{"id":8041,"date":"2021-03-04T07:57:24","date_gmt":"2021-03-04T07:57:24","guid":{"rendered":"https:\/\/zeepedia.com\/?p=8041"},"modified":"2021-05-05T11:23:18","modified_gmt":"2021-05-05T11:23:18","slug":"emend","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/emend\/","title":{"rendered":"Emend &#8211; Aprepitant uses, dose and side effects"},"content":{"rendered":"\n<p> 125 mg and 80 mg\u00a0capsules, hard\u00a0<br>aprepitant<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What EMEND is and what it is used for<\/h2>\n\n\n\n<p>EMEND contains the active substance aprepitant and belongs to a group of medicines called &#8220;neurokinin 1 (NK&nbsp;<sub>1<\/sub>&nbsp;) receptor antagonists&#8221;.&nbsp;There is a special area in the brain that controls nausea and vomiting.&nbsp;EMEND works by blocking signals to that area, thus reducing nausea and vomiting.&nbsp;EMEND capsules are used in adults and adolescents from 12 years of age&nbsp;<strong>in combination with other medicines<\/strong>&nbsp;to prevent nausea and vomiting caused by&nbsp;chemotherapy&nbsp;(cancer treatment) which very or often causes nausea and vomiting (such as cisplatin, cyclophosphamide, doxorubicin, or epirubicin).<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before taking or giving EMEND<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take EMEND<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you or your child are allergic to aprepitant or any of the other ingredients of this medicine (listed in section 6).<\/li><li>together with medicines containing pimozide (used to treat psychiatric illnesses), terfenadine and astemizole (used to treat hay fever and other allergic conditions), cisapride (used to treat indigestion).&nbsp;Tell your doctor if you or your child are using these medicines as the treatment needs to be adjusted before you or your child starts using EMEND.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before taking EMEND or giving this medicine to your child.<br><\/p>\n\n\n\n<p>If you or the child have any liver disease, talk to a doctor before treatment with EMEND.&nbsp;The liver has an important function in breaking down the drug in the body.&nbsp;Your doctor may therefore need to monitor your or your child&#8217;s liver function.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Do not give EMEND 80 mg and 125 mg capsules to children under 12 years of age, as the 80 mg and 125 mg capsules have not been studied in this age group.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and EMEND<\/h2>\n\n\n\n<p>EMEND can affect other medicines both during and after treatment with EMEND.&nbsp;Some medicines should not be used with EMEND (eg pimozide, terfenadine, astemizole,e, and cisapride), or require a dose adjustment of that medicine (see also Do not take EMEND).<br><\/p>\n\n\n\n<p>The effects of EMEND or other medicines may be affected if you or your child take EMEND with other medicines, including those mentioned below.&nbsp;Tell your doctor or pharmacist if you or your child are taking any of the following medicines:<br><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>contraceptives such as&nbsp;birth control pills,&nbsp;birth control&nbsp;patches,&nbsp;implants,&nbsp;and certain uterine inserts (&nbsp;IUDs&nbsp;) that release&nbsp;hormones&nbsp;can have a worse effect if they are used together with EMEND.&nbsp;Alternative or complementary non-hormonal contraceptive methods should be used during ongoing treatment with EMEND and for up to 2 months after use of EMEND.<\/li><li>ciclosporin, tacrolimus, sirolimus, everolimus (immunosuppressive drugs)<\/li><li>alfentanil,&nbsp;fentanyl&nbsp;(&nbsp;painkillers&nbsp;)<\/li><li>quinidine&nbsp;(for the treatment of irregular heartbeat)<\/li><li>irinotecan, etoposide, vinorelbine, ifosamide (cancer medicine)<\/li><li>medicines containing ergot alkaloid derivatives such as&nbsp;ergotamine&nbsp;and ergotamine (used to treat&nbsp;migraines&nbsp;)<\/li><li>warfarin, acenocoumarol (blood thinners, blood tests may be required)<\/li><li>rifampicin, clarithromycin, telithromycin (&nbsp;antibiotics, used to treat&nbsp;infections&nbsp;)<\/li><li>phenytoin&nbsp;(an antispasmodic)<\/li><li>carbamazepine (used to treat depression and&nbsp;epilepsy&nbsp;)<\/li><li>midazolam, triazolam, phenobarbital (medicines that are sedative and help you sleep)<\/li><li>St. John&#8217;s wort&nbsp;(a herbal remedy for depression)<\/li><li>protease inhibitors&nbsp;(for treatment