{"id":8089,"date":"2021-03-05T10:36:11","date_gmt":"2021-03-05T10:36:11","guid":{"rendered":"https:\/\/zeepedia.com\/?p=8089"},"modified":"2021-05-04T16:29:57","modified_gmt":"2021-05-04T16:29:57","slug":"emtricitabine-tenofovir-disoproxil-accord","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/emtricitabine-tenofovir-disoproxil-accord\/","title":{"rendered":"Emtricitabine &#8211; Tenofovir Disoproxil Accord &#8211; Tenofovir Disoproxil uses, dose and side effects"},"content":{"rendered":"\n<p> 200 mg \/ 245 mg\u00a0film-coated tablets\u00a0<br>emtricitabine \/ tenofovir disoproxil<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Emtricitabine \/ Tenofovir Disoproxil Accord is and what it is used for<\/h2>\n\n\n\n<p>Emtricitabine \/ Tenofovir disoproxil Accord contains two active substances,&nbsp;<em>emtricitabine<\/em>&nbsp;and&nbsp;<em>tenofovir disoproxil<\/em>.&nbsp;Both of these active substances are&nbsp;<em>antiretroviral<\/em>&nbsp;drugs used to treat&nbsp;HIV&nbsp;&#8211;&nbsp;infection.&nbsp;Emtricitabine is a&nbsp;<em>nucleoside reverse transcriptase inhibitor<\/em>&nbsp;and tenofovir is a&nbsp;<em>nucleotide reverse transcriptase inhibitor.&nbsp;<\/em>However, both are commonly called NRTIs and act by affecting the normal function of an&nbsp;enzyme&nbsp;(reverse transcriptase) that the&nbsp;virus&nbsp;needs for its reproduction (propagation).<br><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Emtricitabine \/ Tenofovir disoproxil Accord is a treatment for human immunodeficiency virus&nbsp;infection&nbsp;(&nbsp;HIV-&nbsp;1&nbsp;) in adults.<\/strong><\/li><li><strong>It is also used to treat&nbsp;HIV&nbsp;in adolescents aged 12 to 18 years who weigh at least 35 kg<\/strong>&nbsp;and who have already been treated with other&nbsp;HIV&nbsp;medicines that are no longer effective or that have caused&nbsp;side effects.<ul><li>Emtricitabine \/ Tenofovir disoproxil Accord should always be taken in combination with other anti-&nbsp;HIV&nbsp;medicines.<\/li><li>Emtricitabine \/ Tenofovir disoproxil Accord can be used instead of emtricitabine and tenofovir disoproxil given separately.<\/li><\/ul><\/li><\/ul>\n\n\n\n<p><strong>People who are&nbsp;HIV&nbsp;-positive can still transmit&nbsp;HIV&nbsp;-smitten<\/strong>&nbsp;when taking this medicine, even though the risk is reduced with effective&nbsp;antiretroviral&nbsp;treatment.&nbsp;Discuss the necessary steps to avoid infecting others with your doctor.<br><\/p>\n\n\n\n<p><strong>This medicine does not cure&nbsp;HIV&nbsp;&#8211;&nbsp;infection.&nbsp;<\/strong>While taking emtricitabine\/tenofovir disoproxil Accord may still develop&nbsp;infections&nbsp;you or other illnesses associated with&nbsp;HIV&nbsp;&#8211;&nbsp;infection.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Emtricitabine\/tenofovir disoproxil Accord is also used to reduce the risk of becoming infected with&nbsp;HIV&nbsp;-1&nbsp;in adults and adolescents 12 years and up to less than 18 years weighing less than 35 kg<\/strong>&nbsp;when taken daily along with safe sex:&nbsp;<br>See Section 2 for a list of precautions that can be taken against&nbsp;HIV&nbsp;&#8211;&nbsp;infection.<\/li><\/ul>\n\n\n\n<p>Emtricitabine and tenofovir disoproxil contained in Emtricitabine \/ Tenofovir disoproxil Accord may also be approved for the treatment of other conditions not mentioned in this product information.&nbsp;Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take Emtricitabine \/ Tenofovir disoproxil Accord<\/h2>\n\n\n\n<p>Do not take Emtricitabine \/ Tenofovir disoproxil Accord for treatment of&nbsp;HIV&nbsp;or to reduce the risk of HIV infection:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to emtricitabine, tenofovir, tenofovir disoproxil, or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<p>If this applies to you, tell your doctor immediately.