{"id":7413,"date":"2021-02-22T06:42:58","date_gmt":"2021-02-22T06:42:58","guid":{"rendered":"https:\/\/zeepedia.com\/?p=7413"},"modified":"2021-05-25T11:04:05","modified_gmt":"2021-05-25T11:04:05","slug":"detrusitol-sr","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/detrusitol-sr\/","title":{"rendered":"Detrusitol SR &#8211; Tolterodine uses, dose and side effects"},"content":{"rendered":"\n<p> 2 mg and 4 mg\u00a0prolonged-release capsules, hard\u00a0<br>Tolterodine<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. WHAT DETRUSITOL SR IS AND WHAT IT IS USED FOR<\/h2>\n\n\n\n<p>The active substance in Detrusitol SR is tolterodine.&nbsp;Tolterodine belongs to a class of medicines called antimuscarinic medicines.<\/p>\n\n\n\n<p>Detrusitol SR is used to treat symptoms of overactive bladder.&nbsp;If you have an overactive bladder, you may find that:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you have difficulty controlling urination,<\/li><li>you need to rush to the toilet without any warning and\/or go to the toilet often.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">2. BEFORE YOU USE DETRUSITOL SR<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Detrusitol SR<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic (hypersensitive) to tolterodine or any of the other ingredients of Detrusitol SR<\/li><li>if you have bladder emptying difficulties (&nbsp;urinary retention&nbsp;)<\/li><li>if you have uncontrolled&nbsp;glaucoma&nbsp;with a narrow&nbsp;ventricular angle&nbsp;(increased pressure in the eye leading to impaired vision, which is not under optimal control)<\/li><li>if you suffer from&nbsp;myasthenia gravis&nbsp;(severe muscle weakness)<\/li><li>if you suffer from severe&nbsp;ulcerative colitis&nbsp;(ulcers and&nbsp;inflammation&nbsp;of the colon)<\/li><li>if you suffer from toxic megacolon (&nbsp;acute&nbsp;pronounced enlargement of the colon)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Take special care with Detrusitol SR<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you have difficulty throwing water and\/or the weak urine stream<\/li><li>If you have gastrointestinal problems that affect the passage of food and\/or digestion<\/li><li>If you suffer from any kidney disease (impaired kidney function)<\/li><li>If you have any liver disease<\/li><li>If you suffer from any nerve disorder that affects your&nbsp;blood pressure, bowel, or sexual function (&nbsp;neuropathy&nbsp;in the&nbsp;autonomic nervous system&nbsp;)<\/li><li>If you have a hiatus hernia (diaphragmatic hernia)<\/li><li>If you have ever had problems with emptying the bowel or suffered from severe constipation (decreased gastrointestinal movements)<\/li><li>If you have any heart disease such as:<ul><li>an abnormal electrocardiogram (&nbsp;ECG&nbsp;)<\/li><li>slow heart rate (&nbsp;bradycardia&nbsp;)<\/li><li>or have previously had heart problems such as:<\/li><li>cardiomyopathy&nbsp;(weak heart muscle)<\/li><li>myocardial ischemia (decreased blood flow to the heart)<\/li><li>arrhythmia&nbsp;(irregular heartbeat)<\/li><li>heart failure<\/li><\/ul><\/li><li>If you have abnormally low levels of&nbsp;potassium&nbsp;(&nbsp;hypokalaemia&nbsp;),&nbsp;calcium&nbsp;(&nbsp;hypocalcemia&nbsp;), or&nbsp;magnesium&nbsp;(hypomagnesemia) in your blood<\/li><\/ul>\n\n\n\n<p>Before starting treatment with Detrusitol SR, ask your doctor or pharmacist if you think any of the above may apply to you.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Use of other medicines<\/h2>\n\n\n\n<p>Tolterodine, the active substance in Detrusitol SR, may be affected by and\/or affect other medicines.