{"id":7871,"date":"2021-03-02T07:42:42","date_gmt":"2021-03-02T07:42:42","guid":{"rendered":"https:\/\/zeepedia.com\/?p=7871"},"modified":"2023-01-28T04:24:15","modified_gmt":"2023-01-28T04:24:15","slug":"ebetrex","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/ebetrex\/","title":{"rendered":"Ebetrex &#8211; Methotrexate Uses, Dose, And Side Effects"},"content":{"rendered":"\n<p><strong>Ebetrex 20 mg\/ml&nbsp;solution for injection, methotrexate pre-filled&nbsp;syringe&nbsp;<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Ebetrex Is And What Ebetrex Used For<\/h2>\n\n\n\n<p><strong><span style=\"text-decoration: underline;\">Ebetrex is a drug with the following properties:<\/span><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>It prevents the growth of certain cells in the body that are reproduced quickly (anti-tumor drugs)<\/li><li>It reduces unwanted reactions in the body&#8217;s defense mechanism (immunosuppressive agent) and<\/li><li>It has anti-inflammatory effects<\/li><\/ul>\n\n\n\n<p><span style=\"text-decoration: underline;\"><strong>Ebetrex used for:<\/strong><\/span><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Active\u00a0<a href=\"https:\/\/zeepedia.com\/medical\/diseases\/rheumatoid-arthritis-ra\/\">rheumatoid arthritis<\/a>\u00a0(<a href=\"https:\/\/zeepedia.com\/medical\/diseases\/rheumatoid-arthritis-ra\/\">RA<\/a>) in adults<\/li><li>Polyarticular forms (when five or more joints are affected) of severe, active\u00a0juvenile idiopathic arthritis\u00a0(<a href=\"https:\/\/zeepedia.com\/medical\/diseases\/child-rheumatoid-arthritis-jia\/\">JIA<\/a>) when treatment with non-steroidal anti-inflammatory drugs (\u00a0NSAIDs\u00a0) has not given good results.<\/li><li>Severe therapy-resistant disabling\u00a0psoriasis is not sufficiently improved by other therapies such as light therapy (PUVA) and\u00a0retinoids, and severe\u00a0psoriasis affecting the joints (psoriatic arthritis) in adult patients.<\/li><\/ul>\n\n\n\n<p>Methotrexate contained in Ebetrex may also be approved for treating other conditions not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or another healthcare professional if you have further questions, and always follow their instructions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What You Need To Know Before Using Ebetrex<\/h2>\n\n\n\n<p>Ask your doctor or pharmacist if you have questions about using Ebetrex.<\/p>\n\n\n\n<p><strong>Do not use Ebetrex:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are allergic to methotrexate or any of the other ingredients of this medicine (listed in section 6)<\/li><li>If you have significant kidney disease (the doctor decides how severe the disease is)<\/li><li>If you have significant liver disease (the doctor decides how severe the disease is)<\/li><li>If you have any disorders in the blood formation system<\/li><li>If you consume large amounts of alcohol<\/li><li>If the function of the body&#8217;s immune system is impaired<\/li><li>If you have a severe or active\u00a0infection, e.g.,\u00a0tuberculosis\u00a0and\u00a0HIV<\/li><li>If you have ulcers in the gastrointestinal tract (including ulcers in the oral cavity)<\/li><li>If you are pregnant or breastfeeding (see section &#8220;Pregnancy, breastfeeding and fertility&#8221;)<\/li><li>If you are being vaccinated with live vaccines at the same time.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings And Cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before using Ebetrex again<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>You have\u00a0diabetes mellitus,\u00a0which is treated with\u00a0insulin<\/li><li>You have an inactive\u00a0chronic\u00a0infection\u00a0(such as\u00a0tuberculosis,\u00a0hepatitis\u00a0B or C,\u00a0shingles\u00a0(\u00a0herpes\u00a0zoster))<\/li><li>You have or have had any liver or kidney disease<\/li><li>Your lung function is impaired<\/li><li>You have a pathological accumulation of fluid in the abdominal cavity or the space between the lungs and chest wall (\u00a0ascites, pleural effusions)<\/li><li>You are dehydrated or suffer from conditions that lead to dehydration (vomiting, diarrhea,\u00a0stomatitis\u00a0).