{"id":7539,"date":"2021-02-24T09:17:48","date_gmt":"2021-02-24T09:17:48","guid":{"rendered":"https:\/\/zeepedia.com\/?p=7539"},"modified":"2021-05-24T10:16:22","modified_gmt":"2021-05-24T10:16:22","slug":"dinetrel","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/dinetrel\/","title":{"rendered":"Dinetrel &#8211; Amantadine Hydrochloride uses, dose and side effects"},"content":{"rendered":"\n<p> 100 mg\u00a0hard capsules\u00a0<br>amantadine hydrochloride<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Dinetrel is and what it is used for<\/h2>\n\n\n\n<p>Amantadine is a dopaminergic drug, which means it can increase levels of certain chemicals that transmit impulses to the nervous system, including the brain.<br><\/p>\n\n\n\n<p>Dinetrel is used for:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>treatment of&nbsp;Parkinson&#8217;s disease&nbsp;by improving muscle control and reducing stiffness, tremors, and trailing feet.<\/li><\/ul>\n\n\n\n<p>Amantadine hydrochloride contained in Dinetrel may also be approved for the treatment of other conditions not mentioned in this product information.&nbsp;Ask your doctor, pharmacist, or other healthcare professional if you have any further questions, and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before using Dinetrel<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Dinetrel<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to amantadine hydrochloride or any of the other ingredients of this medicine (listed in section 6)<\/li><li>if you have seizures (seizures), e.g.&nbsp;epilepsy<\/li><li>if you have ever had ulcers in your stomach or small intestine<\/li><li>if you have severe kidney disease<\/li><li>if you are pregnant or trying to conceive (see section Pregnancy, breast-feeding and&nbsp;fertility&nbsp;)<\/li><li>if you are breast-feeding (see section Pregnancy, breast-feeding, and&nbsp;fertility&nbsp;).<\/li><\/ul>\n\n\n\n<p>If any of the above apply to you or you are not sure, talk to your doctor or pharmacist before taking Dinetrel.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Dinetrel:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have liver or kidney disease<\/li><li>if you have had cardiovascular disease<\/li><li>if you currently have heart problems or&nbsp;heart failure&nbsp;(heart problems that cause shortness of breath or swelling in the ankles)<\/li><li>if you have a mental illness, e.g.&nbsp;schizophrenia or dementia<\/li><li>if you have increased pressure in the eye (&nbsp;glaucoma&nbsp;).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Dinetrel<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any of the following medicines as they may affect the way Dinetrel works.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>anticholinergic agents<\/td><td>(used to treat&nbsp;Parkinson&#8217;s disease&nbsp;), such as procyclidine<br><\/td><\/tr><tr><td>antispasmodic<\/td><td>(used to treat stomach spasms or cramps), such as hyoscine<\/td><\/tr><tr><td>levodopa<\/td><td>used to treat&nbsp;Parkinson&#8217;s disease<\/td><\/tr><tr><td>psychotic drugs<\/td><td>(used to improve mood, emotions, and behavior when there are disorders in them due to a disease), such as chlorpromazine,&nbsp;haloperidol<\/td><\/tr><tr><td>diuretics&nbsp;(&nbsp;diuretic&nbsp;tablets)<\/td><td>(used to treat the accumulation of fluid in the body and high&nbsp;blood pressure&nbsp;), such as&nbsp;hydrochlorothiazide, amiloride, or triamterene<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Dinetrel with food, drink, and alcohol<\/h2>\n\n\n\n<p>Do not drink alcohol during treatment with Dinetrel as it may increase the risk of&nbsp;side effects&nbsp;and overdose of the drug.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>Do not take Dinetrelom if you are pregnant or trying to become pregnant.&nbsp;Do not take Dinetrel if you are breast-feeding because amantadine passes into breast milk and may harm your baby.<\/p>\n\n\n\n<p>Ask your doctor or pharmacist for advice before taking any medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<br><\/p>\n\n\n\n<p>Dinetrel may cause blurred vision or dizziness.&nbsp;If this happens, do not drive or use machines until the symptoms have passed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Dinetrel contains Lactose<\/h2>\n\n\n\n<p>If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use Dinetrel<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor or pharmacist has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>Swallow the capsules whole with water.