Fertility<\/em><\/p>\n\n\n\nThere is a risk of sterility caused by treatment with epirubicin. Male patients should consider freezing sperm before starting treatment.<\/p>\n\n\n\n
Epirubicin may cause missed menstruation or premature menopause in premenopausal women.<\/p>\n\n\n\n
Driving and using machines<\/h2>\n\n\n\n
Epirubicin Rivopharm may cause episodes of nausea and vomiting that may temporarily impair the ability to drive and use machines.
<\/p>\n\n\n\n
You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased vigilance. One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or side effects. Descriptions of these effects and side effects can be found in other sections. Read all the information in this leaflet for guidance. If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n
Epirubicin Rivopharm contains excipients<\/h2>\n\n\n\n
This medicine contains 3.54 mg of sodium per ml. This should be considered for patients on a controlled sodium diet.
<\/p>\n\n\n\n
3. How to use Epirubicin Rivopharm<\/h2>\n\n\n\n
Epirubicin Rivopharm is given to you by a doctor or nurse, either directly into the bloodstream or into the bladder. The doctor will decide the right dose and treatment time for you. Factors that affect are the type of cancer you have, your health, height, weight, liver function, and any other treatment you receive.
<\/p>\n\n\n\n
Via injection or infusion into a friend<\/em><\/p>\n\n\n\nEpirubicin Rivopharm can be given as an injection into a vein for 3-5 minutes. It can also be diluted and then given slowly, usually as a drip into a vein, for 30 minutes.
<\/p>\n\n\n\n
Via the bladder<\/em><\/p>\n\n\n\nIf the medicine is given directly into the bladder, you must not drink any liquid for 12 hours before the treatment so that the urine does not dilute the medicine too much. The solution should be retained in the bladder for 1-2 hours after injection. You need to turn around a few times during treatment to make sure that all parts of the bladder come in contact with the medicine.
<\/p>\n\n\n\n
Care must be taken to prevent urine from coming into contact with the skin when emptying the bladder. In case of skin contact, wash with soap and water without scrubbing.
<\/p>\n\n\n\n
Doctors will regularly check with blood tests to detect any side effects. To detect possible heart effects, doctors will also perform heart tests for several weeks after treatment.<\/p>\n\n\n\n
If you use more Epirubicin Rivopharm then you should <\/h2>\n\n\n\n
It can affect your heart, lower your blood cells, and cause severe gastrointestinal problems (mainly severe inflammation of the mucous membranes, ( mucositis )). You may experience soreness in your mouth. Because this medicine will be given to you while you are in the hospital, it is unlikely that you will receive too little or too much medicine. Contact a doctor if you are worried about anything.<\/p>\n\n\n\n
4. Possible side effects<\/h2>\n\n\n\n
Like all medicines, this medicine can cause side effects, although not everybody gets them.
<\/p>\n\n\n\n
Tell your doctor immediately if any of the following side effects occur when epirubicin is given as a drip directly into the bloodstream, as these are serious side effects. You may need emergency medical treatment:<\/p>\n\n\n\n
- redness, pain, or swelling at the injection site; Tissue damage can occur if the injection is inadvertently injected outside the vein<\/li>
- symptoms of the heart or blood clots in the lungs, such as chest pain, shortness of breath, swollen ankles (these symptoms may appear up to several weeks after stopping treatment with epirubicin)<\/li>
- severe allergic reaction, symptoms include fainting, rash, swelling of the face and difficulty breathing, wheezing. In some cases, collapse may occur.<\/li>
- fever with an extreme increase in body temperature above 41 \u00b0 C ( hyperpyrexia )<\/li><\/ul>\n\n\n\n
Tell your doctor as soon as possible if you experience any of the following:
<\/p>\n\n\n\n
Very common side effects (may affect more than 1 user in 10):<\/em><\/p>\n\n\n\nBone marrow dysfunction (leading to anemia ), hair loss (usually reversible ), decreased beard growth, red urine for 1 to 2 days after receiving the medicine.
<\/p>\n\n\n\n
Common side effects (may affect up to 1 in 10 people):<\/em><\/p>\n\n\n\nSevere loss of appetite leading to weight loss ( anorexia ), loss of fluid from the body (dehydration), nausea or vomiting, diarrhea (which can cause dehydration), loss of appetite, abdominal pain, inflammation of the esophagus ( esophagitis ), increased pigmentation in the mouth, swelling and pain in the mouth, sores on the lips and\/or tongue and\/or under the tongue, hot flashes, changes in blood cells, leading to bleeding, fever or infection, redness, pain or swelling at the injection site: tissue damage may occur after accidental injection outside a vein, allergic reactions or inflammation in the bladder (sometimes with bleeding) after injection of the drug into the bladder.
<\/p>\n\n\n\n
Uncommon side effects (may affect up to 1 in 100 people):<\/em><\/p>\n\n\n\nDecreased levels of blood clots ( thrombocytopenia ) often cause unusual bruising or bleeding, headaches, increased pigmentation of the skin and nails, reddening of the skin, the sensitivity of the skin to light (with radiation therapy), venous inflammation along with blood clots.
<\/p>\n\n\n\n
Rare side effects (may affect up to 1 in 1000 people):<\/em><\/p>\n\n\n\nLeukemia (blood cancer), severe allergic reaction throughout the body ( anaphylaxis ), hives ( urticaria ), elevated levels of uric acid in the blood (hyperuricemia) which may lead to gout, fever and\/or chills, dizziness, missed periods ( amenorrhea ), decreased sperm production, gout, changes in heart or liver function, general malaise, feeling of weakness.
