{"id":8295,"date":"2021-03-10T07:39:05","date_gmt":"2021-03-10T07:39:05","guid":{"rendered":"https:\/\/zeepedia.com\/?p=8295"},"modified":"2023-01-11T14:52:36","modified_gmt":"2023-01-11T14:52:36","slug":"ergenyl-retard","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/ergenyl-retard\/","title":{"rendered":"Ergenyl Retard &#8211; Sodium Valproate Uses, Dose, And Side Effects"},"content":{"rendered":"\n<p><strong>Ergenyl Retard 100 mg, 250 mg, 500 mg&nbsp;prolonged-release granules&nbsp;sodium valproate<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Ergenyl Retard Is, And What Is It Used For<\/h2>\n\n\n\n<p>The mechanism of action of Ergenyl\u00a0Retard\u00a0is not fully understood, but it is believed that the drug prevents or attenuates impulses in the brain that trigger epileptic seizures.<\/p>\n\n\n\n<p>Ergenyl\u00a0Retard\u00a0is a medicine used to treat\u00a0epilepsy\u00a0and mania. Mania means a state of strong arousal, elation, agitation, enthusiasm, or hyperactivity.\u00a0Mania occurs in a disease called\u00a0bipolar disorder.\u00a0Ergenyl\u00a0Retard\u00a0can be used when you can not take lithium.<br><\/p>\n\n\n\n<p>Sodium valproate contained in Ergenyl\u00a0Retard\u00a0may also be approved for treating other conditions not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or another healthcare professional if you have further questions, and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What You Need To Know Before Taking Ergenyl Retard<\/h2>\n\n\n\n<p>Do not take Ergenyl Retard granules:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you have liver disease or impaired liver function.<\/li><li>If you are allergic to sodium valproate or any of the other ingredients of this medicine (listed in section 6).<\/li><li>If you have\u00a0porphyria\u00a0(increased accumulation of certain blood dyes).<\/li><li>If you have a hereditary problem that causes a disturbance in the cells&#8217; energy supply (eg, Alpers-Huttenlocher syndrome).<\/li><li>If you have a known metabolic disease, i.e.,\u00a0disturbance in urea turnover.<\/li><\/ul>\n\n\n\n<p>Bipolar disease<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>For&nbsp;bipolar disorder, do not use Ergenyl&nbsp;Retard&nbsp;if you are pregnant.<\/li><li>For&nbsp;bipolar disorder, if you are a woman who may have children, do not take Ergenyl&nbsp;Retard&nbsp;unless you are using an effective contraceptive throughout treatment with Ergenyl&nbsp;Retard.&nbsp;Do not stop taking Ergenyl&nbsp;Retard&nbsp;or your contraceptive until you have discussed it with your doctor.&nbsp;Your doctor will give you further advice (see below under &#8220;Pregnancy, breast-feeding and&nbsp;fertility&nbsp;&#8211; Important advice for women&#8221;).<\/li><\/ul>\n\n\n\n<p>Epilepsy<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>For&nbsp;epilepsy, do not use Ergenyl&nbsp;Retard&nbsp;if you are pregnant, except when nothing else works for you.<\/li><li>For&nbsp;epilepsy, if you are a woman who may have children, do not take Ergenyl&nbsp;Retard&nbsp;unless you are using an effective contraceptive throughout treatment with Ergenyl&nbsp;Retard.&nbsp;Do not stop taking Ergenyl&nbsp;Retard&nbsp;or your contraceptive until you have discussed it with your doctor.&nbsp;Your doctor will give you further advice (see below under &#8220;Pregnancy, breast-feeding and&nbsp;fertility&nbsp;&#8211; Important advice for women&#8221;).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings And Cautions<\/h2>\n\n\n\n<p>Treatment with Ergenyl\u00a0Retard\u00a0requires close monitoring, with a call for blood tests regarding liver and pancreatic\u00a0functions\u00a0and\u00a0platelets.\u00a0It would help if you went for these checks.\u00a0This is especially true at the beginning of treatment and during surgeries.<br>The use of\u00a0acetylsalicylic acid\u00a0(for pain and <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cold\/\">fever<\/a>) in children under 3 years of age should be avoided due to the risk of liver damage.<br>In case of blood disease, certain skin diseases (\u00a0SLE\u00a0), impaired kidney function, metabolic disease (especially hereditary enzyme deficiency), or if you easily get bruises or bleeding, the doctor should be informed about this.\u00a0Always follow the doctor&#8217;s prescription carefully!\u00a0Consult your doctor if you are unsure.\u00a0<\/p>\n\n\n\n<p>There is a risk of weight gain when taking Ergenyl\u00a0Retard.\u00a0Contact a doctor if you need help checking your weight.<br>Many people treated with antiepileptic drugs\u00a0such as\u00a0valproate\u00a0have also had thoughts of harming themselves or committing suicide.