li>If skin or whites of the eyes turn yellow (jaundice);&nbsp;it may be a symptom of liver disease<\/li><li>If your&nbsp;blood pressure&nbsp;rises sharply (symptoms may include headache, fatigue, or dizziness)<\/li><li>If you are experiencing migraine-like headaches for the first time<\/li><li>If you become pregnant<\/li><li>If you get symptoms of a blood clot, such as<ul><li>painful swelling and redness of the legs<\/li><li>sudden chest pain<\/li><li>breathing difficulties further information, see below &#8220;Blood clots in a vein (&nbsp;thrombosis&nbsp;)&#8221;<\/li><\/ul><\/li><\/ul>\n\n\n\n<p><strong>Note:<\/strong>&nbsp;Estradot is not a contraceptive.&nbsp;If it is less than 12 months since your last period, or if you are under 50, you may still need to use contraception to avoid pregnancy.&nbsp;Consult your doctor.<br><\/p>\n\n\n\n<p><strong>HRT&nbsp;and cancer<\/strong><br><\/p>\n\n\n\n<p><strong>Severe thickening of the uterine lining (&nbsp;endometrial hyperplasia&nbsp;) and cancer of the uterine lining (endometrial cancer)<\/strong><br><\/p>\n\n\n\n<p>The use of&nbsp;HRT&nbsp;with&nbsp;estrogen&nbsp;alone&nbsp;increases the risk of severe thickening of the uterine lining and cancer of the uterine lining.<br><\/p>\n\n\n\n<p>By taking&nbsp;progestogen&nbsp;as a supplement to&nbsp;estrogen&nbsp;for at least 12 days in each 28-day cycle, you are protected against this extra risk.&nbsp;The doctor will prescribe the&nbsp;progestogen&nbsp;if you have your uterus left.&nbsp;If your uterus has undergone surgery (&nbsp;hysterectomy&nbsp;), you should consult your doctor if you can take the medicine without&nbsp;a progestogen.<br><\/p>\n\n\n\n<p>For women with the uterus left who do not take&nbsp;HRT, an average of 5 out of 1,000 women aged 50-65 will be diagnosed with endometrial cancer.<br><\/p>\n\n\n\n<p>For women aged 50-65 who have the uterus left and who take&nbsp;HRT&nbsp;with&nbsp;estrogen alone, between 10 and 60 women out of 1,000 users will be diagnosed with endometrial cancer (ie between 5 and 55 extra cases), depending on&nbsp;dose&nbsp;one and how as long as it is taken.<br><\/p>\n\n\n\n<p>Estradot 75 and 100 micrograms \/ 24 hours have higher&nbsp;dose&nbsp;estrogen&nbsp;than other&nbsp;HRT-preparat with the only&nbsp;estrogen.&nbsp;The risk of endometrial cancer when used with&nbsp;progestogens&nbsp;is unknown.<br><\/p>\n\n\n\n<p><strong>Unexpected bleeding<\/strong><\/p>\n\n\n\n<p>You will have bleeding once a month (so-called dropout bleeding) when you use Estradot in combination with&nbsp;progestogen.&nbsp;But if you get unexpected bleeding or splashing in addition to your monthly bleeding, and these:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>lasts longer than 6 months<\/li><li>starts after using Estradot for 6 months<\/li><li>continues after you stop using Estradot<\/li><\/ul>\n\n\n\n<p><strong>you should see a doctor as soon as possible.<\/strong><br><\/p>\n\n\n\n<p><strong>Breast cancer<\/strong><\/p>\n\n\n\n<p>Data show that hormone replacement therapy (&nbsp;HRT&nbsp;) with a combination of&nbsp;estrogen-progestogen&nbsp;or with&nbsp;estrogen&nbsp;alone&nbsp;increases the risk of breast cancer.&nbsp;The increased risk depends on how long you use&nbsp;HRT.&nbsp;The increased risk is seen within 3 years.&nbsp;When treatment is stopped, the increased risk decreases over time, but it can persist for 10 years or more if you have used&nbsp;HRT&nbsp;for more than 5 years.<br><\/p>\n\n\n\n<p><em>Comparison<\/em><\/p>\n\n\n\n<p>Of 1,000 women aged 50 to 54 who do not take&nbsp;HRT, an average of 13 to 17 will be diagnosed with breast cancer over a 5-year period.<\/p>\n\n\n\n<p>In women who are 50 years old and start taking&nbsp;HRT&nbsp;with&nbsp;estrogen&nbsp;alone&nbsp;for 5 years, 16-17 cases per 1,000 users (ie 0-3 extra cases) will occur.<\/p>\n\n\n\n<p>In women who are 50 years old and start taking&nbsp;HRT&nbsp;with&nbsp;estrogen-progestogen&nbsp;for 5 years, there will be 21 cases per 1,000 users (ie 4-8 extra cases).