of&nbsp;HIV&nbsp;&#8211;&nbsp;infection&nbsp;s)<\/li><li>ketoconazole&nbsp;excluding&nbsp;shampoo, (for the treatment of Cushing&#8217;s syndrome &#8211; when the body produces an excess of&nbsp;cortisol&nbsp;)<\/li><li>itraconazole, voriconazole, posaconazole (for fungal infections)<\/li><li>nefazodone (for the treatment of depression)<\/li><li>corticosteroids&nbsp;(such as <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/toflacort\/\">dexamethasone<\/a> and methylprednisolone)<\/li><li>antianxiety drugs (like alprazolam)<\/li><li>tolbutamide (a medicine used to&nbsp;treat diabetes&nbsp;)<\/li><\/ul>\n\n\n\n<p>Tell your doctor or pharmacist if you or your child are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>This medicine should not be used if you or your baby are pregnant unless clearly necessary.&nbsp;If you or your baby are pregnant or breast-feeding, think you or your baby may be pregnant or are planning to have a baby, ask your doctor for advice before using this medicine.<br><\/p>\n\n\n\n<p>For information on contraceptive methods, see Other medicines and EMEND.<br><\/p>\n\n\n\n<p>It is not known if EMEND passes into breast milk and therefore breastfeeding is not recommended during treatment with this medicine.&nbsp;It is important to tell your doctor if you or your baby are breast-feeding or planning to breast-feed before taking or giving this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>It should be noted that some people experience dizziness and drowsiness after using EMEND.<\/p>\n\n\n\n<p>If you or your child become dizzy or drowsy after using this medicine, avoid driving, cycling,g or using machines or tools (see section \u201cPossible side effects\u201d).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">EMEND contains sucrose and sodium<\/h2>\n\n\n\n<p><strong>EMEND contains sucrose<\/strong><\/p>\n\n\n\n<p>EMEND capsules contain sucrose.&nbsp;If you have been told by your doctor or child that you or your child is hypersensitive to certain sugars, contact your doctor before using this medicine.<br><\/p>\n\n\n\n<p><strong>EMEND contains&nbsp;sodium<\/strong><\/p>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;sodium&nbsp;per capsule, ie essentially &#8216;sodium-free&#8217;.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take or give EMEND<\/h2>\n\n\n\n<p>Always take this medicine or give this medicine to your child exactly as your doctor, pharmacist or nurse has told you.&nbsp;If you are not sure, talk to your doctor, pharmacist, or nurse.&nbsp;Always take EMEND with other medicines to prevent nausea and vomiting.&nbsp;After treatment with EMEND, your doctor will ask you or your child to continue taking other medicines including a&nbsp;corticosteroid&nbsp;(such as dexamethasone) and a &#8220;5HT&nbsp;3antagonist&#8221; (such as ondansetron) to prevent nausea and vomiting.&nbsp;If you are not sure, talk to your doctor, pharmacist, or nurse.<br><\/p>\n\n\n\n<p>The recommended oral&nbsp;dose&nbsp;of EMEND is:<\/p>\n\n\n\n<p>Day 1:<br><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>a 125 mg capsule 1 hour before starting your chemotherapy treatment<\/li><\/ul>\n\n\n\n<p><strong>and<\/strong>&nbsp;<\/p>\n\n\n\n<p>Day 2 and 3:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>one 80 mg capsule daily<\/li><li>if no&nbsp;chemotherapy&nbsp;is given, take EMEND in the morning<\/li><li>if&nbsp;chemotherapy&nbsp;is given, take EMEND 1 hour before starting&nbsp;chemotherapy.<\/li><\/ul>\n\n\n\n<p>EMEND can be taken with or without food.<br><\/p>\n\n\n\n<p>The capsule should be swallowed whole with liquid.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more EMEND than you should<\/h2>\n\n\n\n<p>Do not take more capsules than your doctor recommends.&nbsp;If you or the child have taken too many capsules, contact your doctor immediately.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take EMEND<\/h2>\n\n\n\n<p>If you or your child have missed a&nbsp;dose, contact your doctor for advice.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects,&nbsp;although not everybody gets them.<br><\/p>\n\n\n\n<p><strong>Stop taking EMEND and contact a doctor immediately if you or your child notice any of the following&nbsp;side effects&nbsp;that may be serious and for which you or your child may need emergency care:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>hives, rash,&nbsp;itching, difficulty breathing, or swallowing (no known frequency, can not be calculated from the available data) &#8211; these are signs of an&nbsp;allergic reaction.