{"id":7654,"date":"2021-02-26T08:58:37","date_gmt":"2021-02-26T08:58:37","guid":{"rendered":"https:\/\/zeepedia.com\/?p=7654"},"modified":"2023-02-27T08:39:48","modified_gmt":"2023-02-27T08:39:48","slug":"dolcontin-unotard","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/dolcontin-unotard\/","title":{"rendered":"Dolcontin Unotard &#8211; Morphine Sulphate Pentahydrate Uses, Dose And Side Effects"},"content":{"rendered":"\n<p><strong>Dolcontin 30 mg, 60 mg, 90 mg, 120 mg, 150 mg, 200 mg\u00a0Prolonged Release Morphine Sulphate Pentahydrate Hard\u00a0Capsules<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What is Dolcontin Unotard, And What Is It Used For?<\/h2>\n\n\n\n<p>Morphine has a strong analgesic effect.\u00a0<strong>Dolcontin Unotard is used for severe pain such as <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/getting-a-cancer-message\/\">cancer<\/a> pain<\/strong>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What You Need To Know Before Using Dolcontin Unotard?<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do Not Use Dolcontin Unotard<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are allergic to the active substance or any of the other ingredients of this medicine (listed in section 6).<\/li><li>Impaired respiratory function<\/li><li>Head injury<\/li><li>Intestinal upset<\/li><li>Severe abdominal pain<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/constipation\/\">Constipation<\/a><\/li><li>Acute\u00a0liver disease<\/li><li>Cramps<\/li><li>Chronic\u00a0respiratory diseases such as\u00a0asthma<\/li><li>Anxiety disorder under the influence of alcohol and sleeping pills<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings And Cautions:<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before using Dolcontin Unotard. Tell your doctor if you have the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Impaired thyroid function<\/li><li>Impaired liver or kidney function<\/li><li>Increased pressure in the skull<\/li><li>Low\u00a0blood pressure\u00a0due to a reduced blood volume<\/li><li>The disease of the bile ducts or urinary tract<\/li><li>Inflammation\u00a0of the pancreas (\u00a0pancreatitis\u00a0)<\/li><li>Inflammatory\u00a0bowel disease<\/li><li>The condition with a lot of mucus in the airways<\/li><li>Enlarged\u00a0prostate<\/li><li>Impaired adrenal cortex function<\/li><\/ul>\n\n\n\n<p>If a total blockage in the bowel occurs, treatment should be discontinued.\u00a0<em>However, always consult your doctor before changing the medication.<\/em><\/p>\n\n\n\n<p>Stop taking Dolcontin Unotard and contact your doctor immediately if you get any of the following symptoms (&nbsp;anaphylactic reaction&nbsp;):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Swelling of the face, tongue, or throat<\/li><li>Difficulty swallowing<\/li><li>Hives\u00a0and difficulty breathing<\/li><\/ul>\n\n\n\n<p>Talk to your doctor or pharmacist if you experience any of the following symptoms while taking Dolcontin Unotard:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Increased pain sensitivity even though you are taking increased\u00a0doses(hyperalgesia).\u00a0Your doctor will decide if you must change the\u00a0dose\u00a0or switch to another analgesic solid\u00a0(painkiller) (see section 2).<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>Weakness, fatigue, loss of appetite, nausea, vomiting, or low\u00a0blood pressure.\u00a0This may be a symptom that the adrenal glands produce too little of the\u00a0hormone\u00a0et\u00a0cortisol, and you may therefore need to take hormone supplements.<\/li><li>Loss of\u00a0libido,\u00a0impotence, missed periods.\u00a0This may be due to decreased production of sex hormones.<\/li><li>If you have once been addicted to drugs or alcohol.\u00a0Also, tell us if you feel you are becoming addicted to Dolcontin Unotard while using it.