{"id":8232,"date":"2021-03-08T06:57:34","date_gmt":"2021-03-08T06:57:34","guid":{"rendered":"https:\/\/zeepedia.com\/?p=8232"},"modified":"2021-04-28T07:52:47","modified_gmt":"2021-04-28T07:52:47","slug":"epirubicin-teva","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/epirubicin-teva\/","title":{"rendered":"Epirubicin Teva &#8211; Epirubicin Hydrochloride uses, dose and side effects"},"content":{"rendered":"\n<p> 2 mg \/ ml\u00a0solution for injection \/ infusion\u00a0<br>epirubicin hydrochloride<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Epirubicin Teva is and what it is used for<\/h2>\n\n\n\n<p><strong>Pharmaceutical<br><\/strong>group Epirubicin belongs to the group of&nbsp;chemotherapy drugs.&nbsp;<br>Epirubicin prevents cancer cells from growing, which eventually kills them.<br><\/p>\n\n\n\n<p><strong>Used for<br><\/strong>Epirubicin is given for the treatment of:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>breast cancer.<\/li><li>stomach cancer.<\/li><li>Epirubicin Teva is also used in the bladder (injected into the bladder) to treat early (superficial) bladder cancer and helps prevent the recurrence of bladder cancer after surgery.<\/li><\/ul>\n\n\n\n<p>Epirubicin is often used at the same time as other anticancer medicines (so-calpolychemotherapyrapy&nbsp;according to schedule).<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before you use Epirubicin Teva<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">You will not be treated with Epirubicin Teva<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to epirubicin, similar medicines (called&nbsp;anthracyclines&nbsp;or anthracenediones, see below), or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you are breast-feeding<\/li><\/ul>\n\n\n\n<p><strong>Depending on the route of administration, Epirubicin Teva will NOT be given to you in the following situations:<\/strong><br><\/p>\n\n\n\n<p><strong>Intravenous&nbsp;(in a vein):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you&nbsp;<strong><em>previously been treated<\/em><\/strong>&nbsp;with other cancer drugs&nbsp;<strong><em>in the high&nbsp;dose&nbsp;you including<\/em><\/strong> doxorubicin and daunorubicin which belong to the same class of drugs as Epirubicin Teva (called&nbsp;<strong><em>anthracycline&nbsp;s<\/em><\/strong>&nbsp;).&nbsp;They have similar&nbsp;side effects(including effects on the heart).<\/li><li>if you suffer from or have had&nbsp;<strong><em>heart disease<\/em><\/strong>.<\/li><li>if you have&nbsp;low blood levels<\/li><li>if you have severe&nbsp;liver disease.<\/li><li>if you suffer from an&nbsp;acute&nbsp;severe&nbsp;infection.<\/li><\/ul>\n\n\n\n<p><strong>Intravesical (directly in the bladder):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if cancer has penetrated the bladder wall.<\/li><li>if you have a urinary tract infection.<\/li><li>if you have pain or&nbsp;inflammation&nbsp;in the bladder.<\/li><li>if it is difficult to insert a&nbsp;catheter&nbsp;into your&nbsp;bladder.<\/li><li>if large amounts of urine remain in your&nbsp;bladder&nbsp;after you urinate<\/li><li>if there is blood in the urine<\/li><li>if you have a narrowed&nbsp;bladder.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before using Epirubicin Teva:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are&nbsp;<em>older <\/em>or a&nbsp;child,&nbsp;as the risk of serious heart side effects is higher.&nbsp;Your heart function will be checked before and after treatment with epirubicin.<\/li><li>if you have&nbsp;or have had&nbsp;heart problems in the&nbsp;past.&nbsp;Inform your doctor.&nbsp;The dose of epirubicin needs to be adjusted.