<\/li><\/ul>\n\n\n\n<p>Acute\u00a0bleeding from the lungs of patients with the underlying rheumatic disease has been reported with methotrexate.\u00a0Contact your doctor immediately if you experience symptoms such as blood in the saliva or bloody cough.<\/p>\n\n\n\n<p>The treatment should be given\u00a0<strong>once a week.<\/strong> Improper intake of methotrexate can lead to serious\u00a0side effects, including potentially fatal ones.<\/p>\n\n\n\n<p>Read section 3 of this leaflet carefully.<\/p>\n\n\n\n<p>If you have previously had skin problems after radiation therapy (radiation-induced\u00a0dermatitis\u00a0) and burns to the skin after sunbathing, these problems may recur during methotrexate treatment (re-reaction).<\/p>\n\n\n\n<p><strong>Children and young people<\/strong><\/p>\n\n\n\n<p>Dosage instructions depend on the patient&#8217;s body weight.\u00a0Use is not recommended for children &lt;3 Years of age due to a lack of experience in this age group.<\/p>\n\n\n\n<p>Children receiving Ebetrex treatment should be monitored particularly closely by specialist physicians so that any\u00a0side effects\u00a0can be identified as early as possible.<\/p>\n\n\n\n<p><strong>Older<\/strong><\/p>\n\n\n\n<p>Older adults receiving Ebetrex treatment should be monitored closely by a doctor so that any\u00a0side effects\u00a0can be identified as early as possible.\u00a0Dosage,\u00a0one for elderly patients, should be relatively low due to age-related liver and kidney function impairment and low folate reserves.<\/p>\n\n\n\n<p>Skin changes caused by\u00a0psoriasis\u00a0may be exacerbated during treatment with Ebetrex with concomitant UV radiation.<\/p>\n\n\n\n<p><em><strong><span style=\"text-decoration: underline;\">Recommended follow-up examinations and precautions:<\/span><\/strong><\/em><\/p>\n\n\n\n<p>Even when Ebetrex is used at low\u00a0doses, serious\u00a0side effects\u00a0can occur.\u00a0The doctor must perform checks and laboratory tests to detect these early.<\/p>\n\n\n\n<p><strong><span style=\"text-decoration: underline;\"><em>Before starting treatment<\/em>:<\/span><\/strong><\/p>\n\n\n\n<p>Before starting treatment, your doctor will check your blood count, kidney function, and liver function.\u00a0You may have a chest X-ray.\u00a0Other tests can also be performed during and after treatment.\u00a0Be sure to come to the agreed blood tests.<\/p>\n\n\n\n<p>If any test result is abnormal, treatment will not resume until all results are normal again.<\/p>\n\n\n\n<p><em><strong><span style=\"text-decoration: underline;\">Special precautions for treatment with Ebetrex<\/span><\/strong><\/em><\/p>\n\n\n\n<p>Methotrexate temporarily affects sperm and egg production, an effect that, in most cases, decreases after the end of treatment.\u00a0Methotrexate can cause miscarriage and severe congenital malformations.\u00a0You must avoid becoming pregnant while using methotrexate for at least 6 months after stopping treatment.\u00a0See also the section &#8220;Pregnancy, breastfeeding and fertility.&#8221;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other Medicines And Ebetrex<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.&nbsp;Remember to tell your doctor that you are being treated with Ebetrex if you are prescribed another medicine while you are being treated.&nbsp;It is especially important to tell your doctor if you are using:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Other treatments for\u00a0rheumatoid arthritis\u00a0or\u00a0psoriasis, such as leflunomide, sulfasalazine (also used for\u00a0ulcerative colitis\u00a0),\u00a0acetylsalicylic acid, phenylbutazone, or amidopyrine<\/li><li>Alcohol (should be avoided)<\/li><li>Live vaccines<\/li><li>Azathioprine (prevents rejection during organ transplants)<\/li><li>Retinoids\u00a0(for\u00a0psoriasis\u00a0and other skin problems)<\/li><li>Anticonvulsant drugs (for seizures)<\/li><li>Cancer treatment<\/li><li>Barbiturates\u00a0(sleeping pills)<\/li><li>Tranquilizer<\/li><li>Birth control pills<\/li><li>Probenecid (for\u00a0gout\u00a0)<\/li><li>Antibiotics<\/li><li>Pyrimethamine (prevention and treatment of\u00a0malaria\u00a0)<\/li><li>Vitamin preparations containing\u00a0folic acid<\/li><li>Proton pump inhibitor\u00a0(for severe heartburn and\u00a0stomach ulcers\u00a0)<\/li><li>Theophylline (for\u00a0asthma\u00a0).