{"id":7608,"date":"2021-02-25T09:35:22","date_gmt":"2021-02-25T09:35:22","guid":{"rendered":"https:\/\/zeepedia.com\/?p=7608"},"modified":"2021-05-22T06:24:43","modified_gmt":"2021-05-22T06:24:43","slug":"dobutamin-hameln","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/dobutamin-hameln\/","title":{"rendered":"Dobutamin Hameln &#8211; Dobutamine uses, dose and side effects"},"content":{"rendered":"\n<p> 12.5 mg \/ mL\u00a0concentrate for\u00a0infusion\u00a0solution\u00a0<br>dobutamine<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Dobutamine Hameln is and what it is used for<\/h2>\n\n\n\n<p>Dobutamine&nbsp;Hameln belongs to the group of drugs&nbsp;catecholamines.&nbsp;This allows the heart to work more efficiently.&nbsp;It works by stimulating the heart&#8217;s pumping power, increasing blood flow in the body, and by dilating your veins and&nbsp;arteries.<br><\/p>\n\n\n\n<p><strong>Dobutamine&nbsp;Hameln is used:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>to treat&nbsp;heart failure&nbsp;(&nbsp;heart failure&nbsp;) if the heart does not beat hard enough (decreased&nbsp;contractility&nbsp;),<\/li><li>in&nbsp;heart failure&nbsp;with severe&nbsp;hypotension&nbsp;(&nbsp;hypotension&nbsp;),<\/li><li>to detect poor blood supply to the heart (in a working&nbsp;ECG&nbsp;).<\/li><\/ul>\n\n\n\n<p><strong>Pediatric&nbsp;population<\/strong><\/p>\n\n\n\n<p>Dobutamine&nbsp;is indicated for all pediatric age groups (from newborns to 18 years) as inotropic support in conditions of decreased&nbsp;cardiac output&nbsp;with hypoperfusion caused by decompensated&nbsp;heart failure, after cardiac surgery,&nbsp;cardiomyopathy&nbsp;and in&nbsp;cardiogenic&nbsp;or&nbsp;septic&nbsp;shock.<br><\/p>\n\n\n\n<p>Dobutamine contained&nbsp;in&nbsp;Dobutamine&nbsp;Hameln may also be approved for the treatment of other conditions not mentioned in this leaflet.&nbsp;Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before you use Dobutamine Hameln<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Dobutamine Hameln if:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>you are&nbsp;<strong>allergic<\/strong>&nbsp;(hypersensitive) to&nbsp;<strong>Dobutamine<\/strong>&nbsp;or&nbsp;<strong>any of the other ingredients<\/strong>&nbsp;(see content declaration in section 6).&nbsp;An&nbsp;allergic reaction&nbsp;may include rash,&nbsp;itching, difficulty breathing, or swelling of the face, lips, throat, or tongue.&nbsp;You may have experienced this before.<\/li><li>there is a&nbsp;<strong>narrowing in the heart<\/strong>&nbsp;or the&nbsp;<strong>blood vessels which prevents the heart from filling up or pumping out the blood properly<\/strong>&nbsp;(your doctor will know if this is the case.)<\/li><li>the&nbsp;<strong>circulating blood volume is insufficient<\/strong>&nbsp;(&nbsp;hypovolemia&nbsp;).<\/li><\/ul>\n\n\n\n<p>If you have any problems with your heart or blood vessels,&nbsp;Dobutamine&nbsp;Hameln should not be used to detect poor blood supply to the heart.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Tell your doctor if you have any of the following conditions:<\/p>\n\n\n\n<p>&#8211;&nbsp;asthma&nbsp;and is allergic to sulfites,<\/p>\n\n\n\n<p>&#8211; severe coronary heart disease,<\/p>\n\n\n\n<p>&#8211;&nbsp;acute&nbsp;(sudden)&nbsp;heart failure.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children<\/h2>\n\n\n\n<p>Increased heart rate and increased&nbsp;blood pressure&nbsp;appear to be more frequent and intense in children than in adults.<\/p>\n\n\n\n<p>The cardiovascular system in newborns has been reported to be less sensitive to&nbsp;dobutamine&nbsp;and hypotonic (blood pressure lowering) effects appear to be observed more often in adult patients than in young children.&nbsp;The use of&nbsp;dobutamine&nbsp;in children should therefore be closely monitored.<\/p>\n\n\n\n<p>Caution should be exercised when high&nbsp;dose&nbsp;you&nbsp;dobutamine&nbsp;given to children.&nbsp;Your doctor will carefully adjust the required&nbsp;dose&nbsp;for your child.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Dobutamine Hameln<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.&nbsp;This is especially important with the following medicines as they may&nbsp;interact&nbsp;with&nbsp;DobutamineHameln:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>beta-blockers&nbsp;(treatment for high&nbsp;blood pressure&nbsp;and irregular heartbeat),<\/li><li>alpha-blockers&nbsp;(treatment for high&nbsp;blood pressure&nbsp;and prostate enlargement),<\/li><li>vasodilators (&nbsp;vasodilators, used to treat angina or severe&nbsp;heart failure&nbsp;),<\/li><li>diabetes drugs (treatment for&nbsp;diabetes&nbsp;),<\/li><li>ACE inhibitors&nbsp;(treatment for high&nbsp;blood pressure&nbsp;and&nbsp;heart failure&nbsp;),<\/li><li>dopamine&nbsp;(used to increase heart rate and&nbsp;blood pressure&nbsp;),<\/li><li>inhalation anesthetics<\/li><\/ul>\n\n\n\n<p>It is still possible that you may be treated with&nbsp;Dobutamine&nbsp;Hameln and your doctor will be able to determine what is right for you.