<br><\/p>\n\n\n\n<p><strong>Before you take&nbsp;<\/strong><strong>Emtricitabine \/ Tenofovir disoproxil Accord&nbsp;<\/strong><strong>to reduce your risk of getting HIV:<\/strong><br><\/p>\n\n\n\n<p>Emtricitabine \/ Tenofovir disoproxil Accord can only help reduce the risk of getting&nbsp;HIV&nbsp;<strong>before<\/strong>&nbsp;you become infected.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>To reduce your risk of getting&nbsp;HIV&nbsp;you must be&nbsp;HIV&nbsp;negative before starting Emtricitabine \/ Tenofovir disoproxil Accord.&nbsp;You must be tested to ensure that you do not already have&nbsp;HIV&nbsp;&#8211;&nbsp;infection.&nbsp;Do not take Emtricitabine \/ Tenofovir disoproxil Accord to reduce your risk of infection unless you have been confirmed to be&nbsp;HIV-&nbsp;negative.&nbsp;People with&nbsp;HIV&nbsp;must take Emtricitabine \/ Tenofovir disoproxil Accord in combination with other medicines.<\/li><li>Many&nbsp;HIV&nbsp;tests can miss a&nbsp;recent&nbsp;infection.&nbsp;If you get a flu-like illness, it could mean that you have recently been infected with&nbsp;HIV.&nbsp;These may be signs of&nbsp;HIV infection:<br><ul><li>fatigue<\/li><li>fever<\/li><li>joint or muscle pain<\/li><li>headache<\/li><li>vomiting or diarrhea<\/li><li>rash<\/li><li>night sweats<\/li><li>enlarged&nbsp;lymph nodes&nbsp;in the throat or groin.<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>Tell your doctor about any&nbsp;flu-like symptoms&nbsp;&#8211; either during the month before starting treatment with Emtricitabine \/ Tenofovir disoproxil Accord or at any time while you are taking Emtricitabine \/ Tenofovir disoproxil Accord.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p><strong>While taking Emtricitabine \/ Tenofovir disoproxil Accord to reduce your risk of getting HIV:<\/strong><br><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Take emtricitabine\/tenofovir disoproxil Accord every day to reduce the risk, not just when you think you have been exposed to the risk of getting&nbsp;HIV&nbsp;&#8211;&nbsp;infection.&nbsp;Do not miss any&nbsp;dose&nbsp;of Emtricitabine \/ Tenofovir disoproxil Accord or stop taking it.&nbsp;If you miss&nbsp;the dose&nbsp;you may be more likely that you suffer from&nbsp;HIV&nbsp;&#8211;&nbsp;infection increase.<\/li><li>Get tested regularly for&nbsp;HIV.<\/li><li>If you think you have been infected with&nbsp;HIV, tell your doctor immediately.&nbsp;Your doctor may want to perform several tests to make sure you are still&nbsp;HIV-&nbsp;negative.<\/li><li>Taking Emtricitabine \/ Tenofovir disoproxil Accord alone may not prevent you from getting&nbsp;HIV.<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>Always exercise safe sex.&nbsp;Use a condom to reduce contact with semen, vaginal fluids, or blood.<\/li><li>Do not share personal items where there may be blood or body fluids, e.g.&nbsp;toothbrushes and razor blades.<\/li><li>Do not share or reuse needles or other injection or drug equipment.<\/li><li>Get tested for other sexually transmitted&nbsp;infections&nbsp;such as&nbsp;syphilis&nbsp;and&nbsp;gonorrhea.<\/li><li>These&nbsp;infections&nbsp;make it easier for you to get infected with&nbsp;HIV.<\/li><\/ul>\n\n\n\n<p>Ask your doctor if you have more questions about how to prevent getting&nbsp;HIV&nbsp;or transmitting&nbsp;HIV&nbsp;to other people.<br><\/p>\n\n\n\n<p><strong>While taking Emtricitabine \/ Tenofovir disoproxil Accord for treatment of&nbsp;HIV&nbsp;or to reduce the risk of getting HIV:<\/strong><br><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Emtricitabine \/ Tenofovir disoproxil Accord may affect your kidneys.&nbsp;Before and during treatment, your doctor may&nbsp;prescribe&nbsp;some blood tests to measure&nbsp;your&nbsp;kidney function.&nbsp;Tell your doctor if you have a history of kidney disease or if tests have shown that you have kidney problems.&nbsp;Emtricitabine \/ Tenofovir disoproxil Accord should not be used in adolescents with pre-existing kidney problems.