\u00a0If you ever get these thoughts, contact your doctor immediately.<br><\/p>\n\n\n\n<p><em>Always consult a doctor if the following symptoms occur: <\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><em>Loss of appetite<\/em><\/li><li><em>Nausea<\/em><\/li><li><em>Drowsiness<\/em><\/li><li>Fatigue sometimes occurs with repeated vomiting or abdominal pain, jaundice, swelling in the legs or feet, and the case of sudden impaired seizure control.\u00a0This can be a sign of a serious effect on the liver or pancreas.\u00a0This is especially true in infants and children under 3 years of age with severe epilepsy\u00a0(especially children with brain damage, developmental disorders, genetic and metabolic diseases) and combination therapy with other\u00a0antiepileptic drugs.\u00a0See also section 4, Possible\u00a0side effects.<\/li><\/ul>\n\n\n\n<p>Talk to your doctor if you know that your family has a hereditary problem that is disrupting the cells&#8217; energy supply.<br>As with other antiepileptic medicines,\u00a0seizures\u00a0may worsen or occur more often when you take this medicine.\u00a0Contact a doctor immediately if this happens.<br>You should not stop the medication abruptly, as the risk of seizures may increase.\u00a0Never change the\u00a0prescribed\u00a0dose\u00a0yourself\u00a0without consulting a doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children And Young People<\/h2>\n\n\n\n<p>Ergenyl\u00a0Retard\u00a0should not be used in children and adolescents under 18 years of age to treat mania.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other Medicines And Ergenyl Retard<\/h2>\n\n\n\n<p>Ergenyl\u00a0Retard\u00a0may affect or be affected by other medicines, such as:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Painkillers (\u00a0acetylsalicylic acid\u00a0)<\/li><li>Agent against\u00a0gastric ulcers\u00a0(cimetidine)<\/li><li>drugs against cardiovascular disease (nimodipine)<\/li><li>Agents against\u00a0epilepsy\u00a0(ethosuximide, felbamate, phenobarbital,\u00a0phenytoin, carbamazepine, lamotrigine, primidone, rufinamide, topiramate)<\/li><li>Anti-anxiety drugs (lorazepam)<\/li><li>Anti-malarial\u00a0drugs (mefloquine)<\/li><li>Anesthetic (propofol)<\/li><li>Agents for viral infections (zidovudine)<\/li><li>Remedies for\u00a0<a href=\"https:\/\/zeepedia.com\/medical\/diseases\/psychosis\/\">psychosis<\/a>\u00a0and certain other mental illnesses<\/li><li>Antidepressants and sleeping pills<\/li><li>Certain blood thinners (\u00a0warfarin\u00a0)<\/li><li>Certain\u00a0antibiotics\u00a0(erythromycin, rifampicin, carbapenems such as ertapenem, imipenem, meropenem, and panipenem)<\/li><li>Certain lipid-lowering drugs (cholestyramine)<\/li><li>Certain anti-glaucoma\u00a0drugs\u00a0(acetazolamide)<\/li><li>Treatment with\u00a0antibiotics\u00a0containing pivalic acid (pivampicillin, pivmecillinam) should be avoided.<\/li><li>Estrogen-containing agents\u00a0(including some\u00a0birth control pills\u00a0)<\/li><\/ul>\n\n\n\n<p>Therefore, you need to tell your doctor or pharmacist if you have taken, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Ergenyl&nbsp;Retard is&nbsp;unlikely to&nbsp;affect the effect of&nbsp;birth control pills.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Ergenyl Retard With Food And Drink<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Do not use\u00a0granules\u00a0with\u00a0<em>hot<\/em>\u00a0food or drink.<\/li><li>Alcohol should not be consumed during treatment, as Ergenyl\u00a0Retard\u00a0increases the effect of alcohol.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, Breastfeeding, And Fertility<\/h2>\n\n\n\n<p><strong>Important advice for women<\/strong><br><em>Bipolar disease<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>For\u00a0bipolar disorder, do not use Ergenyl\u00a0Retard\u00a0if you are pregnant.<\/li><li>For\u00a0bipolar disorder, if you are a woman who may have children, do not take Ergenyl\u00a0Retard\u00a0unless you use an effective contraceptive throughout treatment with Ergenyl\u00a0Retard\u00a0\u00a0Do not stop taking Ergenyl\u00a0Retard\u00a0or your contraceptive until you have discussed it with your doctor.\u00a0Your doctor will give you further advice.<\/li><\/ul>\n\n\n\n<p><em>Epilepsy<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>For&nbsp;epilepsy, do not use Ergenyl&nbsp;Retard&nbsp;if you are pregnant, except when nothing else works for you.