<br><\/p>\n\n\n\n<p>Among women aged 50\u201359 who do not use&nbsp;HRT, an average of 27 out of 1,000 will be diagnosed with breast cancer over a 10-year period.<\/p>\n\n\n\n<p>In women who are 50 years old and start taking&nbsp;HRT&nbsp;with&nbsp;estrogen&nbsp;alone&nbsp;for 10 years, 34 cases per 1,000 users (ie 7 extra cases) will occur.<\/p>\n\n\n\n<p>In women who are 50 years old and start taking&nbsp;HRT&nbsp;with&nbsp;estrogen-progestogen&nbsp;for 10 years, 48 \u200b\u200bcases per 1,000 users (ie 21 extra cases) will occur.<br><\/p>\n\n\n\n<p><strong>Check your breasts regularly.&nbsp;Contact a doctor if you notice changes such as:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>indentations or pits<\/li><li>changes of the nipple<\/li><li>nodules you can see or feel<\/li><\/ul>\n\n\n\n<p>It is also recommended that you participate in a mammography examination when you are called to do so.&nbsp;At the mammogram, you must tell the nurse\/healthcare professional who performs the examination that you are using&nbsp;HRT, as this medicine may increase the density of the breasts.&nbsp;An increased density in the breasts can make it more difficult to detect lumps on the mammography images.<br><\/p>\n\n\n\n<p><strong>Ovarian cancer (&nbsp;ovarian cancer&nbsp;)<\/strong><\/p>\n\n\n\n<p>Ovarian cancer is rare &#8211; much more rare than breast cancer.&nbsp;Use of&nbsp;HRT&nbsp;with&nbsp;estrogen&nbsp;alone&nbsp;or combined&nbsp;estrogen-progestogen&nbsp;has been associated with a slightly increased risk of ovarian cancer.<br><\/p>\n\n\n\n<p>The risk of ovarian cancer varies with age.&nbsp;The diagnosis of ovarian cancer will, for example, be made on about 2 women out of 2,000 aged 50 to 54 who do not take&nbsp;HRT&nbsp;for a 5-year period.&nbsp;For women who have taken&nbsp;HRT&nbsp;for 5 years, there will be about 3 cases per 2,000 users (ie about 1 extra case).<br><\/p>\n\n\n\n<p><strong>How&nbsp;HRT&nbsp;affects the heart and blood circulation<\/strong><br><\/p>\n\n\n\n<p><strong>Blood clots in a vein (&nbsp;thrombosis&nbsp;)<\/strong><\/p>\n\n\n\n<p>The risk of&nbsp;<strong>blood clots in the veins<\/strong>&nbsp;is 1.3\u20133 times higher for women who take&nbsp;HRT than for those who do not, especially during the first year of treatment.<br><\/p>\n\n\n\n<p>Blood clots can be serious.&nbsp;If a blood clot ends up in the lungs, it can cause chest pain, shortness of breath, collapse or even lead to death.<br><\/p>\n\n\n\n<p>You are more likely to get a blood clot in a vein if any of the following apply to you.&nbsp;Tell your doctor if any of the following apply to you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>You have not been able to walk or stand for a long time due to a major operation, injury or illness (see also section 3, \u201cIf you need surgery\u201d)<\/li><li>You are severely overweight (&nbsp;BMI&nbsp;over 30 kg \/ m&nbsp;<sup>2<\/sup>&nbsp;)<\/li><li>You have a coagulation disorder that requires long-term treatment with drugs that prevent blood clots<\/li><li>If a close relative has had a blood clot in the bone, lung, or another organ<\/li><li>You have&nbsp;SLE&nbsp;(systemic lupus erythematosus)<\/li><li>You have cancer<\/li><\/ul>\n\n\n\n<p>The symptoms of a blood clot are described in the section &#8220;You should contact a doctor immediately and stop the treatment&#8221;.<br><\/p>\n\n\n\n<p><em>Comparison<\/em><\/p>\n\n\n\n<p>For women in their 50s who do not take&nbsp;HRT, over a 5-year period, an average of 4-7 out of 1,000 are expected to get a blood clot in a vein.<\/p>\n\n\n\n<p>For women in their 50s who have taken&nbsp;HRT&nbsp;with&nbsp;estrogen-progestogen&nbsp;for more than 5 years, 9 &#8211; 12 out of 1,000 users are expected to get a blood clot in a vein (ie 5 extra cases)<\/p>\n\n\n\n<p>For women in their 50s without a uterus who take&nbsp;estrogen&nbsp;alone&nbsp;for more than 5 years, 5 &#8211; 8 out of 1,000 users are expected to get a blood clot in a vein (ie 1 extra case).