{"id":8236,"date":"2021-03-08T07:00:31","date_gmt":"2021-03-08T07:00:31","guid":{"rendered":"https:\/\/zeepedia.com\/?p=8236"},"modified":"2021-04-28T07:43:35","modified_gmt":"2021-04-28T07:43:35","slug":"eplerenone-accord","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/eplerenone-accord\/","title":{"rendered":"Eplerenone Accord &#8211; Eplerenone uses, dose and side effects"},"content":{"rendered":"\n<p> 25 mg, 50 mg\u00a0film-coated tablets\u00a0<br>eplerenone<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Eplerenone Accord is and what it is used for<\/h2>\n\n\n\n<p>Eplerenone Accord belongs to a group of medicines called selective aldosterone antagonists.&nbsp;These&nbsp;antagonists&nbsp;inhibit the effect of&nbsp;aldosterone, a substance that the body produces to regulate&nbsp;blood pressure&nbsp;and heart function.&nbsp;High levels of&nbsp;aldosterone&nbsp;can cause changes in the body that lead to&nbsp;heart failure.<br><\/p>\n\n\n\n<p>Eplerenone Accord is used to treat&nbsp;heart failure&nbsp;to prevent worsening and reduce the number of hospital stays if you have:<br><\/p>\n\n\n\n<p>1. have had a recent heart attack, in combination with other medicines used to treat your&nbsp;heart failure, or<\/p>\n\n\n\n<p>2. had persistent, mild symptoms despite the treatment you have received so far.<br><\/p>\n\n\n\n<p>Eplerenone contained in the Eplerenone Accord may also be approved for the treatment of other conditions not mentioned in this product information.&nbsp;Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before taking Eplerenone Accord<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Eplerenone Accord<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to eplerenone or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you have elevated levels of&nbsp;potassium&nbsp;in your blood (hyperkalemia)<\/li><li>if you take&nbsp;diuretics&nbsp;that reduce the body&#8217;s excess fluid (potassium-sparing&nbsp;diuretics&nbsp;)<\/li><li>if you have severe kidney disease<\/li><li>if you have severe liver disease<\/li><li>if you are taking medicines for fungal infections (&nbsp;ketoconazole&nbsp;or itraconazole)<\/li><li>if you take medicines to prevent&nbsp;viruses&nbsp;to treat&nbsp;HIV&nbsp;(nelfinavir or ritonavir)<\/li><li>if you are taking&nbsp;antibiotics&nbsp;to treat bacterial&nbsp;infections&nbsp;(clarithromycin or telithromycin)<\/li><li>if you are taking nefazodone to treat depression<\/li><li>if you are taking medicines to treat certain heart conditions or high&nbsp;blood pressure&nbsp;(so-called angiotensin-converting&nbsp;enzyme&nbsp;[ACE] inhibitors and an angiotensin receptor blocker [ARB] together).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before taking Eplerenone Accord<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have kidney or liver disease (see also \u201cDo not take Eplerenone Accord\u201d)<\/li><li>if you are taking lithium (commonly used for depressive illness, also known as&nbsp;bipolar disorder&nbsp;)<\/li><li>if you are taking tacrolimus or cyclosporine (to treat skin conditions such as&nbsp;psoriasis&nbsp;or&nbsp;eczema&nbsp;and to prevent organ rejection after organ transplantation)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>The safety and efficacy of eplerenone in children and adolescents have not been established.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Eplerenone Accord<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Itraconazole or&nbsp;ketoconazole&nbsp;(for the treatment of fungal infections), ritonavir, nelfinavir (medicines to prevent&nbsp;infections&nbsp;against&nbsp;HIV&nbsp;&#8211;&nbsp;infection&nbsp;), clarithromycin, telithromycin (drugs for bacterial infections), or nefazadone (depression), then these drugs can reduce the degradation of Eplerenone Accord and thereby prolonging its effect in the body.<\/li><li>Potassium-sparing&nbsp;diuretics&nbsp;(medicines that help reduce the body&#8217;s excess fluid) and potassium supplements (salt tablets), as these medicines increase the risk of elevated levels of&nbsp;potassium&nbsp;in the blood.<\/li><li>Angiotensin-converting&nbsp;enzyme&nbsp;(ACE) inhibitors and angiotensin receptor blockers (ARBs) together (which are used to treat high&nbsp;blood pressure, heart disease, or certain kidney conditions), as these medicines may increase the risk of high levels of&nbsp;potassium&nbsp;in the blood.