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Ebetrex With Food, Drink, And Alcohol<\/h2>\n\n\n\n<p>It would be best not to drink alcohol during treatment with Ebetrex.\u00a0Avoid drinking too much coffee, caffeinated cold drinks, or black tea.\u00a0Make sure you drink plenty of fluids during treatment with Ebetrex, as dehydration (reduction of body fluids) may increase the harmful effects of Ebetrex.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, Breastfeeding, And Fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p><strong><span style=\"text-decoration: underline;\">Pregnancy<\/span><\/strong><\/p>\n\n\n\n<p>Do not use Ebetrex during pregnancy or if you are trying to get pregnant.\u00a0Methotrexate can cause congenital malformations, congenital disabilities, and miscarriages.\u00a0It is associated with malformations of the skull, face, heart and blood vessels, brain and arms, and legs.\u00a0It is, therefore, very important that methotrexate is not given to pregnant patients or patients planning to become pregnant.<\/p>\n\n\n\n<p>For infertile women, pregnancy must be ruled out by appropriate measures, e.g.,\u00a0a pregnancy test before starting treatment.<\/p>\n\n\n\n<p>You must avoid becoming pregnant while taking methotrexate and for at least 6 months after stopping treatment by using reliable contraception (see the section &#8220;Warnings and precautions&#8221;).<\/p>\n\n\n\n<p>If you become pregnant during treatment or suspect you may be pregnant, talk to your doctor as soon as possible.\u00a0You should be offered medical advice on the risk of harmful effects on the child due to the treatment.<\/p>\n\n\n\n<p>If you wish to become pregnant, consult your doctor, who may refer you to specialist advice before the planned start of treatment.<\/p>\n\n\n\n<p><strong><span style=\"text-decoration: underline;\">Breastfeeding<\/span><\/strong><\/p>\n\n\n\n<p>Do not breastfeed during treatment as methotrexate passes into breast milk.\u00a0If your treating doctor considers methotrexate treatment necessary during breastfeeding, you must stop breastfeeding.<\/p>\n\n\n\n<p><strong><span style=\"text-decoration: underline;\">Fertility\u00a0in men<\/span><\/strong><\/p>\n\n\n\n<p>Available data do not indicate an increased risk of malformations or miscarriages if the father takes less methotrexate than 30 mg\/week.<\/p>\n\n\n\n<p>However, risk cannot be completely ruled out.\u00a0Methotrexate may be genotoxic.\u00a0This means that the drug can cause gene mutation.<\/p>\n\n\n\n<p>Methotrexate can affect sperm production and can cause congenital malformations.\u00a0Therefore, you should avoid getting a woman pregnant and donating sperm while taking methotrexate and for at least 6 months after stopping treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving And Using Machines<\/h2>\n\n\n\n<p>Side effects\u00a0from the\u00a0central nervous system, such as fatigue and dizziness, may occur during treatment with Ebetrex.\u00a0Therefore, the ability to drive vehicles and use machines may sometimes be impaired.\u00a0If you feel tired or dizzy, do not drive or use machines.<\/p>\n\n\n\n<p>You are responsible for assessing whether you can drive a motor vehicle or perform work requiring sharpened attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\u00a0side effects.<\/p>\n\n\n\n<p>Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Ebetrex Contains Sodium Chloride And Sodium Hydroxide<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)\u00a0sodium\u00a0per weekly dose, i.e., essentially &#8216;sodium-free.