200 mg\u00a0injection, solution in a prefilled\u00a0pen\u00a0
dupilumab<\/p>\n\n\n\n
What Dupixent is<\/strong><\/p>\n\n\n\n Dupixent contains the active substance dupilumab. Dupilumab is a monoclonal antibody (a type of specialized protein ) that blocks the action of the proteins IL-4 and IL-13. Both play an important role in causing the signs and symptoms of asthma. What Dupixent is used for<\/strong><\/p>\n\n\n\n Dupixent is used to treat adults and adolescents aged 12 years and older with moderate to severe atopic dermatitis, also called atopic eczema. Dupixent is also used to treat children aged 6 to 11 years with severe atopic dermatitis (see section Children and adolescents). Dupixent can be used alone or with eczema medicines that you apply to the skin. Dupixent is used in combination with other asthma medicines for the maintenance treatment of severe asthma in adults and adolescents (12 years and older) whose asthma is not controlled by their current asthma medicine. How Dupixent works<\/strong><\/p>\n\n\n\n Using Dupixent for atopic dermatitis ( atopic eczema ) may improve the condition of the skin and reduce itching. Dupixent has also been shown to relieve the symptoms of pain, anxiety, and depression associated with atopic dermatitis. Also, Dupixent reduces sleep disorders and provides an improved quality of life. Dupixent helps prevent severe asthma attacks ( exacerbations ) and can improve breathing. Dupixent can also help reduce the amount of another group of medicines you need to control your asthma, called oral corticosteroids while preventing severe asthma attacks and improving breathing. Talk to your doctor, pharmacist, or nurse before using Dupixent. Dupixent is not an emergency medicine<\/strong> and should not be used to treat a sudden asthma attack. Allergic reactions<\/strong><\/p>\n\n\n\n Eosinophilic conditions<\/strong><\/p>\n\n\n\n Parasite infections (in the intestinal tract)<\/strong><\/p>\n\n\n\n Asthma<\/strong><\/p>\n\n\n\n If you have asthma and use asthma medications, do not change or stop them without discussing them with your doctor. Talk to your doctor before stopping Dupixent or if your asthma remains uncontrolled or worsens during treatment with this medicine. Eye problems<\/strong><\/p>\n\n\n\n Talk to your doctor if you experience new or worsening eye problems, including eye pain or vision changes.<\/p>\n\n\n\n Tell your doctor or pharmacist<\/p>\n\n\n\n Other medicines for asthma<\/strong><\/p>\n\n\n\n Do not stop or reduce the dose of your asthma medicine unless your doctor tells you to.<\/p>\n\n\n\n Dupixent is unlikely to affect your ability to drive or use machines.<\/p>\n\n\n\n This medicine contains less than 1 mmol sodium (23 mg) per 200 mg dose, ie essentially ‘ sodium-free’. it is basically “sodium-free”.<\/p>\n\n\n\n Always use this medicine exactly as your doctor or pharmacist has told you. Ask your doctor or pharmacist if you are unsure. How Dupixent is given<\/strong><\/p>\n\n\n\n Dupixent is given by injection under the skin ( subcutaneous injection ). How much Dupixent you will get<\/strong><\/p>\n\n\n\n Your doctor will decide which dose of Dupixent is right for you. The recommended dose in adolescents with atopic dermatitis<\/strong><\/p>\n\n\n\n The recommended dose of Dupixent for adolescents (12 to 17 years) with atopic dermatitis is based on body weight: <\/p>\n\n\n\n The recommended dose in children with atopic dermatitis<\/strong><\/p>\n\n\n\n The recommended dose of Dupixent for adolescents (6 to 11 years) with atopic dermatitis is based on body weight: <\/p>\n\n\n\n * Dose one can be increased to 200 mg every two weeks based on a doctor’s assessment. The recommended dose in adults and adolescents with asthma (12 years and older)<\/strong><\/p>\n\n\n\n For most patients with severe asthma, the recommended dose is one of Dupixent:<\/p>\n\n\n\n For patients with severe asthma who receive oral corticosteroids or for patients with severe asthma and concomitant moderate to severe atopic dermatitis or adults with concomitant severe chronic sinusitis with nasal polyps, the recommended dose is one of Dupixent:<\/p>\n\n\n\n Injection of Dupixent<\/strong><\/p>\n\n\n\n Dupixent is given by injection under the skin ( subcutaneous injection ). You and your doctor or nurse will decide together whether to inject Dupixent yourself. Before you inject Dupixent yourself, you must have been trained by your doctor or nurse. Your healthcare provider may also give you Dupixent after being trained by a doctor or nurse. Each pre-filled pen contains a dose of Dupixent (200 mg). Do not shake the pre-filled pen. Read the “Instructions for use” for the pre-filled pen carefully before using Dupixent.<\/p>\n\n\n\n If you take more Dupixent than you should or if you have been given a dose too soon, talk to your doctor, pharmacist, or nurse.<\/p>\n\n\n\n If you forget to inject a dose of Dupixent, talk to your doctor, pharmacist, or nurse.