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>Dobutamine Hamelin&nbsp;should not be given to pregnant women unless medically justified.&nbsp;It is recommended that you stop breast-feeding during treatment with&nbsp;Dobutamine&nbsp;Hameln.&nbsp;Ask your doctor or pharmacist for advice before taking any medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Discuss with your doctor if you are unsure.<br><\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Therefore, learn all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Dobutamine Hameln contains sodium metabisulfite<\/h2>\n\n\n\n<p>(E223) which in rare cases may cause severe&nbsp;hypersensitivity reactions&nbsp;and convulsions in the trachea.<br><\/p>\n\n\n\n<p><strong>Dobutamine&nbsp;contains&nbsp;sodium<\/strong><\/p>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;<strong>sodium<\/strong>&nbsp;per 1 ml, ie essentially &#8216;sodium-free&#8217;.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use Dobutamine Hameln<\/h2>\n\n\n\n<p>Dobutamine&nbsp;Hameln is administered by specially trained healthcare professionals at a location where emergency equipment is available.<br><\/p>\n\n\n\n<p><strong>Dosage<\/strong><\/p>\n\n\n\n<p>The required infusion rate depends on how you respond to the treatment and any&nbsp;side effects.&nbsp;Your doctor will decide how many doses of&nbsp;Dobutamine&nbsp;Hameln you will receive and adjust the flow rate and duration of the infusion.<br><\/p>\n\n\n\n<p><em>Dosage&nbsp;for adults:<\/em><\/p>\n\n\n\n<p>Most patients respond to&nbsp;doses&nbsp;of 2.5\u201310 micrograms&nbsp;of dobutamine&nbsp;per kg body weight per minute.&nbsp;Doses of&nbsp;up to 40 micrograms&nbsp;of dobutamine&nbsp;per kg body weight per minute have been administered.<br><\/p>\n\n\n\n<p><em>Dosage&nbsp;for children:<\/em><\/p>\n\n\n\n<p>A starting dose of 5 micrograms\/kg\/minute, adjusted according to the clinical response to 2-20 micrograms\/kg\/minute, is recommended for all pediatric age groups (newborns up to 18 years).&nbsp;Occasionally, a response of&nbsp;the dose&nbsp;is&nbsp;induced&nbsp;down to 0.5-1.0 micrograms\/kg\/minute.<\/p>\n\n\n\n<p>The required&nbsp;dose&nbsp;for children should be titrated given the probably narrower &#8220;therapeutic window&#8221; for children.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines,&nbsp;Dobutamine&nbsp;Hameln can cause&nbsp;side effects,&nbsp;although not everybody gets them.<br><\/p>\n\n\n\n<p><strong>The following&nbsp;side effects&nbsp;have been reported:<\/strong><\/p>\n\n\n\n<p><em>Very common<\/em>&nbsp;(in more than 1 in 10 patients)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>increased heart rate<\/li><li>chest pain<\/li><li>heart rhythm disorders<\/li><\/ul>\n\n\n\n<p><em>Common<\/em>&nbsp;(in less than 1 in 10, but more than 1 in 100 patients)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>increase in blood pressure or drop in blood pressure<\/li><li>vasoconstriction (&nbsp;vasoconstriction&nbsp;)<\/li><li>irregular heartbeat (&nbsp;palpitation&nbsp;)<\/li><li>headache<\/li><li>bronchospasm&nbsp;\/ asthma-like symptoms (&nbsp;bronchospasm&nbsp;)<\/li><li>shortness of breath<\/li><li>increased&nbsp;white blood cell count&nbsp;(&nbsp;eosinophilia&nbsp;)<\/li><li>inhibited ability of the blood to clot<\/li><li>increased need to urinate (at high&nbsp;doses&nbsp;)<\/li><li>nausea (nausea)<\/li><li>skin rash (exanthema)<\/li><li>fever<\/li><li>inflammation&nbsp;of the vein at the injection site (&nbsp;phlebitis&nbsp;)<\/li><\/ul>\n\n\n\n<p><em>Uncommon<\/em>&nbsp;(in less than 1 in 100, but more than 1 in 1,000 patients)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>rapid contractions in the heart chambers<\/li><li>uncontrolled contractions of the heart chambers (&nbsp;ventricular tachycardia&nbsp;)<\/li><li>heart attack (heart attack)<\/li><\/ul>\n\n\n\n<p><em>Very rare<\/em>&nbsp;(in less than 1 in 10,000, including isolated cases)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>slow heartbeat (&nbsp;bradycardia&nbsp;)<\/li><li>insufficient blood supply to the heart (myocardial ischemia)<\/li><li>low&nbsp;potassium&nbsp;(&nbsp;hypokalaemia&nbsp;)<\/li><li>spots