{"id":8043,"date":"2021-03-04T07:58:35","date_gmt":"2021-03-04T07:58:35","guid":{"rendered":"https:\/\/zeepedia.com\/?p=8043"},"modified":"2021-05-05T11:20:28","modified_gmt":"2021-05-05T11:20:28","slug":"emerade","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/emerade\/","title":{"rendered":"Emerade &#8211; Adrenaline uses, dose and side effects"},"content":{"rendered":"\n<p> 150 micrograms, 300 micrograms, 500 micrograms solution for injection in a pre-filled pen\u00a0<br>adrenaline<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Emerade is and what it is used for<\/h2>\n\n\n\n<p>Emerade is an autoinjector that contains&nbsp;adrenaline&nbsp;in a solution for&nbsp;injection&nbsp;that is injected into the muscle (&nbsp;intramuscularly&nbsp;).<br><\/p>\n\n\n\n<p>Adrenaline&nbsp;counteracts blood pressure drops in severe allergic (anaphylactic) reactions.&nbsp;It also stimulates the heart and facilitates breathing.<br><\/p>\n\n\n\n<p>Emerade is used in the acute treatment of life-threatening allergic reactions (anaphylactic&nbsp;shock&nbsp;) caused by food, medicine, insect bites or bites, and other&nbsp;allergens&nbsp;as well as those that have been triggered by physical exertion or unknown causes.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before using Emerade<\/h2>\n\n\n\n<p>Your doctor should have explained to you when and how to use Emerade.&nbsp;If you are not sure or have any questions, talk to your doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Emerade can always be used in an&nbsp;acute&nbsp;life-threatening allergic situation.&nbsp;If you are allergic (hypersensitive) to sodium metabisulfite or any of the other ingredients of Emerade, your doctor will need to instruct you in what circumstances Emerade should be used.<br><\/p>\n\n\n\n<p>Talk to your doctor before using Emerade if you have:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>heart disease<\/li><li>high&nbsp;blood pressure<\/li><li>overactive&nbsp;thyroid gland<\/li><li>diabetes<\/li><li>a&nbsp;tumor&nbsp;of the adrenal gland<\/li><li>elevated pressure in the eye<\/li><li>renal impairment<\/li><li>prostate disease<\/li><li>low potassium or high calcium in the blood<\/li><\/ul>\n\n\n\n<p>If you have&nbsp;asthma, you may be at increased risk of a severe&nbsp;allergic reaction.<br><\/p>\n\n\n\n<p>Anyone who has had&nbsp;anaphylaxis&nbsp;should visit their doctor to test for substances they may be allergic to so that these can be absolutely avoided in the future.&nbsp;It is important to be aware that an&nbsp;allergy&nbsp;to a substance can lead to&nbsp;allergies&nbsp;to several related substances.<\/p>\n\n\n\n<p>If you have food allergies, it is important to check the ingredients in everything you eat (including medicines) as even small amounts can cause serious reactions.<br><\/p>\n\n\n\n<p>If you are older or pregnant, the risk of&nbsp;side effects&nbsp;increases.<br><\/p>\n\n\n\n<p>The operating instructions must be followed carefully to avoid accidental&nbsp;injection.<\/p>\n\n\n\n<p>Emerade should be injected&nbsp;intramuscularly&nbsp;on the outside of the thigh.&nbsp;It should not be given in the buttocks due to the risk of accidentally injecting into a blood vessel.<br><\/p>\n\n\n\n<p><em>Warning<\/em><\/p>\n\n\n\n<p>Accidental&nbsp;injection&nbsp;into hands or feet can lead to decreased blood flow to these parts.&nbsp;Seek medical attention immediately for treatment if you accidentally inject it into your hands or feet.<br><\/p>\n\n\n\n<p>If you have a thick layer of subcutaneous fat, there is a risk that a&nbsp;dose&nbsp;of Emerade will not be enough.&nbsp;Then the second&nbsp;injection&nbsp;of Emerade may be needed.&nbsp;Follow the user instructions in section 3 carefully.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children<\/h2>\n\n\n\n<p>Emerade should not be used for children under 15 kg.<\/p>\n\n\n\n<p>A&nbsp;dose&nbsp;below 150 micrograms cannot be given with sufficient accuracy to children weighing less than 15 kg and use is therefore not recommended except in life-threatening situations and on the advice of a physician.