<\/li><li>Lithium (commonly used for manic-depressive illness, also called&nbsp;bipolar disorder).&nbsp;The use of lithium in combination with&nbsp;diuretics&nbsp;and&nbsp;ACE inhibitors&nbsp;(for the treatment of high&nbsp;blood pressure&nbsp;and heart disease) has been shown to cause high levels of lithium in the blood, which can cause side effects: loss of appetite, visual disturbances, fatigue, muscle weakness, and muscle twitching.<\/li><li>Cyclosporine or tacrolimus (to treat skin conditions such as&nbsp;psoriasis&nbsp;or&nbsp;eczema and to prevent organ rejection after organ transplantation).&nbsp;These drugs can cause problems with the kidneys and thus increase the risk of elevated levels of&nbsp;potassium&nbsp;in the blood.<\/li><li>Non-steroidal&nbsp;anti-inflammatory&nbsp;drugs (so-called&nbsp;NSAIDs&nbsp;&#8211; painkillers such as&nbsp;ibuprofen, for the treatment of pain, stiffness, and&nbsp;inflammation&nbsp;).&nbsp;These drugs can lead to kidney problems and thus increase the risk of elevated levels of&nbsp;potassium&nbsp;in the blood.<\/li><li>Trimethoprim (a medicine used to treat bacterial infections) may increase the risk of high levels of&nbsp;potassium&nbsp;in the blood.<\/li><li>Alpha-1 receptor blockers, such as prazosin or alfuzosin (used for high&nbsp;blood pressure&nbsp;and certain prostate conditions) can cause a drop in blood pressure and dizziness when standing up.<\/li><li>Tricyclic antidepressants&nbsp;such as&nbsp;amitriptyline or amoxapine (for the treatment of depression), antipsychotics (also called&nbsp;neuroleptics&nbsp;) such as chlorpromazine or&nbsp;haloperidol&nbsp;(for the treatment of mental illness), amifostine (used during cancer treatment), and baclofen (for the treatment of muscle cramps).&nbsp;These medicines can cause a drop in blood pressure and dizziness when standing up.<\/li><li>Glucocorticoids&nbsp;such as&nbsp;hydrocortisone&nbsp;or prednisone (used to treat&nbsp;inflammation and certain skin conditions) and tetracosactide (used mainly to diagnose and treat disorders of the&nbsp;adrenal cortex&nbsp;) may reduce the blood pressure-lowering effect of Eplerenone Accord.<\/li><li>Digoxin&nbsp;(for heart disease).&nbsp;The levels of&nbsp;digoxin&nbsp;in the blood can increase when taken together with Eplerenone Accord.<\/li><li>Warfarin&nbsp;(medicine for blood clots): Caution&nbsp;should be exercised when treating&nbsp;warfarin as high levels of&nbsp;warfarin&nbsp;in the blood may cause changes in the effect of Eplerenone Accord in the body.<\/li><li>Erythromycin (for bacterial infections), saquinavir (drugs that counteract&nbsp;viruses used in the treatment of&nbsp;HIV&nbsp;),&nbsp;fluconazole&nbsp;(antifungal),&nbsp;amiodarone,&nbsp;diltiazem, and verapamil (for cardiac problems, high&nbsp;blood pressure&nbsp;) decreases degradation of Eplerenone Accord, thus prolonging Eplerenone Accords effect in the body.<\/li><li>St. John&#8217;s wort&nbsp;(herbal medicine), rifampicin (for bacterial infections), carbamazepine,&nbsp;phenytoin,&nbsp;and phenobarbital (medicines for&nbsp;epilepsy,&nbsp;among others&nbsp;) can increase the breakdown of Eplerenone Accord and thus reduce its effect.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Eplerenone Accord with food and drink<\/h2>\n\n\n\n<p>Eplerenone tablets can be taken with or without food<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.&nbsp;The efficacy of Eplerenone Accord during human pregnancy has not been studied.<br><\/p>\n\n\n\n<p>It is not known whether eplerenone is excreted in human breast milk.&nbsp;Discuss with your doctor before deciding whether to stop breast-feeding or discontinue treatment with this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>You may feel dizzy after taking Eplerenone Accord.&nbsp;In this case, do not drive or use machines.<br><\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Eplerenone Accord contains lactose monohydrate<\/h2>\n\n\n\n<p>Eplerenone Accord contains&nbsp;lactose monohydrate&nbsp;(a sugar).&nbsp;If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Eplerenone Accord<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor or pharmacist has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<br><\/p>\n\n\n\n<p>Eplerenone Accord can be taken with food or on an empty stomach.&nbsp;Swallow the tablets whole along with a copious amount of water.<br><\/p>\n\n\n\n<p>Eplerenone Accord is normally given together with other medicines for&nbsp;heart failure, e.g.