&nbsp;Your doctor will regularly check that your heart is functioning normally.<\/li><li>if you&nbsp;have been previously treated&nbsp;with anti-cancer drugs (such as doxorubicin or daunorubicin, anthracenedione derivatives, or <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/trazimera\/\">trastuzumab<\/a>) or if you have received radiation therapy over the chest area, as the risk of serious heart effects is greater.&nbsp;Tell your doctor as this is part of the assessment of the total&nbsp;dose of epirubicin you will receive.<\/li><li>if you have&nbsp;liver or kidney disease.&nbsp;This can cause more&nbsp;side effects.&nbsp;Both renal function and liver function will be checked regularly and the&nbsp;dose&nbsp;adjusted if necessary.<\/li><li>if you&nbsp;want to have children&nbsp;&nbsp;Both men and women should use effective contraception both during and up to 6 months after treatment.&nbsp;Men are advised to ask for information about the possibility of freezing sperm before treatment.<\/li><li>if you have&nbsp;an infection&nbsp;or bleeding.&nbsp;Epirubicin may affect the&nbsp;bone marrow.&nbsp;The number of&nbsp;white blood cells&nbsp;in your blood will decrease, making you more susceptible to&nbsp;infection&nbsp;(&nbsp;leukopenia&nbsp;).&nbsp;Bleeding may occur more easily (&nbsp;thrombocytopenia&nbsp;).&nbsp;These&nbsp;side effects&nbsp;are temporary.&nbsp;The number of&nbsp;white blood cells&nbsp;is at least 10-14 days after the drug is given and usually returns to normal 21 days after the drug is given.&nbsp;The doctor will take regular samples.<\/li><li>if you have recently received or wish to receive any&nbsp;vaccination.<br><\/li><\/ul>\n\n\n\n<p>Take special care with Epirubicin Teva:<br><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if the uric acid level in your blood needs to be checked.&nbsp;Your doctor will check this.<\/li><li>if blood clots form in your blood vessels (&nbsp;thromboembolism&nbsp;).&nbsp;This can lead to&nbsp;inflammation&nbsp;in a vein (&nbsp;thrombophlebitis&nbsp;) or blockage of the pulmonary artery (&nbsp;pulmonary embolism&nbsp;)<\/li><li>if you get severe&nbsp;inflammation&nbsp;or sore mouth.<\/li><li>if you get a&nbsp;<em>burning sensation<\/em>&nbsp;where an&nbsp;injection is&nbsp;given.&nbsp;This may mean that epirubicin is leaking from the blood vessel.&nbsp;Make the doctor aware of this.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Epirubicin Teva<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<br><\/p>\n\n\n\n<p>An&nbsp;interaction&nbsp;means that (drugs) used together can affect each other&#8217;s effect and\/or&nbsp;side effects.&nbsp;An&nbsp;interaction&nbsp;may occur during concomitant use of this solution and:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>previous or concomitant therapy with other agents related to epirubicin (called anthracyclines; (eg cancer drugs&nbsp;mitomycin C, dacarbazine, dactinomycin, and cyclophosphamide&nbsp;)), other medications that may affect the heart (for example, cancer drugs&nbsp;5-fluorouracil, cyclophosphamide, cisplatin, taxanes, trastuzumab&nbsp;);&nbsp;the harmfulness of the heart may increase.&nbsp;Extra control of the heart is then necessary.<\/li><li>epirubicin may increase the effects of radiation.&nbsp;Even quite a long time after the radiation, it can cause serious&nbsp;side effects&nbsp;over the radiated area.<\/li><li>rifampicin&nbsp;(an agent used in the treatment of&nbsp;tuberculosis&nbsp;) and&nbsp;barbiturate&nbsp;s&nbsp;(an agent used for insomnia or&nbsp;epilepsy, such as phenobarbital);&nbsp;These agents reduce the amount of epirubicin in the blood, which can lead to a reduced effect of epirubicin.