<\/li><li>For&nbsp;epilepsy, if you are a woman who may have children, do not take Ergenyl&nbsp;Retard&nbsp;unless you are using an effective contraceptive throughout treatment with Ergenyl&nbsp;Retard.&nbsp;Do not stop taking Ergenyl&nbsp;Retard&nbsp;or your contraceptive until you have discussed it with your doctor.&nbsp;Your doctor will give you further advice.<\/li><\/ul>\n\n\n\n<p><em>The risks of&nbsp;valproate&nbsp;when taken during pregnancy (regardless of the disease for which&nbsp;valproate&nbsp;is used):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tell your doctor immediately if you are planning to become pregnant or are pregnant.<\/li><li>Valproate\u00a0is a risk if taken during pregnancy.\u00a0The higher the\u00a0dose, the higher the risk, but all\u00a0doses\u00a0involve a risk.<\/li><li>It can cause serious birth defects and can affect how the baby develops as it grows.\u00a0Fetal injuries that have been reported include\u00a0spina bifida\u00a0(where the bones of the spine are not properly developed), malformations of the face and skull,\u00a0heart, kidney, urinary tract, and malformations of the genitals as well as malformations of the\u00a0extremities\u00a0er.\u00a0Hearing problems or <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/sudden-hearing-loss-sudden-deafness\/\">deafness<\/a> have been reported in children exposed to\u00a0valproate\u00a0during pregnancy.<\/li><li>If you take\u00a0valproate\u00a0during pregnancy, you are at greater risk than other women of having a child with birth defects that require medical treatment.\u00a0Since\u00a0valproate\u00a0has been used for many years, we know that about 10 children out of 100 will have birth defects in women taking valproate.\u00a0This compares with 2 to 3 children in 100 born to women without\u00a0epilepsy.<\/li><li>It is estimated that up to 30-40% of preschool children whose mothers took\u00a0valproate\u00a0during pregnancy may have problems with early childhood development.\u00a0Affected children may be late to walk and talk, have a lower intellectual ability than other children, and have difficulty with language and memory.<\/li><li>Autism spectrum disorders are more commonly diagnosed in children exposed to\u00a0valproate\u00a0during pregnancy. There is some support that children exposed to\u00a0valproate\u00a0during pregnancy have a higher risk of developing\u00a0ADHD\u00a0(Attention Deficit Hyperactivity Disorder).<\/li><li>Before you are prescribed this medicine, your doctor will have explained what can happen to your baby if you become pregnant while taking\u00a0valproate.\u00a0If you later decide to have a child, do not stop taking your medicine or contraceptive until you have discussed it with your doctor.<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are the parent or caregiver of a girl treated with&nbsp;valproate, consult your doctor when your child using&nbsp;valproate&nbsp;gets his first period.<br><\/li><li>Some&nbsp;birth control pills&nbsp;(estrogen-containing birth control pills&nbsp;) can lower the valproate levels in your blood.&nbsp;Make sure you talk to your doctor about which contraceptive (birth control) is most suitable for you.<\/li><li>Talk to your doctor about taking&nbsp;folic acid&nbsp;when trying to conceive.&nbsp;Folic acid&nbsp;can lower the overall risk of&nbsp;<em>spina bifida<\/em>&nbsp;and early miscarriage that occurs with all pregnancies.&nbsp;However, it is unlikely that it will reduce the risk of birth defects in connection with valproate use.<br><\/li><\/ul>\n\n\n\n<p><strong>Please select and read the situations that apply to you from the situations described below:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>I BEGIN TREATMENT WITH ERGENYL\u00a0RETARD<\/li><li>I TAKE ERGENYL\u00a0RETARD,\u00a0BUT I DON&#8217;T PLAN TO HAVE CHILDREN<\/li><li>I TAKE ERGENYL\u00a0RETARD\u00a0AND PLAN TO HAVE CHILDREN<\/li><li>I AM PREGNANT, AND I TAKE\u00a0ERGENYL RETARD<\/li><\/ul>\n\n\n\n<p><strong>I BEGIN TREATMENT WITH ERGENYL&nbsp;RETARD<\/strong><\/p>\n\n\n\n<p>If this is the first time you have been prescribed Ergenyl\u00a0Retard, your doctor will explain the risks to an unborn baby if you become pregnant.\u00a0If you can have children, you must ensure that you use an effective method of contraception without interruption during your treatment with Ergenyl\u00a0Retard.\u00a0Talk to your doctor or midwife if you need contraceptive advice.<\/p>\n\n\n\n<p><strong>Main message:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Pregnancy must be ruled out as a result of a pregnancy test, which has been confirmed by your doctor before starting treatment with Ergenyl\u00a0Retard.