{"id":8388,"date":"2021-03-11T10:55:22","date_gmt":"2021-03-11T10:55:22","guid":{"rendered":"https:\/\/zeepedia.com\/?p=8388"},"modified":"2021-04-14T17:54:11","modified_gmt":"2021-04-14T17:54:11","slug":"esmya","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/esmya\/","title":{"rendered":"Esmya &#8211; Ulipristal Acetate uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n5 mg&nbsp;tablets&nbsp;<br>Ulipristal acetate<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Esmya is and what it is used for<\/h2>\n\n\n\n<p>Esmya contains the active substance ulipristal acetate.&nbsp;It is used to treat moderate to severe symptoms of&nbsp;uterine fibroids&nbsp;in the uterus (also known as fibroids) which&nbsp;tumor&nbsp;you (not cancer) in the womb (&nbsp;uterus&nbsp;).<\/p>\n\n\n\n<p>Esmya is used in adult women (over 18 years of age) who have not reached menopause (&nbsp;menopause&nbsp;).<br><\/p>\n\n\n\n<p>In some women,&nbsp;fibroids&nbsp;in the uterus can cause heavy menstrual bleeding, pelvic pain (discomfort in the belly), and create pressure on other organs.<br><\/p>\n\n\n\n<p>This drug works by affecting the activity of&nbsp;progesterone, which is a naturally occurring&nbsp;hormone&nbsp;in the body.&nbsp;It is used for the long-term treatment of&nbsp;fibroids&nbsp;to reduce their size, stop or reduce bleeding and increase the number of&nbsp;red blood cells.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before taking Esmya<\/h2>\n\n\n\n<p>You should be aware that most women do not have any menstrual bleeding during treatment and for a few weeks afterward.<br><\/p>\n\n\n\n<p><strong>Do not take Esmya<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to ulipristal acetate or any of the other ingredients of Esmya (listed in section 6)<\/li><li>if you have liver disease.<\/li><li>if you are pregnant or breast-feeding<\/li><li>if you have vaginal bleeding not caused by&nbsp;uterine fibroids&nbsp;in the uterus<\/li><li>if you have cancer of the uterus (&nbsp;uterus&nbsp;),&nbsp;cervix, ovaries, or breasts.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Before starting treatment with Esmya, blood tests will be taken to find out how well your liver is working.&nbsp;Based on the results of the tests, your doctor will decide if you can be treated with Esmya.&nbsp;These blood tests will be repeated every month during the first two courses of treatment.&nbsp;For more treatment regimens, the liver is checked once before starting the treatment regimen and if you experience any of the symptoms listed below.&nbsp;Also, an additional check-up of your liver is performed 2-4 weeks after the end of treatment.&nbsp;If you experience any symptoms from the liver during treatment such as nausea or vomiting, fatigue, severe fatigue, jaundice (yellow eyes or yellow skin), dark urine,&nbsp;itching, or pain in the upper abdomen, discontinue treatment and seek medical attention immediately.&nbsp;Your doctor will check how your liver is working and determine if you can continue treatment.<\/li><li>If you are currently taking hormone&nbsp;contraceptives&nbsp;(eg&nbsp;birth control pills&nbsp;) (see &#8220;Other medicines and Esmya&#8221;), you should use another reliable barrier contraceptive method (eg condoms) when taking Esmya.<\/li><li>If you have liver or kidney disease, consult your doctor or pharmacist before taking Esmya.<\/li><li>If you suffer from severe&nbsp;asthma, treatment with Esmya may not be suitable for you.&nbsp;You should discuss this with your doctor.<br><\/li><\/ul>\n\n\n\n<p>Treatment with Esmya usually leads to a sharp reduction or complete cessation of menstrual bleeding during the first 10 days of treatment.&nbsp;If you continue to bleed profusely, talk to your doctor.<br><\/p>\n\n\n\n<p>Your period generally returns within 4 weeks of stopping treatment with Esmya.&nbsp;The&nbsp;lining of the&nbsp;uterus&nbsp;may become thicker or change as a result of treatment with Esmya.&nbsp;These changes stop when the treatment is stopped and your period returns.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and teenagers<\/h2>\n\n\n\n<p>Esmya should not be taken by children under 18 years of age as the safety and efficacy of ulipristal acetate have not been established in this age group.