&nbsp;If you have kidney problems, your doctor may advise you to stop taking Emtricitabine \/ Tenofovir disoproxil Accord or, if you already have&nbsp;HIV, to take the tablets less often.&nbsp;Emtricitabine \/ Tenofovir disoproxil Accord is not recommended if you have severe kidney disease or if you are on&nbsp;dialysis.<\/li><\/ul>\n\n\n\n<p>Bone problems (sometimes resulting in&nbsp;fractures&nbsp;s) may also occur due to damage to kidney tubule cells (see section 4,&nbsp;<em>Possible&nbsp;side effects&nbsp;s<\/em>&nbsp;).<br><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tell your doctor if you already have or have had liver disease, including&nbsp;hepatitis.&nbsp;HIV patients with liver disease (including&nbsp;chronic&nbsp;hepatitis&nbsp;B or C) treated with antiretroviral agents are at increased risk for severe and potentially fatal liver complications.&nbsp;If you have&nbsp;hepatitis&nbsp;B or C, your doctor will carefully choose the best treatment for you.<\/li><li>Find out your&nbsp;hepatitis&nbsp;B virus status (HBV status) before starting Emtricitabine \/ Tenofovir disoproxil Accord.&nbsp;If you have HBV, there is a serious risk of liver problems when you stop taking Emtricitabine \/ Tenofovir disoproxil Accord, whether you have&nbsp;HIV&nbsp;or not.&nbsp;It is important not to stop taking Emtricitabine \/ Tenofovir disoproxil Accord without talking to your doctor, see section 3, \u201cDo not stop taking Emtricitabine \/ Tenofovir disoproxil Accord\u201d.<\/li><li>Talk to your doctor if you are over 65 years old.&nbsp;Emtricitabine \/ Tenofovir disoproxil Accord has not been studied in patients over 65 years of age.<\/li><li>Talk to your doctor if you do not tolerate&nbsp;lactose&nbsp;(see &#8216;Emtricitabine \/ Tenofovir disoproxil Accord contains lactose&#8217; later in this section).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Emtricitabine \/ Tenofovir disoproxil Accord should not be used in children and adolescents under 12 years of age.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Emtricitabine \/ Tenofovir disoproxil Accord<\/h2>\n\n\n\n<p>Do not take Emtricitabine \/ Tenofovir disoproxil Accord if you are already taking other medicines that contain the components of Emtricitabine \/ Tenofovir disoproxil Accord, emtricitabine and tenofovir disoproxil, or other antiviral medicines that contain tenofoviralafenamide, <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/triumeq\/\">lamivudine<\/a>, or adefovir dipivoxil.<br><\/p>\n\n\n\n<p><em>Taking Emtricitabine \/ Tenofovir disoproxil Accord with other medicines that can damage your kidneys:<\/em>&nbsp;it is especially important to tell your doctor if you are taking any of these medicines, including<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>aminoglycoside&nbsp;is (against a bacterial&nbsp;infection&nbsp;)<\/li><li>amphotericin B (against fungal infection)<\/li><li>foscarnet (against a viral infection)<\/li><li>ganciclovir (for virus infection)<\/li><li>pentamidine (against&nbsp;infection&nbsp;)<\/li><li>vancomycin (against a bacterial&nbsp;infection&nbsp;)<\/li><li>interleukin&nbsp;-2 (for the treatment of cancer)<\/li><li>cidofovir (for virus infection)<\/li><li>non-steroidal anti-inflammatory drugs (&nbsp;NSAIDs, to relieve skeletal or muscle pain)<br><\/li><\/ul>\n\n\n\n<p>If you are taking other antiviral medicines, called&nbsp;protease inhibitors, for the treatment of&nbsp;HIV, your doctor may&nbsp;prescribe&nbsp;blood tests to closely monitor your kidney function.<br><\/p>\n\n\n\n<p>It is also important that you tell your doctor if you are taking ledipasvir \/ sofosbuvir, sofosbuvir \/ velpatasvir or sofosbuvir \/ velpatasvir \/ voxilprevir to treat hepatitis C&nbsp;infection&nbsp;.<br><\/p>\n\n\n\n<p><em>Taking emtricitabine\/tenofovir disoproxil Accord with other medicines containing didanosine (for the treatment of&nbsp;HIV&nbsp;&#8211;&nbsp;infection&nbsp;):<\/em>&nbsp;If you take emtricitabine\/tenofovir disoproxil Accord with other antiviral medicines that contain didanosine, blood levels of didanosine increase and CD4 cell counts.