<br><\/p>\n\n\n\n<p>Therefore, concomitant use of tolterodine with:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>certain&nbsp;antibiotics&nbsp;(eg erythromycin, clarithromycin)<\/li><li>medicines used to treat fungal infections (eg&nbsp;ketoconazole, itraconazole)<\/li><li>medicines used to treat&nbsp;HIV<\/li><\/ul>\n\n\n\n<p>Tolterodine should be used with caution when taken concomitantly<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>medicines that affect the passage of food (eg metoclopramide and cisapride)<\/li><li>drugs for the treatment of irregular heartbeat (eg&nbsp;amiodarone, sotalol,&nbsp;quinidine,&nbsp;procainamide&nbsp;)<\/li><li>other drugs with a similar mechanism of action as Detrusitol SR (antimuscarinic properties) or drugs with the opposite mechanism of action as Detrusitol SR (cholinergic properties).&nbsp;Ask your doctor if you are unsure.<\/li><\/ul>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Taking Detrusitol SR with food and drink<\/h2>\n\n\n\n<p>Detrusitol SR can be taken before, after, or during a meal.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p><em>Pregnancy<\/em><\/p>\n\n\n\n<p>You should not use Detrusitol SR if you are pregnant.&nbsp;Tell your doctor immediately if you are pregnant, think you may be pregnant, or are planning to have a baby.<\/p>\n\n\n\n<p><em>Breast-feeding<\/em><\/p>\n\n\n\n<p>It is unknown whether tolterodine, the active substance in Detrusitol SR, passes into breast milk.&nbsp;Breast-feeding is not recommended when using Detrusitol SR.<br><\/p>\n\n\n\n<p>Talk to your doctor or pharmacist before taking any medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Detrusitol SR may make you feel dizzy, tired, or affect your vision.&nbsp;Your ability to drive or use machines may be affected.<br><\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;The description of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Important information about some of the ingredients of Detrusitol SR<\/h2>\n\n\n\n<p>This medicine contains sucrose (a type of sugar).&nbsp;If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before using this medicine.&nbsp;Patients with rare hereditary problems of&nbsp;fructose intolerance,&nbsp;glucose-galactose intolerance, or glucose-isomaltase insufficiency should not take this medicine.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. HOW TO USE DETRUSITOL SR<\/h2>\n\n\n\n<p><em>Dosage<\/em><\/p>\n\n\n\n<p>Always take Detrusitol SR exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<br><\/p>\n\n\n\n<p>The usual&nbsp;dose&nbsp;is one 4 mg&nbsp;prolonged-release capsule&nbsp;daily, except for patients with kidney or liver problems or troublesome&nbsp;side effects.&nbsp;Then the doctor may reduce the&nbsp;dose&nbsp;one to one 2 mg&nbsp;prolonged-release capsule&nbsp;daily.<br><\/p>\n\n\n\n<p>Detrusitol SR is not recommended for use in children.<br><\/p>\n\n\n\n<p>Swallow the prolonged-release capsules whole.&nbsp;Do not chew.<br><\/p>\n\n\n\n<p><em>Treatment time<\/em><\/p>\n\n\n\n<p>Your doctor will tell you how long Detrusitol SR treatment will last.&nbsp;Do not stop treatment earlier because you do not see any immediate effect.&nbsp;Your bladder needs some time to adjust.&nbsp;Therefore, you should complete your treatment with prolonged-release capsules prescribed by your doctor.&nbsp;If you do not get any effect after stopping treatment, talk to your doctor.<br><\/p>\n\n\n\n<p>The benefit of treatment should be re-evaluated after 2 or 3 months.<br><\/p>\n\n\n\n<p><em>Always consult your doctor if you are considering stopping treatment.<\/em><br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Detrusitol SR then you should<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if e.g.&nbsp;a child ingested the medicine accidentally contact a doctor, hospital, or the Poison Information Center for risk assessment and advice.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Detrusitol SR<\/h2>\n\n\n\n<p>Do not take a double&nbsp;dose&nbsp;to make up for a forgotten&nbsp;dose.&nbsp;If you have missed a&nbsp;dose&nbsp;as you usually take it, you can take it as soon as you remember if it is not soon for the next&nbsp;dose.