<\/p>\n\n\n\n
No known frequency (cannot be calculated from the available data):<\/em><\/p>\n\n\n\nPneumonia ( CAP ), blood poisoning ( sepsis ), septicemia with severe complications ( septic shock ), bleeding and lack of oxygen in body tissues s, redness and eye swelling, shock, occlusion of a blood vessel caused by a blood clot (e.g., the lungs), rash, itching, skin changes, skin redness, a severe bacterial infection in the skin, pain in the mouth, burning sensation inside the mouth.
<\/p>\n\n\n\n
If epirubicin hydrochloride is injected directly into the bladder, you may experience pain or difficulty urinating, or frequent urination. Blood can also be seen in the urine.<\/p>\n\n\n\n
Reporting of side effects ar<\/strong><\/p>\n\n\n\nIf you get any side effects, talk to your doctor or pharmacist. This also applies to side effects that are not mentioned in this information. You can also report side effects directly (see details below). By reporting side effects, you can help increase drug safety information.
<\/p>\n\n\n\n
The Medical Products Agency<\/p>\n\n\n\n
Box 26<\/p>\n\n\n\n
<\/p>\n\n\n\n
5. How to store Epirubicin Rivopharm<\/h2>\n\n\n\n
Keep this medicine out of the sight and reach of children.
<\/p>\n\n\n\n
Store in a refrigerator (2\u00baC-8\u00baC).<\/p>\n\n\n\n
Keep the vial in the outer carton. Sensitive to light.
<\/p>\n\n\n\n
Do not use this medicine after the expiry date which is stated on the label and carton after \u201cEXP.\u201d Or EXP. The expiration date is the last day of the specified month.
<\/p>\n\n\n\n
Do not use this medicine if there are visible deteriorations.
<\/p>\n\n\n\n
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.<\/p>\n\n\n\n
6. Contents of the packaging and other information<\/h2>\n\n\n\nContent declaration<\/h2>\n\n\n\n- The active substance is epirubicin hydrochloride. One milliliter solution for injection contains 2 mg epirubicin hydrochloride.<\/li>
- Other excipients are sodium chloride, hydrochloric acid (for pH adjustment), and water for injections.<\/li><\/ul>\n\n\n\n
What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n
Epirubicin Rivopharm 2 mg\/ml solution for injection is a clear, red solution.
<\/p>\n\n\n\n
Pack sizes<\/em><\/p>\n\n\n\n1 x 5 ml vial (10 mg in 5 ml)<\/p>\n\n\n\n
1 x 10 ml vial (20 mg in 10 ml)<\/p>\n\n\n\n
1 x 25 ml vial (50 mg in 25 ml)<\/p>\n\n\n\n
1 x 50 ml vial (100 mg in 50 ml)<\/p>\n\n\n\n
1 x 100 ml vial (200 mg in 100 ml)
<\/p>\n\n\n\n
One 5 ml bottle of Epirubicin Rivopharm 2 mgmt\/pollution for injection contains 10 mg epirubicin hydrochloride equivalent to 9.35 mg epirubicin.
<\/p>\n\n\n\n
One 10 ml bottle of Epirubicin Rivopharm 2 mg\/ml solution for injection contains 20 mg epirubicin hydrochloride equivalent to 18.7 mg epirubicin.
<\/p>\n\n\n\n
One 25 ml vial of Epirubicin Rivopharm 2 mg\/ml solution for injection contains 50 mg epirubicin hydrochloride equivalent to 46.75 mg epirubicin.
<\/p>\n\n\n\n
One 50 ml vial of Epirubicin Rivopharm 2 mg\/ml solution for injection contains 100 mg epirubicin hydrochloride equivalent to 93.5 mg epirubicin.
<\/p>\n\n\n\n
One 100 ml bottle of Epirubicin Rivopharm 2 mg\/ml solution for injection contains 200 mg epirubicin hydrochloride equivalent to 187 mg epirubicin.<\/p>\n\n\n\n
Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n
Rivopharm Ltd.<\/p>\n\n\n\n
17 Corrig Road<\/p>\n\n\n\n
Sandyford, Dublin 18, Ireland
<\/p>\n\n\n\n
Agent<\/strong><\/p>\n\n\n\nSanoSwiss UAB<\/p>\n\n\n\n
Aukstaiciu str. 26A<\/p>\n\n\n\n
LT-44169 Kaunas<\/p>\n\n\n\n
Lithuania<\/p>\n\n\n\n
+370 700 01320<\/p>\n\n\n\n
info@sanoswiss.com
<\/p>\n","protected":false},"excerpt":{"rendered":"
Epirubicin Rivopharm is a medicine used to treat cancer. Drugs used to treat cancer are often called chemotherapy drugs. Epirubicin Rivopharm belongs to a group of medicines called anthracyclines. These work by slowing down or stopping the growth of fast-growing cells and thus increasing the likelihood of the cells dying.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2205,2200],"tags":[4021,4024,4025,4023,4031,4033,4034,4032,2216,2213],"class_list":["post-8230","post","type-post","status-publish","format-standard","hentry","category-e","category-medicines","tag-epirubicin-hydrochloride","tag-epirubicin-hydrochloride-dose","tag-epirubicin-hydrochloride-side-effects","tag-epirubicin-hydrochloride-uses","tag-epirubicin-rivopharm","tag-epirubicin-rivopharm-dose","tag-epirubicin-rivopharm-side-effects","tag-epirubicin-rivopharm-uses","tag-injections","tag-medicines"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8230","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=8230"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8230\/revisions"}],"predecessor-version":[{"id":10471,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8230\/revisions\/10471"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=8230"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=8230"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=8230"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}