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Esmya<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<br><\/p>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking any of the medicines listed below, as these medicines may affect Esmya or may be affected by Esmya:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>certain medicines used to treat the heart (eg&nbsp;digoxin&nbsp;)<\/li><li>certain medicines used to prevent strokes and blood clots (eg dabigatran etexilate)<\/li><li>certain medicines used to treat&nbsp;epilepsy&nbsp;(eg&nbsp;phenytoin, fosphenytoin, phenobarbital, carbamazepine, oxcarbazepine, primidone)<\/li><li>certain drugs used to treat&nbsp;HIV&nbsp;&#8211;&nbsp;infection&nbsp;(ritonavir, efavirenz, nevirapine)<\/li><li>medicines used to treat certain bacterial infections (eg rifampicin, telithromycin, clarithromycin, erythromycin, rifabutin)<\/li><li>certain medicines used to treat fungal infections (eg&nbsp;ketoconazole&nbsp;[other than shampoo], itraconazole)<\/li><li>herbal herbal remedies containing&nbsp;St. John&#8217;s wort&nbsp;(&nbsp;<em>Hypericum perforatum<\/em>&nbsp;) and used for depression or anxiety<\/li><li>certain medicines used to treat depression (eg nefazodone)<\/li><li>certain medicines used to treat high&nbsp;blood pressure&nbsp;(eg verapamil).<\/li><\/ul>\n\n\n\n<p>Esmya is likely to make some hormone contraceptives less effective.&nbsp;Also, hormonal contraceptives&nbsp;and&nbsp;progestogens&nbsp;(eg norethindrone or levonorgestrel) are likely to make Esmya less effective.&nbsp;Therefore, hormone contraceptives are not recommended and you should use another reliable barrier contraceptive method, e.g.&nbsp;condom, under treatment with Esmya.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Esmya with food and drink<\/h2>\n\n\n\n<p>Avoid drinking grapefruit juice while you are being treated with Esmya.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<br><\/p>\n\n\n\n<p>Do not take Esmya if you are pregnant.&nbsp;Treatment during pregnancy can affect the pregnancy (it is not known if Esmya could harm your baby or cause a miscarriage).&nbsp;If you become pregnant during treatment with Esmya, stop taking Esmya immediately and contact your doctor or pharmacist.<br><\/p>\n\n\n\n<p>Esmya is likely to make some hormone contraceptives less effective (see &#8220;Other medicines and Esmya&#8221;).<\/p>\n\n\n\n<p>Esmya is excreted in human milk, so you should not breast-feed while taking Esmya.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Esmya may cause mild dizziness (see section 4 \u201cPossible side effects\u201d).&nbsp;Do not drive or use machines if you get these symptoms.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to take Esmya<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;is one 5 mg tablet a day for treatment regimens of up to 3 months each.&nbsp;If you have been prescribed several courses of treatment for 3 months with Esmya, you should start each period at the earliest during the second menstrual period after the end of the previous treatment.<\/p>\n\n\n\n<p>You should always start taking Esmya during the first week of your period.<\/p>\n\n\n\n<p>The tablet should be swallowed with water and can be taken with or without food.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Esmya then you should<\/h2>\n\n\n\n<p>Experience with Esmya when several&nbsp;doses&nbsp;are taken at the same time is limited.&nbsp;There have been no reports of serious&nbsp;side effects&nbsp;after taking several&nbsp;doses&nbsp;of this medicine at the same time.&nbsp;You should still consult a doctor or pharmacist if you have taken too much Esmya.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Esmya<\/h2>\n\n\n\n<p>If you miss a&nbsp;dose&nbsp;of fewer than 12 hours, take it as soon as you remember.&nbsp;If you miss a&nbsp;dose&nbsp;of more than 12 hours, skip the forgotten tablet and only take one tablet as usual.&nbsp;Do not take a double&nbsp;dose&nbsp;to make up for a forgotten tablet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Esmya<\/h2>\n\n\n\n<p>Esmya should be taken daily during treatment courses of up to 3 months in a row.&nbsp;During each course of treatment, do not stop taking the tablets without first consulting a doctor even if you feel better, as symptoms may return later.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects,&nbsp;although not everybody gets them.<br><\/p>\n\n\n\n<p>Stop taking Esmya and contact a doctor immediately, if you experience any of the following symptoms:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>swelling of the face, tongue, or throat, difficulty swallowing,&nbsp;hives,&nbsp;or difficulty breathing.&nbsp;This may be a symptom of&nbsp;angioedema&nbsp;(no known frequency).