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other drugs and Emerade<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<br><\/p>\n\n\n\n<p>This is especially important if you use any of the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Antidepressants such as&nbsp;tricyclic antidepressants&nbsp;or&nbsp;monoamine oxidase inhibitors&nbsp;(&nbsp;MAOIs&nbsp;), as the effect of adrenaline, may be enhanced.<\/li><li>Drugs for the treatment of&nbsp;Parkinson&#8217;s disease&nbsp;such as catechol-O-methyltransferase inhibitors (COMT inhibitors), as the effect of adrenaline, may be enhanced.<\/li><li>Drugs that can make the heartbeat unevenly (&nbsp;arrhythmias&nbsp;), such as&nbsp;digitalis&nbsp;and&nbsp;quinidine.<\/li><li>Drugs used to treat heart disease or drugs used to treat diseases of the nervous system, so-called alpha- and beta-blockers, can reduce the effect of&nbsp;adrenaline.<\/li><\/ul>\n\n\n\n<p>Diabetics should carefully monitor their blood sugar levels after using Emerade as&nbsp;adrenaline&nbsp;can raise blood sugar.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before using this medicine.<\/p>\n\n\n\n<p>There is limited experience with the use of&nbsp;adrenaline&nbsp;during pregnancy.&nbsp;If you are pregnant, do not hesitate to use Emerade in an emergency as your life may be in danger.<br><\/p>\n\n\n\n<p>You can breast-feed after using Emerade.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>The ability to drive a motor vehicle or use machines is not affected by injection of adrenaline, however, it can be affected by a severe&nbsp;anaphylactic reaction.&nbsp;If your driving ability is affected, do not drive.<br><\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Emerade contains sodium metabisulfite and sodium<\/h2>\n\n\n\n<p>Sodium metabisulphite can in rare cases cause severe allergic reactions or difficulty breathing (&nbsp;bronchospasm&nbsp;).&nbsp;If you are allergic (hypersensitive) to sodium metabisulphite, your doctor will instruct you in which situations Emerade should be used.<br><\/p>\n\n\n\n<p>Emerade contains less than 1 mmol&nbsp;sodium&nbsp;(23 mg) per&nbsp;dose, ie it is essentially &#8216;sodium-free&#8217;.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use Emerade<\/h2>\n\n\n\n<p>Use Emerade immediately if signs of&nbsp;an acute&nbsp;severe&nbsp;allergic reaction&nbsp;occur.&nbsp;Symptoms of a severe&nbsp;allergic reaction&nbsp;may occur within a few minutes after contact with the allergen and maybe, for example, skin rash,&nbsp;redness,&nbsp;or swelling.&nbsp;More severe reactions also affect blood circulation and respiration.<br><\/p>\n\n\n\n<p>Always use Emerade exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<br><\/p>\n\n\n\n<p>Before using Emerade, make sure you understand the situations in which you will use Emerade.&nbsp;You must always Emerade available if there is a risk of an&nbsp;acute&nbsp;allergic reaction.<\/p>\n\n\n\n<p>You must store Emerade in the outer original box.&nbsp;However, the patient\/caregiver may store the pen in a specially designed case that is included.&nbsp;The pen should always be stored in the case to protect it and the label describing how to use the pen in an emergency.&nbsp;Always keep this leaflet in case.<br><\/p>\n\n\n\n<p><strong>Dosage<\/strong><\/p>\n\n\n\n<p>Dose&nbsp;one is determined by the doctor, who will adjust it individually for you for example depending on your body weight.<br><\/p>\n\n\n\n<p><em><strong>Adults<\/strong><\/em><br><\/p>\n\n\n\n<p><em>Adults weighing less than 60 kg<\/em><\/p>\n\n\n\n<p>The usual&nbsp;dose&nbsp;is 300 micrograms.<br><\/p>\n\n\n\n<p><em>Adults weighing more than 60 kg<\/em><\/p>\n\n\n\n<p>The usual&nbsp;dose&nbsp;is 300 to 500 micrograms.<br><\/p>\n\n\n\n<p><em><strong>Children and young people<\/strong><\/em><\/p>\n\n\n\n<p>Emerade 500 micrograms are not recommended for use in children.<br><\/p>\n\n\n\n<p><em>Children&nbsp;<\/em><em>weighing&nbsp;<\/em><em>between 15&nbsp;<\/em><em>kg&nbsp;<\/em><em>and 30 kg<\/em>&nbsp;<\/p>\n\n\n\n<p>The usual&nbsp;dose&nbsp;is 150 micrograms.<br><\/p>\n\n\n\n<p><em>Children&nbsp;<\/em><em>weighing more than&nbsp;<\/em><em>30 kg<\/em><\/p>\n\n\n\n<p>The usual&nbsp;dose&nbsp;is 300 micrograms.