<\/p>\n\n\n\n Do not stop using Dupixent without talking to your doctor first. If you have any further questions on the use of this product, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n Like all medicines, this medicine can cause side effects, although not everybody gets them. Dupixent can cause serious side effects, such as very rare allergic (hypersensitivity) reactions including anaphylactic reactions. Signs of an allergic reaction or anaphylactic reaction may include:<\/p>\n\n\n\n If you develop an allergic reaction, stop using Dupixent and talk to your doctor straight away. Other side effects are<\/strong> Very common<\/strong> (may affect more than 1 user in 10) for atopic dermatitis and asthma:<\/p>\n\n\n\n Common<\/strong> (may affect up to 1 in 10 people) for atopic dermatitis only:<\/p>\n\n\n\n Uncommon<\/strong> (may affect up to 1 in 100 people):<\/p>\n\n\n\n No known frequency<\/strong><\/p>\n\n\n\n The following side effects have been reported with post-marketing experience with Dupixent, however, the frequency with which they have been reported is unknown:<\/p>\n\n\n\n Keep this medicine out of the sight and reach of children. Do not use this medicine after the expiry date which is stated on the label and carton after EXP. The expiration date is the last day of the specified month. Store in a refrigerator (2 \u00b0 C to 8 \u00b0 C). If required, pre-filled pens can be stored at room temperature for up to 25 \u00b0 C for a maximum of 14 days. Do not store above 25 \u00b0 C. If you need to remove the carton from the refrigerator permanently, write the date of removal from the refrigerator at the designated place on the carton, and use Dupixent within 14 days. Store in the original package. Sensitive to light. Do not use this medicine if the solution is cloudy, discolored, or contains particles. Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.<\/p>\n\n\n\n Dupixent is a clear to slightly opalescent, colorless to pale yellow solution in a pre-filled pen. Dupixent is available as 200 mg pre-filled pens in packs containing 1, 2, 3, or 6 pre-filled pens. Not all pack sizes may be marketed.<\/p>\n\n\n\n Sanofi-aventis group<\/p>\n\n\n\n 54, rue La Bo\u00e9tie<\/p>\n\n\n\n 75008 Paris<\/p>\n\n\n\n France Manufacturer<\/strong><\/p>\n\n\n\n SANOFI WINTHROP INDUSTRY<\/p>\n\n\n\n 1051 Boulevard Industriel,<\/p>\n\n\n\n 76580 LE TRAIT,<\/p>\n\n\n\n FRANCE Sanofi-Aventis Deutschland GmbH<\/p>\n\n\n\n Br\u00fcningstrasse 50<\/p>\n\n\n\n Industrial park Hoechst<\/p>\n\n\n\n 65926 FRANKFURT AM MAIN<\/p>\n\n\n\n GERMANY Contact the representative of the marketing authorization holder to find out more about this medicine: Sanofi AB<\/p>\n\n\n\n Tel: +46 (0) 8 634 50 00 Dupixent contains the active substance dupilumab.. Dupilumab is a monoclonal antibody (a type of specialized protein ) that blocks the action of the proteins IL-4 and IL-13. Both play an important role in causing the signs and symptoms of asthma.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2204,2200],"tags":[4966,4969,4968,4970,4973,4972,2215,2213,4967,4971],"class_list":["post-7809","post","type-post","status-publish","format-standard","hentry","category-d","category-medicines","tag-dupilumab","tag-dupilumab-injection","tag-dupilumab-side-effects","tag-dupixent","tag-dupixent-injection","tag-dupixent-side-effects","tag-injection","tag-medicines","tag-what-is-dupilumab","tag-what-is-dupixent"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7809","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=7809"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7809\/revisions"}],"predecessor-version":[{"id":10817,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7809\/revisions\/10817"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=7809"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=7809"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=7809"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
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<\/p>\n\n\n\n2. What you need to know before using Dupixent<\/h2>\n\n\n\n
Do not use Dupixent<\/h2>\n\n\n\n
Warnings and cautions<\/h2>\n\n\n\n
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Other medicines and Dupixent<\/h2>\n\n\n\n
Pregnancy and breastfeeding<\/h2>\n\n\n\n
Driving and using machines<\/h2>\n\n\n\n
Dupixent contains sodium<\/h2>\n\n\n\n
3. How to use Dupixent<\/h2>\n\n\n\n
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<\/p>\n\n\n\nPatient’s body weight<\/strong><\/td> Initial <\/strong> dose<\/strong><\/td> Followers <\/strong>island <\/strong>FOLLOWS dose s (every two weeks)<\/strong><\/td><\/tr> less than 60 kg<\/td> 400 mg (two 200 mg injections)<\/td> 200 mg<\/td><\/tr> 60 kg or more<\/td> 600 mg (two 300 mg injections)<\/td> 300 mg<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n Bodyweight (kg)<\/strong><\/td> Initial <\/strong> dose<\/strong><\/td> Followers island FOLLOWS does you<\/strong><\/td><\/tr> 15 kg to less than 60 kg<\/td> 300 mg (a 300 mg injection ) on day 1, followed by 300 mg on day 15<\/td> 300 mg was f <\/strong>\u00e4 <\/strong>RDE * week,<\/strong> starting 4 weeks after dose day 15 <\/td><\/tr> 60 kg or more<\/td> 600 mg (two 300 mg injections)<\/td> 300 mg every two weeks<\/strong><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n
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<\/p>\n\n\n\nIf you use more Dupixent then you should <\/h2>\n\n\n\n
If you forget to use Dupixent<\/h2>\n\n\n\n
If you stop using Dupixent<\/h2>\n\n\n\n
<\/p>\n\n\n\n4. Possible side effects<\/h2>\n\n\n\n
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<\/p>\n\n\n\n5. How to store Dupixent<\/h2>\n\n\n\n
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<\/p>\n\n\n\n6. Contents of the packaging and other information<\/h2>\n\n\n\n
Content declaration<\/h2>\n\n\n\n
What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n
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<\/p>\n\n\n\nMarketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n
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