&nbsp;Rare cases of pancreatitis and lactic acidosis (excess&nbsp;lactic acid&nbsp;in the blood), in some cases fatal, have been reported during concomitant treatment with drugs containing tenofovir disoproxil and didanosine.&nbsp;Your doctor will carefully consider whether you can be treated with a combination of tenofovir and didanosine.<br><\/p>\n\n\n\n<p>Tell your doctor if you are taking any of these medicines.&nbsp;Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Emtricitabine \/ Tenofovir disoproxil Accord with food and drink<\/h2>\n\n\n\n<p>Whenever possible, Emtricitabine \/ Tenofovir disoproxil Accord should be taken with food.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<br><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Although there are limited clinical data on the use of Emtricitabine \/ Tenofovir disoproxil Accord during pregnancy, it is not usually used unless necessary.<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are a woman who may become pregnant during treatment with Emtricitabine \/ Tenofovir disoproxil Accord, you must use an effective method of contraception to avoid pregnancy.&nbsp;<br><\/li><li>If you are becoming or planning to become pregnant, you must contact your doctor to discuss the benefits and risks of treatment with Emtricitabine \/ Tenofovir disoproxil Accord for you and your baby.&nbsp;<br><\/li><\/ul>\n\n\n\n<p>If you have taken Emtricitabine \/ Tenofovir disoproxil Accord during your pregnancy, your doctor may ask you to have regular blood tests and other diagnostic tests to check your baby&#8217;s development.&nbsp;For children with a&nbsp;mother&nbsp;who has taken NRTIs during pregnancy, the benefit of&nbsp;HIV&nbsp;protection outweighs the&nbsp;risk of&nbsp;side effects.<br><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Do not breast-feed during treatment with Emtricitabine \/ Tenofovir disoproxil Accord.&nbsp;<\/strong>This is because the active substances in this medicine are excreted in human breast milk.<br><\/li><li>If you are an&nbsp;HIV-&nbsp;infected woman, do not breast-feed your baby to avoid transmitting&nbsp;HIV&nbsp;to&nbsp;your&nbsp;baby through breast milk.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Emtricitabine \/ Tenofovir disoproxil Accord may cause dizziness.&nbsp;Do not drive or use any tools or machines if you feel dizzy while taking Emtricitabine \/ Tenofovir disoproxil Accord.<br><\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Emtricitabine \/ Tenofovir disoproxil Accord contains lactose<\/h2>\n\n\n\n<p>Tell your doctor if you are lactose intolerant or intolerant to any other sugars.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Emtricitabine \/ Tenofovir disoproxil Accord<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<br><\/p>\n\n\n\n<p><strong>The recommended&nbsp;dose&nbsp;of&nbsp;Emtricitabine \/ Tenofovir disoproxil Accord&nbsp;for&nbsp;HIV treatment&nbsp;is:<\/strong><br><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Adults:<\/strong>&nbsp;one tablet daily, if possible with food.<\/li><li><strong>Adolescents aged 12 years and up to less than 18 years who weigh at least 35 kg:<\/strong>&nbsp;one tablet daily, if possible with food.<\/li><\/ul>\n\n\n\n<p><strong>The recommended&nbsp;dose&nbsp;of&nbsp;<\/strong><strong>Emtricitabine \/ Tenofovir disoproxil Accord&nbsp;<\/strong><strong>to reduce the risk of getting&nbsp;HIV&nbsp;is:<\/strong>&nbsp;<br><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Adults:<\/strong>&nbsp;one tablet daily, if possible with food.<\/li><li><strong>Adolescents aged 12 years and up to less than 18 years who weigh at least 35 kg:<\/strong>&nbsp;one tablet daily, if possible with food.<\/li><\/ul>\n\n\n\n<p>If you have difficulty swallowing, you can crush the tablet with the tip of a spoon.