\u00a0You may have started thinking a lot about when you can take the next\u00a0dose, even if you do not need it for the pain.<\/li><li>Withdrawal symptoms or addiction.\u00a0The most common withdrawal symptoms are mentioned in section 3. If this happens, your doctor may change the type of medicine or the times between\u00a0doses.<\/li><\/ul>\n\n\n\n<p>The effects of Dolcontin Unotard may lead to addiction.\u00a0Proper use with prolonged, severe pain reduces the risk of addiction.<br>Drink alcohol while taking Dolcontin Unotard. It may make you feel more sleepy or increase the risk of serious\u00a0side effects\u00a0such as\u00a0shallow breathing with a risk of respiratory arrest and unconsciousness.\u00a0You should not drink alcohol while taking Dolcontin Unotard.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other Medicines And Dolcontin Unotard:<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take other medicines. You must tell your doctor or pharmacist if you are taking the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Rifampicin to e.g.\u00a0treat\u00a0tuberculosis<\/li><li>Other strong painkillers (opioids)<\/li><li>Sedatives, hypnotics (eg\u00a0benzodiazepines\u00a0)<\/li><li>Anesthetics for anesthesia before e.g.,\u00a0an operation<\/li><li>Certain medicines for mental illness<\/li><li>Muscle relaxants<\/li><li>Certain antidepressants (clomipramine, amitriptyline)<\/li><li>Specific hydrochloric acid inhibitors (cimetidine, for example, for\u00a0stomach ulcers\u00a0)<\/li><li>Medicines for high\u00a0blood pressure<\/li><li>Combined morphine agonists \/\u00a0antagonists\u00a0(buprenorphine, nalbuphine, pentazocine)<\/li><li>Some medicines used to prevent blood clots (e.g., clopidogrel, prasugrel, ticagrelor) may have a delayed or reduced effect when taken with morphine.<\/li><\/ul>\n\n\n\n<p>Concomitant use of Dolcontin Unotard with\u00a0sedatives\u00a0or sleeping pills such as\u00a0benzodiazepines\u00a0or related drugs increases the risk of:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Drowsiness<\/li><li>Difficulty breathing (\u00a0respiratory depression\u00a0)<\/li><li>Coma and may be life-threatening<\/li><\/ul>\n\n\n\n<p>Concomitant use should only be considered when other treatment options are lacking.\u00a0However, if your doctor prescribes Dolcontin Unotard with\u00a0sedative\u00a0drugs,\u00a0your doctor\u00a0should limit the\u00a0dolcontin dosering and the duration of concomitant treatment.\u00a0Tell your doctor about all\u00a0your sedative medicines, and follow your doctor&#8217;s dose recommendation.\u00a0It may be helpful to ask friends or relatives to be aware of the signs and symptoms mentioned above.\u00a0Contact a doctor when you experience such symptoms.<\/p>\n\n\n\n<p><em>Avoid<\/em>&nbsp;concomitant treatment with Dolcontin Unotard and:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Barbiturates\u00a0(mainly used for anesthesia and severe epileptic seizures) as the combination impairs respiratory function<\/li><li>MAO inhibitors, e.g.,\u00a0selegiline\u00a0and rasagiline (used in\u00a0Parkinson&#8217;s disease\u00a0) and moclobemide (used in depression).\u00a0If you have been treated with\u00a0MAOIs, two weeks must pass before treatment with Dolcontin Unotard can begin.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, Breastfeeding, And Fertility<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p><em><strong><span style=\"text-decoration: underline;\">Pregnancy<\/span><\/strong><\/em><\/p>\n\n\n\n<p>There is a risk that the fetus is affected.\u00a0Dolcontin Unotard should, therefore, not be used during pregnancy.\u00a0Always consult a doctor\u00a0before\u00a0using Dolcontin Unotard during pregnancy.\u00a0With long-term use of Dolcontin Unotard during pregnancy, there is a risk that the newborn baby will develop drug-withdrawal symptoms (\u00a0abstinence\u00a0) that a doctor must treat.