{"id":7461,"date":"2021-02-23T08:47:00","date_gmt":"2021-02-23T08:47:00","guid":{"rendered":"https:\/\/zeepedia.com\/?p=7461"},"modified":"2021-05-25T10:23:11","modified_gmt":"2021-05-25T10:23:11","slug":"diafer","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/diafer\/","title":{"rendered":"Diafer &#8211; Iron uses, dose and side effects"},"content":{"rendered":"\n<p> 50 mg \/ ml\u00a0injection\u00a0solution\u00a0<br>Iron<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Diafer is and what it is used for<\/h2>\n\n\n\n<p>Diaphragms contain a combination of iron and derisomaltose (a chain of sugar molecules).&nbsp;The type of iron found in Diafer is the same as that found naturally in the body.<\/p>\n\n\n\n<p>Diaphragms are given at low iron levels (called &#8220;iron deficiency&#8221;) if you have a&nbsp;chronickidney disease and are on&nbsp;dialysis, provided that oral iron cannot be used.<br><\/p>\n\n\n\n<p>Diaphragms are used to replenish and maintain the body&#8217;s iron stores through repeated treatment.<br><\/p>\n\n\n\n<p>Iron found in Diafer may also be approved for the treatment of other diseases not mentioned in this product information.&nbsp;Ask your doctor, pharmacist, or other healthcare professional if you have any further questions, and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before using Diafer<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">You must not be given Diafer<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have&nbsp;anemia&nbsp;that is not caused by low iron values \u200b\u200b(iron deficiency) e.g.&nbsp;&#8220;Hemolytic anemia&#8221;<\/li><li>if you have too much iron in your body (overload) or disorders in your body&#8217;s use of iron<\/li><li>if you are allergic (hypersensitive) to the product or any of the other ingredients of this medicine (listed in section 6)<\/li><li>if you have had severe allergic reactions to other injectable iron preparations<\/li><li>if you have an active liver disease<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or nurse before giving Diafer:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have previously been allergic to medicines<\/li><li>if you have systemic lupus erythematosus<\/li><li>if you have&nbsp;rheumatoid arthritis<\/li><li>if you have severe&nbsp;asthma,&nbsp;eczema,&nbsp;or other&nbsp;allergies&nbsp;you<\/li><li>if you have an ongoing bacterial infection in your blood<\/li><\/ul>\n\n\n\n<p>One ml of undiluted Diafer contains up to 4.6 mg (0.2 mmol) of&nbsp;sodium.&nbsp;This should be considered by patients on a low-salt diet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Diaphragms have not been tested in children and adolescents.&nbsp;For this reason, children and adolescents should not take Diafer.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Diafer<\/h2>\n\n\n\n<p>If Diafer is given together with oral iron preparations (by mouth) this may reduce the uptake of the oral iron preparation.&nbsp;Tell your doctor if you are taking or have recently taken or will take any other medicines.&nbsp;This also includes over-the-counter and herbal remedies.&nbsp;This is because Diafer may affect the effectiveness of other medicines.&nbsp;Some other medicines may also affect the effect of Diafer.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>Diaphragms have not been tested on pregnant women.&nbsp;It is important that you tell your doctor if you are pregnant, think you may be pregnant or are planning to have a baby.&nbsp;If you become pregnant during treatment, you must consult your doctor.&nbsp;Your doctor will decide if you should receive this medicine or not.<br><\/p>\n\n\n\n<p>If you are breast-feeding, talk to your doctor before giving Diafer.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Diafer is unlikely to impair the ability to drive or use machines.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use Diafer<\/h2>\n\n\n\n<p>Your doctor or nurse will give you Diafer by&nbsp;injection&nbsp;into a vein or in the dialyzer.&nbsp;Diaphragms are given in an environment where allergic reactions can be treated immediately.<br><\/p>\n\n\n\n<p>You will be observed for at least 30 minutes by your doctor or nurse after each&nbsp;administration.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you received too much<\/h2>\n\n\n\n<p>Diaphragms are given by a qualified person.&nbsp;It is unlikely that you will get too much.&nbsp;Your&nbsp;dose&nbsp;and your blood will be controlled to prevent iron from accumulating in your body.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, Diafer can cause&nbsp;side effects,&nbsp;although not everybody gets them.<br><\/p>\n\n\n\n<p>Allergic reactions<\/p>\n\n\n\n<p>Contact your doctor immediately if you experience any of the following signs and symptoms that may indicate a severe allergic reaction: swelling of the face, tongue or throat, difficulty swallowing,&nbsp;hives&nbsp;and difficulty breathing, and chest pain, which may be a sign of a potentially serious&nbsp;allergic reaction&nbsp;called Kuoni&#8217;s syndrome.