<br><\/p>\n\n\n\n<p><strong>Heart disease (heart attack)<\/strong><\/p>\n\n\n\n<p>There is no evidence that&nbsp;HRT&nbsp;prevents heart attacks.<\/p>\n\n\n\n<p>For women over the age of 60 who take&nbsp;HRT&nbsp;with&nbsp;estrogen-progestin, the risk of developing heart disease is slightly higher than those who do not take&nbsp;HRT.<\/p>\n\n\n\n<p>For women without a uterus who take&nbsp;estrogen&nbsp;alone, there is no increased risk of developing heart disease.<br><\/p>\n\n\n\n<p><strong>Stroke&nbsp;(apoplexy)<\/strong><\/p>\n\n\n\n<p>The risk of&nbsp;stroke&nbsp;is about 1.5 times higher for those who take&nbsp;HRT&nbsp;compared to those who do not.&nbsp;The risk of&nbsp;stroke&nbsp;is age-dependent, therefore the number of cases of&nbsp;stroke&nbsp;increases&nbsp;due to the use of&nbsp;HRT&nbsp;with increasing age.<br><\/p>\n\n\n\n<p><em>Comparison<\/em><\/p>\n\n\n\n<p>For women in their 50s who do not take&nbsp;HRT, an average of 8 out of 1,000 people is expected to have a&nbsp;stroke&nbsp;over a 5-year period.<\/p>\n\n\n\n<p>For women in their 50s who have taken&nbsp;HRT&nbsp;for more than 5 years, 11 out of 1,000 users are expected to have a&nbsp;stroke&nbsp;(ie 3 extra cases)<br><\/p>\n\n\n\n<p><strong>Other conditions<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Using&nbsp;HRT&nbsp;does not prevent memory loss.&nbsp;The risk of memory loss may be slightly higher in women who start using&nbsp;HRT&nbsp;after the age of 65.&nbsp;Consult your doctor.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Estradot<\/h2>\n\n\n\n<p>Some medicines may affect the way Estradot works, which may lead to irregular bleeding.&nbsp;The following applies:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Medicines for&nbsp;<strong>epilepsy<\/strong>&nbsp;(eg phenobarbital,&nbsp;phenytoin,&nbsp;and carbamazepine)<\/li><li>Medicines for&nbsp;<strong>tuberculosis<\/strong>&nbsp;(eg rifampicin, rifabutin)<\/li><li>Drugs for&nbsp;<strong>HIV&nbsp;&#8211;&nbsp;infection<\/strong>&nbsp;(for example, nevirapine, efavirenz, ritonavir, and nelfinavir)<\/li><li>An herbal medicine containing&nbsp;<strong>St. John&#8217;s wort<\/strong>&nbsp;(&nbsp;<em>Hypericum perforatum<\/em>&nbsp;)<\/li><li>Other&nbsp;<strong>anti-infective drugs<\/strong>&nbsp;(eg&nbsp;ketoconazole, erythromycin).<\/li><\/ul>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription and herbal remedies.<br><\/p>\n\n\n\n<p><strong>Results from blood test analyze<\/strong><\/p>\n\n\n\n<p>If you need to take a blood sample, tell your doctor, or the person taking the blood sample, that you are using Estradot as it may affect the results of some tests.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>Estradot is intended for women whose menstruation has stopped.&nbsp;If you become pregnant, stop using Estradot and consult a doctor.&nbsp;You should not use Estradot if you are pregnant or breast-feeding.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>No known effects on the ability to drive and use machines.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use Estradot<\/h2>\n\n\n\n<p>Always use this medicine exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.&nbsp;Your doctor will strive to use the lowest&nbsp;dose, which will give you relief of symptoms, and to use Estradot for the shortest possible time.&nbsp;Talk to your doctor if you do not get any relief from the symptoms, or feel that the&nbsp;dose&nbsp;is too high.<br><\/p>\n\n\n\n<p><strong>How long should Estradot be used?<\/strong><\/p>\n\n\n\n<p>It is important to use the lowest possible effective&nbsp;dose&nbsp;and only for as long as necessary.&nbsp;Discuss with your doctor from time to time if he\/she thinks you are still in need of treatment.<br><\/p>\n\n\n\n<p><strong>When should treatment be started?