<\/p>\n\n\n\n<p><em><strong><span style=\"text-decoration: underline;\">Breast-feeding<\/span><\/strong><\/em><\/p>\n\n\n\n<p>Morphine passes into breast milk.\u00a0Dolcontin Unotard should, therefore, not be used during breast-feeding.\u00a0Always consult a doctor\u00a0<em>before<\/em>\u00a0using Dolcontin Unotard when breast-feeding.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving And Using Machines:<\/h2>\n\n\n\n<p>During treatment with Dolcontin Unotard, the ability to react may be reduced.\u00a0This should be considered when sharper attention is required, e.g.,\u00a0when driving and using machines.<\/p>\n\n\n\n<p>You are responsible for assessing whether you can drive a motor vehicle or perform work requiring sharpened attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\u00a0side effects.<\/p>\n\n\n\n<p>Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist. <\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How To Use Dolcontin Unotard?<\/h2>\n\n\n\n<p><strong><span style=\"text-decoration: underline;\">Dolcontin unotard uses<\/span><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Always use this medicine exactly as your doctor has told you.\u00a0Always follow your doctor&#8217;s\u00a0prescription\u00a0and the instructions on the pharmacy label.\u00a0Ask your doctor or pharmacist if you are unsure.<\/li><li>Dolcontin dosering one is determined by the doctor, who adjusts it individually for you.<\/li><li>The capsules are swallowed whole or divided.\u00a0The contents are then swallowed with a glass of water or sprinkled with suitable food, e.g.,\u00a0film milk, porridge, or ice cream.\u00a0Note that the\u00a0granules\u00a0are designed to give an even and long-lasting effect and must not be crushed or chewed.<\/li><li>The medicine must be taken immediately after mixing it with water or food.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If You Use More Dolcontin Unotard, Then You Should:<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if, e.g.,\u00a0a child ingested the medicine by mistake, contact a doctor, hospital, or the Poison Information Center (tel. 112) for risk assessment and advice. In case of overdose, the following symptoms may occur:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Pneumonia\u00a0occurs by pulling down vomit or foreign matter in the lungs, with symptoms such as:<ul><li>Shortness of breath, <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cough-in-children\/\">cough<\/a>, and <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cold\/\">fever<\/a><\/li><\/ul><\/li><li>Difficulty breathing leading to unconsciousness or even death<\/li><li>Pupil reduction (pin-sized\u00a0pupils\u00a0)\u00a0<\/li><li>Low\u00a0blood pressure.<\/li><li>Circulatory disorders and\u00a0coma\u00a0can occur in severe cases<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If You Forget To Use Dolcontin Unotard:<\/h2>\n\n\n\n<p>Do not take a double\u00a0dose\u00a0to make up for a forgotten\u00a0dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If You Stop Using Dolcontin Unotard:<\/h2>\n\n\n\n<p>Withdrawal symptoms often occur if long-term treatment with Dolcontin Unotard is abruptly discontinued. Do not stop treatment with Dolcontin Unotard unless you have agreed to do so with your doctor.<\/p>\n\n\n\n<p>If you want to stop treatment with Dolcontin Unotard, ask your doctor how to lower your\u00a0dose\u00a0slowly to avoid withdrawal symptoms.