&#8217;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How To Use Ebetrex<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Important warning regarding the\u00a0single dose\u00a0of Ebetrex (methotrexate):<\/strong><ul><li>Ebetrex should only be used once a week\u00a0to treat rheumatoid\u00a0arthritis,\u00a0juvenile idiopathic arthritis,\u00a0and\u00a0psoriasis.\u00a0Using too much Ebetrex (methotrexate) can be life-threatening.\u00a0Read section 3 of this leaflet very carefully.\u00a0If you have any further questions about the use of this product, ask your doctor or pharmacist.<\/li><\/ul><ul><li>Ebetrex should only be prescribed by a doctor with sufficient experience in the drug&#8217;s properties and mechanism of action.<\/li><li>Always use this medicine exactly as your doctor or pharmacist has told you.\u00a0Ask your doctor or pharmacist if you are unsure.<\/li><li>Ebetrex is given\u00a0<strong>only once a week<\/strong>.\u00a0You will agree with your doctor on a suitable day of the week when you will receive your\u00a0injection.<\/li><li>Improper intake of Ebetrex can lead to serious\u00a0side effects, including potentially fatal ones.<\/li><\/ul><\/li><li><strong>The usual\u00a0dose\u00a0is:<\/strong><ul><li><strong><em>Patients with\u00a0rheumatoid arthritis<\/em><\/strong><ul><li>The recommended starting dose is 7.5 mg of methotrexate once a week.\u00a0Ebetrex is injected as a single dose under the skin, into a muscle, or into a vein (see section &#8220;Method of administration and duration of treatment&#8221;).<\/li><li>If the effect is still insufficient, the\u00a0dose of\u00a0one of Ebetrex may be increased if it is well tolerated.\u00a0The average weekly dose is 15\u201120 mg.\u00a0In general, a weekly dose of 25 mg should not be exceeded.\u00a0After the desired treatment goal has been achieved, the\u00a0dose\u00a0should, if possible, be reduced to the lowest still effective maintenance dose.<\/li><li><em>Children and adolescents under 16 years of age with polyarticular forms of\u00a0juvenile idiopathic arthritis<\/em><\/li><li>The recommended\u00a0dose\u00a0is 10\u201115 mg \/ m\u00a0<sup>2<\/sup>\u00a0body surface area\/week.\u00a0If the recommended\u00a0dose\u00a0is insufficient, the weekly dose can be increased up to 20 mg \/ m\u00a02\u00a0body surface area\/week.\u00a0However, regular inspections should be carried out more often.<\/li><li>As there are only limited data on\u00a0intravenous\u00a0(in a vein) use in children and adolescents,\u00a0the administration\u00a0should only be by\u00a0subcutaneous\u00a0injection\u00a0(under the skin) or\u00a0intramuscularly\u00a0(in a muscle).<\/li><li>Use is not recommended for children &lt;3 Years of age due to a lack of experience in this age group.<\/li><li><em>Adults with severe forms of\u00a0psoriasis\u00a0Vulgaris or psoriatic arthritis<\/em><\/li><li>A 5-10 mg test dose is recommended to evaluate any adverse effects.<\/li><li>This\u00a0dose\u00a0can be injected\u00a0subcutaneously\u00a0(under the skin),\u00a0intramuscularly\u00a0(into a muscle), or\u00a0intravenously\u00a0(into a vein).<\/li><li>If no changes in the blood picture have been observed after one week, treatment is continued with approximately 7.5 mg.\u00a0The dose\u00a0can be increased gradually (in steps of 5-7.5 mg per week while monitoring the blood count) until optimal treatment results are achieved.\u00a0A weekly dose of 20 mg can generally be associated with a\u00a0significant\u00a0increase in\u00a0toxicity.\u00a0A weekly dose of 30 mg should not be exceeded.<\/li><li>After achieving the desired treatment goal, the\u00a0dose\u00a0should\u00a0be reduced weekly to the lowest effective maintenance\u00a0dose.<\/li><\/ul><\/li><\/ul><\/li><li><em><strong><span style=\"text-decoration: underline;\">Patients with renal impairmen<\/span>t<\/strong><\/em><ul><li>For patients with renal impairment, a\u00a0dose\u00a0may\u00a0need to be reduced.<\/li><li><em>Method of administration and duration of treatment<\/em><\/li><li>The attending physician decides how long the treatment should last.\u00a0Ebetrex is injected\u00a0once a week!\u00a0You and your doctor must determine a fixed day of the week for\u00a0injection.