<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>If you are not already using any other hormone replacement therapy<\/strong>&nbsp;(&nbsp;patches&nbsp;or tablets) or&nbsp;<strong>if you have used&nbsp;continuous&nbsp;combined hormone replacement therapy<\/strong>&nbsp;(where&nbsp;estrogen&nbsp;and&nbsp;progestin&nbsp;are given daily without interruption), you can start Estradot any day.<\/li><li><strong>If you switch from a cyclic or sequential hormone replacement therapy<\/strong>(where&nbsp;progestogens&nbsp;are added for 12-14 days of the cycle), you can start treatment with Estradot the day after the end of the previous treatment cycle.<\/li><\/ul>\n\n\n\n<p><strong>When should Estradot be applied?<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The Estradot patch should be replaced twice a week (every three to four days).&nbsp;It is best to always change the patch on the same day of the week each week (eg Monday and Thursday).&nbsp;On the inside of the Estradot packaging, there is space to note down your dosing schedule.&nbsp;Select the two-day schedule that you intend to follow.&nbsp;Always&nbsp;change patches&nbsp;on the two days of the week you have marked.<\/li><li>The Estradot patch should be on all the time until it is time to replace it with a new&nbsp;patch.<\/li><\/ul>\n\n\n\n<p>Any remaining adhesive on the skin can be easily rubbed off.&nbsp;Then apply the new Estradot patch elsewhere on the skin.<br><\/p>\n\n\n\n<p><strong>Women whose uterus has been removed<\/strong><\/p>\n\n\n\n<p>Estradot is used continuously, without interruption.&nbsp;Additional treatment with&nbsp;progestogen&nbsp;is not required if you do not have a disease that causes the uterine lining to also grow outside the uterus (&nbsp;endometriosis&nbsp;).&nbsp;Familiarize yourself with the general risks associated with hormone replacement therapy (Section 2 \u201cWarnings and Precautions\u201d).<br><\/p>\n\n\n\n<p><strong>Women with an intact uterus<\/strong><\/p>\n\n\n\n<p>Your doctor should give you another&nbsp;hormone,&nbsp;progestin, in addition to Estradot to reduce the risk of uterine cancer.&nbsp;Estradot is used continuously and without interruption, while the progestogen tablets are taken for a period of at least 12-14 days each month \/ 28-day cycle.&nbsp;Familiarize yourself with the general risks associated with hormone replacement therapy (Section 2 \u201cWarnings and Precautions\u201d).<\/p>\n\n\n\n<p>You may experience some irregular bleeding or splashing bleeding during the first months of treatment.&nbsp;Tell your doctor if you experience heavy bleeding or continue to have bleeding or splashing bleeding after a few months of treatment so that your treatment can be re-evaluated if necessary (see section 2 &#8220;Unexpected bleeding&#8221;).<br><\/p>\n\n\n\n<p><strong>Where should the Estradot be attached?<\/strong><\/p>\n\n\n\n<p>Attach the patch to the lower abdomen, below the waist.&nbsp;Avoid the waist as clothes can cause the patch to wear away.&nbsp;Never attach the patch to or near your breasts.<br><\/p>\n\n\n\n<p>When you have to change&nbsp;patches,&nbsp;ie.&nbsp;twice a week according to your schedule, you should attach the new patch to another location.&nbsp;It should take at least a week before the same skin surface is used again.<br><\/p>\n\n\n\n<p>Before applying Estradot, make sure that your skin is:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>clean, dry, and cool<\/li><li>free from powder, oil, moisturizer, or skin lotion<\/li><li>free from damage and\/or irritation<\/li><\/ul>\n\n\n\n<p><strong>How should the Estradot be attached?<\/strong><\/p>\n\n\n\n<p>Each&nbsp;patch&nbsp;is individually packaged in a protective envelope.&nbsp;Tear up this envelope at the mark (do not use scissors as the patch may be damaged) and remove the patch.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20040607005750#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/res\/RootMedia\/Novartis\/Media\/Bilder20till20Estradot\/Bild201.jpg\" alt=\"Picture 1\"\/><\/a><\/figure>\n\n\n\n<p>A protective film covers the adhesive side of the patch.&nbsp;The rigid protective film must be removed before the patch is applied to the skin.