{"id":8227,"date":"2021-03-08T06:51:51","date_gmt":"2021-03-08T06:51:51","guid":{"rendered":"https:\/\/zeepedia.com\/?p=8227"},"modified":"2021-04-28T08:00:35","modified_gmt":"2021-04-28T08:00:35","slug":"epirubicin-ebewe","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/epirubicin-ebewe\/","title":{"rendered":"Epirubicin Ebewe &#8211; Epirubicin Hydrochloride uses, dose and side effects"},"content":{"rendered":"\n<p> 2 mg \/ ml\u00a0injection \/ concentrate for\u00a0infusion\u00a0solution\u00a0<br>epirubicin hydrochloride<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Epirubicin Ebewe is and what it is used for<\/h2>\n\n\n\n<p>Epirubicin Ebewe is a cancer medicine that belongs to a group of medicines called&nbsp;anthracyclines.&nbsp;These work by damaging the cells&#8217; genome, the damage prevents the cell from growing and multiplying.&nbsp;Epirubicin Ebewe can be used alone or in combination with other anticancer medicines.<br><\/p>\n\n\n\n<p>Epirubicin Ebewe can be used to treat breast and bladder cancer.<br><\/p>\n\n\n\n<p>Epirubicin contained in Epirubicin Ebewe may also be approved for the treatment of other conditions not mentioned in this product information.&nbsp;Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take Epirubicin Ebewe<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Epirubicin Ebewe<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to epirubicin or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you are breast-feeding<\/li><\/ul>\n\n\n\n<p><em>Also, Epirubicin Ebewe should not be given to you:<\/em><\/p>\n\n\n\n<p><strong>by&nbsp;injection&nbsp;(&nbsp;intravenously&nbsp;):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have a sharp decrease in the number of blood cells (myelosuppression) or severe&nbsp;infection&nbsp;and sores in the mouth caused by cancer drugs or radiation therapy<\/li><li>if you have pronounced impairment of liver function<\/li><li>if you have severe&nbsp;heart failure, recent heart attack, or severe arrhythmias in the heart<\/li><li>if you have been given the maximum lifetime dose of the group of medicines to which Epirubicin Ebewe belongs (&nbsp;anthracyclines&nbsp;) or of anthracenediones<\/li><li>if you have a serious&nbsp;infection<\/li><li>if you have angina (&nbsp;unstable angina&nbsp;pectoris)<\/li><li>if you have a heart muscle disease<\/li><\/ul>\n\n\n\n<p><strong>directly in the bladder (intravesical):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have a urinary tract infection<\/li><li>if you have a&nbsp;tumor&nbsp;in the bladder that has penetrated the bladder wall<\/li><li>if you have&nbsp;inflammation&nbsp;of the bladder<\/li><li>have blood in the urine<\/li><li>if your doctor has difficulty inserting the catheter into your bladder<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or nurse before receiving Epirubicin Ebewe.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you have persistent&nbsp;side effects&nbsp;from previous rounds of treatment such as general&nbsp;infection&nbsp;or sores and&nbsp;mouth&nbsp;infection.<\/li><li>If you have heart&nbsp;vascular&nbsp;disease<\/li><li>If you have impaired liver or kidney function<\/li><li>If you have or should receive radiation therapy in the chest region<\/li><li>If you have been given epirubicin or similar anticancer medicines to treat cancer before<\/li><li>If you experience discomfort or pain in or around the injection site during&nbsp;infusion.&nbsp;Tell your doctor immediately.&nbsp;There may be leakage to surrounding&nbsp;tissue.<\/li><\/ul>\n\n\n\n<p>Your doctor will make regular check-ups before and during treatment that your heart and liver are functioning normally and blood tests will be taken to check that the number of&nbsp;blood cells&nbsp;in your blood is satisfactory.<br><\/p>\n\n\n\n<p>The urine may turn red for 1-2 days after&nbsp;administration&nbsp;of Epirubicin Ebewe.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Epirubicin Ebewe<\/h2>\n\n\n\n<p>Tell your doctor, nurse, or pharmacist if you are taking, have recently taken, or might take any other medicines.<br><\/p>\n\n\n\n<p>Epirubicin Ebewe can affect or be affected by other medicines such as:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Cimetidine (medicine that reduces the acid in the stomach)<\/li><li>Other anticancer medicines such as paclitaxel, <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/trazimera\/\">trastuzumab<\/a>, cyclophosphamide, 5-fluorouracil, and docetaxel<\/li><li>Calcium&nbsp;&#8211;&nbsp;antagonistic&nbsp;s (cardiovascular&nbsp;drugs)<\/li><li>Interferon&nbsp;\u03b12b (for certain cancers and liver diseases)<\/li><li>Quinine (for seizures or&nbsp;malaria&nbsp;)<\/li><li>Dexverapamil (medicines that increase the effectiveness of certain cancer medicines)<\/li><li>Sulfonamides&nbsp;(diuretics),<\/li><li>Chloramphenicol (&nbsp;antibiotics&nbsp;),<\/li><li>Phenytoin&nbsp;(for&nbsp;epilepsy&nbsp;),<\/li><li>Amidopyrine derivatives (used to treat pain),<\/li><li>Antiretroviral agents (medicines used to treat viral illness)<\/li><li>Dexrazoxane (other medicines used to treat cancer)<\/li><li>Other medicines that can cause similar&nbsp;side effects&nbsp;on the heart,&nbsp;bone marrow, and\/or liver such as Epirubicin Ebewe<\/li><\/ul>\n\n\n\n<p>If Epirubicin Ebewe is given with other anticancer medicines, the&nbsp;side effects of&nbsp;these medicines&nbsp;may&nbsp;be more severe.