<\/li><li>Ebetrex is injected under the skin, into a muscle, or a vein and must not be given\u00a0intravenously\u00a0to children and adolescents.<\/li><li>Treatment with Ebetrex in\u00a0rheumatoid arthritis,\u00a0juvenile idiopathic arthritis,\u00a0psoriasis\u00a0Vulgaris or psoriatic arthritis is a long-term treatment.<\/li><\/ul><\/li><li><em><strong><span style=\"text-decoration: underline;\">Rheumatoid arthritis<\/span><\/strong><\/em><ul><li>Treatment response can usually be expected 4-8 weeks after starting treatment.<\/li><li>Symptoms may return after stopping treatment with Ebetrex.<\/li><li><em>Severe forms of\u00a0psoriasis\u00a0Vulgaris<\/em> and psoriatic arthritis (\u00a0psoriasis\u00a0arthropathic<em>)<\/em><\/li><li>Treatment response can usually be expected after 2-6 weeks.<\/li><li>Treatment may be continued or terminated depending on the clinical picture and laboratory values changes.<\/li><li>At the beginning of treatment, Ebetrex is injected by healthcare professionals.\u00a0However, your doctor may decide that it is appropriate for you to learn how to inject Ebetrex under your skin.\u00a0You will receive appropriate training to be able to do this.\u00a0Under no circumstances should you try to inject yourself if you have not been trained.<\/li><\/ul><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If You Use More Ebetrex Than You Should<\/h2>\n\n\n\n<p>Follow your doctor&#8217;s dosing recommendations.\u00a0Do not change the\u00a0dose\u00a0on your own. If you have ingested too much medicine or if, e.g.,\u00a0a child has inadvertently ingested the medicine, contact a doctor, hospital, or the Poison Information Center for risk assessment and advice.<\/p>\n\n\n\n<p>Overdose of methotrexate may cause severe adverse effects.\u00a0Overdose symptoms may include <\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Bruising or bleeding<\/li><li>Abnormal weakness<\/li><li>Cold sores<\/li><li>Nausea<\/li><li>Vomiting<\/li><li>Black or bloody stools<\/li><li>Bloody coughs<\/li><li>Vomiting similar to coffee grounds<\/li><li>Decreased urination<\/li><\/ul>\n\n\n\n<p>See also section 4. Take the medicine pack with you if you see a doctor or hospital. The antidote for an overdose is calcium folinate.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If You Forget To Use Ebetrex<\/h2>\n\n\n\n<p>Do not take a double&nbsp;dose&nbsp;to make up for a forgotten&nbsp;dose, but continue to take your prescribed&nbsp;dose.&nbsp;Ask your doctor for advice.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If You Stop Using Ebetrex<\/h2>\n\n\n\n<p>It would be best if you did not stop or stop taking Ebetrex unless you have discussed it with your doctor.\u00a0Contact a doctor immediately if you suspect serious\u00a0side effects.<\/p>\n\n\n\n<p>If you have any further questions about the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible Ebetrex Side Effects<\/h2>\n\n\n\n<p>This medicine can cause side effects like all medicines, although not everybody gets them.<\/p>\n\n\n\n<p>Tell your doctor immediately if you experience <\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Sudden wheezing<\/li><li>Difficulty breathing<\/li><li>Eyelids, face, or lips swelling, rash, or\u00a0itching\u00a0(especially if it affects the whole body)<\/li><li>Fainting (this may be a sign of severe allergic reactions or anaphylactic\u00a0shock\u00a0)<\/li><\/ul>\n\n\n\n<p>Serious&nbsp;side effects&nbsp;are<\/p>\n\n\n\n<p>If any of the following&nbsp;side effects&nbsp;occur, contact your doctor immediately:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Lung problems (with symptoms such as general malaise, <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cough-in-children\/\">dry cough<\/a>, shortness of breath, shortness of breath at rest, chest pain, or fever)<\/li><li>Blood in saliva or cough<\/li><li>Severe blisters or flaky skin (this may also affect the mouth, eyes, or genitals)<\/li><li>Abnormal bleeding (including bloody vomiting) or bruising<\/li><li>Severe diarrhea<\/li><li>Cold sores<\/li><li>Black or tar-like stools<\/li><li>Blood in the