&nbsp;beta-blockers.&nbsp;The usual starting dose is 25 mg once daily, which after about 4 weeks is increased to 50 mg once daily (either as one 50 mg tablet or two&nbsp;<br>25 mg tablets).&nbsp;The maximum&nbsp;dosage&nbsp;is 50 mg daily.<br><\/p>\n\n\n\n<p>Potassium levels in the blood should be monitored before treatment with Eplerenone Accord, during the first week of treatment and, one month after starting a treatment or changing the&nbsp;dose.&nbsp;Dosage&nbsp;one may need to be adjusted by your doctor, depending on the potassium levels in your blood.<\/p>\n\n\n\n<p>If you have mild renal impairment, you should start with a 25 mg tablet every day.&nbsp;And if you have moderate renal impairment, you should start with a 25 mg tablet every other day.&nbsp;These&nbsp;doses&nbsp;can be adjusted if your doctor recommends so and based on the levels of&nbsp;potassium&nbsp;in your blood.<br><\/p>\n\n\n\n<p>Eplerenone Accord is not recommended for patients with severe renal impairment.<\/p>\n\n\n\n<p>The starting dose does not need to be adjusted in patients with mild to moderate hepatic impairment.&nbsp;If you have liver or kidney problems, your potassium levels may need to be checked more often (see also \u201cDo not take Eplerenone Accord\u201d).<br><\/p>\n\n\n\n<p>Elderly: No adjustment of the starting dose is required.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Use for children and adolescents<\/h2>\n\n\n\n<p>Eplerenone Accord is not recommended.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Eplerenone Accord then you should<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if e.g.&nbsp;a child inadvertently ingested the medicine immediately contact a doctor, hospital, or the Poisons Information Center for risk assessment and advice.&nbsp;<br>If you have taken too much of your medicine, the most likely symptoms will be low&nbsp;blood pressure&nbsp;(may manifest as a &#8220;slight&#8221; feeling in the head, dizziness, blurred vision, weakness,&nbsp;acute&nbsp;unconsciousness) or&nbsp;hyperkalemia, elevated levels of&nbsp;potassium&nbsp;in the blood ( may manifest as muscle cramps, diarrhea, nausea, dizziness or headache).<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Eplerenone Accord<\/h2>\n\n\n\n<p>If it is soon time for your next&nbsp;dose, skip the missed tablet and take the next one as usual.<br><\/p>\n\n\n\n<p>Otherwise, take it as soon as you remember, provided it takes more than 12 hours for you to take the next tablet.&nbsp;Then return to your regular medication.<\/p>\n\n\n\n<p>Do not take a double&nbsp;dose&nbsp;to make up for a forgotten tablet.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Eplerenone Accord<\/h2>\n\n\n\n<p>It is important to continue taking Eplerenone Accord as&nbsp;prescribed&nbsp;unless your doctor tells you to stop your treatment.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<br><\/p>\n\n\n\n<p><strong>If you get any of the following&nbsp;side effects,&nbsp;talk&nbsp;<\/strong>&nbsp;<strong>to your healthcare provider immediately:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>swelling of the face, tongue, or throat<\/li><li>difficulty swallowing<\/li><li>hives&nbsp;and difficulty breathing<\/li><\/ul>\n\n\n\n<p>These are symptoms of&nbsp;angioneurotic edema, a less common&nbsp;side effect&nbsp;(may affect up to 1 in 100 people).<br><\/p>\n\n\n\n<p>Other reported&nbsp;side effects&nbsp;include:<br><\/p>\n\n\n\n<p><strong>Common&nbsp;<\/strong>&nbsp;<strong>side effects&nbsp;are<\/strong>&nbsp;(may affect up to 1 in 10):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>high potassium levels in the blood (symptoms include muscle cramps, diarrhea, nausea, dizziness, or headache)<\/li><li>dizziness<\/li><li>fainting<\/li><li>increase&nbsp;in blood&nbsp;cholesterol<\/li><li>insomnia (difficulty sleeping)<\/li><li>headache<\/li><li>heart problems, e.g.