<\/li><li>You must use an effective contraceptive throughout the treatment with Ergenyl\u00a0Retard.<\/li><li>You must discuss appropriate birth control methods (contraception) with your doctor.\u00a0Your doctor will give you information on how to prevent pregnancy and can refer you to a specialist doctor for advice on birth control.<\/li><li>You must have regular (at least annual) appointments with a specialist doctor who has experience in treating\u00a0bipolar disorder\u00a0or\u00a0epilepsy.\u00a0During this visit, your doctor should make sure that you are well aware of and understand all the risks and advice related to using\u00a0valproate\u00a0during pregnancy.<\/li><li>Tell your doctor if you want to get pregnant.<\/li><li>Tell your doctor immediately if you are pregnant or think you may be pregnant.<\/li><\/ul>\n\n\n\n<p><strong>I TAKE ERGENYL\u00a0RETARD,\u00a0BUT I DON&#8217;T PLAN TO HAVE CHILDREN<\/strong><\/p>\n\n\n\n<p>If you continue treatment with Ergenyl\u00a0Retard\u00a0but do not plan to have children, make sure you use an effective contraceptive without interruption throughout the treatment with Ergenyl\u00a0Retard.\u00a0Talk to your doctor or midwife if you need contraceptive advice.<\/p>\n\n\n\n<p><strong>Main message:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>You must use an effective contraceptive throughout the treatment with Ergenyl\u00a0Retard.<\/li><li>It would help if you discussed contraception (birth control) with your doctor.\u00a0Your doctor will give you information on preventing pregnancy and may refer you to a specialist for birth control advice.<\/li><li>You must have regular (at least annual) appointments with a specialist doctor who has experience treating\u00a0bipolar disorder\u00a0or\u00a0epilepsy.\u00a0During this visit, your doctor should make sure that you are well aware of and understand all the risks and advice related to using\u00a0valproate\u00a0during pregnancy.<\/li><li>Tell your doctor if you want to get pregnant.<\/li><li>Tell your doctor immediately if you are pregnant or think you may be pregnant.<\/li><\/ul>\n\n\n\n<p><strong>I TAKE ERGENYL&nbsp;RETARD&nbsp;AND PLAN TO HAVE CHILDREN<\/strong><\/p>\n\n\n\n<p>If you plan to have a baby, make an appointment with your doctor.<br>Do not stop taking Ergenyl\u00a0Retard\u00a0or your contraceptive until you have discussed it with your doctor.\u00a0Your doctor will give you further advice.<br>Children born to mothers who have taken\u00a0valproate\u00a0have a serious risk of birth defects and developmental disorders that can be severely impaired.\u00a0Your doctor will refer you to a specialist with experience treating\u00a0bipolar disorder\u00a0or\u00a0epilepsy\u00a0so that other treatment options can be evaluated early.\u00a0Your specialist doctor can take several measures so that your pregnancy goes as smoothly as possible and any risks to you and your unborn child are reduced as much as possible.<\/p>\n\n\n\n<p><br>Your specialist doctor may decide to change the\u00a0dose\u00a0of Ergenyl\u00a0Retard\u00a0or switch to another medicine, or stop your treatment with Ergenyl\u00a0Retard, well in advance of your pregnancy &#8211; to ensure that your disease is stable.<br>Consult your doctor about taking\u00a0folic acid\u00a0when planning to have children.\u00a0Folic acid can lower the overall risk of\u00a0<em>spina bifida<\/em>\u00a0and early miscarriage that occurs with all pregnancies.\u00a0However, it is unlikely to reduce the risk of birth defects associated with valproate use.<br><\/p>\n\n\n\n<p><strong>Main message:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Do not stop taking Ergenyl\u00a0Retard\u00a0unless your doctor tells you to.<\/li><li>Do not stop using your contraceptive until you have talked to your doctor and worked out a plan to ensure that your condition is stable and that the risks to your child are reduced.<\/li><li>Book an appointment with your doctor.\u00a0During this visit, your doctor should make sure that you are well aware of and understand all the risks and advice related to using\u00a0valproate\u00a0during pregnancy.<\/li><li>Your doctor will try to switch to another medicine or stop your treatment with Ergenyl\u00a0Retard\u00a0well before you become pregnant.<\/li><li>Tell your doctor immediately if you are pregnant or think you may be pregnant.<\/li><\/ul>\n\n\n\n<p><strong>I AM PREGNANT, AND I TAKE\u00a0ERGENYL RETARD<\/strong><\/p>\n\n\n\n<p>Do not stop taking Ergenyl\u00a0Retard\u00a0unless your doctor tells you that your condition may be getting worse.