2.5 mg\u00a0film-coated tablets\u00a0
apixaban<\/p>\n\n\n\n
Eliquis contains the active substance apixaban and belongs to a group of medicines called anticoagulants (blood thinners). This medicine helps prevent blood clots from forming by blocking factor Xa which is an important component in the clotting of the blood.
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Eliquis is used for adults:<\/p>\n\n\n\n
Talk to your doctor, pharmacist, or nurse before taking this medicine<\/strong> if you have any of the following:<\/p>\n\n\n\n Take special care with Eliquis<\/p>\n\n\n\n If you need to have surgery or another procedure that may cause bleeding, your doctor may ask you to temporarily stop taking this medicine for a short time. If you are not sure if a procedure can cause bleeding, consult your doctor.<\/p>\n\n\n\n This medicine is not recommended for children and adolescents under 18 years of age.<\/p>\n\n\n\n Tell your doctor, pharmacist, or nurse if you are taking, have recently taken, or might take any other medicines. Some medicines may increase the effect of Eliquis and some may weaken it. Your doctor will decide if you should be treated with Eliquis when you take such medicines and how closely you need to be monitored. The following medicines may increase the effect of Eliquis and increase the risk of unwanted bleeding:<\/p>\n\n\n\n The following medicines may reduce Eliqui’s ability to prevent blood clots:<\/p>\n\n\n\n If you are pregnant or breast-feeding, think you may be pregnant,t or are planning to have a baby, ask your doctor, pharmacist, or nurse for advice before taking this medicine. Eliqui’s effects on pregnancy and the unborn baby are not known. You should not take this medicine if you are pregnant. Contact your doctor immediately<\/strong> if you become pregnant while being treated with this medicine. It is not known if Eliquis passes into breast milk. If you are breast-feeding, ask your doctor, pharmacist, or nurse before taking this medicine. They will advise you to either stop breast-feeding or to stop \/ not start this medicine.<\/p>\n\n\n\n Eliquis has no or negligible effect on the ability to drive and use machines.<\/p>\n\n\n\n If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<\/p>\n\n\n\n This medicine contains less than 1 mmol (23 mg) sodium per tablet, ie it is essentially ‘sodium-free’. Always take this medicine exactly as your doctor or pharmacist has told you. If you are not sure, talk to your doctor, pharmacist, or nurse. Dosage<\/strong> Swallow the tablet with a glass of water. Eliquis can be taken with or without food.<\/p>\n\n\n\n Try to take the tablets at the same time each day to get the best effect from the treatment. If you have difficulty swallowing the tablet whole, talk to your doctor about other ways to take Eliquis. The tablet can be crushed and mixed with water, or 5% glucose solution, or apple juice or apple puree, immediately before taking it. Instructions for crushing:<\/strong><\/p>\n\n\n\n If necessary, your doctor may also give you the crushed Eliquit tablet mixed in 60 ml of water or 5% glucose solution, through a tube through your nose to your stomach. Take Eliquis as recommended for the following:<\/strong> To prevent blood clots from forming after hip or knee joint surgery.<\/strong><\/em><\/p>\n\n\n\n The recommended dose is one Eliquis 2.5 mg tablet twice daily. For example, one in the morning and one in the evening. You should take the first tablet within 12 to 24 hours after the operation. If you have had major hip surgery<\/strong>, you will usually take the tablets for 32 to 38 days.<\/p>\n\n\n\n If you have had major knee surgery<\/strong>, you will usually take the tablets for 10 to 14 days. To prevent blood clots from forming in the heart of patients with an irregular heartbeat and at least one additional risk factor.<\/strong><\/em> The recommended dose is one Eliquis 5 mg<\/strong> tablet twice daily. The recommended dose is one Eliquis 2.5 mg<\/strong> tablet twice daily if:<\/p>\n\n\n\n The recommended dose is one tablet twice daily, such as one in the morning and one in the evening. Your doctor will decide how long you need to continue treatment. To treat blood clots in the veins of the legs and blood clots in the lungs<\/strong><\/em> The recommended dose is two tablets of<\/strong> Eliquis 5 mg<\/strong> twice daily for the first 7 days, for example, two in the morning and two in the evening. After 7 days, the recommended dose is one Eliquis 5 mg tablet<\/strong> twice daily, for example, one in the morning and one in the evening. To prevent blood clots from recurring after 6 months of treatment<\/strong><\/em> The recommended dose is one Eliquis 2.5 mg<\/strong> tablet twice daily, for example, one in the morning and one in the evening. Your doctor will decide how long you need to continue treatment. Your doctor may replace your blood-thinning treatment as follows:<\/em><\/strong> Patients undergoing conversion<\/em><\/strong><\/p>\n\n\n\n If your irregular heartbeat needs to be restored to a normal rhythm through a procedure called conversion, you should take this medicine at the times your doctor tells you to prevent blood clots in the blood vessels of the brain and other blood vessels in your body.<\/p>\n\n\n\n Tell your doctor immediately if<\/strong> you have taken more of this medicine than the prescribed dose. Take the medicine pack with you, even if the tablets are out of stock. If you take more Eliquis than recommended, you may be at increased risk of bleeding. If bleeding occurs, surgery, blood transfusions, or other treatment that may reverse anti-factor Xa activity may be required.