&nbsp;Apply the patch immediately after opening the envelope and removing the protective film.<br><\/p>\n\n\n\n<p>Hold the patch with the protective film against you.&nbsp;Remove one-half of the protective film and discard it.&nbsp;Try to avoid your fingers touching the side with glue on.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20040607005750#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/res\/RootMedia\/Novartis\/Media\/Bilder20till20Estradot\/Bild202.jpg\" alt=\"Picture 2\"\/><\/a><\/figure>\n\n\n\n<p>Use the other half of the protective film to hold and apply the adhesive side of the patch to a dry skin surface on the lower abdomen.&nbsp;Press the adhesive side of the patch onto the skin and smooth it out.&nbsp;Fold up the remaining side of the patch.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20040607005750#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/res\/RootMedia\/Novartis\/Media\/Bilder20till20Estradot\/Bild203.jpg\" alt=\"Picture 3\"\/><\/a><\/figure>\n\n\n\n<p>Grasp the straight edge of the protective film and pull it off the patch.<br><\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20040607005750#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/res\/RootMedia\/Novartis\/Media\/Bilder20till20Estradot\/Bild204.jpg\" alt=\"Picture 4\"\/><\/a><\/figure>\n\n\n\n<p>Apply the rest of the patch to the skin and smooth it out.&nbsp;Press the patch with the palm of your hand for about 10 seconds.<br><\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20040607005750#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/res\/RootMedia\/Novartis\/Media\/Bilder20till20Estradot\/Bild205.jpg\" alt=\"Picture 5\"\/><\/a><\/figure>\n\n\n\n<p>Check that the patch is firmly attached by feeling with a finger around the edges of the patch.<br><\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20040607005750#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/res\/RootMedia\/Novartis\/Media\/Bilder20till20Estradot\/Bild206.jpg\" alt=\"Figure 6\"\/><\/a><\/figure>\n\n\n\n<p>When changing&nbsp;patches, peel off the patch and fold it double with the adhesive side inwards.&nbsp;See section 5, \u201cHow to store the Estradot\u201d for instructions on how to dispose of the patch safely.&nbsp;Do not flush it down the toilet.<br><\/p>\n\n\n\n<p><strong>Other important information<\/strong><\/p>\n\n\n\n<p>If the patch is firmly attached, it is good to bathe, swim, shower or exercise.&nbsp;If the patch should fall off, e.g.&nbsp;in connection with a bath or shower, shake off the water from the patch.&nbsp;Allow the skin to dry and cool and apply the same&nbsp;patch&nbsp;elsewhere on the lower abdomen (see &#8220;Where should the Estradot be attached?&#8221;).<br><\/p>\n\n\n\n<p>If the patch does not adhere properly to the skin, a new&nbsp;patch&nbsp;can be applied.&nbsp;You should continue to follow the same replacement schedule as before, without taking into account the day the new patch was applied.<br><\/p>\n\n\n\n<p>The patch should be covered when you sunbathe, even in a solarium.&nbsp;When you swim, the patch can be put under the swimsuit.<br><\/p>\n\n\n\n<p><strong>If you need surgery<\/strong><\/p>\n\n\n\n<p>If you are going to have surgery, tell your surgeon that you are using Estradot.&nbsp;You may need to stop using Estradot for 4 to 6 weeks before surgery to avoid the risk of blood clots (see section 2, \u201cBlood clots in a vein (&nbsp;thrombosis&nbsp;)\u201d).&nbsp;Ask your doctor when it is appropriate to start using Estradot again.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Estradot then you should<\/h2>\n\n\n\n<p>Remove the patch if you have used too much Estradot.&nbsp;If you have taken too much medicine or if e.g.&nbsp;If a child has accidentally taken the medicine, contact a doctor, hospital, or the Poison Information Center for risk assessment and advice.<br><\/p>\n\n\n\n<p>The symptoms of overdose are usually breast tenderness and\/or vaginal bleeding.