<br><\/p>\n\n\n\n<p>Very common (affects more than 1 user in 10):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>no<\/li><\/ul>\n\n\n\n<p>Common (affects less than 1 user in 10 and more than 1 user in 100):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>no<\/li><\/ul>\n\n\n\n<p>Uncommon (affects 1 to 10 users in 1,000):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>dimsyn<\/li><li>numbness<\/li><li>huskiness<\/li><li>nausea, vomiting, constipation, pain in and around the abdomen<\/li><li>cramps<\/li><li>hypersensitivity (&nbsp;redness,&nbsp;itching, rash, shortness of breath)<\/li><li>feeling hot (or fever)<\/li><li>tenderness and swelling around the injection site<\/li><\/ul>\n\n\n\n<p>Rare (affects 1 to 10 users in 10,000):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>heart rhythm disorders<\/li><li>chest pain<\/li><li>unconsciousness<\/li><li>seizures<\/li><li>dizziness, restlessness, fatigue<\/li><li>diarrhea, sweating, trembling<\/li><li>angioedema&nbsp;(severe&nbsp;allergic reaction&nbsp;causing swelling of the face and throat)<\/li><li>pain in muscles or joints<\/li><li>low&nbsp;blood pressure&nbsp;with the mental impact<\/li><\/ul>\n\n\n\n<p>Very rare (affects less than 1 user in 10,000):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>slow&nbsp;pulse&nbsp;in the fetus<\/li><li>palpitation<\/li><li>the lower number of&nbsp;red blood cells&nbsp;than usual (seen during blood tests)<\/li><li>headache<\/li><li>strange feeling in the skin<\/li><li>transient deafness<\/li><li>high&nbsp;blood pressure<\/li><li>acute&nbsp;and severe&nbsp;allergic reaction<\/li><\/ul>\n\n\n\n<p>Has been reported (occurs in an unknown number of users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Flu-like illness can occur for a few hours up to several days after&nbsp;injection&nbsp;and is usually characterized by symptoms such as high temperature, and aches and pains in muscles and joints.<\/li><\/ul>\n\n\n\n<p>If you get any&nbsp;side effects, talk to your doctor.&nbsp;This includes any&nbsp;side effects&nbsp;not mentioned in this leaflet.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Diafer<\/h2>\n\n\n\n<p>Keep diapers out of the reach and sight of children.<br><\/p>\n\n\n\n<p>Do not freeze.<br><\/p>\n\n\n\n<p>Healthcare professionals ensure that the product is stored and disposed of properly.&nbsp;Do not use this medicine after the expiry date which is stated on the&nbsp;ampoule&nbsp;and carton.&nbsp;EXP is an abbreviation for the expiration date.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>The active substance in Diafer is iron (III) derisomaltose.&nbsp;One milliliter solution contains 50 mg of iron in the form of iron (III) derisomaltose.&nbsp;One&nbsp;ampoule&nbsp;of 2 ml contains 100 mg of iron in the form of ferric derisomaltose.<\/p>\n\n\n\n<p>The other ingredients are water for injections, sodium chloride, sodium hydroxide (&nbsp;pH&nbsp;regulator), and&nbsp;hydrochloric acid&nbsp;(&nbsp;pH&nbsp;regulator).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Diafer is a dark brown&nbsp;solution for injection&nbsp;in a&nbsp;glass ampoule.<br><\/p>\n\n\n\n<p>Available in the following pack sizes:<\/p>\n\n\n\n<p>Pack sizes for ampoules: 1 x 2 ml, 5 x 2 ml, 10 x 2 ml, 25 x 2 ml<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Pharmacosmos A \/ S<\/p>\n\n\n\n<p>Roervangsvej 30<\/p>\n\n\n\n<p>DK-4300 Holbaek<\/p>\n\n\n\n<p>Denmark<\/p>\n\n\n\n<p>Tel .: +45 59 48 59 59<\/p>\n\n\n\n<p>Fax: +45 59 48 59 60<\/p>\n\n\n\n<p>Email Address: info@pharmacosmos.com<br><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Diaphragms contain a combination of iron and derisomaltose (a chain of sugar molecules). The type of iron found in Diafer is the same as that found naturally in the body.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2204,2200],"tags":[5675,5678,5677,2216,5671,5674,5673,2212,5676,5672],"class_list":["post-7461","post","type-post","status-publish","format-standard","hentry","category-d","category-medicines","tag-diafer","tag-diafer-injection","tag-diafer-side-effects","tag-injections","tag-iron","tag-iron-injection","tag-iron-side-effects","tag-medicine","tag-what-is-diafer","tag-what-is-iron"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7461","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=7461"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7461\/revisions"}],"predecessor-version":[{"id":11033,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7461\/revisions\/11033"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=7461"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=7461"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=7461"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}