<\/p>\n\n\n\n If you do not know what to do or if you have missed more than one dose<\/strong>, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n Do not stop taking this medicine without talking to your doctor first. The risk of blood clots can increase if you stop treatment too soon. If you have any further questions on the use of this product, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n Like all medicines, this medicine can cause side effects, although not everybody gets them. Eliquis can be given in three different medical conditions. The known side effects, and the frequencies at which they occur, in these medical conditions, may vary and are listed separately below. In these conditions, the most common side effect of this drug is bleeding, which can be life-threatening and require immediate medical attention. The following side effects are known during treatment with Eliquis to prevent the formation of blood clots after knee or hip surgery.<\/strong> Common side effects (may affect up to 1 in 10 people)<\/strong><\/p>\n\n\n\n Uncommon side effects (may affect up to 1 in 100 people)<\/strong><\/p>\n\n\n\n Rare side effects (may affect up to 1 in 1,000 people)<\/strong><\/p>\n\n\n\n No known frequency (frequency can not be calculated from available data)<\/strong><\/p>\n\n\n\n The following side effects are known during treatment with Eliquis to prevent the formation of blood clots in the heart in patients with an irregular heartbeat and at least one additional risk factor.<\/strong> Common side effects (may affect up to 1 in 10 people)<\/strong><\/p>\n\n\n\n Uncommon side effects (may affect up to 1 in 100 people)<\/strong><\/p>\n\n\n\n Rare side effects (may affect up to 1 in 1,000 people)<\/strong><\/p>\n\n\n\n The following side effects are known during treatment with Eliquis to treat or prevent the recurrence of blood clots in the veins of the legs and blood clots in the blood vessels in the lungs.<\/strong> Common side effects (may affect up to 1 in 10 people)<\/strong><\/p>\n\n\n\n Uncommon side effects (may affect up to 1 in 100 people)<\/strong><\/p>\n\n\n\n Rare side effects (may affect up to 1 in 1,000 people)<\/strong><\/p>\n\n\n\n No known frequency (frequency can not be calculated from available data)<\/strong><\/p>\n\n\n\n Keep out of sight and reach of children. Do not use this medicine after the expiry date which is stated on the carton and blister after EXP. The expiration date is the last day of the specified month. This medicine has no special storage instructions. Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.<\/p>\n\n\n\n The film-coated tablets are yellow, round (5.95 mm in diameter), and marked with \u201c893\u201d on one side and \u201c2\u00bd\u201d on the other side. Not all pack sizes may be marketed. Patient card: instructions for handling<\/strong><\/p>\n\n\n\n The package with Eliquis contains a patient card together with the package leaflet, or your doctor may give you a similar card.<\/p>\n\n\n\n This patient information card may be helpful for you and inform other physicians that you are taking Eliquis. You should always have this card with you.<\/strong> Bristol-Myers Squibb \/ Pfizer EEIG<\/p>\n\n\n\n Plaza 254 Ireland Manufacturer<\/strong><\/p>\n\n\n\n CATALENT ANAGNI SRL<\/p>\n\n\n\n Loc. Fontana del Ceraso snc<\/p>\n\n\n\n Strada Provinciale Casilina, 41<\/p>\n\n\n\n 03012 Anagni (FR)<\/p>\n\n\n\n Italy Pfizer Manufacturing Deutschland GmbH<\/p>\n\n\n\n Company Freiburg<\/p>\n\n\n\n Mooswaldallee 1<\/p>\n\n\n\n 79090 Freiburg<\/p>\n\n\n\n Germany Swords Laboratories T \/ A Bristol-Myers Squibb Pharmaceutical Operations, External Manufacturing Ireland<\/p>\n\n\n\nChildren and young people<\/h2>\n\n\n\n
Other medicines and Eliquis<\/h2>\n\n\n\n
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Eliquis contains lactose (a sugar) and sodium.<\/h2>\n\n\n\n
<\/p>\n\n\n\n3. How to take Eliquis<\/h2>\n\n\n\n
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Stop taking Eliquis. Start treatment with another blood-thinning medicine (such as heparin ) at the time you should have taken the next tablet.
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<\/li>If you take more Eliquis than you should<\/h2>\n\n\n\n
<\/p>\n\n\n\nIf you forget to take Eliquis<\/h2>\n\n\n\n
If you stop taking Eliquis<\/h2>\n\n\n\n
<\/p>\n\n\n\n4. Possible side effects<\/h2>\n\n\n\n
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<\/li><\/ul><\/li><\/ul>\n\n\n\n5. How to store Eliquis<\/h2>\n\n\n\n
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<\/p>\n\n\n\n6. Contents of the packaging and other information<\/h2>\n\n\n\n
Content declaration<\/h2>\n\n\n\n
What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n
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<\/li><\/ul><\/li>Marketing Authorization Holder<\/h2>\n\n\n\n
Blanchardstown Corporate Park 2
Dublin 15, D15 T867<\/p>\n\n\n\n
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Plaza 254
Blanchardstown Corporate Park 2
Dublin 15, D15 T867<\/p>\n\n\n\nBelgium \/ Belgique \/ Belgien<\/strong>NV Bristol-Myers Squibb Belgium SATel: + 32 2 352 76 11<\/td> Lithuania<\/strong>Pfizer Luxembourg SARL branches in LithuaniaTel. +3705 2514000<\/td><\/tr> Bulgaria<\/strong>Pfizer Luxembourg SAAR\u041b, Clone of BulgariaTel: +359 2 970 4333<\/td> Luxembourg \/ Luxemburg<\/strong>NV Bristol-Myers Squibb Belgium SATel: + 32 2 352 76 11<\/td><\/tr> Czech Republic<\/strong>Pfizer, spol. s roTel: + 420-283-004-111<\/td> Hungary<\/strong>Pfizer Kft.Tel .: + 36 1 488 37 00<\/td><\/tr> Denmark<\/strong>Bristol-Myers Squibb DenmarkTel: + 45 45 93 05 06<\/td> Malta<\/strong>Vivian Corporation Ltd.Tel: + 356 21 344610<\/td><\/tr>