&nbsp;Then mix the powder with about 100 ml (half a glass) of water, orange juice, or grape juice and drink immediately.<br><\/p>\n\n\n\n<p>Always take the&nbsp;dose&nbsp;prescribed by&nbsp;your&nbsp;doctor to ensure that the medicine is effective and to reduce the development of&nbsp;resistance&nbsp;to treatment.&nbsp;Do not change the&nbsp;dose&nbsp;unless your doctor tells you to.<\/p>\n\n\n\n<p>If you are being treated for&nbsp;HIV&nbsp;infection, your doctor will prescribe Emtricitabine \/ Tenofovir disoproxil Accord in combination with other antiretroviral medicines.&nbsp;Read the package leaflets for these medicines for instructions on how to take them.<\/p>\n\n\n\n<p>If you are taking Emtricitabine \/ Tenofovir disoproxil Accord to reduce the risk of getting&nbsp;HIV, take Emtricitabine \/ Tenofovir disoproxil Accord every day, not just when you think you have been exposed to the risk of becoming infected with&nbsp;HIV.<br><\/p>\n\n\n\n<p>Ask your doctor if you have any questions about how to prevent getting&nbsp;HIV&nbsp;or transmitting&nbsp;HIV&nbsp;to other people.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Emtricitabine \/ Tenofovir disoproxil Accord then you should<\/h2>\n\n\n\n<p>If you take more Emtricitabine \/ Tenofovir disoproxil Accord then you should&nbsp;If a child has inadvertently ingested the medicine, contact a doctor, hospital, or the Poison Information Center for risk assessment and advice.&nbsp;Save the jar or blister so you can easily describe what you have taken.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Emtricitabine \/ Tenofovir disoproxil Accord<\/h2>\n\n\n\n<p>It is important that you do not miss a&nbsp;dose&nbsp;of Emtricitabine \/ Tenofovir disoproxil Accord.<br><\/p>\n\n\n\n<p>If you notice it within 12 hours from the time you usually take Emtricitabine \/ Tenofovir disoproxil Accord, take the tablet, preferably with food, as soon as possible.&nbsp;Then take the next&nbsp;dose&nbsp;at the usual time.<br><\/p>\n\n\n\n<p>If you notice it 12 hours or more after the time you usually take<\/p>\n\n\n\n<p>Emtricitabine \/ Tenofovir Disoproxil Accord, ignore the missed&nbsp;dose&nbsp;.&nbsp;Wait and take the next&nbsp;dose, preferably with food, at the usual time.<br><\/p>\n\n\n\n<p>If you vomit within less than 1 hour after a&nbsp;dose of&nbsp;Emtricitabine \/ Tenofovir disoproxil Accord, take a new tablet.&nbsp;You do not need to take a new tablet if you vomit more than 1 hour after taking Emtricitabine \/ Tenofovir disoproxil Accord.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Do not stop taking Emtricitabine \/ Tenofovir disoproxil Accord<\/h2>\n\n\n\n<p>If you are taking Emtricitabine \/ Tenofovir disoproxil Accord for the treatment of&nbsp;HIVinfection: if you stop taking the tablets, the effect of the anti-&nbsp;HIV&nbsp;treatment your doctor has recommended&nbsp;may be&nbsp;reduced.<\/p>\n\n\n\n<p>If you are taking Emtricitabine \/ Tenofovir disoproxil Accord to reduce your risk of getting&nbsp;HIV&nbsp;, do not stop taking Emtricitabine \/ Tenofovir disoproxil Accord or miss any&nbsp;dose&nbsp;.&nbsp;If you stop using emtricitabine \/ tenofovir disoproxil Accord, or miss&nbsp;the dose&nbsp;you, the risk of you getting&nbsp;HIV&nbsp;&#8211;&nbsp;infection&nbsp;increase.<br><\/p>\n\n\n\n<p>Do not stop taking Emtricitabine \/ Tenofovir disoproxil Accord without first talking to your doctor.<br><\/p>\n\n\n\n<p>If you have&nbsp;chronic&nbsp;hepatitis&nbsp;B, it is especially important that you do not stop taking Emtricitabine \/ Tenofovir disoproxil Accord without talking to your doctor first.&nbsp;You may need to submit blood samples for several months after stopping treatment.&nbsp;In some patients with advanced liver disease or&nbsp;cirrhosis&nbsp;, discontinuation of treatment is not recommended as this may lead to&nbsp;worsening of&nbsp;hepatitis&nbsp;A, which may be life-threatening.