\u00a0Tell your doctor immediately if you are pregnant or think you may be pregnant.\u00a0Your doctor will give you further advice.<br>Children born to mothers who have taken\u00a0valproate\u00a0have a serious risk of birth defects and developmental disorders that can be severely impaired.<\/p>\n\n\n\n<p><br>You will be referred to a specialist with experience treating\u00a0bipolar disorder\u00a0or\u00a0epilepsy\u00a0so that other treatment options can be evaluated.<\/p>\n\n\n\n<p><br>In the exceptional circumstances when Ergenyl\u00a0Retard\u00a0is the only available treatment option during pregnancy, you will be examined very carefully regarding your illness and to check how your unborn baby is developing.\u00a0You and your partner can get advice and support regarding pregnancy exposure to\u00a0valproate.<\/p>\n\n\n\n<p>Ask your doctor for\u00a0folic acid.\u00a0Folic acid\u00a0can lower the overall risk of\u00a0<em>spina bifida<\/em>\u00a0and early miscarriage that occurs with all pregnancies.\u00a0However, it is unlikely to reduce the risk of birth defects associated with valproate use.<\/p>\n\n\n\n<p><strong>Main message:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tell your doctor immediately if you are pregnant or think you may be pregnant.<\/li><li>Do not stop taking Ergenyl\u00a0Retard\u00a0unless your doctor tells you to.<\/li><li>Make sure you are referred to a specialist with experience treating\u00a0a bipolar disorder\u00a0or\u00a0epilepsy\u00a0to evaluate the need for alternative treatment options.<\/li><li>You must get detailed advice on the risks of Ergenyl\u00a0Retard\u00a0during pregnancy, including the risk of\u00a0birth defects\u00a0and developmental disorders in children.<\/li><li>Make sure you are referred to a &#8220;prenatal monitoring&#8221; specialist to detect possible birth defects in the unborn baby.<\/li><\/ul>\n\n\n\n<p><strong>Make sure you read the patient information brochure you will receive from your doctor.\u00a0Your doctor will discuss the annual risk confirmation form and ask you to sign and keep it.\u00a0You will also receive a patient card from your doctor to remind you of the risks of\u00a0valproate\u00a0during pregnancy.<\/strong><br><\/p>\n\n\n\n<p>Extremely rare cases of blood coagulation problems have been reported in neonates whose mothers were treated with\u00a0valproate\u00a0during pregnancy.\u00a0However,\u00a0hypoglycemia\u00a0(low blood glucose) and\u00a0hypothyroidism\u00a0(thyroid gland malfunction, which can cause tiredness and weight increase) may occur in the newborn.<br>Withdrawal symptoms may occur in newborns whose mothers took Ergenyl\u00a0Retardduring the last third of pregnancy.<\/p>\n\n\n\n<p><strong>Breast-feeding<\/strong><\/p>\n\n\n\n<p>Valproate\u00a0passes into breast milk.\u00a0Talk to your doctor before using Ergenyl\u00a0Retardduring breastfeeding.<\/p>\n\n\n\n<p><strong>Fertility<\/strong><\/p>\n\n\n\n<p>Ergenyl&nbsp;Retard&nbsp;may reduce&nbsp;fertility&nbsp;in both men and women.&nbsp;However, available information indicates that&nbsp;fertility&nbsp;returns to normal when treatment with Ergenyl&nbsp;Retard is&nbsp;stopped.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving And Using Machines<\/h2>\n\n\n\n<p>You are\u00a0<em>responsible<\/em>\u00a0for assessing whether you can drive a motor vehicle or perform work that requires increased vigilance.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\u00a0side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Ergenyl Retard Contains Sodium<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><em>100 mg:<\/em><ul><li>Consult a physician or pharmacist if you need 45 sachets or more daily for an extended period, especially if you have been prescribed a low-salt (sodium-poor) diet.<\/li><\/ul><\/li><li><em>250 mg:<\/em><ul><li>Consult a physician or pharmacist if you need 18 sachets daily for an extended period, especially if you have been prescribed a low-salt (sodium-poor) diet.<\/li><\/ul><\/li><li><em>500 mg:<\/em><ul><li>Consult your doctor or pharmacist if you need 9 sachets or more daily for an extended period, especially if you have been prescribed a low-salt (sodium-poor) diet.<\/li><\/ul><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">3. How To Take Ergenyl Retard<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><em>Treatment with Ergenyl\u00a0Retard\u00a0must be initiated and supervised by a doctor who specializes in the treatment of\u00a0bipolar disorder\u00a0or\u00a0epilepsy.<\/em><\/li><li>Ergenyl\u00a0Retard\u00a0granules\u00a0should be taken regularly according to your doctor&#8217;s instructions.