<\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;for Parkinson&#8217;s disease:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>Adults<\/td><td>1 capsule (100 mg) daily for the first week.&nbsp;Your doctor will increase the&nbsp;dose one to 2 capsules daily (200 mg).&nbsp;Higher&nbsp;doses&nbsp;of up to 4 capsules (400 mg) daily may be given in some cases.<\/td><\/tr><tr><td>Adults over 65 years<\/td><td>1 capsule (100 mg) once daily.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>If you have kidney problems, your doctor may&nbsp;prescribe&nbsp;a lower&nbsp;dose<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Dinetrel than you should &nbsp;<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if e.g.&nbsp;If a child has inadvertently ingested the medicine, contact a doctor, hospital, or the Poison Information Center for risk assessment and advice.&nbsp;Show any remaining tablets or the empty package to the doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Dinetrel<\/h2>\n\n\n\n<p>If you forget to take a&nbsp;dose&nbsp;at the right time, take the missed&nbsp;dose&nbsp;as soon as you remember.&nbsp;However, do not take a double&nbsp;dose&nbsp;to make up for a forgotten&nbsp;dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Dinetrel<\/h2>\n\n\n\n<p>Do not suddenly stop taking Dinetrel as your symptoms may get worse.<\/p>\n\n\n\n<p>If you want to stop taking Dinetrel, consult your doctor who will tell you how to reduce the&nbsp;dose&nbsp;gradually.<br><\/p>\n\n\n\n<p>If you are taking psychotropic drugs (for the treatment of mental disorders) and suddenly stop taking Dinetrel, you may experience the following symptoms:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>fever<\/li><li>sweating<\/li><li>fast heart rate<\/li><li>muscle stiffness (difficulty moving)<\/li><li>lost control of the bladder (sudden, the urgent need for urination).<\/li><\/ul>\n\n\n\n<p>If any of these symptoms occur, contact your doctor immediately.<br><\/p>\n\n\n\n<p>Some patients may notice that the effect of this medicine starts to diminish after a few months of regular use.&nbsp;Tell your doctor if this happens.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.&nbsp;These&nbsp;side effects&nbsp;are often mild and may go away after a few days of treatment.&nbsp;Tell your doctor or pharmacist if the&nbsp;side effects&nbsp;are severe or last for more than a couple of days.<br><\/p>\n\n\n\n<p>If any of the following symptoms occur, contact your doctor or nearest hospital immediately:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>dizziness or confusion<\/li><li>fainting<\/li><li>seizures (seizures).<\/li><\/ul>\n\n\n\n<p>Tell your doctor or pharmacist if you have any of the following or other problems with Dinetrel:<br><\/p>\n\n\n\n<p><strong>A very common&nbsp;side effect&nbsp;is<\/strong>&nbsp;(can occur in more than 1 in 10)&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>swollen ankles<\/li><li>red skin spots.<\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;are<\/strong>&nbsp;(may affect up to 1 in 10 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>anxiety<\/li><li>excessive elation<\/li><li>Depression<\/li><li>difficulty sleeping<\/li><li>confusion<\/li><li>nightmares<\/li><li>difficult to concentrate<\/li><li>headache<\/li><li>fatigue<\/li><li>difficulties in controlling movements<\/li><li>unclear number<\/li><li>nervousness<\/li><li>muscle aches<\/li><li>hallucinations<\/li><li>fast or irregular heartbeat<\/li><li>low&nbsp;blood pressure&nbsp;when you get up.&nbsp;It may make you feel dizzy or faint.<\/li><li>dry mouth<\/li><li>loss of appetite<\/li><li>nausea or vomiting<\/li><li>constipation<\/li><li>sweating.<\/li><\/ul>\n\n\n\n<p><strong>Less common&nbsp;side effects&nbsp;are<\/strong>&nbsp;(may affect up to 1 in 100 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>dimsyn.<\/li><\/ul>\n\n\n\n<p><strong>Rare&nbsp;side effects&nbsp;are<\/strong>&nbsp;(may affect up to 1 in 1000 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>disorientation (not knowing where you are)<\/li><li>a thought or behavior disorders, such as delusions<\/li><li>tremors<\/li><li>mobility difficulties<\/li><li>neuroleptic malignant syndrome.&nbsp;May cause heat sensation and muscle stiffness.<\/li><li>diarrhea<\/li><li>rash<\/li><li>eye problems, such as&nbsp;itching&nbsp;or&nbsp;redness<\/li><li>lost bladder control.&nbsp;You may have difficulty urinating or a sudden urge to urinate.<\/li><li>corneal ulcer, corneal swelling, impaired&nbsp;visual acuity.