on the skin (petechial hemorrhage)<\/li><li>heart block<\/li><li>contraction of&nbsp;vessels&nbsp;one that supplies the heart with blood (coronary spasm)<\/li><li>restlessness<\/li><li>tingling and numbness (&nbsp;paresthesia&nbsp;)<\/li><li>tremor<\/li><li>feeling hot and worry \/ anxiety<\/li><li>muscle spasm (myoclonic&nbsp;spasm&nbsp;)<\/li><\/ul>\n\n\n\n<p><em>No known frequency<\/em>&nbsp;(cannot be calculated from the available data)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>takotsubosyndrome \/ stress-induced&nbsp;cardiomyopathy&nbsp;(SIC)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Dobutamine Hameln<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Your doctor or pharmacist is responsible for storing&nbsp;Dobutamin&nbsp;Hameln.&nbsp;They are also responsible for ensuring that unused medicines are discarded according to current instructions.<\/li><li>Keep this medicine out of the sight and reach of children.<\/li><li>Do not use this medicine after the expiry date which is stated on the outer carton after EXP.&nbsp;dat.&nbsp;and on&nbsp;ampoule&nbsp;one after EXP.&nbsp;The expiration date is the last day of the specified month.<\/li><li>Do not&nbsp;use Dobutamine&nbsp;Hameln if the solution is cloudy or contains particles or if the container is damaged.<\/li><li>Keep the&nbsp;vial&nbsp;are in the outer carton.&nbsp;Sensitive to light.<\/li><li>Store in a cool place or do not freeze.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>The active substance is dobutamine hydrochloride.<\/p>\n\n\n\n<p>1 ml solution contains 12.5 mg&nbsp;dobutamine.<br><\/p>\n\n\n\n<p>Each 20 ml&nbsp;ampoule of&nbsp;Dobutamine&nbsp;Hameln contains dobutamine hydrochloride equivalent to 250 mg&nbsp;dobutamine&nbsp;.<br><\/p>\n\n\n\n<p>The other ingredients are sodium metabisulfite (E223),&nbsp;hydrochloric acid,&nbsp;and water for injections.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Dobutamine&nbsp;Hameln is a clear, colorless, or almost colorless concentrate for&nbsp;a solution for&nbsp;infusion.<br><\/p>\n\n\n\n<p>Dobutamine&nbsp;Hameln is supplied in 20 ml clear&nbsp;glass&nbsp;ampoules.&nbsp;It is available in original packaging containing 1, 5, or 50&nbsp;ampoules.<br><\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>hameln pharma gmbh<\/p>\n\n\n\n<p>Inselstra\u00dfe 1<\/p>\n\n\n\n<p>31787 Hameln<\/p>\n\n\n\n<p>Germany<br><\/p>\n\n\n\n<p>Siegfried Hameln GmbH<\/p>\n\n\n\n<p>Langes Feld 13<\/p>\n\n\n\n<p>31789 Hameln<\/p>\n\n\n\n<p>Germany<br><\/p>\n\n\n\n<p><strong>This medicinal product is authorized under the European Economic Area under the names: <\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>THE<\/td><td>Dobutamine&nbsp;hameln 12.5 mg \/ ml<\/td><\/tr><tr><td>FI<\/td><td>Dobutamine&nbsp;Hameln 12.5 mg \/ ml infusion concentrate, liuosta varten<\/td><\/tr><tr><td>NL<\/td><td>Dobutamine Hameln 12.5 mg \/ ml sterile concentrate, concentrate for solution for infusion<\/td><\/tr><tr><td>NO<\/td><td>Dobutamine&nbsp;Hameln 12.5 mg \/ ml concentrate for solution for infusion<\/td><\/tr><tr><td>SEE<\/td><td>Dobutamine&nbsp;Hameln 12.5 mg \/ mL concentrate for&nbsp;infusionsolution<\/td><\/tr><tr><td>UK<\/td><td>Dobutamine 12.5 mg \/ ml concentrate for solution for&nbsp;infusion<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Dobutamine Hameln belongs to the group of drugs catecholamines. This allows the heart to work more efficiently. It works by stimulating the heart&#8217;s pumping power, increasing blood flow in the body, and by dilating your veins and arteries.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2204,2200],"tags":[5376,5380,5378,5379,5371,5374,5373,5375,2212,5377,5372],"class_list":["post-7608","post","type-post","status-publish","format-standard","hentry","category-d","category-medicines","tag-dobutamin-hameln","tag-dobutamin-hameln-dose","tag-dobutamin-hameln-side-effects","tag-dobutamin-hameln-use","tag-dobutamine","tag-dobutamine-dose","tag-dobutamine-side-effects","tag-dobutamine-uses","tag-medicine","tag-what-is-dobutamin-hameln","tag-what-is-dobutamine"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7608","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=7608"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7608\/revisions"}],"predecessor-version":[{"id":10937,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7608\/revisions\/10937"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=7608"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=7608"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=7608"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}