<\/li><\/ul>\n\n\n\n<p>Other&nbsp;side effects&nbsp;that have been reported are listed below.<br><\/p>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;(may affect up to 1 in 10 people) are:<\/strong><br><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>constipation, indigestion<\/li><li>headache<\/li><li>fatigue<\/li><li>decreased appetite<\/li><li>hiccup<\/li><li>elevated levels of liver enzymes in the blood.<\/li><\/ul>\n\n\n\n<p><strong>Uncommon&nbsp;side effects&nbsp;(may affect up to 1 in 100 people) are:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>dizziness, drowsiness<\/li><li>acne, skin rash<\/li><li>anxiety<\/li><li>belching, nausea, vomiting, heartburn, stomach pain,&nbsp;dry mouth, gas in the stomach<\/li><li>increased painful or burning urination<\/li><li>weakness, general malaise<\/li><li>hot flashes\/redness of the face or redness of the skin<\/li><li>fast or irregular heartbeat<\/li><li>fever with increased risk of&nbsp;infection, decreased number of&nbsp;red blood cells<\/li><\/ul>\n\n\n\n<p><strong>Rare&nbsp;side effects&nbsp;(may affect up to 1 in 1,000 people) are:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>difficulty thinking, lack of energy, taste changes<\/li><li>skin sensitivity to sunlight, increased sweating, oily skin, skin ulcers, itchy rash, Stevens-Johnson syndrome \/ toxic&nbsp;epidermal&nbsp;necrolysis&nbsp;(rare, severe skin reaction)<\/li><li>euphoria&nbsp;(extreme happiness), disorientation<\/li><li>bacterial infection, fungal infection<\/li><li>severe constipation,&nbsp;gastric ulcer,&nbsp;inflammation&nbsp;of the small intestine and large intestine, ulcers in the mouth, bloating in the stomach<\/li><li>denser urination, the greater amount of urine than usual, presence of sugar or blood in the urine<\/li><li>the feeling of discomfort in the chest, swelling, altered gait<\/li><li>cough, runny nose running down the throat, irritation of the throat, sneezing, sore throat<\/li><li>watery and itchy eyes<\/li><li>tinnitus<\/li><li>muscle spasms, muscle weakness<\/li><li>increased thirst<\/li><li>slow heartbeat, cardiovascular disease<\/li><li>fewer&nbsp;white blood cells, low sodium levels in the blood, weight loss.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store EMEND<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton after EXP.&nbsp;The expiration date is the last day of the specified month.<br><br><\/p>\n\n\n\n<p>Store in the original package.&nbsp;Moisture sensitive.<br><br><\/p>\n\n\n\n<p>Do not push the capsule out of the blister until you take it.<br><br><\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>&#8211; The active substance is aprepitant.&nbsp;Each 125 mg hard capsule contains 125 mg of aprepitant.&nbsp;Each 80 mg hard capsule contains 80 mg of aprepitant.<\/p>\n\n\n\n<p>The other ingredients are sucrose, microcrystalline cellulose (E460), hydroxypropyl cellulose (E463), sodium lauryl sulfate, gelatin, titanium dioxide (E171), shellac, potassium hydroxide, and black iron oxide (E172);&nbsp;125 mg hard capsule also contains red iron oxide (E172) and yellow iron oxide (E172).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>The 125 mg hard capsule is opaque with a white body and a pink body.&nbsp;&#8220;462&#8221; and &#8220;125 mg&#8221; are printed in black ink across the bottom of the capsule.<\/p>\n\n\n\n<p>The 80 mg hard capsule is opaque with a white bottom and top, and with \u201c461\u201d and \u201c80 mg\u201d printed in black ink across the bottom of the capsule.<br><\/p>\n\n\n\n<p>EMEND 125 mg and 80 mg hard capsules are supplied in the following pack sizes:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Aluminum blister containing an 80 mg capsule<\/li><li>Pack of 2 days treatment containing two 80 mg capsules<\/li><li>5 aluminum blisters each containing an 80 mg capsule<\/li><li>Aluminum blister containing a 125 mg capsule<\/li><li>5 aluminum blisters each containing a 125 mg capsule<\/li><li>Pack of 3 days treatment containing one 125 mg capsule and two 80 mg capsules.