&nbsp;Acute&nbsp;overdose is unlikely due to the route of administration (&nbsp;patches&nbsp;).&nbsp;If symptoms persist, consult your doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Estradot<\/h2>\n\n\n\n<p>If you forget to change the patch, do so as soon as you remember.&nbsp;Then continue to change&nbsp;patches&nbsp;on the same days as before, without taking into account the day on which the new patch was applied.&nbsp;<strong>Never use more than one&nbsp;patch&nbsp;at a time to compensate for forgotten&nbsp;patches.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Estradot<\/h2>\n\n\n\n<p>When treatment with Estradot is stopped, the risk of breakthrough bleeding or splashing increases.&nbsp;After a long period of discontinuation of treatment, you should consult your doctor before using the patches again.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<br><\/p>\n\n\n\n<p>The following diseases are more common in women who take&nbsp;HRT&nbsp;than those who do not:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Breast cancer<\/li><li>Severe thickening of the uterine lining (&nbsp;endometrial hyperplasia&nbsp;) or cancer of the uterine lining (endometrial cancer)<\/li><li>Ovarian cancer (&nbsp;ovarian cancer&nbsp;)<\/li><li>Blood clots in veins in bones or lungs (venous&nbsp;thromboembolism&nbsp;)<\/li><li>Heart disease<\/li><li>Stroke&nbsp;(apoplexy)<\/li><li>Probable memory loss, if treatment with&nbsp;HRT is&nbsp;started after the age of 65<\/li><\/ul>\n\n\n\n<p>See section 2 for more information on these&nbsp;side effects.<br><\/p>\n\n\n\n<p><strong>Some&nbsp;side effects&nbsp;can be serious<\/strong><\/p>\n\n\n\n<p>The following symptoms require immediate medical attention:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Sudden chest pain<\/li><li>Chest pain that radiates to the arm or neck<\/li><li>Breathing difficulties<\/li><li>Painful swelling and&nbsp;redness&nbsp;in the legs<\/li><li>Yellowing of the eyes and face, dark urine,&nbsp;itching&nbsp;(jaundice)<\/li><li>Unexpected&nbsp;vaginal&nbsp;bleeding or spotting (breakthrough bleeding) when Estradot has been used for some time or after stopping treatment<\/li><li>Changes in the breasts, such as&nbsp;indentations or pits in the skin of the breasts, changes in the nipples, lumps you can see or feel (breast cancer)<\/li><li>Painful menstruation<\/li><li>Unexplained migraine-like headache<\/li><\/ul>\n\n\n\n<p><strong>Discontinue use of Estradot and consult a doctor immediately<\/strong>&nbsp;if you get any of the above symptoms.&nbsp;Familiarize yourself with the general risks associated with hormone replacement therapy (Section 2 \u201cWarnings and Precautions\u201d).<\/p>\n\n\n\n<p><strong>Other side effects:<\/strong><\/p>\n\n\n\n<p>The following&nbsp;side effects&nbsp;have also been reported with Estradot.&nbsp;<strong>If any of these&nbsp;side effects&nbsp;gets serious, or talk to a doctor or pharmacist.<\/strong><br><\/p>\n\n\n\n<p><strong>Very common<\/strong>&nbsp;(may affect more than 1 user in 10):<\/p>\n\n\n\n<p>Headache, skin reactions at the application site (including irritation, burning, rash, dryness, bleeding, bruising,&nbsp;inflammation, swelling, skin pigmentation, hives, and blisters), tension and pain in the breasts, menstrual pain, menstrual disorder.<br><\/p>\n\n\n\n<p><strong>Common<\/strong>(may affect up to 1 in 10 people):<\/p>\n\n\n\n<p>Depression, nervousness, mood swings, insomnia, nausea, indigestion, diarrhea, abdominal pain, feeling bloated,&nbsp;acne, rash, dry skin,&nbsp;itching, breast enlargement, heavy menstrual bleeding, white or yellowish discharge from the vagina, irregular vaginal bleeding, contractions of the vagina, inflammation&nbsp;of the vagina, abnormal growth of the uterine lining (&nbsp;endometrial hyperplasia&nbsp;), pain (eg back pain, arms, legs, wrists, ankles), weakness, fluid accumulation (&nbsp;edema&nbsp;) in arms and legs, weight changes.