<br><\/p>\n\n\n\n<p><em>Adolescents weighing more than 30 kg<\/em><\/p>\n\n\n\n<p>The dose recommendations for adult patients should be followed.<br><\/p>\n\n\n\n<p><strong>How Emerade is given<\/strong><\/p>\n\n\n\n<p>The operating instructions must be followed carefully to avoid accidental&nbsp;injection.<\/p>\n\n\n\n<p>It is recommended that your family members, caregivers, or teachers also receive instructions on the proper use of Emerade.<\/p>\n\n\n\n<p>Emerade should only be used for&nbsp;injection&nbsp;into the outside of the thigh.&nbsp;Injection occurs when Emerade is pressed lightly against the thigh.&nbsp;It can be done through clothing.&nbsp;Never inject into the buttocks.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><th scope=\"row\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20111209000051#\" rel=\"noopener\"><\/a><br><br><br><br><\/th><td>1. Remove the needle cover.<\/td><\/tr><tr><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20111209000051#\" rel=\"noopener\"><\/a><br><br><br><br><\/td><td>2. Place and press Emerade&nbsp;<em>against the outside of the thigh<\/em>.&nbsp;<em>A click is heard<\/em>&nbsp;when an&nbsp;injection&nbsp;enters the muscle.<\/td><\/tr><tr><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20111209000051#\" rel=\"noopener\"><\/a><br><\/td><td>3. Hold the Emerade firmly against the thigh for about 5 seconds.&nbsp;Massage the injection site lightly afterward. <strong>Contact a doctor or hospital immediately<\/strong><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>The needle in Emerade is protected before, during, and after&nbsp;injection.<\/p>\n\n\n\n<p>After&nbsp;injection&nbsp;one, the plunger rod is visible in the display window, if you lift the label.<br><\/p>\n\n\n\n<p>Sometimes a&nbsp;dose&nbsp;of&nbsp;adrenaline is&nbsp;not enough to eliminate a severe&nbsp;allergic reaction.&nbsp;This is why your doctor will probably prescribe more than one Emerade.&nbsp;If the symptoms have not improved or worsened within 5-15 minutes after the first&nbsp;injection, either you or the person you are with should give a second&nbsp;injection.&nbsp;For this reason, you should always have more than one Emerade with you.<br><\/p>\n\n\n\n<p>Emerade is only intended for emergency treatment.&nbsp;You should always seek help immediately after using Emerade. &#8220;anaphylaxis&#8221;&nbsp;<strong>even if symptoms seem to improve<\/strong>.&nbsp;You will need to go to the hospital for observation and further treatment as needed.&nbsp;This is because the reaction may return later.&nbsp;Take your used autoinjector with you.<br><\/p>\n\n\n\n<p>While waiting for an ambulance, you should lie down with your feet up, unless this makes you breathless, in which case you should sit up.&nbsp;Ask someone to stay with you until the ambulance arrives in case you feel unwell again.<br><\/p>\n\n\n\n<p>Unconscious patients should be placed in a supine position.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><strong>Do not remove the needle cover until it is time to use Emerade.<\/strong><\/p>\n\n\n\n<p>Some liquid may remain in the Emerade after use.&nbsp;The autoinjector cannot be reused.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Emerade than you should &nbsp;<\/h2>\n\n\n\n<p>If you have taken too much medicine, if you have accidentally injected Emerade into a blood vessel or in a hand or if e.g.&nbsp;If a child has inadvertently ingested the medicine, contact a doctor, hospital, or the Poison Information Center for risk assessment and advice.<br><\/p>\n\n\n\n<p>Blood pressure&nbsp;can rise sharply.&nbsp;Overdose of&nbsp;adrenaline&nbsp;can cause a sudden increase in&nbsp;blood pressure, irregular heartbeat, and accumulation of fluid in the lungs that can make it difficult to breathe.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<br><\/p>\n\n\n\n<p>The following&nbsp;side effects&nbsp;are based on experience with treatment with&nbsp;adrenaline, but the frequency of&nbsp;side effects&nbsp;can not be calculated:<br><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>heart problems such as irregular or rapid heartbeat, chest pain<\/li><li>high&nbsp;blood pressure, vasoconstriction<\/li><li>sweating<\/li><li>nausea, vomiting<\/li><li>breathing difficulties<\/li><li>headache, dizziness<\/li><li>weakness, tremors<\/li><li>anxiety, hallucinations<\/li><li>fainting<\/li><li>changes in blood values \u200b\u200bsuch as increased blood sugar decreased&nbsp;potassium&nbsp;and increased acidity.