urine or feces<\/li><li>Pin-sized red dots on the skin<\/li><li>Fever<\/li><li>Yellowing of the skin (jaundice)<\/li><li>Difficult or painful to urinate<\/li><li>Swelling of the hands, ankles, or feet or changes in how often you need to urinate or a decrease or lack of urine (signs of\u00a0kidney failure\u00a0)<\/li><li>Thirst and frequent urination<\/li><li>Cramps<\/li><li>Unconsciousness<\/li><li>Blurred vision or impaired vision<\/li><\/ul>\n\n\n\n<p>The following\u00a0side effects\u00a0have also been reported:<\/p>\n\n\n\n<p><strong>Very common (may affect more than 1 user in 10):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Loss of appetite<\/li><li>Nausea<\/li><li>Vomiting<\/li><li>Abdominal pain<\/li><li>Inflammation\u00a0and sores in the mouth and throat<\/li><li>Increase in liver enzymes.<\/li><\/ul>\n\n\n\n<p><strong>Common (may affect up to 1 in 10 people):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Reduced\u00a0blood cell formation with decreased number of white and\u00a0red blood cells\u00a0and\u00a0platelets\u00a0(\u00a0leukopenia,\u00a0anemia,\u00a0thrombocytopenia\u00a0)<\/li><li>Headache<\/li><li>Fatigue<\/li><li>Drowsiness<\/li><li>Irritating, tingling, stinging, or burning sensation in the skin<\/li><li>Rash<\/li><li>Reddening of the skin<\/li><li>Itching<\/li><li>Pneumonia\u00a0(\u00a0Pneumonitis\u00a0)<\/li><li>Diarrhea<\/li><\/ul>\n\n\n\n<p><strong>Uncommon (may affect up to 1 in 100 people):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Shingles\u00a0(\u00a0herpes\u00a0zoster)<\/li><li>Lymphoma\u00a0(a type of lymph node cancer) (which spontaneously recurred in several patients as soon as treatment with Ebetrex was stopped)<\/li><li>Reduction in the number of\u00a0blood cells\u00a0and\u00a0platelets<\/li><li>Severe allergic reactions<\/li><li>Diabetes<\/li><li>Depression<\/li><li>Weakness in the entire left or right half of the body<\/li><li>Dizziness<\/li><li>Confusion<\/li><li>Cramps<\/li><li>Brain damage (leukoencephalopathy\/encephalopathy)<\/li><li>Inflammation\u00a0of blood vessels<\/li><li>Lung damage, water around the lungs<\/li><li>Ulcers and bleeding in the gastrointestinal tract<\/li><li>Inflammation\u00a0of the pancreas<\/li><li>Liver problem<\/li><li>Decreasing blood proteins<\/li><li>Hives\u00a0(only)<\/li><li>Photosensitivity<\/li><li>Tanning of the skin<\/li><li>Severe toxic skin reactions, including blistering and loosening of the upper layer of the skin (\u00a0Stevens-Johnson syndrome,\u00a0Lyell&#8217;s syndrome\u00a0)<\/li><li>Hair loss<\/li><li>Increase in rheumatic nodules (lumps under the skin)<\/li><li>Painful\u00a0psoriasis<\/li><li>Joint or muscle pain<\/li><li>Osteoporosis\u00a0(decreased bone mass)<\/li><li>Inflammation\u00a0and ulcers in the bladder (possibly with blood in the urine)<\/li><li>Painful urination<\/li><li>Fetal malformations<\/li><li>Inflammation\u00a0and ulcers in the\u00a0vagina<\/li><li>Burning sensation or\u00a0tissue\u00a0damage\u00a0after\u00a0injection\u00a0of Ebetrex into the muscle<\/li><\/ul>\n\n\n\n<p><strong>Rare (may affect up to 1 in 1,000 people):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Sepsis\u00a0(blood poisoning)<\/li><li>Very large\u00a0red blood cells\u00a0(megaloblastic\u00a0anemia\u00a0)<\/li><li>Mood swings<\/li><li>Temporary problems with perception (sensory impressions)<\/li><li>The weakening of well-controlled movements throughout the body<\/li><li>Trouble speaking<\/li><li>Serious eye problems<\/li><li>Low\u00a0blood pressure<\/li><li>Blood clots<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/sore-throat\/\">Sore throat<\/a><\/li><li>Respiratory arrest<\/li><li>Inflammation\u00a0of the gastrointestinal tract<\/li><li>Bloody stools<\/li><li>Inflammation\u00a0of the gums<\/li><li>Acute\u00a0hepatitis\u00a0(inflammation of the liver)<\/li><li>Discoloration of the nails, nail detachment<\/li><li>Acne, red or purple spots on the skin caused by bleeding from blood vessels<\/li><li>Bone fracture due to exertion<\/li><li>Electrolyte disturbances<\/li><li>Miscarriage<\/li><li>Defective\u00a0sperm