<\/li><li>paclitaxel&nbsp;and&nbsp;docetaxel&nbsp;(agents used to treat certain types of cancer);&nbsp;When paclitaxel is given before epirubicin or docetaxel is given immediately after epirubicin, the amount of epirubicin in the blood increases, which can lead to an increase in&nbsp;side effects.&nbsp;<\/li><li>dexverapamil&nbsp;(a drug used to treat certain types of heart disease);&nbsp;when used with epirubicin it can harm the&nbsp;bone marrow.<\/li><li>interferon&nbsp;alfa-2b&nbsp;(a drug used in certain types of cancer and lymphoma and certain forms of hepatitis(jaundice)).<\/li><li>quinine&nbsp;(a drug used to treat&nbsp;malaria&nbsp;and leg cramps);&nbsp;Quinine can accelerate the rapid release of epirubicin into the body, which can have adverse effects on red&nbsp;blood cells.<\/li><li>dexrazoxane&nbsp;(a drug sometimes used with doxorubicin to reduce the risk of heart problems);&nbsp;epirubicin may not remain in the body for as long, which may lead to a reduced effect of epirubicin.<\/li><li>cimetidine&nbsp;(an agent that reduces the amount of stomach acid);&nbsp;the amount of epirubicin in the blood increases, which can lead to an increase in&nbsp;side effects.<\/li><li>previous or concomitant therapy with other agents affecting the&nbsp;bone marrow&nbsp;(for example,&nbsp;other anticancer drugs, sulfonamide, chloramphenicol, diphenylhydantoin, amidopyrinderivat, agents against certain&nbsp;viruses&nbsp;);&nbsp;the formation of&nbsp;red blood cells&nbsp;can be disturbed.<\/li><li>agents that cause&nbsp;heart failure<\/li><li>agents that affect liver function;&nbsp;The breakdown of epirubicin in the liver can be affected, which can cause a reduced effect of epirubicin or an increase in&nbsp;side effects.<\/li><li>live vaccines;&nbsp;there is a risk of fatal disease, therefore this combination is not recommended.<\/li><li><strong><em>ciclosporin&nbsp;(<\/em><\/strong>&nbsp;an agent that inhibits the immune system);&nbsp;the immune system can be inhibited too much.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Epirubicin Teva with food and drink<\/h2>\n\n\n\n<p>You should not drink any fluid for 12 hours before the epirubicin treatment is given in the bladder.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p><em>Pregnancy and&nbsp;fertility<\/em><\/p>\n\n\n\n<p>Anti-cancer drugs are only given in extreme cases during pregnancy.&nbsp;The benefits to the mother must be weighed against the potential risk to the unborn child.&nbsp;In animal studies, epirubicin is harmful to the unborn baby and can cause birth defects.&nbsp;Both men and women should use effective contraception (&nbsp;birth control pills, condoms) both during treatment and 6 months after the end of treatment to prevent pregnancy.&nbsp;<br>You should also avoid getting pregnant if your partner is being treated with epirubicin.&nbsp;<br>If a pregnancy occurs during treatment with epirubicin, genetic counseling is recommended.&nbsp;<br>Men who wish to have children in the future should seek advice on sperm freezing before starting epirubicin treatment.<br><\/p>\n\n\n\n<p><em>Breast-feeding<\/em>&nbsp;<br>It is unknown whether epirubicin is excreted in human milk.&nbsp;You should stop breast-feeding during treatment with Epirubicin Teva.<br><\/p>\n\n\n\n<p>Ask your doctor or pharmacist for advice before taking any medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>As many patients become very nauseous or have to vomit during treatment, driving and using machines can not be recommended.<br><\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased vigilance.