&nbsp;irregular heartbeat and&nbsp;heart failure<\/li><li>cough<\/li><li>constipation<\/li><li>low&nbsp;blood pressure<\/li><li>diarrhea<\/li><li>nausea<\/li><li>vomiting<\/li><li>impaired renal function<\/li><li>rash<\/li><li>itching<\/li><li>back pain<\/li><li>impotence<\/li><li>muscle twitching<\/li><li>increased level of&nbsp;urea&nbsp;in the blood<\/li><li>increased content of&nbsp;creatinine&nbsp;in the blood, which may indicate problems with the kidneys<br><\/li><\/ul>\n\n\n\n<p><strong>Uncommon&nbsp;<\/strong>side effects&nbsp;(may affect up to 1 in 100 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>infection<\/li><li>eosinophilia&nbsp;(increase in certain&nbsp;white blood cells&nbsp;)<\/li><li>dehydration<\/li><li>increase in&nbsp;triglycerides&nbsp;(fats) in the blood<\/li><li>decreased&nbsp;sodium&nbsp;levels in the blood<\/li><li>fast heartbeat<\/li><li>inflammation&nbsp;of the gallbladder<\/li><li>lowered&nbsp;blood pressure&nbsp;which can cause dizziness when standing up<\/li><li>thrombosis&nbsp;(blood clot) in the legs<\/li><li>sore throat<\/li><li>gas formation<\/li><li>underactive&nbsp;thyroid gland<\/li><li>elevated blood sugar<\/li><li>the decreased sensation on touch<\/li><li>increased sweating<\/li><li>musculoskeletal pain<\/li><li>general malaise<\/li><li>kidney inflammation<\/li><li>breast augmentation in men<\/li><li>changes in certain blood test results<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Eplerenone Accord<\/h2>\n\n\n\n<p>Keep this medicine out of sight&nbsp;<strong>&#8211;<\/strong>&nbsp;and the sight of children.<\/p>\n\n\n\n<p>No special storage instructions.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton after EXP.&nbsp;dat and blister after EXP.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>The active substance is eplerenone.&nbsp;Each tablet contains 25 mg or 50 mg of eplerenone.<br><\/p>\n\n\n\n<p>The other ingredients are&nbsp;lactose monohydrate, microcrystalline cellulose, hypromellose, croscarmellose sodium, talc, magnesium stearate.<br><\/p>\n\n\n\n<p>The tablet coating (Opadry 13B52001 yellow) contains hypromellose, titanium dioxide (E171), macrogol 400, polysorbate 80, yellow iron oxide (E172), red iron oxide (E172).<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Eplerenone Accord 25 mg: yellow, diamond-shaped, biconvex film-coated tablets, marked with \u201cE1\u201d on one side and no label on the other.&nbsp;Length 7.20 \u00b1 0.3 mm, width 6.40 \u00b1 0.3 mm and thickness 3.15 \u00b1 0.3 mm.<br><\/p>\n\n\n\n<p>Eplerenone Accord 50 mg: yellow, diamond-shaped, biconvex film-coated tablets, marked with \u201cE2\u201d on one side and no label on the other side.&nbsp;Length 9.00 \u00b1 0.3 mm, width 8.10 \u00b1 0.3 mm, and thickness 4.25 \u00b1 0.3 mm.<br><\/p>\n\n\n\n<p>Eplerenone Accord 25 mg and 50 mg film-coated tablets are packaged in blisters containing 10, 20, 28, 30, 50, 90 or 100 tablets or in perforated unit dose blisters containing 10 x 1, 20 x 1, 28 x 1, 30 x 1, 50 x 1, 90 x 1 or 100 x 1 tablets.<br><\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Accord Healthcare BV<\/p>\n\n\n\n<p>Winthontlaan 200<\/p>\n\n\n\n<p>3526 kV Utrecht<\/p>\n\n\n\n<p>Netherlands<br><\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Accord Healthcare Limited,<\/p>\n\n\n\n<p>Sage House, 319 Pinner Road,<\/p>\n\n\n\n<p>North Harrow,<\/p>\n\n\n\n<p>Middlesex HA1 4HF,<\/p>\n\n\n\n<p>UK<br><\/p>\n\n\n\n<p>Accord Healthcare Polska Sp.z oo,<\/p>\n\n\n\n<p>ul.&nbsp;Lutomierska 50,95-200 Pabianice, Poland<br><\/p>\n\n\n\n<p>Accord Healthcare BV<\/p>\n\n\n\n<p>Winthontlaan 200<\/p>\n\n\n\n<p>3526 KV Utrecht<\/p>\n\n\n\n<p>Netherlands<br><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Eplerenone Accord belongs to a group of medicines called selective aldosterone antagonists. These antagonists inhibit the effect of aldosterone, a substance that the body produces to regulate blood pressure and heart function. High levels of aldosterone can cause changes in the body that lead to heart failure.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2205,2200],"tags":[3996,4012,4014,4011,3998,2213,2211,3997,4013],"class_list":["post-8236","post","type-post","status-publish","format-standard","hentry","category-e","category-medicines","tag-eplerenone","tag-eplerenone-accord","tag-eplerenone-accord-side-effects","tag-eplerenone-dose","tag-eplerenone-side-effects","tag-medicines","tag-tablets","tag-what-is-eplerenone","tag-what-is-eplerenone-accord"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8236","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=8236"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8236\/revisions"}],"predecessor-version":[{"id":10465,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8236\/revisions\/10465"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=8236"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=8236"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=8236"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}