<\/li><li>The granules\u00a0are tasteless and only intended to be taken by mouth.<\/li><li>Ergenyl Retard\u00a0prolonged-release granules\u00a0are a formulation that is specially adapted for children (when they can swallow easily chewed food) and for adults with difficulty swallowing.\u00a0Granules\u00a0have a so-called modified\u00a0release.\u00a0This means that the body absorbs the active ingredient for a longer period, giving the drug a more even level.\u00a0Because\u00a0granules\u00a0have a modified\u00a0release, they also contain inert ingredients that are insoluble.\u00a0These are not absorbed by the body but disappear with feces, where they can sometimes be seen.<\/li><li><strong>Epilepsy: <\/strong>\u00a0<ul><li>The daily dose can vary greatly depending on age, body weight, and the severity of the seizures.\u00a0<\/li><li><em>A usual starting dose for adults<\/em>\u00a0is 10-15 mg\/kg body weight daily.\u00a0<\/li><li>The usual maintenance dose\u00a0is 20-30 mg\/kg body weight daily.\u00a0<\/li><li>Granules\u00a0can also be used for children where appropriate.\u00a0The usual\u00a0dose\u00a0for children\u00a0is around 30 mg\/kg body weight daily.<\/li><\/ul><\/li><li><strong>Mania:<\/strong>\u00a0<ul><li>The daily\u00a0dose\u00a0should be determined and monitored individually by your doctor.\u00a0<\/li><li><em>Starting dose<\/em>\u00a0<\/li><\/ul><ul><li>The recommended daily starting dose is 750 mg.\u00a0<\/li><li><em>Average daily\u00a0dose<\/em>\u00a0<\/li><li>The recommended daily\u00a0dose\u00a0is usually between 1000 mg and 2000 mg.<\/li><\/ul><\/li><li>Dose\u00a0one can be increased or decreased depending on the patient&#8217;s reaction.\u00a0<\/li><li>Dose\u00a0one can be given once or twice daily.\u00a0<\/li><li>The sachet is intended to be used on a single occasion.\u00a0It must not be shared and saved for later use.\u00a0<\/li><li>Granules are\u00a0sprinkled on or mixed into food or drink (e.g., yogurt, juice, softened ice cream,\u00a0cream\u00a0), which is\u00a0<a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cold\/\">cold<\/a> or at room temperature.\u00a0Granules\u00a0can also be poured directly into the mouth and rinsed with a cold drink.\u00a0<\/li><li>Granules\u00a0should\u00a0not\u00a0be given hot food or drink (e.g., soup, coffee, tea).\u00a0<\/li><li>Ergenyl\u00a0Retard\u00a0granules\u00a0should not be given in baby bottles because granules\u00a0can block the hole in the pacifier.\u00a0<\/li><li>When\u00a0granules\u00a0are given together with liquid, the glass should be rinsed afterward with a small amount of water so that no grains get stuck.\u00a0<\/li><li>Mixture\u00a0one should be swallowed immediately and not chewed.\u00a0It must not be saved for later intake.<\/li><\/ul>\n\n\n\n<p>Always take Ergenyl\u00a0Retard\u00a0granules\u00a0exactly as your doctor has told you.\u00a0If you are not sure, talk to your doctor or\u00a0pharmacist.\u00a0Do not stop treatment without consulting your doctor.\u00a0Otherwise, the disease may worsen.<\/p>\n\n\n\n<p>If you have the impression that the effect of Ergenyl&nbsp;Retard&nbsp;granules&nbsp;is too strong or too weak, talk to your doctor or&nbsp;pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If You Take More Ergenyl Retard, Then You Should<\/h2>\n\n\n\n<p>If you take too much medicine, always contact a doctor, hospital, or the Poison Information Center.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If You Forget To Take Ergenyl Retard<\/h2>\n\n\n\n<p>If you forget to take your medicine, take a&nbsp;dose&nbsp;as soon as you remember.&nbsp;Do not take a double&nbsp;dose&nbsp;to make up for a forgotten&nbsp;dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible Ergenyl Retard Side Effects<\/h2>\n\n\n\n<p>This medicine can cause side effects like all medicines, although not everybody gets them.<br><strong>Angioedema\u00a0<\/strong><em>Uncommon (may affect up to 1 in 100 people):<\/em>\u00a0<\/p>\n\n\n\n<p>Stop taking Ergenyl and contact a doctor immediately if you get any of the following symptoms (&nbsp;angioedema&nbsp;):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Swelling of the face, tongue, or throat<\/li><li>Difficulty swallowing<\/li><li>Hives\u00a0and difficulty breathing<\/li><\/ul>\n\n\n\n<p><strong>Severe effects on the liver or pancreas&nbsp;<\/strong>&nbsp;<em>Uncommon (may&nbsp;<\/em><strong>affect&nbsp;<\/strong><em>up to 1 in 100 people):<\/em>&nbsp;<\/p>\n\n\n\n<p>Contact a doctor immediately if the following symptoms occur: <\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Loss of appetite<\/li><li>Nausea<\/li><li>Drowsiness<\/li><li>Fatigue sometimes occurs with repeated vomiting or abdominal pain, jaundice, swelling in the legs or feet, and the case of sudden impaired seizure control.