<\/li><li>nausea or vomiting, severe fatigue, jaundice (yellow eyes or yellow skin), dark urine,&nbsp;itching,&nbsp;or pain in the upper abdomen.&nbsp;These symptoms may be signs of liver damage (no known frequency), which is a few cases that have led to liver transplantation.&nbsp;See also section 2 Warnings and Precautions.<\/li><\/ul>\n\n\n\n<p><strong>Very common<\/strong>&nbsp;(may affect more than 1 in 10 people) side effects:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>reduction or cessation of menstrual bleeding (&nbsp;amenorrhea&nbsp;)<\/li><li>thickening of the lining of the uterus (endometrial thickening).<\/li><\/ul>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 people) side effects:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>headache<\/li><li>dizziness (&nbsp;vertigo&nbsp;)<\/li><li>abdominal pain, malaise (nausea)<\/li><li>acne<\/li><li>muscle and bone pain (musculoskeletal pain)<\/li><li>bladder fluid (ovarian cyst), tenderness\/pain in the breast, lower abdominal pain (pelvis), hot flashes<\/li><li>fatigue (exhaustion)<\/li><li>weight gain<\/li><\/ul>\n\n\n\n<p><strong>Uncommon<\/strong>&nbsp;(may affect up to 1 in 100 people) side effects:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>drug allergy<\/li><li>anxiety<\/li><li>Mood swings<\/li><li>dizziness<\/li><li>dry mouth, constipation<\/li><li>hair loss, dry skin, increased sweating<\/li><li>back pain<\/li><li>urine leakage<\/li><li>uterine bleeding (uterine bleeding), vaginal discharge, abnormal&nbsp;vaginal&nbsp;bleeding<\/li><li>chest pleasure<\/li><li>swelling due to fluid retention (&nbsp;edema&nbsp;)<\/li><li>extreme fatigue (&nbsp;asthenia&nbsp;)<\/li><li>increased blood cholesterol levels detected in blood tests, increased fat levels (&nbsp;triglycerides&nbsp;) in the blood detected in blood tests.<\/li><\/ul>\n\n\n\n<p><strong>Rare<\/strong>&nbsp;(may affect up to 1 in 1,000 people) side effects:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>nosebleeds<\/li><li>poor digestion, flatulence<\/li><li>rupture of the fluid bladder in the ovaries (ruptured ovarian cyst)<\/li><li>breast swelling.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Esmya<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton and blister after EXP.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>Store the blister pack in the outer carton.&nbsp;Sensitive to light.<br><\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is ulipristal acetate.&nbsp;One tablet contains 5 mg of ulipristal acetate.<\/li><li>The other ingredients are microcrystalline cellulose, mannitol, croscarmellose sodium, talc, and magnesium stearate.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Esmya is a white to off-white, round and biconvex tablet of 7 mm with \u201cES5\u201d printed on one side.<\/p>\n\n\n\n<p>It is available in Al \/ PVC \/ PE \/ PVDC blister packs in cartons of 28, 30, and 84 tablets or Al \/ PVC \/ PVDC blister packs in cartons of 28 and 84 tablets.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Gedeon Richter Plc.<\/p>\n\n\n\n<p>Gy\u00f6mr\u0151i out 19-21.<\/p>\n\n\n\n<p>1103 Budapest<\/p>\n\n\n\n<p>Hungary<br><\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Cenexi<\/p>\n\n\n\n<p>17, rue de Pontoise<\/p>\n\n\n\n<p>F-95520 Osny<\/p>\n\n\n\n<p>France<br><\/p>\n\n\n\n<p>Gedeon Richter Plc.<\/p>\n\n\n\n<p>Gy\u00f6mr\u0151i out 19-21.<\/p>\n\n\n\n<p>1103 Budapest<\/p>\n\n\n\n<p>Hungary<\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p> 5 mg tablets<br \/>\nUlipristal acetate<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2205,2200],"tags":[3644,3646,3647,3645,2212,2211,3640,3642,3643,3641],"class_list":["post-8388","post","type-post","status-publish","format-standard","hentry","category-e","category-medicines","tag-esmya","tag-esmya-dose","tag-esmya-side-effects","tag-esmya-uses","tag-medicine","tag-tablets","tag-ulipristal-acetate","tag-ulipristal-acetate-dose","tag-ulipristal-acetate-side-effects","tag-ulipristal-acetate-uses"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8388","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=8388"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8388\/revisions"}],"predecessor-version":[{"id":10187,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8388\/revisions\/10187"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=8388"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=8388"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=8388"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}