<br><\/p>\n\n\n\n<p><strong>Uncommon<\/strong>&nbsp;(may affect up to 1 in 100 people):<\/p>\n\n\n\n<p>Migraine, dizziness, increase in blood pressure, vomiting, discoloration of the skin, impaired liver function values.<br><\/p>\n\n\n\n<p><strong>Rare<\/strong>&nbsp;(may affect up to 1 in 1,000 people):<\/p>\n\n\n\n<p>Tingling and numbness in hands and feet, blood clots,&nbsp;gallstones, hair loss, muscle weakness, benign growth of&nbsp;smooth muscle&nbsp;in the uterus (&nbsp;fibroids&nbsp;), cysts (blisters) near the fallopian tubes,&nbsp;the polyp&nbsp;your cervix, changes in sexual desire, allergic reactions such as&nbsp;rash.<br><\/p>\n\n\n\n<p><strong>Very rare<\/strong>&nbsp;(may affect up to 1 in 10,000 people):<\/p>\n\n\n\n<p>Hives, signs of a severe&nbsp;allergic reaction&nbsp;(including difficulty breathing, swelling of the face, tongue, throat, or skin; dizziness and&nbsp;rash&nbsp;), decreased tolerance to certain sugars (carbohydrates), involuntary movements that may affect the eyes, head, and neck, contact lens problems, severe skin damage, strong hair growth.<br><\/p>\n\n\n\n<p><strong>No known frequency<\/strong>(cannot be calculated from the available data):<\/p>\n\n\n\n<p>Breast cancer, abnormal liver function values, allergic skin inflammation, benign lumps in the breast (not cancer).<br><\/p>\n\n\n\n<p><strong>The following&nbsp;side effects&nbsp;have been reported with other HRTs:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The disease of the gallbladder<\/li><li>Various skin diseases:<ul><li>dark skin spots, especially on the face and neck, so-called &#8220;pregnancy spots&#8221; (chloasma)<\/li><li>painful reddish-purple bumps on the skin (erythema nodosum)<\/li><li>annular redness or sore rash (erythema multiforme)<\/li><\/ul><\/li><li>Impaired memory and thought activity (possible dementia)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Estradot<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Keep this medicine out of the sight and reach of children.<\/li><li>Store the Estradot in the original package in a cool, dry place.&nbsp;Once the protective envelope has been opened, the patch should be applied to the skin immediately.<\/li><li>Do not store Estradot in the refrigerator.&nbsp;Do not freeze.<\/li><li>Do not use this medicine after the expiry date which is stated on the carton and patch envelope after EXP.&nbsp;The expiration date is the last day of the specified month.<\/li><li>Do not use this medicine if you notice that the package is damaged or shows signs of being opened earlier.<\/li><li>After the patch has been removed, it should be folded with the adhesive side inwards and stored safely so that children do not have access to the patch.&nbsp;Return used or unused&nbsp;patches&nbsp;to pharmacies, preferably in the original packaging.&nbsp;Medicines should not be disposed of via wastewater.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>A&nbsp;25 microgram \/ 24-hour&nbsp;patch&nbsp;contains 0.39 mg of estradiol (as hemihydrate) and releases approximately 25 micrograms of estradiol per day (24 hours).<br><\/p>\n\n\n\n<p>A&nbsp;patch&nbsp;of 37.5 micrograms \/ 24 hours contains 0.585 mg of estradiol (as hemihydrate) and releases approximately 37.5 micrograms of estradiol per day (24 hours).<br><\/p>\n\n\n\n<p>A&nbsp;50 microgram \/ 24 h&nbsp;patch&nbsp;contains 0.78 mg of estradiol (as hemihydrate) and releases approximately 50 micrograms of estradiol per day (24 hours).<br><\/p>\n\n\n\n<p>A&nbsp;75 microgram \/ 24 h&nbsp;patch&nbsp;contains 1.17 mg of estradiol (as hemihydrate) and releases approximately 75 micrograms of estradiol per day (24 hours).<br><\/p>\n\n\n\n<p>A&nbsp;100 microgram \/ 24 h&nbsp;patch&nbsp;contains 1.56 mg of estradiol (as hemihydrate) and releases approximately 100 micrograms of estradiol per day (24 hours).<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is estradiol (as hemihydrate)<\/li><li>The other ingredients in the adhesive are acrylic and silicone adhesive, oleyl alcohol, propylene glycol, povidone (E 1201).