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Emerade<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Store Emerade in the outer carton.&nbsp;However, the patient\/caregiver may store the pen in a specially designed case that is included.&nbsp;The pen should always be stored in the case to protect it.<\/p>\n\n\n\n<p>Do not store above 25 \u00b0 C.&nbsp;Do not freeze.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the labels and the outer carton after EXP.&nbsp;The expiration date is the last day of the specified month.&nbsp;Discard and replace Emerade after the expiration date.&nbsp;Check the solution regularly, by lifting the label over the display window on the auto-injector, to ensure that the solution is clear and colorless.&nbsp;Discard and replace Emerade if the solution is discolored or contains a&nbsp;precipitate.<br><\/p>\n\n\n\n<p>Inspect the auto-injector if it is dropped.&nbsp;Replace it if you discover damage or leakage.<br><\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>The active substance is&nbsp;adrenaline&nbsp;(like adrenaline tartrate).<\/p>\n\n\n\n<p>Emerald 150 micrograms provide 150 micrograms of&nbsp;adrenaline&nbsp;in 0.15 ml&nbsp;solution for injection.<\/p>\n\n\n\n<p>Emerade 300 micrograms provide 300 micrograms of&nbsp;adrenaline&nbsp;in 0.3 ml&nbsp;solution for injection.<\/p>\n\n\n\n<p>Emerade 500 micrograms provide 500 micrograms of&nbsp;adrenaline&nbsp;in 0.5 ml&nbsp;solution for injection.<br><\/p>\n\n\n\n<p>The other ingredients are sodium chloride, sodium metabisulfite (E223), disodium edetate,&nbsp;hydrochloric acid,&nbsp;and water for injections.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Emerade is a&nbsp;pen&nbsp;that provides a single dose of&nbsp;adrenaline.&nbsp;Emerade contains a clear and colorless&nbsp;injection solution&nbsp;in an ice cream syringe.&nbsp;Emerade is latex-free.<\/p>\n\n\n\n<p>The pen is a white cylinder with a needle cover that covers the needle and the activation mechanism.<br><\/p>\n\n\n\n<p><em>The exposed length of the cannula<\/em><\/p>\n\n\n\n<p>Emerade 150 micrograms: 16 mm<\/p>\n\n\n\n<p>Emerade 300 micrograms and Emerade 500 micrograms: 23 mm<br><\/p>\n\n\n\n<p>Pack sizes: 1 or 2 pre-filled pens.<br><\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><em><br>Marketing Authorisation Holder<\/em><\/p>\n\n\n\n<p>PharmaSwiss Czech Republic sro<\/p>\n\n\n\n<p>Jankovcova 1569 \/ 2c<\/p>\n\n\n\n<p>170 00 Prague 7<\/p>\n\n\n\n<p>The Czech Republic<br><\/p>\n\n\n\n<p><em>Information providing companies:<\/em><\/p>\n\n\n\n<p>Medica Pharma AB<\/p>\n\n\n\n<p>Box 24005<\/p>\n\n\n\n<p>750 24 UPPSALA<\/p>\n\n\n\n<p>Phone 018-25 85 30<br><\/p>\n\n\n\n<p><em>Manufacturer<\/em><\/p>\n\n\n\n<p>Rechon Life Science AB<\/p>\n\n\n\n<p>Box 60043<\/p>\n\n\n\n<p>216 10 Limhamn<br><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Emerade is an autoinjector that contains adrenaline in a solution for injection that is injected into the muscle ( intramuscularly ).<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2205,2200],"tags":[4044,4471,4046,4472,4475,4474,2213,4045,4473],"class_list":["post-8043","post","type-post","status-publish","format-standard","hentry","category-e","category-medicines","tag-adrenaline","tag-adrenaline-injection","tag-adrenaline-side-effects","tag-emerade","tag-emerade-injection","tag-emerade-side-effects","tag-medicines","tag-what-is-adrenaline","tag-what-is-emerade"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8043","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=8043"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8043\/revisions"}],"predecessor-version":[{"id":10634,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8043\/revisions\/10634"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=8043"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=8043"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=8043"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}