formation<\/li><li>Menstrual disorders<\/li><\/ul>\n\n\n\n<p><strong>Very rare (may affect up to 1 in 10,000 people):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Cold sores (\u00a0herpes\u00a0simplex)<\/li><li>Hepatitis\u00a0(\u00a0inflammation\u00a0of the liver)<\/li><li>Severe bone marrow failure<\/li><li>Immunodeficiency (\u00a0hypogammaglobulinemia\u00a0)<\/li><li>pain<\/li><li>Muscle weakness<\/li><li>Taste changes (metallic taste)<\/li><li>Inflammation\u00a0of the meninges leads to paralysis or vomiting<\/li><li>Red eyes<\/li><li>Inflammation\u00a0of the sac around the heart<\/li><li>Fluid in the sac around the heart<\/li><li>Pneumonia, difficulty breathing<\/li><li>Asthma<\/li><li>Vomiting blood<\/li><li>Liver failure<\/li><li>Infection\u00a0around a fingernail<\/li><li>Boils<\/li><li>Small blood vessels in the skin<\/li><li>Protein\u00a0in the urine<\/li><li>Fetal death<\/li><li>Problems forming eggs (women) and sperm (men)<\/li><li>Decreased sex drive<\/li><li>Problems getting\u00a0an erection<\/li><li>Discharge from the vagina<\/li><li>Infertility<\/li><li>Mild local skin reactions if Ebetrex is given under the skin<\/li><li>Lymphoproliferative disorders (abnormal growth of\u00a0white blood cells\u00a0)<\/li><li>the feeling of numbness or crawling \/ lower sensitivity to stimulation than normal.<\/li><\/ul>\n\n\n\n<p>Has been reported (occurs in an unknown number of users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The infection,\u00a0which in some cases can be fatal<\/li><li>Swollen\u00a0lymph nodes<\/li><li>The immune system is not working properly<\/li><li>Fever<\/li><li>Inflammation\u00a0of small blood vessels caused by an\u00a0allergic reaction<\/li><li>Inflammation\u00a0of the gastric mucosa<\/li><li>Slow wound healing<\/li><li>Bleeding from the lungs<\/li><li>Bone damage in the jaw (as a result of abnormal growth of\u00a0white blood cells\u00a0)<\/li><li>Tissue destruction at the injection site<\/li><li>Reddening of the skin and scaly skin<\/li><li>Swelling<\/li><\/ul>\n\n\n\n<p>When methotrexate is given\u00a0intramuscularly, it is common for local\u00a0side effects(burning sensation) or damage (formation of\u00a0a sterile\u00a0abscess, destruction of fatty tissue) to occur at the injection site.<\/p>\n\n\n\n<p>Subcutaneous\u00a0application of methotrexate is well tolerated locally.\u00a0<\/p>\n\n\n\n<p>Only mild skin reactions have been observed, which subside during treatment.<\/p>\n\n\n\n<p>Methotrexate may cause a decrease in the number of\u00a0white blood cells,\u00a0and your resistance to\u00a0infection\u00a0may be weakened.\u00a0<\/p>\n\n\n\n<p>Get an infection with symptoms such as fever and severe deterioration of your general condition or with local infection symptoms such as sore throat \/ sore throat\/pain in the mouth or problems with urination. <\/p>\n\n\n\n<p>You should contact your doctor immediately.\u00a0Your doctor will take a blood test to check for a possible decrease in\u00a0white blood cell count\u00a0(\u00a0agranulocytosis).\u00a0You must tell your doctor about your medicine.<\/p>\n\n\n\n<p>Methotrexate can cause serious (sometimes life-threatening)\u00a0side effects.\u00a0<\/p>\n\n\n\n<p>Therefore, your doctor will perform tests to check if there is anything abnormal in your blood (e.g., low\u00a0white blood cell count, low\u00a0platelet count,\u00a0lymphoma\u00a0) and changes in your kidneys or liver.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How To Store Ebetrex<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Keep this medicine out of sight and reach of children.<\/li><li>Do not use this medicine after the pre-filled syringe&#8217;s expiry date is stated on the label and the carton after EXP.\u00a0The expiration date is the last day of the specified month.<\/li><li>Store in the original package.\u00a0Sensitive to light.<\/li><li>Do not store above 25 \u00b0 C.<\/li><li>Must be used immediately after opening.<\/li><li>Do not use Ebetrex if the solution is not clear or contains particles.<\/li><li>For single use only.\u00a0New solutions should be discarded.