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Epirubicin Teva contains sodium<\/h2>\n\n\n\n<p>This medicine contains 18 mg of&nbsp;sodium&nbsp;(the main ingredient in baking soda) in each 5 ml&nbsp;vial.&nbsp;This corresponds to 0.9% of the recommended daily intake of&nbsp;sodium&nbsp;for an adult.<\/p>\n\n\n\n<p>This medicine contains 35 mg&nbsp;sodium&nbsp;(the main ingredient in baking soda) in each 10 ml&nbsp;vial.&nbsp;This corresponds to 1.8% of the recommended daily&nbsp;sodium&nbsp;intake&nbsp;for an adult.<\/p>\n\n\n\n<p>This medicine contains 89 mg of&nbsp;sodium&nbsp;(the main ingredient in baking soda) in each 25 ml&nbsp;vial.&nbsp;This corresponds to 4.4% of the recommended daily&nbsp;sodium&nbsp;intake&nbsp;for an adult.<\/p>\n\n\n\n<p>This medicine contains 266 mg of&nbsp;sodium&nbsp;(the main ingredient in baking soda) in each 75 ml&nbsp;vial.&nbsp;This corresponds to 13.3% of the recommended daily&nbsp;sodium&nbsp;intake&nbsp;for an adult.<\/p>\n\n\n\n<p>This medicine contains 354 mg of&nbsp;sodium&nbsp;(the main ingredient in baking soda) in each 100 ml&nbsp;vial.&nbsp;This corresponds to 17.7% of the recommended daily intake of&nbsp;sodium&nbsp;for an adult.<br><\/p>\n\n\n\n<p>This medicine contains 3.5 mg (0.154 mmol)&nbsp;sodium&nbsp;per ml solution.&nbsp;This should be considered by patients on a low-salt diet.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use Epirubicin Teva<\/h2>\n\n\n\n<p>Epirubicin Teva will only be given to you under the supervision of a doctor specializing in this type of treatment.&nbsp;Ask your doctor or pharmacist if you are unsure.<br><\/p>\n\n\n\n<p>The dose&nbsp;you receive depends on the type of cancer you have, your health, your age, how well your liver is working, and what other medications you are taking.<br><\/p>\n\n\n\n<p><em>Venous administration&nbsp;(&nbsp;intravenous&nbsp;administration&nbsp;)<\/em><\/p>\n\n\n\n<p>The dosing schedule is adapted to your health and any previous treatments, and your height and weight are taken into account.&nbsp;The amounts in the dosing schedule are expressed in several milligrams per square meter of body surface area.<br><\/p>\n\n\n\n<p>The medicine will be given as an&nbsp;injection&nbsp;into a vein for 3-5 minutes or as an&nbsp;infusion&nbsp;into a vein for a maximum of 30 minutes.&nbsp;<br>If only epirubicin hydrochloride is given, ie without other cancer drugs, the recommended&nbsp;dose is&nbsp;60-90 mg \/ m&nbsp;<sup>2<\/sup>&nbsp;body surface area.&nbsp;Dose&nbsp;one is given as a single dose or divided into 2-3 consecutive days.&nbsp;This is repeated every 21 days.&nbsp;In combination with other cancer drugs,&nbsp;dose&nbsp;one is&nbsp;reduced.&nbsp;<br>The administration&nbsp;is via a&nbsp;catheter&nbsp;or by a side tap to the ongoing&nbsp;infusion&nbsp;of physiological saline or&nbsp;glucose&nbsp;(sugar solution).&nbsp;<br>A higher dose&nbsp;er can be given in the treatment of breast cancer (100-120 mg \/ m&nbsp;<sup>2<\/sup>&nbsp;body surface area).<br><\/p>\n\n\n\n<p><em><strong>Administration&nbsp;via the bladder (&nbsp;intravesical&nbsp;administration&nbsp;) The<br><\/strong><\/em>the drug can be given directly into the bladder (for the treatment of bladder cancer) using a catheter.&nbsp;If this method is used, do not drink any liquid for 12 hours before treatment so that the urine does not dilute the drug too much.&nbsp;The solution should remain in the bladder 1-2 hours after it is injected.&nbsp;You need to turn around a few times during treatment to make sure that all parts of the bladder come in contact with the medicine.&nbsp;<br>When emptying your bladder after taking the medicine, be careful not to let the urine come in contact with your skin.&nbsp;In case of skin contact, wash with soap and water without scrubbing.