<\/li><\/ul>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Merck Sharp &amp; Dohme BV<\/p>\n\n\n\n<p>Waarderweg 39<\/p>\n\n\n\n<p>2031 BN Haarlem<\/p>\n\n\n\n<p>Netherlands<br><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgique \/ Belgi\u00eb \/ Belgien<\/strong>MSD Belgium BVBA \/ SPRLTel: +32 (0) 27766211dpoc_belux@merck.com<\/td><td><strong>Lithuania<\/strong>UAB Merck Sharp &amp; DohmeTel .: +370 5278 02 47msd_lietuva@merck.com<br><\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Mark Harp and Doom Bulgaria BulgariaTel: +359 2 819 3737info-msdbg@merck.com<\/td><td><strong>Luxembourg \/ Luxemburg<\/strong>MSD Belgium BVBA \/ SPRLTel: +32 (0) 27766211dpoc_belux@merck.com<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Merck Sharp &amp; Dohme, sroTel .: +420 233 010 111dpoc_czechslovak@merck.com<\/td><td><strong>Hungary<\/strong>MSD Pharma Hungary Kft.Tel .: +36 1 888 5300hungary_msd@merck.com<br><\/td><\/tr><tr><td><strong>Denmark<\/strong>MSD Danmark ApSTel: +45 4482 4000dkmail@merck.com<br><br><\/td><td><strong>Malta<\/strong>Merck Sharp &amp; Dohme Cyprus LimitedTel: 8007 4433 (+356 99917558)malta_info@merck.com<\/td><\/tr><tr><td><strong>Germany<\/strong>MSD SHARP &amp; DOHME GMBHTel: 0800 673 673 673 (+49 89 4561 2612)email@msd.de<\/td><td><strong>The Netherlands<\/strong>Merck Sharp &amp; Dohme BVTel: 0800 9999000(+31 23 5153153)medicalinfo.nl@merck.com<br><\/td><\/tr><tr><td><strong>Eesti<\/strong>Merck Sharp &amp; Dohme O\u00dcTel .: +372 6144 200msdeesti@merck.com<br><\/td><td><strong>Norway<\/strong>MSD (Norway) ASTel: +47 32 20 73 00msdnorge@msd.no<br><\/td><\/tr><tr><td><strong>Elad<\/strong>MSD A.\u03a6.BEE:\u0397\u03bb: +30 210 98 97 300dpoc_greece@merck.com<br><\/td><td><strong>Austria<\/strong>Merck Sharp &amp; Dohme Ges.mbHTel: +43 (0) 1 26 044msd-medizin@merck.com<\/td><\/tr><tr><td><strong>Spain<\/strong>Merck Sharp &amp; Dohme de Espa\u00f1a, SATel: +34 91 321 06 00msd_info@merck.com<\/td><td><strong>Poland<\/strong>MSD Polska Sp.z ooTel: +48 22 549 51 00msdpolska@merck.com<br><\/td><\/tr><tr><td><strong>France<\/strong>MSD FranceTel: +33 (0) 1 80 46 40 40<br><br><\/td><td><strong>Portugal<\/strong>Merck Sharp &amp; Dohme, LdaTel: +351 21 4465700inform_pt@merck.com<br><\/td><\/tr><tr><td><strong>Croatia<\/strong>Merck Sharp &amp; Dohme dooTel: + 385 1 6611 333croatia_info@merck.com<br><\/td><td><strong>Romania<\/strong>Merck Sharp &amp; Dohme Romania SRLTel: + 40 21 529 29 00msdromania@merck.com<\/td><\/tr><tr><td><strong>Ireland<\/strong>Merck Sharp &amp; Dohme Ireland (&nbsp;HumanHealth) LimitedTel: +353 (0) 1 2998700medinfo_ireland@merck.com<\/td><td><strong>Slovenia<\/strong>Merck Sharp &amp; Dohme, an innovative freelance dooTel: + 386 1 5204 201msd_slovenia@merck.com<br><\/td><\/tr><tr><td><strong>Iceland<\/strong>Vistor hf.Phone: +354 535 7000<br><br><\/td><td><strong>Slovak Republic<\/strong>Merck Sharp &amp; Dohme, sroTel .: +421 2 58282010dpoc_czechslovak@merck.com<br><\/td><\/tr><tr><td><strong>Italy<\/strong>MSD Italia SrlTel: +39 06 361911medicalinformation.it@merck.com<\/td><td><strong>Finland \/ Finland<\/strong>MSD Finland OyPuh \/ Tel: +358 (0) 9 804650info@msd.fi<br><\/td><\/tr><tr><td><strong>Latvia<\/strong>SIA Merck Sharp &amp; Dohme LatvijaTel: +371 67364224msd_lv@merck.com.<\/td><td><strong>United Kingdom<\/strong>Merck Sharp &amp; Dohme LimitedTel: +44 (0) 1992 467272medicalinformationuk@merck.com<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>EMEND contains the active substance aprepitant and belongs to a group of medicines called &#8220;neurokinin 1 (NK 1 ) receptor antagonists&#8221;. There is a special area in the brain that controls nausea and vomiting. EMEND works by blocking signals to that area, thus reducing nausea and vomiting. EMEND capsules are used in adults and adolescents from 12 years of age in combination with other medicines to prevent nausea and vomiting caused by chemotherapy (cancer treatment) which very or often causes nausea and vomiting (such as cisplatin, cyclophosphamide, doxorubicin, or epirubicin).<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2205,2200],"tags":[4476,4479,4478,4480,4483,4482,4484,4477,4481],"class_list":["post-8041","post","type-post","status-publish","format-standard","hentry","category-e","category-medicines","tag-aprepitant","tag-aprepitant-capsules","tag-aprepitant-side-effects","tag-emend","tag-emend-capsules","tag-emend-side-effects","tag-medicies","tag-what-is-aprepitant","tag-what-is-emend"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8041","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=8041"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8041\/revisions"}],"predecessor-version":[{"id":10636,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/8041\/revisions\/10636"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=8041"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=8041"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=8041"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}