<\/li><\/ul>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.\u00a0Ask your pharmacist how to dispose of medicines that are no longer required.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents Of The Packaging And Other Information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content Declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is methotrexate.<\/li><li>1 ml\u00a0solution for injection\u00a0contains 20 mg methotrexate (as 21.94 mg methotrexate disodium).<\/li><li>1 pre-filled\u00a0syringe\u00a0with 0.375 ml\u00a0solution for injection\u00a0contains 7.5 mg methotrexate.<\/li><li>1 pre-filled\u00a0syringe\u00a0with 0.5 ml\u00a0solution for injection\u00a0contains 10 mg methotrexate.<\/li><li>1 pre-filled\u00a0syringe\u00a0with 0.625 ml\u00a0solution for injection\u00a0contains 12.5 mg methotrexate.<\/li><li>1 pre-filled\u00a0syringe\u00a0with 0.75 ml\u00a0solution for injection\u00a0contains 15 mg methotrexate.<\/li><li>1 pre-filled\u00a0syringe\u00a0with 0.875 ml\u00a0solution for injection\u00a0contains 17.5 mg methotrexate.<\/li><li>1 pre-filled\u00a0syringe\u00a0with 1 ml\u00a0solution for injection\u00a0contains 20 mg methotrexate.<\/li><li>1 pre-filled\u00a0syringe\u00a0with 1.125 ml\u00a0solution for injection\u00a0contains 22.5 mg methotrexate.<\/li><li>1 pre-filled\u00a0syringe\u00a0with 1.25 ml\u00a0solution for injection\u00a0contains 25 mg methotrexate.<\/li><li>1 pre-filled\u00a0syringe\u00a0with 1.375 ml\u00a0solution for injection\u00a0contains 27.5 mg methotrexate.<\/li><li>1 pre-filled\u00a0syringe\u00a0with 1.5 ml\u00a0solution for injection\u00a0contains 30 mg methotrexate.<\/li><li>The other ingredients are <ul><li>Sodium chloride<\/li><li>Sodium hydroxide (for\u00a0pH\u00a0adjustment)<\/li><li>Water for injections<\/li><\/ul><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What The Medicine Looks Like And The Contents Of The Pack<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Ebetrex\u00a0solution for injection is\u00a0supplied in pre-filled syringes as a clear, yellowish solution for\u00a0injection.<\/li><li>Each carton contains 1 pre-filled\u00a0syringe\u00a0with 0.375 ml, 0.5 ml, 0.625 ml, 0.75 ml, 0.875 ml, 1 ml, 1.125 ml, 1.25 ml, 1.375 ml, or 1.5 ml\u00a0solution for injection, disposable injection needles with or without safety needle, and alcohol swabs.<\/li><li>Multiple packs contain 4, 5, 6, 1,2, or 30 pre-filled syringes (1 pre-filled\u00a0syringe\u00a0per carton).<\/li><li>Not all pack sizes may be marketed.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder And Manufacturer<\/h2>\n\n\n\n<p>EBEWE Pharma Ges.mbH Nfg.KG, Mondseestrasse 11, 4866 Unterach, Austria<\/p>\n\n\n\n<p><em>Agent<\/em><\/p>\n\n\n\n<p>Sandoz A \/ S, Edvard Thomsens Vej 14, 2300 Copenhagen S, Denmark<br><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ebetrex is used to treat leukemia and cancers of the breast, skin, head &#038; neck, lung, and uterus. It is also used to treat people with severe psoriasis and rheumatoid arthritis.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2205,2200],"tags":[4862,4865,4864,2216,2213,4858,4861,4860,4863,4859],"class_list":["post-7871","post","type-post","status-publish","format-standard","hentry","category-e","category-medicines","tag-ebetrex","tag-ebetrex-injection","tag-ebetrex-side-effects","tag-injections","tag-medicines","tag-methotrexate","tag-methotrexate-injection","tag-methotrexate-side-effects","tag-what-is-ebetrex","tag-what-is-methotrexate"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7871","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=7871"}],"version-history":[{"count":108,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7871\/revisions"}],"predecessor-version":[{"id":46924,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7871\/revisions\/46924"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=7871"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=7871"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=7871"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}