<br><\/p>\n\n\n\n<p>Inform your doctor immediately about any new and unexpected symptoms that occur after stopping treatment, especially symptoms that you usually associate with your&nbsp;hepatitis&nbsp;B&nbsp;infection&nbsp;.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<br><\/p>\n\n\n\n<p><strong>Possible serious side effects:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Lactic acidosis (excess&nbsp;lactic acid&nbsp;in the blood) is a rare but potentially life-threatening&nbsp;side effect&nbsp;.&nbsp;Lactic acidosis occurs more frequently in women, especially if they are overweight, and in people with liver disease.&nbsp;The following may be signs of lactic acidosis:<br><ul><li>deep, rapid breathing<\/li><li>drowsiness<\/li><li>nausea, vomiting<\/li><li>abdominal pain<br><\/li><\/ul><\/li><\/ul>\n\n\n\n<p>If you think you may have lactic acidosis, seek medical attention immediately.<br><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Any signs of&nbsp;inflammation&nbsp;or&nbsp;infection.&nbsp;<\/strong>In some patients with advanced&nbsp;HIV&nbsp;&#8211;&nbsp;infection&nbsp;(&nbsp;AIDS&nbsp;) and a history of opportunistic&nbsp;infection,&nbsp;you (&nbsp;the infection&nbsp;you that occurs in people with a weak immune system), signs and symptoms of&nbsp;inflammation&nbsp;from previous&nbsp;infections&nbsp;you may occur soon after the treatment against&nbsp;HIV&nbsp;begin.&nbsp;It is believed that these symptoms are due to an improvement in the body&#8217;s immune system and enable the body to fight&nbsp;infections&nbsp;that may have existed without any visible symptoms.<\/li><li><strong>Autoimmune disorders,<\/strong>&nbsp;where the immune system attacks healthy body tissue, can also occur after you start taking medicines for the treatment of&nbsp;HIV&nbsp;&#8211;&nbsp;infection.&nbsp;Autoimmune disorders can occur many months after starting treatment.&nbsp;Be aware of any symptoms of&nbsp;infection&nbsp;or other symptoms such as:<br><ul><li>muscle weakness<\/li><li>weakness that begins in the hands and feet and moves upwards towards the torso<\/li><li>palpitations, tremors or hyperactivity.<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>If you notice these or any symptoms of&nbsp;inflammation&nbsp;or&nbsp;infection&nbsp;, seek medical attention immediately.<br><\/p>\n\n\n\n<p><strong>Possible side effects:<\/strong><br><\/p>\n\n\n\n<p><strong>Very common&nbsp;side effect&nbsp;are<\/strong>&nbsp;(can occur in more than 1 in 10):<br><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>diarrhea, vomiting, nausea<\/li><li>dizziness, headache<\/li><li>rash<\/li><li>feeling weak<\/li><\/ul>\n\n\n\n<p><em>Samples can also show:<\/em><br><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>lowering of phosphate levels in the blood<\/li><li>elevated creatine kinase.<br><\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;are<\/strong>&nbsp;(may affect up to 10 of 100 patients)<br><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>pain, abdominal pain<\/li><li>difficulty sleeping, abnormal dreams<\/li><li>indigestion which results in discomfort after meals, feeling of bloating, flatulence<\/li><li>skin rash (including red spots or skin blemishes sometimes with blistering and swelling of the skin) which may be allergic reactions,&nbsp;itching&nbsp;, discoloration of the skin including dark spots on the skin<\/li><li>other allergic reactions, such as wheezing \/ wheezing, swelling or intoxication<\/li><\/ul>\n\n\n\n<p><em>Samples can also show:<\/em><br><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>low&nbsp;white blood cell count&nbsp;(a decrease in&nbsp;white blood cell count&nbsp;may make you more likely to get an&nbsp;infection&nbsp;)<\/li><li>elevated levels of&nbsp;triglycerides&nbsp;(fatty acids) in the blood, increased amount of bile pigments in the blood or elevated blood sugar<\/li><li>liver and pancreatic disorders.