\u00a0Withdrawal symptoms can include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Body aches<\/li><li>Tremors<\/li><li>Diarrhea<\/li><li>Abdominal pain<\/li><li>Nausea<\/li><li>Flu-like symptoms<\/li><li>Palpitations<\/li><li>Enlarged\u00a0pupils<\/li><li>Psychological symptoms include:<ul><li>Intense dissatisfaction<\/li><li>Anxiety\/worry<\/li><li>Irritability<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>If you have any further questions on using this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible Dolcontin Unotard Side Effects:<\/h2>\n\n\n\n<p>This medicine can cause side effects like all medicines, although not everybody gets them. Important signs and symptoms to be observant of and what to do if you are affected:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The severe&nbsp;allergic reaction&nbsp;causes difficulty breathing or dizziness.<\/li><\/ul>\n\n\n\n<p>If you get this\u00a0side effect,\u00a0talk\u00a0to your doctor immediately. If you get\u00a0any side effects, talk to your doctor or pharmacist.\u00a0This also applies to any\u00a0side effects\u00a0not mentioned in this information.<br><strong>Stop taking Dolcontin Unotard and contact your doctor immediately if you get any of the following symptoms:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li> <em>Uncommon (affects less than 1 user in 100)<\/em> &#8211; Seizures<\/li><li><em>Uncommon (affects less than 1 user in 100)<\/em> &#8211; Abdominal pain (\u00a0colic\u00a0)<\/li><li><em>Uncommon (affects less than 1 user in 100)<\/em> &#8211; Hallucinations or dizziness<\/li><li><em>Rare (affects less than 1 user in 1,000)<\/em> &#8211; Hypersensitivity reaction\u00a0with fever, rash, swelling, and sometimes drop in blood pressure<\/li><li><em>Rare (affects less than 1 user in 1,000)<\/em> &#8211; Fainting<\/li><\/ul>\n\n\n\n<p><strong>Other\u00a0side effects\u00a0ar<\/strong><br><em><strong>Common (affects more than 1 user in 100):<\/strong><\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Headache<\/li><li>Drowsiness, which usually subsides after a few days<\/li><li>Involuntary muscle contractions<\/li><li>Respiratory cramps<\/li><li>Subdued cough reflex<\/li><li>Abdominal pain<\/li><li>Reduced appetite<\/li><li>Constipation<\/li><li>The feeling of discomfort in the upper abdomen<\/li><li>Nausea and vomiting, which usually subside after a period of medication<\/li><li>Difficulty throwing water<\/li><li>Dry mouth<\/li><li>Sweating<\/li><li>Rash<\/li><li>Itching<\/li><li>Insomnia<\/li><li>Impotence<\/li><li>Disorientation<\/li><\/ul>\n\n\n\n<p><strong><em>Uncommon (affects less than 1 user in 100):<\/em>\u00a0<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Impaired respiratory function<\/li><li>Blush<\/li><li>Palpitation<\/li><li>Dizziness<\/li><li>Muscle tension<\/li><li>Emotional disorders<\/li><li>Pupil reduction<\/li><li>Pulmonary edema<\/li><li>Tarmvred<\/li><li>Spasm of ureter<\/li><li>Bile and urinary tract spasms<\/li><li>Taste changes<\/li><li>Mood swings<\/li><li>Feeling of excitement<\/li><li>Restlessness<\/li><li>Depression<\/li><li>The diffuse feeling of discomfort<\/li><li>Absence of menstruation<\/li><li>Decreased sex drive<\/li><li>Impotence<\/li><li>Elevated liver values<\/li><\/ul>\n\n\n\n<p><em><strong>Rare (affects less than 1 user in 1,000):<\/strong><\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Hives<\/li><li>Lowered&nbsp;blood pressure&nbsp;and heart rate<\/li><li>Fluid accumulation<\/li><li>Dimsyn<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/distinction-and-double-vision-in-adults\/\">Double vision<\/a><\/li><li>Asthma attacks in sensitive people<\/li><\/ul>\n\n\n\n<p><em><strong>Has been reported (occurs in an unknown number of users)<\/strong>:<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Withdrawal syndrome in newborns<\/li><li>Increased pain sensitivity<\/li><li>Withdrawal symptoms or addiction (for symptoms, see section 3: If you stop using Dolcontin Unotard).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">5. How To Store Dolcontin Unotard?<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Keep this medicine out of sight and reach of children.