<br><\/p>\n\n\n\n<p>When epirubicin is given, your doctor will take blood samples to measure the effect of the medicine.&nbsp;Your doctor will also do checks to see how your heart is working.&nbsp;Both blood tests and cardiac function tests are performed before and during treatment with epirubicin.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Epirubicin Teva then you should<\/h2>\n\n\n\n<p>Because this medicine is given to you by healthcare professionals, the risk of an overdose is unlikely.&nbsp;Contact your doctor immediately if you suspect you have been given too much Epirubicin Teva.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Epirubicin Teva<\/h2>\n\n\n\n<p>As this medicine is given by healthcare professionals, it is unlikely that a&nbsp;dose will&nbsp;be missed.&nbsp;<br>Check with your doctor if you are unsure.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Epirubicin Teva<\/h2>\n\n\n\n<p>Consult your doctor.&nbsp;<br>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects,&nbsp;although not everybody gets them.<br><\/p>\n\n\n\n<p>Adverse reactions&nbsp;are expected to occur in over 10 percent of patients treated with epirubicin.&nbsp;The most common&nbsp;side effects&nbsp;are bone marrow depression, gastrointestinal disorders, loss of appetite, hair loss, and&nbsp;infections.<br><\/p>\n\n\n\n<p>The following&nbsp;side effects&nbsp;may include:<br><\/p>\n\n\n\n<p>Very common (may affect more than 1 user in 10)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>decreased production of&nbsp;blood cells&nbsp;(bone marrow inhibition; leading to a lack of white and&nbsp;red blood cells&nbsp;and&nbsp;platelets&nbsp;), which leads to an increased susceptibility to&nbsp;infections&nbsp;and&nbsp;anemia.<\/li><li>hair loss (&nbsp;alopecia&nbsp;in 60-90% of patients. This includes reduced beard growth in men. Hair loss is dose-related and transient in most patients).<\/li><li>red urine after&nbsp;administration&nbsp;for the following 1-2 days<br><\/li><\/ul>\n\n\n\n<p>Common (may affect up to 1 in 10 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>infection&nbsp;is<\/li><li>hot flashes<\/li><li>loss of appetite (&nbsp;anorexia&nbsp;), dehydration<\/li><li>inflammation&nbsp;of the mucosa (&nbsp;mucositis&nbsp;may appear 5-10 days after the start),&nbsp;inflammation&nbsp;of the esophagus&nbsp;mucosa&nbsp;(&nbsp;esophagitis&nbsp;) or oral mucosa (&nbsp;stomatitis), vomiting, diarrhea (which may cause disturbance of the fluid balance in the body), nausea (nausea and vomiting, often within the first 24 hours, in almost all patients)<\/li><li>redness&nbsp;of the skin where the injection\/infusion was given<\/li><li>inflammation&nbsp;of the bladder, sometimes with bleeding, local reactions such as burning, and an increased need to urinate if the drug has been given to the bladder<br><\/li><\/ul>\n\n\n\n<p>Uncommon (may affect up to 1 in 100 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>bleeding and an increased tendency to get bruises (due to lack of&nbsp;platelets[thrombocytopenia])<\/li><li>redness&nbsp;along the veins (&nbsp;phlebitis&nbsp;), vasculitis with the formation of a blood clot, often feels like a painful, slightly hard nucleus with&nbsp;redness&nbsp;over it (&nbsp;thrombophlebitis&nbsp;)<br><\/li><\/ul>\n\n\n\n<p>Rare (may affect up to 1 in 1,000 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>certain forms of blood cancer (&nbsp;acute&nbsp;lymphocytic&nbsp;leukemia&nbsp;(ALL),&nbsp;acute myeloid leukemia&nbsp;(AML))<\/li><li>severe, immediate&nbsp;allergic reaction&nbsp;(anaphylactic\/anaphylactoid reaction) with or without&nbsp;shock&nbsp;including