<\/li><\/ul>\n\n\n\n<p><strong>Less common&nbsp;side effects&nbsp;are<\/strong>&nbsp;(may affect up to 1 in 100):&nbsp;<br><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>abdominal pain (stomach) caused by&nbsp;inflammation&nbsp;of the pancreas<\/li><li>swelling of the face, lips, tongue or throat<\/li><li>anemia&nbsp;(low&nbsp;red blood cell count&nbsp;)<\/li><li>muscle breakdown, muscle pain or muscle weakness that can occur due to damage to kidney tubules<\/li><\/ul>\n\n\n\n<p><em>Samples can also show:<\/em><br><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>decreased potassium levels in the blood<\/li><li>elevated creatinine content in the blood<\/li><li>changes in the urine.<br><\/li><\/ul>\n\n\n\n<p><strong>Rare&nbsp;side effects&nbsp;are<\/strong>&nbsp;(may affect up to 1 in 1000):<br><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>lactic acidosis (see Possible serious&nbsp;side effects&nbsp;)<\/li><li>fatty liver<\/li><li>yellow skin or yellow eyes,&nbsp;itching, or pain in the abdomen (stomach) caused by&nbsp;inflammation&nbsp;of the liver<\/li><li>kidney inflammation, urinating a lot and feeling thirsty,&nbsp;kidney failure, damage to kidney tubules.<\/li><li>impaired bone hardness (which causes skeletal pain and sometimes leads to&nbsp;fractures&nbsp;)<\/li><li>back pain caused by kidney problems.<br><\/li><\/ul>\n\n\n\n<p>Damage to kidney tubules can be associated with muscle breakdown, decreased bone hardness (which causes skeletal pain and sometimes leads to&nbsp;fractures&nbsp;), muscle pain, muscle weakness and decreased&nbsp;potassium&nbsp;or phosphate levels in the blood.<br><\/p>\n\n\n\n<p>If you notice any of the above&nbsp;side effects&nbsp;or if any of the&nbsp;side effects&nbsp;gets serious, talk to your doctor or pharmacist.<br><\/p>\n\n\n\n<p>The frequency of the following&nbsp;side effects&nbsp;is unknown.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Skeletal problem.&nbsp;<\/strong>Some patients taking combination antiretroviral medicines such as Emtricitabine \/ Tenofovir disoproxil Accord may develop a bone disease called&nbsp;<em>osteonecrosis&nbsp;<\/em>(bone tissue death caused by lost blood supply to the bone tissue).&nbsp;Some of the many risk factors for developing this disease are long-term use of this type of drug, use of&nbsp;corticosteroids&nbsp;, use of alcohol, very weak immune system and obesity.&nbsp;Signs of&nbsp;osteonecrosis&nbsp;are:<br><ul><li>joint stiffness<\/li><li>joint pain and pain (especially in the hip joint, knee joint and shoulder joint)<\/li><li>difficulty moving.<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>Tell your doctor if you notice any of these symptoms.<\/p>\n\n\n\n<p>During treatment for&nbsp;HIV&nbsp;, there may be weight gain and an increase in blood fat and blood glucose levels.&nbsp;This is partly related to improved health and lifestyle and as far as blood fats are concerned, sometimes with the&nbsp;HIV&nbsp;drugs themselves.&nbsp;Your doctor will take samples for this.<br><\/p>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;are in children<\/strong><br><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Children who have been given emtricitabine have very often suffered from discoloration of the skin including<ul><li>dark spots on the skin.<\/li><\/ul><\/li><li>Children often suffer from too low a number of&nbsp;red blood cells&nbsp;(&nbsp;anemia&nbsp;)<ul><li>this can lead to the child becoming tired or short of breath.<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>Tell your doctor if you notice any of these symptoms.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Emtricitabine \/ Tenofovir disoproxil Accord<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the can and carton after EXP.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>OPA-Al-PVC \/ Al-blister: Store in the original package.&nbsp;Moisture sensitive.