<br><\/p>\n\n\n\n<p>Vaccination with live vaccine should be avoided in patients receiving Epirubicin Ebewe.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant, or are planning to have a baby, ask your doctor or nurse for advice before taking this medicine.<br><\/p>\n\n\n\n<p>Epirubicin Ebewe can cause birth defects if used during pregnancy.&nbsp;You must tell your doctor if you are pregnant or become pregnant during treatment.&nbsp;You should not use Epirubicin Ebewe during pregnancy unless your doctor specifically recommends it.<br><\/p>\n\n\n\n<p>If you or your partner are being treated with Epirubicin Ebewe, effective contraception is recommended to avoid pregnancy during treatment.&nbsp;If you or your partner becomes pregnant during treatment, you should contact your doctor.<br><\/p>\n\n\n\n<p>There is a risk that treatment with Epirubicin Ebewe will cause damage to sperm production.&nbsp;Male patients should consider freezing sperm before starting treatment.<br><\/p>\n\n\n\n<p>Epirubicin Ebewe can cause missed periods or premature menopause in women who have not yet experienced menopause.<br><\/p>\n\n\n\n<p>Epirubicin Ebewe can be harmful to breast-fed babies.&nbsp;Therefore, mothers must stop breast-feeding before starting treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Epirubicin Ebewe contains sodium<\/h2>\n\n\n\n<p>This medicine contains 9 mg&nbsp;sodium&nbsp;per ml.&nbsp;This should be considered by patients on a low-salt diet.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to get Epirubicin Ebewe<\/h2>\n\n\n\n<p>Epirubicin Ebewe is given to you by a doctor or nurse, either directly into the bloodstream or into the bladder.&nbsp;The doctor will decide the right&nbsp;dose&nbsp;and treatment time for you.&nbsp;How large a&nbsp;dose&nbsp;you receive is affected by the type of cancer you have, your health, height, weight, liver function, and any other treatment you receive.<br><\/p>\n\n\n\n<p><em>Breast cancer<\/em><\/p>\n\n\n\n<p>Epirubicin Ebewe can be given as an&nbsp;injection&nbsp;into a vein for 5-15 minutes.&nbsp;It can also be diluted and then given slowly as a drip into a vein, usually for 30-60 minutes.&nbsp;Doseone in one treatment cycle can be given as a single dose or divided into 2-3 days.&nbsp;The usual time interval between treatments is 3 weeks.<br><\/p>\n\n\n\n<p><em>Bladder cancer<\/em><\/p>\n\n\n\n<p>In the treatment of bladder cancer, Epirubicin Ebewe is injected into the bladder via a&nbsp;catheter&nbsp;(tube), usually 8 times a week.<br><\/p>\n\n\n\n<p>The solution should be kept in the bladder for at least 1 hour after it has been injected.&nbsp;You need to turn around a few times during treatment to make sure that all parts of the bladder come in contact with the medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Epirubicin Ebewe then you should<\/h2>\n\n\n\n<p>You will be given this medicine in a hospital and it is unlikely that you will be given too much epirubicin.&nbsp;If you are worried that you have been given too high a&nbsp;dose&nbsp;or if you have any questions about the&nbsp;dose&nbsp;you have been given, talk to your doctor or nurse who will give you the medicine.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor, pharmacist, or nurse<strong>.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<br><\/p>\n\n\n\n<p>If you experience any of the following symptoms, tell your doctor or healthcare professional immediately:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Redness, pain, or swelling at the injection site.&nbsp;This can occur if the drug leaks outside the blood vessel and&nbsp;injection&nbsp;should then be stopped<\/li><li>Rapid&nbsp;pulse, shortness of breath, or swelling of the ankles.&nbsp;These symptoms may appear several weeks after the end of treatment and indicate cardiac effects<\/li><li>Difficulty breathing, wheezing, swelling of the face, difficulty swallowing, reddening of the skin, may indicate a severe&nbsp;allergic reaction<\/li><li>Chest pain, pain when breathing, cough, and shortness of breath.