&nbsp;In that case, follow the usual dosing schedule instead.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. POSSIBLE SIDE EFFECTS<\/h2>\n\n\n\n<p>Like all medicines, Detrusitol SR can cause&nbsp;side effects,&nbsp;although not everybody gets them.<br><\/p>\n\n\n\n<p>You should contact a doctor immediately or see an emergency department if you experience signs of&nbsp;angioedema&nbsp;such as<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>swollen face, tongue, and throat<\/li><li>difficulty swallowing<\/li><li>hives&nbsp;and difficulty breathing<\/li><\/ul>\n\n\n\n<p>You should also see a doctor if you experience hypersensitivity (such as&nbsp;itching, skin rash,&nbsp;hives, difficulty breathing).&nbsp;Such reactions are less common (occurring in less than 1 in 100 patients).<br><\/p>\n\n\n\n<p>Contact a doctor immediately or see an emergency department if you experience the following symptoms:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>chest pain, difficulty breathing, pronounced fatigue (even at rest), difficulty breathing at night, swollen legs.<\/li><\/ul>\n\n\n\n<p>These symptoms may be signs of&nbsp;heart failure, which is less common (occurring in less than 1 in 100 patients).<br><\/p>\n\n\n\n<p>The following&nbsp;side effects&nbsp;have been observed during treatment with Detrusitol SR with the following frequency:<br><\/p>\n\n\n\n<p><strong>A very common&nbsp;side effect&nbsp;is<\/strong>&nbsp;(in more than 1 in 10):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>dry mouth<\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;adverse&nbsp;s<\/strong>&nbsp;(less than 1 in 10):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>sinusitis<\/li><li>dizziness, drowsiness, headache<\/li><li>dry eyes, blurred vision<\/li><li>digestive problems (&nbsp;dyspepsia&nbsp;), constipation, abdominal pain, flatulence<\/li><li>pain or difficulty throwing water<\/li><li>fatigue<\/li><li>fluid accumulation in the body that causes swelling (taxi ankles)<\/li><li>diarrhea<\/li><\/ul>\n\n\n\n<p><strong>Less common&nbsp;<\/strong><strong>side effects&nbsp;are<\/strong>&nbsp;(less than 1 in 100):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>allergic reactions<\/li><li>concern<\/li><li>an ant crawls in fingers and toes<\/li><li>dizziness<\/li><li>palpitations,&nbsp;heart failure, irregular heart rate<\/li><li>inability to empty the bladder<\/li><li>chest pain<\/li><li>memory impairment<\/li><\/ul>\n\n\n\n<p>Other&nbsp;side effects&nbsp;that have been reported include severe allergic reactions, confusion, hallucinations, increased heart rate, reddening of the skin, heartburn, vomiting,&nbsp;angioedema, dry skin, and disorientation.&nbsp;There have also been reports of worsening dementia symptoms in patients being treated for dementia.<br><\/p>\n\n\n\n<p>If any of the&nbsp;side effects&nbsp;gets serious, or if you notice any&nbsp;side effects&nbsp;not listed in this leaflet, please tell your doctor or pharmacist.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. HOW TO STORE DETRUSITOL SR<\/h2>\n\n\n\n<p>Keep out of sight and reach of children.<br><\/p>\n\n\n\n<p>Do not use Detrusitol SR after the expiry date which is stated on the label\/carton.<\/p>\n\n\n\n<p>The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>Do not store above 25 \u00b0 C.<br><\/p>\n\n\n\n<p>Jar: Store in the original package.<\/p>\n\n\n\n<p>Blister: Store blister in the outer carton.<br><\/p>\n\n\n\n<p>The medicine should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. FURTHER INFORMATION<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>The active substance in Detrusitol SR 2 mg prolonged-release&nbsp;capsule&nbsp;is 2 mg <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tolterodine-teva\/\">tolterodine tartrate<\/a>, equivalent to 1.37 mg tolterodine.