&nbsp;Do not store above 30 \u00b0 C.<br><\/p>\n\n\n\n<p>HDPE jar: Store in the original package.&nbsp;Moisture sensitive.&nbsp;Close the jar tightly.&nbsp;No special temperature instructions.<br><\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substances are emtricitabine and tenofovir disoproxil.&nbsp;Each tablet Emtricitabine \/ Tenofovir disoproxil Accord contains 200 mg emtricitabine and 245 mg tenofovir disoproxil (equivalent to 136 mg tenofovir).<br><\/li><li>Other ingredients are:<br>Tablet core: Crushed caramel sodium,&nbsp;lactose monohydrate&nbsp;, microcrystalline cellulose (&nbsp;PH&nbsp;101 and&nbsp;PH&nbsp;102), magnesium stearate, pregelatinized corn starch<br>Film coating: Opadry blue containing hypromellose 15 mPa,&nbsp;lactose monohydrate, titanium dioxide (E171), triacetin, indigo carmine (E132)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Emtricitabine \/ Tenofovir disoproxil Accord are blue, cassette-shaped, film-coated tablets marked with \u201cH\u201d on one side and \u201cE29\u201d on the other.<br><\/p>\n\n\n\n<p>OPA-Al-PVC \/ Al-blister containing 30, 60 and 90 tablets per pack.&nbsp;Also available as OPA-Al-PVC \/ Al perforated unit dose blister containing 30&#215;1, 60&#215;1 and 90&#215;1 tablets per pack.<br><\/p>\n\n\n\n<p>Packs of 30 tablets and 90 tablets (3 cans of 30 tablets) in a jar of white, opaque, high density polyethylene (HDPE) with a child-resistant closure of white, opaque polypropylene and silica gel desiccant in a cylindrical container.&nbsp;Each jar contains desiccant of silica gel in a cylindrical container that should be in the jar to protect the tablets and should not be swallowed.<br><\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Accord Healthcare BV<\/p>\n\n\n\n<p>Winthontlaan 200<\/p>\n\n\n\n<p>3526 VK Utrecht<\/p>\n\n\n\n<p>Netherlands<br><\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Accord Healthcare Limited<\/p>\n\n\n\n<p>Sage House, 319 Pinner Road<\/p>\n\n\n\n<p>North Harrow, Middlesex, HA1 4HF<\/p>\n\n\n\n<p>UK<br><\/p>\n\n\n\n<p>Pharmadox Healthcare, Ltd.<\/p>\n\n\n\n<p>KW20A Kordin Industrial Park,<\/p>\n\n\n\n<p>Paola, PLA 3000<\/p>\n\n\n\n<p>Malta<br><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Emtricitabine \/ Tenofovir disoproxil Accord contains two active substances, emtricitabine and tenofovir disoproxil. Both of these active substances are antiretroviral drugs used to treat HIV &#8211; infection. Emtricitabine is a nucleoside reverse transcriptase inhibitor and tenofovir is a nucleotide reverse transcriptase inhibitor. However, both are commonly called NRTIs and act by affecting the normal function of an enzyme (reverse transcriptase) that the virus needs for its reproduction (propagation).<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2205,2200],"tags":[3398,3401,4328,2213,3389,4350,4352,4353,4331,4349,4318,4330,4351],"class_list":["post-8089","post","type-post","status-publish","format-standard","hentry","category-e","category-medicines","tag-emtricitabine","tag-emtricitabine-side-effects","tag-emtricitabine-tablet","tag-medicines","tag-tenofovir-disoproxil","tag-tenofovir-disoproxil-accord","tag-tenofovir-disoproxil-accord-side-effects","tag-tenofovir-disoproxil-accord-tablet","tag-tenofovir-disoproxil-side-effects","tag-tenofovir-disoproxil-tanet","tag-what-is-emtricitabine","tag-what-is-tenofovir-disoproxil","tag-what-is-tenofovir-disoproxil-accord"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8089","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=8089"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8089\/revisions"}],"predecessor-version":[{"id":10594,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8089\/revisions\/10594"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=8089"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=8089"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=8089"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}