\u00a0This can be a sign of a serious effect on the liver or pancreas (sometimes fatal).\u00a0This has usually affected children under the age of 3 with several disabilities, children who have received high\u00a0doses\u00a0in combination with other antiepileptic drugs, and rare children who only take Ergenyl.<\/li><\/ul>\n\n\n\n<p><strong>Agranulocytosis&nbsp;<\/strong><em>Rare (may affect up to 1 in 1,000 people):<\/em>&nbsp;<\/p>\n\n\n\n<p>Ergenyl can, in rare cases, affect the white\u00a0blood cells\u00a0so that the defense against infection deteriorates.\u00a0Get an infection with symptoms such as fever with severe general deterioration or local infection symptoms such as sore throat\/throat\/mouth or difficulty urinating. You should see a doctor as soon as possible so that blood tests can rule out a lack of\u00a0white blood cells\u00a0(\u00a0agranulocytosis\u00a0).\u00a0It is important that you then provide information about your medication.<br><\/p>\n\n\n\n<p><strong>Rhabdomyolysis<\/strong><em>&nbsp;Rare (may affect up to 1 in 1,000 people):<\/em><\/p>\n\n\n\n<p>Stop taking Ergenyl and contact your doctor as soon as possible if you experience unexplained muscle pain, muscle cramps, or muscle weakness.\u00a0(There is an increased risk of\u00a0rhabdomyolysis\u00a0in people with a certain enzyme deficiency, CPT type II.)<br><\/p>\n\n\n\n<p><strong>Lyell&#8217;s syndrome\u00a0(\u00a0toxic epidermal necrolysis\u00a0)\u00a0is <\/strong><em>Rare (may affect up to 1 in 1,000 people):<\/em><\/p>\n\n\n\n<p>Contact a doctor immediately if you get serious widespread skin damage (skin peeling of the epidermis and superficial mucous membranes).<br><\/p>\n\n\n\n<p><strong>Stevens-Johnson syndrome<\/strong><em>&nbsp;Rare (may affect up to 1 in 1,000 people):<\/em><\/p>\n\n\n\n<p>An extremely severe\u00a0allergic reaction\u00a0with skin rash, usually in the form of blisters or sores in the oral cavity and eyes and other mucous membranes, such as genitals.<\/p>\n\n\n\n<p>Contact a doctor immediately if you get such a reaction.<\/p>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;that may occur<\/strong><\/p>\n\n\n\n<p><em>Very common (may affect more than 1 user in 10):<\/em>&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tremors<\/li><li>Nausea<\/li><\/ul>\n\n\n\n<p><em>Common (may affect up to 1 in 10 people):<\/em>&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Stomach upset in the form of pain, vomiting, and diarrhea<\/li><li>Gum problems,\u00a0inflammation\u00a0of the oral mucosa<\/li><li>Transient and dose-dependent hair loss<\/li><li>Problems with nails and\u00a0nail bed<\/li><li>Allergic skin reactions<\/li><li>Increased appetite, abnormal weight gain, loss of appetite, and weight loss<\/li><li>Confusion, hallucinations, aggression,\u00a0agitation, problems with attention<\/li><li>Dizziness<\/li><li>Extrapyramidal symptoms<ul><li>Stiffness<\/li><li>Drowsiness<\/li><li>Cramps<\/li><li>Impaired memory<\/li><li>Headache<\/li><li>Rapid and uncontrolled eye movements<\/li><\/ul><\/li><li>Increased tendency to bleed due to decreased\u00a0platelet count\u00a0(\u00a0thrombocytopenia\u00a0) or prolonged bleeding time, bleeding,\u00a0anemia<\/li><li>Painful menstruation<\/li><li>Deafness<\/li><li>Liver damage, the effect on liver function with a change in liver function values<\/li><li>Reduced amount of\u00a0sodium\u00a0in the blood, which i.a.\u00a0can lead to confusion<\/li><li>Urinary incontinence (accidental urination)<\/li><\/ul>\n\n\n\n<p><em>Uncommon (may affect up to 1 in 100 people):<\/em>&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Difficulty sleeping<\/li><li>An ant crawling and tingling, disorders of coordination (ability to coordinate), transient\u00a0parkinsonism\u00a0(shaking, stiffness), unsteady gait, decreased level of consciousness,\u00a0coma, effects on the brain, aggravated seizures that may occur more often.<\/li><li>Reduction in the number of\u00a0white blood cells\u00a0(\u00a0leukopenia\u00a0), shortage of all types of\u00a0blood cell\u00a0s<\/li><li>More frequent urinary incontinence impaired kidney function<\/li><li>Swelling of the legs or feet (\u00a0edema\u00a0), water in the lung sac, increased amount of fluid in the body<\/li><li>Lowered body temperature<\/li><li>Fatigue<\/li><li>Hair problems (change in hair color, hair structure, hair growth)<\/li><li>Irregular or missed periods, too high levels of male sex hormones<\/li><li>Inflammation\u00a0of the pancreas<\/li><li>Inflammation\u00a0of a vessel wall (\u00a0vasculitis\u00a0)<\/li><li>Skeletal diseases, e.g.,\u00a0reduced bone density, osteoporosis, and bone fractures.