<\/li><li>The patch film is an ethylene\/vinyl acetate copolymer and vinylidene chloride\/methyl acrylate copolymer laminate.<\/li><li>The protective film (which is removed before application) is a polyester film coated with a fluoropolymer.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Estradot 25 micron \/ 24 hours is a rectangular&nbsp;patch&nbsp;of 2.5 cm&nbsp;<sup>2<\/sup>&nbsp;with rounded corners.&nbsp;The patch consists of a pressure-sensitive, adhesive layer containing estradiol and is provided with a translucent polymer film on one side and a protective film on the other.<br><\/p>\n\n\n\n<p>Estradot 37.5 micron \/ 24 hours is a rectangular&nbsp;patch&nbsp;of 3.75 cm&nbsp;<sup>2<\/sup>&nbsp;with rounded corners.&nbsp;The patch consists of a pressure-sensitive, adhesive layer containing estradiol and is provided with a translucent polymer film on one side and a protective film on the other.<br><\/p>\n\n\n\n<p>Estradot 50 micron \/ 24 hours is a rectangular&nbsp;patch&nbsp;of 5 cm&nbsp;<sup>2<\/sup>&nbsp;with rounded corners.&nbsp;The patch consists of a pressure-sensitive, adhesive layer containing estradiol and is provided with a translucent polymer film on one side and a protective film on the other.<br><\/p>\n\n\n\n<p>Estradot 75 micron \/ 24 hours is a rectangular&nbsp;patch&nbsp;of 7.5 cm&nbsp;<sup>2<\/sup>&nbsp;with rounded corners.&nbsp;The patch consists of a pressure-sensitive, adhesive layer containing estradiol and is provided with a translucent polymer film on one side and a protective film on the other.<br><\/p>\n\n\n\n<p>Estradot 100 micron \/ 24 hours is a rectangular&nbsp;patch&nbsp;of 10 cm&nbsp;<sup>2<\/sup>&nbsp;with rounded corners.&nbsp;The patch consists of a pressure-sensitive, adhesive layer containing estradiol and is provided with a translucent polymer film on one side and a protective film on the other.<br><\/p>\n\n\n\n<p>Estradot is available in five different strengths: 25, 37.5, 50, 75 and 100 micrograms \/ 24 hours.&nbsp;Not all strengths may be marketed.<br><\/p>\n\n\n\n<p>Estradot is supplied in cartons of 2, 8, 24, and 26&nbsp;patches.&nbsp;Not all pack sizes may be marketed.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Novartis Sverige AB<\/p>\n\n\n\n<p>Box 1218<\/p>\n\n\n\n<p>164 28 Kista<br><\/p>\n\n\n\n<p><strong>Manufacturer:<\/strong><\/p>\n\n\n\n<p>Novartis Pharmac\u00e9utica, SA<\/p>\n\n\n\n<p>Ronda de Santa Mar\u00eda, 158<\/p>\n\n\n\n<p>08210 Barber\u00e1 del Vall\u00e9s (Barcelona)<\/p>\n\n\n\n<p>Spain<br><\/p>\n\n\n\n<p>Novartis Pharma GmbH<\/p>\n\n\n\n<p>Roonstrasse 25<\/p>\n\n\n\n<p>D-90429 Nuremberg<\/p>\n\n\n\n<p>Germany<br><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Estradot 25 micrograms \/ 24 hours transdermal patch<br \/>\nEstradot 37.5 micrograms \/ 24 hours transdermal patch<br \/>\nEstradot 50 micrograms \/ 24 hours transdermal patch<br \/>\nEstradot 75 micrograms \/ 24 hours transdermal patch<br \/>\nEstradot 100 micrograms \/ 24 hours transdermal patch<br \/>\nestradiol (as hemihydrate)<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2205,2200],"tags":[3093,3095,3096,3094,3572,3574,3575,3573,2212,2905],"class_list":["post-8438","post","type-post","status-publish","format-standard","hentry","category-e","category-medicines","tag-estradiol","tag-estradiol-dose","tag-estradiol-side-effects","tag-estradiol-uses","tag-estradot","tag-estradot-dose","tag-estradot-side-effects","tag-estradot-uses","tag-medicine","tag-patch"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8438","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=8438"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8438\/revisions"}],"predecessor-version":[{"id":10138,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8438\/revisions\/10138"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=8438"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=8438"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=8438"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}