&nbsp;It may indicate a blood clot in the lung<\/li><\/ul>\n\n\n\n<p>The following&nbsp;side effects&nbsp;have been reported:<br><\/p>\n\n\n\n<p>Very common (may affect more than 1 user in 10):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Decreased production of blood cells in your&nbsp;bone marrow&nbsp;(myelosuppression)<\/li><li>Decreased amounts of&nbsp;white blood cells<\/li><li>Anemia<\/li><li>Hair loss<\/li><li>Red urine for 1 to 2 days after&nbsp;administration<\/li><\/ul>\n\n\n\n<p>Common (may affect up to 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Infection&nbsp;is<\/li><li>Loss of appetite<\/li><li>Dehydration<\/li><li>Hemorrhoids<\/li><li>Nausea<\/li><li>Vomiting<\/li><li>Diarrhea<\/li><li>Inflammation&nbsp;of the gastrointestinal tract, esophagus, and mouth (mucositis,&nbsp;esophagitis,&nbsp;stomatitis&nbsp;)<\/li><li>Redness&nbsp;at the&nbsp;injection&nbsp;or infusion&nbsp;site<\/li><li>Inflammation&nbsp;of the bladder after&nbsp;dosing&nbsp;directly to the bladder<\/li><li>Burning\/burning sensation and frequent bladder emptying after&nbsp;dosing&nbsp;directly to the bladder<\/li><\/ul>\n\n\n\n<p>Uncommon (may affect up to 1 in 100 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Reduced&nbsp;platelet count<\/li><li>Inflammation&nbsp;of blood vessels with or without concomitant blood clots<\/li><\/ul>\n\n\n\n<p>Rare (may affect up to 1 in 1,000 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Blood cancer (&nbsp;leukemia&nbsp;)<\/li><li>Severe allergic reactions (anaphylaxis \/ anaphylactoid reactions)<\/li><li>Very slow&nbsp;pulse&nbsp;with a tendency to faint<\/li><li>Increased amounts of&nbsp;uric acid&nbsp;in the blood<\/li><li>Dizziness<\/li><li>Heart failure&nbsp;(&nbsp;chronic&nbsp;heart failure&nbsp;)<\/li><li>Adverse reactions to the heart (cardiotoxicity) such as irregular heartbeat or heart muscle disease<\/li><li>Fast or slow&nbsp;pulse<\/li><li>Hives<\/li><li>Absence of menstruation<\/li><li>Absence of sperm in the semen<\/li><li>Fever, chills, malaise, weakness.<\/li><li>Changed liver values<\/li><\/ul>\n\n\n\n<p>Has been reported (occurs in an unknown number of users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Blood poisoning with or without&nbsp;shock.<\/li><li>Pneumonia<\/li><li>Bleeding and lack of oxygen to&nbsp;tissue&nbsp;due to impaired bone marrow function.<\/li><li>Inflammation&nbsp;of the eye (conjunctivitis,&nbsp;keratitis&nbsp;)<\/li><li>Shock<\/li><li>Blood clots that may include blood clots in the lung<\/li><li>Damage to&nbsp;tissue&nbsp;at the injection site such as rash,&nbsp;itching, skin changes,&nbsp;redness<\/li><li>Increased&nbsp;pigmentation&nbsp;of skin and nails<\/li><li>Hypersensitivity to light<\/li><li>Radiation-recall reaction<\/li><li>Reduction of left ventricular capacity without any symptoms<\/li><li>Hard and less elastic veins (phlebosclerosis), pain, severe tissue inflammation (&nbsp;cellulite&nbsp;), tissue death after accidental&nbsp;injection&nbsp;into the surrounding&nbsp;tissue.<\/li><li>Cold sores, pain in the mouth, bleeding in the mouth, burning sensation in the mucous membranes, and sores on the oral mucosa.<\/li><li>Pigmentation&nbsp;of the oral mucosa.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Epirubicin Ebewe<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>Store in a refrigerator (2 \u00b0 C-8 \u00b0 C).<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton after EXP.&nbsp;Dat or EXP.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is epirubicin hydrochloride 2 mg\/ml.<\/li><li>The other ingredients are sodium chloride,&nbsp;hydrochloric acid, water for injections<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Clear red solution.<\/p>\n\n\n\n<p>Pack sizes: 5 ml, 5 x 5 ml, 25 ml, 50 ml and 100 ml in&nbsp;vial&nbsp;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Ebewe Pharma Ges.mbH Nfg KG<\/p>\n\n\n\n<p>Mondseestrasse 11<\/p>\n\n\n\n<p>A-4866 Unterach<\/p>\n\n\n\n<p>Austria<br><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Epirubicin Ebewe is a cancer medicine that belongs to a group of medicines called anthracyclines. These work by damaging the cells&#8217; genome, the damage prevents the cell from growing and multiplying. Epirubicin Ebewe can be used alone or in combination with other anticancer medicines.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2205,2200],"tags":[4035,4038,4037,4021,4024,4025,4023,2216,2213,4036,4022],"class_list":["post-8227","post","type-post","status-publish","format-standard","hentry","category-e","category-medicines","tag-epirubicin-ebewe","tag-epirubicin-ebewe-side-effects","tag-epirubicin-ebewe-uses","tag-epirubicin-hydrochloride","tag-epirubicin-hydrochloride-dose","tag-epirubicin-hydrochloride-side-effects","tag-epirubicin-hydrochloride-uses","tag-injections","tag-medicines","tag-what-is-epirubicin-ebewe","tag-what-is-epirubicin-hydrochloride"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8227","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=8227"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8227\/revisions"}],"predecessor-version":[{"id":10473,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8227\/revisions\/10473"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=8227"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=8227"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=8227"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}