\u00a0Contact your doctor or pharmacist if you have been treated with epilepsy medication for a long time, if you know you have osteoporosis or if you are on medication with\u00a0steroids.<\/li><\/ul>\n\n\n\n<p><em>Rare (may affect up to 1 in 1,000 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Prolonged bleeding time, abnormal coagulation tests, increased\u00a0white blood cell count, impaired bone marrow function, which includes very severe\u00a0anemia\u00a0(pure red cell aplasia), conditions where normal blood formation is disturbed,\u00a0anemia with enlarged\u00a0red blood cells<\/li><li>SLE\u00a0(a severe\u00a0autoimmune\u00a0disease)<\/li><li>Psychosis, behavioral disorders, hyperactivity, learning disabilities, memory impairment, transient dementia, <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/distinction-and-double-vision-in-adults\/\">double vision<\/a><\/li><li>Constipation<\/li><li>Severe liver effects in older children<\/li><li>Elevated levels of ammonium ions in the blood<\/li><li>Bedwetting,\u00a0inflammation\u00a0of the kidneys, transient renal impairment (Fanconi syndrome)<\/li><li>Impaired thyroid function<\/li><li>Infertility\u00a0in men, polycystic ovaries (ovaries produce more blisters than normal)<\/li><li>Biotin deficiency (b-vitamin component)<\/li><li>Obesity<\/li><li>In rare cases, severe brain effects have been reported, especially with concomitant treatment with topiramate or phenobarbital or a sudden increase in the sodium valproate dose.<\/li><li>A condition with drug-induced skin rash, enlarged\u00a0lymph nodes,\u00a0and the possible deterioration of other organs has been reported.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">5. How To Store Ergenyl Retard<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Do not store above 25 \u00b0 C.\u00a0<\/li><li>Store in a cold place.\u00a0<\/li><li>Granules\u00a0should not be exposed to heat.\u00a0<\/li><li>Store in the original package.\u00a0Moisture sensitive.<\/li><li>Do not use this medicine after the expiry date stated on the carton\/sachet (EXP).\u00a0The expiration date is the last day of the specified month.<\/li><li>Do not use this medicine if\u00a0granules\u00a0appear to have melted or clumped together.<\/li><li>Keep out of sight and reach of children.<\/li><\/ul>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.\u00a0Ask your pharmacist how to dispose of medicines that are no longer required.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging And Other Information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content Declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substances are sodium valproate and\u00a0valproic acid\u00a0corresponding to 100 mg, 250 mg, and 500 mg sodium valproate.<\/li><li>The other ingredients are solid paraffin, glycerol behenate,\u00a0and colloidal\u00a0aqueous silica.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder:<\/h2>\n\n\n\n<p>Sanofi AB, Box 30052, 104 25 Stockholm<\/p>\n\n\n\n<p>Detailed and updated information about this product is available by scanning the QR code contained in the package leaflet with a smartphone.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The mechanism of action of Ergenyl Retard is not fully understood, but it is believed that the drug prevents or attenuates impulses in the brain that trigger epileptic seizures.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2205,2200],"tags":[3938,3940,2213,3935,3937,3939,3936],"class_list":["post-8295","post","type-post","status-publish","format-standard","hentry","category-e","category-medicines","tag-ergenyl-retard","tag-ergenyl-retard-side-effects","tag-medicines","tag-sodium-valproate","tag-sodium-valproate-side-effects","tag-what-is-ergenyl-retard","tag-what-is-sodium-valproate"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8295","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=8295"}],"version-history":[{"count":44,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8295\/revisions"}],"predecessor-version":[{"id":44417,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8295\/revisions\/44417"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=8295"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=8295"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=8295"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}