<\/li><\/ul>\n\n\n\n<p><strong>Very rare&nbsp;side effects&nbsp;are<\/strong>&nbsp;(may affect up to 1 in 10 000 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>heart problems that can cause shortness of breath or swollen ankles<\/li><li>decreased number of&nbsp;white blood cells&nbsp;which increases the likelihood of getting&nbsp;infection&nbsp;s<\/li><li>changes in blood tests that show liver function<\/li><li>sensitivity to sunlight.<\/li><\/ul>\n\n\n\n<p><strong>Has been reported<\/strong>&nbsp;(occurs in an unknown number of users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>the compelling need to behave unusually &#8211; a strong impulse to excessive gambling, altered or increased sexual interest, uncontrollable and excessive need to buy things and spend money, binge eating (eating large amounts of food in a short time), or compulsive eating ( to eat more food than normal and more than is needed to satisfy your hunger)<\/li><li>delirium&nbsp;(state of confusion)<\/li><li>hypomania&nbsp;and mania (increased energy, self-confidence and well-being, morbidly agitated)<\/li><\/ul>\n\n\n\n<p>If any of the&nbsp;side effects&nbsp;gets serious, or if you notice any&nbsp;side effects&nbsp;not listed in this leaflet, please tell your doctor or pharmacist.<br><\/p>\n\n\n\n<p><strong>Reporting of&nbsp;side effects&nbsp;ar<\/strong><\/p>\n\n\n\n<p>If you get&nbsp;any side effects, talk to your doctor or pharmacist.&nbsp;This also applies to any&nbsp;side effects&nbsp;not mentioned in this information.&nbsp;You can also report&nbsp;side effects directly (see details below).&nbsp;By reporting&nbsp;side effects, you can help increase drug safety information.<br><\/p>\n\n\n\n<p>The Medical Products Agency<\/p>\n\n\n\n<p>Box 26<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Dinetrel<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the blister and carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Do not store above 25 \u00b0 C.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>The active substance is amantadine hydrochloride.&nbsp;A hard gelatin capsule contains 100 mg of amantadine hydrochloride.<br><\/p>\n\n\n\n<p>Other ingredients are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Capsule contents:&nbsp;lactose monohydrate, povidone (E1201), and magnesium stearate (E470b).<\/li><li>Capsule shell: gelatin, titanium dioxide (E171), sodium lauryl sulfate, and red iron oxide (E172).<\/li><li>Ink &#8211; white: shellac (E904), titanium dioxide (E171), and propylene glycol (E1520)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Daintree is brown-red, hard gelatin capsules of size 3 with white embossing AM100 on both the upper and lower part of the capsule.<br><\/p>\n\n\n\n<p>The capsules are packaged in PVC \/ PVdC aluminum blisters.&nbsp;Pack sizes: 5, 7, 10, 14, 28, 30 and 56 capsules.<br><\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Morningside Healthcare (Malta) Ltd.<\/p>\n\n\n\n<p>93, Mill Street<\/p>\n\n\n\n<p>Qormi QRM 3102<\/p>\n\n\n\n<p>Malta<br><\/p>\n\n\n\n<p><strong>Local representative<\/strong><\/p>\n\n\n\n<p>2care4 Generics ApS<\/p>\n\n\n\n<p>Stenhuggervej 12-14<\/p>\n\n\n\n<p>6710 Esbjerg V<\/p>\n\n\n\n<p>Denmark<br><\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Morningside Pharmaceuticals Ltd.<\/p>\n\n\n\n<p>5 Pavilion Way<\/p>\n\n\n\n<p>Loughborough, LE11 5GW, UK<br><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Amantadine is a dopaminergic drug, which means it can increase levels of certain chemicals that transmit impulses to the nervous system, including the brain.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2204,2200],"tags":[5519,5522,5521,2240,5523,5526,5525,2212,5520,5524],"class_list":["post-7539","post","type-post","status-publish","format-standard","hentry","category-d","category-medicines","tag-amantadine-hydrochloride","tag-amantadine-hydrochloride-capsule","tag-amantadine-hydrochloride-side-effects","tag-capsules","tag-dinetrel","tag-dinetrel-capsule","tag-dinetrel-side-effects","tag-medicine","tag-what-is-amantadine-hydrochloride","tag-what-is-dinetrel"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7539","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=7539"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7539\/revisions"}],"predecessor-version":[{"id":10983,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7539\/revisions\/10983"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=7539"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=7539"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=7539"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}