<\/li><li>Do not store above 25 \u00b0 C.<\/li><li>Do not use this medicine after the expiry date on the carton after EXP.<\/li><li>The expiration date is the last day of the specified month.<\/li><\/ul>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.\u00a0Ask your pharmacist how to dispose of medicines that are no longer required.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents Of The Packaging And Other Information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content Declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is morphine sulfate pentahydrate 30 mg, 60 mg, 90 mg, 120 mg, 150 mg, and 200 mg, respectively, corresponding to morphine 22.5 mg, 45 mg, 67.5 mg, 90 mg, 112.5 mg, and 150 mg, respectively.<\/li><li>Other ingredients are:<ul><li><em>Tablet core:<\/em> Saturated vegetable fat, polyethylene glycol 6000, talc, magnesium stearate.<\/li><\/ul><ul><li><em>Capsule shell:<\/em>\u00a0Gelatin (containing sodium dodecyl sulphate)<\/li><li><em>Dyes:\u00a0<\/em>\u00a0<em>30 mg<\/em>: E132, E171,\u00a0<em>60 mg<\/em>\u00a0: E172, E132, E171,\u00a0<em>90 m<\/em>: E127, E172, E171,\u00a0<em>120 mg<\/em>: E132, E172, E171,\u00a0<em>150 mg<\/em>: E127, E172, E132, E171,\u00a0<em>200 mg<\/em>: E172, E171.<\/li><li><em>Capsule writing:<\/em>\u00a0Shellack, black iron oxide (dye E172), propylene glycol.<\/li><\/ul><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What The Medicine Looks Like And The Contents Of The Pack?<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Dolcontin Unotard prolonged-release capsules have the following appearance:<ul><li>30 mg: Light blue capsules labeled MS-OD 30.<\/li><li>60 mg: Brown capsules labeled MS-OD 60.<\/li><li>90 mg: Pink capsules labeled MS-OD 90.<\/li><li>120 mg: Olive green capsules labeled MS-OD 120.<\/li><li>150 mg: Blue capsules labeled MS-OD 150.<\/li><li>200 mg: Stainless steel capsules labeled MS-OD 200.<\/li><\/ul><\/li><li>Dolcontin Unotard prolonged-release capsules are supplied in blister packs of 28 prolonged-release capsules.<\/li><li>Not all pack sizes may be marketed.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder And Manufacturer<\/h2>\n\n\n\n<p><em>Marketing Authorisation Holder<\/em><\/p>\n\n\n\n<p>Pfizer AB<\/p>\n\n\n\n<p>191 90 Sollentuna<\/p>\n\n\n\n<p>Phone: 08-550 520 00<\/p>\n\n\n\n<p>Email: eumedinfo@pfizer.com<\/p>\n\n\n\n<p><em>Manufacturer<\/em><\/p>\n\n\n\n<p>Bard Pharmaceuticals Ltd<\/p>\n\n\n\n<p>Cambridge, United Kingdom<\/p>\n\n\n\n<p>or<\/p>\n\n\n\n<p>Mundipharma DC BV<\/p>\n\n\n\n<p>Leusderend 16, Leusden 3832RC<\/p>\n\n\n\n<p>Netherlands<br><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dolcontin Unotard is used for severe pain such as cancer pain. <\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2204,2200],"tags":[2239,5327,5330,5329,2212,5323,5326,5325,5328,5324],"class_list":["post-7654","post","type-post","status-publish","format-standard","hentry","category-d","category-medicines","tag-capsule","tag-dolcontin-unotard","tag-dolcontin-unotard-capsule","tag-dolcontin-unotard-side-effects","tag-medicine","tag-morphine-sulphate-pentahydrate","tag-morphine-sulphate-pentahydrate-capsules","tag-morphine-sulphate-pentahydrate-side-effects","tag-what-is-dolcontin-unotard","tag-what-is-morphine-sulphate-pentahydrate"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7654","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=7654"}],"version-history":[{"count":68,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7654\/revisions"}],"predecessor-version":[{"id":52326,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7654\/revisions\/52326"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=7654"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=7654"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=7654"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}