rash and&nbsp;itching, fever, and chills<\/li><li>abnormally high level of uric acid in the blood (hyperuricemia)<\/li><li>dizziness<\/li><li>risk of the weakened heart resulting in blood overflow (&nbsp;chronic&nbsp;heart failure&nbsp;),&nbsp;heart failure&nbsp;(shortness of breath; accumulation of fluid throughout the body [edema]), liver enlargement, accumulation of fluid in the abdominal cavity (&nbsp;ascites&nbsp;), accumulation of fluid in the lungs (&nbsp;pulmonary edema, pleural effusion), heart rhythm disorders [canter rhythm], cardiotoxicity (eg, abnormal&nbsp;ECG, arrhythmias, heart muscle disease [cardiomyopathy]) increased heart rate in chambers of the lower part of the heart (ventricular tachycardia), slow heartbeat (&nbsp;bradycardia&nbsp;), break impulse conduction in the heart (&nbsp;AV block, branch block)<\/li><li>formation of small sips (&nbsp;hives&nbsp;) or severe&nbsp;itching&nbsp; local flushing reactions in the&nbsp;vessel&nbsp;where the injection\/infusion was given<\/li><li>missed menstruation, lack of sperm in the semen<\/li><li>feeling sick, a strong feeling of weakness, fever, chills<\/li><li>changes in the content of certain&nbsp;enzymes&nbsp;(&nbsp;transaminases&nbsp;)<br><\/li><\/ul>\n\n\n\n<p>Has been reported (occurs in an unknown number of users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>blood poisoning (&nbsp;sepsis&nbsp;) and&nbsp;shock&nbsp;as a result of a decrease in the production of&nbsp;blood&nbsp;ar (myelosuppression),&nbsp;pneumonia<\/li><li>bleeding, lack of oxygen in&nbsp;tissue&nbsp;are<\/li><li>certain nerve diseases (&nbsp;peripheral&nbsp;neuropathy&nbsp;), headache<\/li><li>inflammation&nbsp;of the eye (&nbsp;conjunctivitis,&nbsp;keratitis&nbsp;)<\/li><li>shock, blood clot formation (&nbsp;thromboembolism&nbsp;), also in the lungs (&nbsp;pulmonary embolism, in very rare cases with fatal outcome)<\/li><li>abrasion of the oral mucosa, sores in the mouth, pain in the mouth, burning sensation in the mucous membrane, bleeding in the mouth, staining of the oral cavity (cheek pigmentation)<\/li><li>local reactions, rash,&nbsp;itching, skin changes,&nbsp;redness, hot flashes, and burning in the skin, changes in the skin and on the nails (hyperpigmentation), photosensitivity, hypersensitivity of the skin to radiation (recall phenomena)<\/li><li>increased amounts&nbsp;of protein&nbsp;in the urine (&nbsp;proteinuria&nbsp;) of patients given high&nbsp;dose&nbsp;s<\/li><li>local pain, severe&nbsp;cellulite&nbsp;(&nbsp;inflammation&nbsp;of cell tissue), tissue death (tissue necrosis), thickening or increased stiffness of the vessel wall (phlebosclerosis) after accidental&nbsp;injection&nbsp;outside the vein<\/li><li>the decrease in the amount of blood pumped from the ventricle at each heartbeat (&nbsp;asymptomatic&nbsp;decrease in left ventricular&nbsp;ejection fraction&nbsp;)<br><\/li><\/ul>\n\n\n\n<p><strong>Intravesical (in the bladder):<\/strong>&nbsp;When Epirubicin Teva has been given in the bladder, serious&nbsp;side effects&nbsp;throughout the body and allergic reactions have been rare.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Epirubicin Teva<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the label\/carton after EXP.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>Store in a refrigerator (2 \u00b0 C-8 \u00b0 C).&nbsp;<br>Store and transport cold (2 \u00b0 C-8 \u00b0 C).&nbsp;<br>Do not freeze.<br><\/p>\n\n\n\n<p>After opening, the product should be used immediately.