<br><\/p>\n\n\n\n<p>The active substance in Detrusitol SR 4 mg prolonged-release&nbsp;capsule&nbsp;is 4 mg tolterodine tartrate, equivalent to 2.74 mg tolterodine.<br><\/p>\n\n\n\n<p>Other ingredients are:<\/p>\n\n\n\n<p>Capsule contents: Sugar spheres (sucrose and maize starch), hypromellose, and Surelease E-7-19010 (ethylcellulose, medium-chain triglycerides,&nbsp;and oleic acid).<br><\/p>\n\n\n\n<p>Capsule shell: Gelatin and dyes.<br><\/p>\n\n\n\n<p>Dyes:<\/p>\n\n\n\n<p>Teal 2 mg prolonged-release capsule: Indigo carmine (E 132), titanium dioxide (E 171), and yellow iron oxide (E 172).<\/p>\n\n\n\n<p>Blue 4 mg prolonged-release capsule: Indigo carmine (E 132) and titanium dioxide (E 171).<br><\/p>\n\n\n\n<p>Pressure: Shellac, titanium dioxide (E 171), propylene glycol, and simethicone<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Detrusitol SR is a hard prolonged-release&nbsp;capsule, developed to be dosed once a day.<br><\/p>\n\n\n\n<p>Detrusitol SR 2 mg prolonged-release capsules are blue-green and marked with white print (symbol and &#8216;2&#8217;).<br><\/p>\n\n\n\n<p>Detrusitol SR 4 mg prolonged-release capsules are blue and marked with white print (symbol and &#8216;4&#8217;).<br><\/p>\n\n\n\n<p>Detrusitol SR 2 mg and 4 mg prolonged-release capsules are available in the following pack sizes:<br><\/p>\n\n\n\n<p>Blister packs containing:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>7 prolonged-release capsules<\/li><li>14 depot capsules<\/li><li>28 prolonged-release capsules<\/li><li>49 prolonged-release capsules<\/li><li>84 prolonged-release capsules<\/li><li>98 prolonged-release capsules<\/li><li>280 prolonged-release capsules<\/li><\/ul>\n\n\n\n<p>Jars containing 30, 100, and 200 capsules.&nbsp;Hospital packs are available containing 80, 160, and 320 capsules.&nbsp;Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Marketing Authorization Holder<\/p>\n\n\n\n<p>In Finland:<\/p>\n\n\n\n<p>Pfizer Oy<\/p>\n\n\n\n<p>Datagr\u00e4nden 4<\/p>\n\n\n\n<p>00330 Helsinki<\/p>\n\n\n\n<p>Tel: (09) 430 040<br><\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Pfizer Italia Srl<\/p>\n\n\n\n<p>Located in Marino del Tronto, 63100 Ascoli Piceno<\/p>\n\n\n\n<p>Italy<br><\/p>\n\n\n\n<p>This medicinal product is authorized in the following Member States within the European Economic Area under the names:<\/p>\n\n\n\n<p><strong>Detrusitol retard:<\/strong>&nbsp;Belgium, Denmark, Iceland, Italy, Luxembourg, Portugal, Germany, and Austria<\/p>\n\n\n\n<p><strong>Detrusitol SR:<\/strong>&nbsp;Finland, Greece, Ireland, the Netherlands, Norway<\/p>\n\n\n\n<p><strong>Detrusitol LP:<\/strong>&nbsp;France<\/p>\n\n\n\n<p><strong>Detrusitol Neo:<\/strong>&nbsp;Spain<\/p>\n\n\n\n<p><strong>Detrusitol XL:<\/strong>&nbsp;United Kingdom<br><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The active substance in Detrusitol SR is tolterodine. Tolterodine belongs to a class of medicines called antimuscarinic medicines.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2204,2200],"tags":[2240,5743,5746,5745,2212,5739,5741,5744,5740],"class_list":["post-7413","post","type-post","status-publish","format-standard","hentry","category-d","category-medicines","tag-capsules","tag-detrusitol-sr","tag-detrusitol-sr-capsule","tag-detrusitol-sr-side-effects","tag-medicine","tag-tolterodine","tag-tolterodine-side-effects","tag-what-is-detrusitol-sr","tag-what-is-tolterodine"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7413","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=7413"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7413\/revisions"}],"predecessor-version":[{"id":11053,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7413\/revisions\/11053"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=7413"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=7413"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=7413"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}