<br><\/p>\n\n\n\n<p>The chemical and physical durability after opening is as follows:<br><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><th scope=\"col\"><strong>Viaflo (non-PVC) bag<\/strong><\/th><th scope=\"col\"><strong>In the refrigerator 2\u20138 \u00b0 C<\/strong><\/th><th scope=\"col\"><strong>At room temperature 15\u201325 \u00b0 C, in normal lighting<\/strong><\/th><\/tr><\/thead><tbody><tr><td>0.9% sodium chloride&nbsp;solution for injection<\/td><td>28 days<\/td><td>14 days<\/td><\/tr><tr><td>5%&nbsp;glucose&nbsp;solution for injection<\/td><td>28 days<\/td><td>28 days<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><th scope=\"col\"><strong>Polypropylene syringe<\/strong><\/th><th scope=\"col\"><strong>In the refrigerator 2\u20138 \u00b0 C<\/strong><\/th><th scope=\"col\"><strong>At room temperature 15\u201325 \u00b0 C, in normal lighting<\/strong><\/th><\/tr><\/thead><tbody><tr><td>0.9% sodium chloride&nbsp;solution for injection<\/td><td>28 days<\/td><td>14 days<\/td><\/tr><tr><td>Water for injections<\/td><td>28 days<\/td><td>7 days<\/td><\/tr><tr><td>Undiluted<\/td><td>28 days<\/td><td>14 days<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>From a&nbsp;microbiological&nbsp;point of view, the medicine should be used immediately.&nbsp;If the solution is not used directly, the storage time and storage conditions before use are the responsibility of the user and should not normally be longer than 24 hours at 2 \u00b0 C-8 \u00b0 C.<br><\/p>\n\n\n\n<p>Refrigerator storage of&nbsp;solution for injection&nbsp;may result in the formation of a jelly-like product.&nbsp;This&nbsp;gel&nbsp;returns to a slightly viscous to the free-flowing solution after two up to a maximum of four hours after the solution has reached room temperature (15 \u00b0 C-25 \u00b0 C).<br><\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is epirubicin hydrochloride;&nbsp;a 1 ml solution contains 2 mg epirubicin hydrochloride.<\/li><li>The other ingredients are sodium chloride,&nbsp;hydrochloric acid,&nbsp;and water for injections.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Epirubicin Teva is a clear red solution for injection or infusion.&nbsp;It is supplied in glass vials of 5 ml (10 mg), 10 ml (20 mg), 25 ml (50 mg), 75 ml (150 mg) or 100 ml (200 mg) solution for injection \/ infusion.<br><\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<p><em>Manufacturer:<\/em>&nbsp;<br>Pharmachemie BV, Swensweg 5, PO Box 552, 2003 RN Haarlem, The Netherlands<br><\/p>\n","protected":false},"excerpt":{"rendered":"<p>group Epirubicin belongs to the group of chemotherapy drugs.<br \/>\nEpirubicin prevents cancer cells from growing, which eventually kills them.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2205,2200],"tags":[4021,4024,4025,4023,4026,4028,4029,4027,2216,2213,4022,4030],"class_list":["post-8232","post","type-post","status-publish","format-standard","hentry","category-e","category-medicines","tag-epirubicin-hydrochloride","tag-epirubicin-hydrochloride-dose","tag-epirubicin-hydrochloride-side-effects","tag-epirubicin-hydrochloride-uses","tag-epirubicin-teva","tag-epirubicin-teva-dose","tag-epirubicin-teva-side-effects","tag-epirubicin-teva-uses","tag-injections","tag-medicines","tag-what-is-epirubicin-hydrochloride","tag-what-is-epirubicin-teva"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8232","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=8232"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8232\/revisions"}],"predecessor-version":[{"id":10469,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8232\/revisions\/10469"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=8232"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=8232"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=8232"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}