{"id":7315,"date":"2021-02-21T08:16:15","date_gmt":"2021-02-21T08:16:15","guid":{"rendered":"https:\/\/zeepedia.com\/?p=7315"},"modified":"2021-05-27T06:26:29","modified_gmt":"2021-05-27T06:26:29","slug":"delstrigo","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/delstrigo\/","title":{"rendered":"Delstrigo &#8211; Doravirin &#8211; lamivudine &#8211; tenofovir disoproxil uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n100 mg \/ 300 mg \/ 245 mg&nbsp;film-coated tablets&nbsp;<br>doravirin \/ <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/triumeq\/\">lamivudine<\/a> \/ tenofovir disoproxil<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Delstrigo is and what it is used for<\/h2>\n\n\n\n<p><strong>What Delstrigo is<\/strong><\/p>\n\n\n\n<p>Substring is used to treat&nbsp;HIV&nbsp;(&#8220;human immunodeficiency virus&#8221;)&nbsp;infection.&nbsp;It belongs to a group of medicines called &#8220;antiretroviral medicines&#8221;.<br><\/p>\n\n\n\n<p>Substring contains the active substances:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Moravian &#8211; a non-nucleoside&nbsp;reverse transcriptase inhibitor (NNRTI)<\/li><li>lamivudine &#8211; a&nbsp;nucleoside&nbsp;reverse transcriptase inhibitor (NRTI)&nbsp;analogue<\/li><li>tenofovir disoproxil &#8211; a&nbsp;nucleoside&nbsp;reverse transcriptase inhibitor (NRTI)&nbsp;analogue.<br><\/li><\/ul>\n\n\n\n<p><strong>What Delstrigo is used for<\/strong><\/p>\n\n\n\n<p>Substrigo is used to treat&nbsp;HIV&nbsp;infection&nbsp;in people aged 18 and older.&nbsp;HIV&nbsp;is the&nbsp;virus that causes&nbsp;AIDS&nbsp;(&#8220;acquired immune deficiency syndrome&#8221;).&nbsp;You should not take Delstrigo if your doctor has told you that the&nbsp;virus&nbsp;that causes your&nbsp;infection&nbsp;is&nbsp;resistant&nbsp;(resistant) to any of the active substances in Delstrigo.<br><\/p>\n\n\n\n<p><strong>How Delstrigo works<\/strong><\/p>\n\n\n\n<p>Delstrigo works by preventing&nbsp;HIV&nbsp;from making more&nbsp;viruses&nbsp;in your body.&nbsp;It helps by:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>reduce the amount of&nbsp;HIV&nbsp;in the blood (the so-called &#8220;amount of virus&#8221;)<\/li><li>increase the number of&nbsp;white blood cells, so-called &#8220;CD4&nbsp;<sup>+&nbsp;<\/sup>&nbsp;T&#8221;.&nbsp;It can make your immune system stronger and can reduce the risk of premature death or getting&nbsp;infected&nbsp;because your immune system is weak.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before you take Delstrigo<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Delstrigo<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to Moravian, lamivudine or tenofovir disoproxil, or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you are taking any of the following medicines:<ul><li>carbamazepine, oxcarbazepine, phenobarbital,&nbsp;phenytoin&nbsp;(anticonvulsant)<\/li><li>rifampicin, rifapentine (a medicine used to treat&nbsp;tuberculosis&nbsp;)<\/li><li>St. John&#8217;s wort&nbsp;(&nbsp;Hypericum perforatum, a herbal remedy for depression and anxiety) or products containing&nbsp;St. John&#8217;s wort<\/li><li>mitotane (anti-cancer drug)<\/li><li>enzalutamide (a drug for prostate cancer)<\/li><li>lumacaftor (a drug for&nbsp;cystic fibrosis&nbsp;)<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>Do not take Delstrigo if any of the above apply to you.&nbsp;If you are not sure, talk to your doctor, pharmacist, or nurse before taking Delstrigo.&nbsp;See also section \u201cOther medicines and Delstrigo\u201d.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before taking Delstrigo.<br><\/p>\n\n\n\n<p><strong>Transmission of&nbsp;HIV&nbsp;to others<\/strong><\/p>\n\n\n\n<p>HIV is&nbsp;spread through contact with blood or through sexual contact with a person who has&nbsp;HIV.&nbsp;You can still infect others with&nbsp;HIV&nbsp;when you take Delstrigo, although effective treatment reduces the risk.&nbsp;Talk to your doctor about what you can do to avoid infecting others.<br><\/p>\n\n\n\n<p><strong>Exacerbated&nbsp;hepatitis&nbsp;B&nbsp;infection<\/strong><\/p>\n\n\n\n<p>If you have both&nbsp;HIV&nbsp;and&nbsp;hepatitis&nbsp;B&nbsp;virus&nbsp;infections, your&nbsp;hepatitis&nbsp;B may get worse if you stop taking Delstrigo.&nbsp;You may need to submit blood samples for several months after stopping treatment.&nbsp;Discuss your&nbsp;hepatitis&nbsp;B treatment with your doctor.<br><\/p>\n\n\n\n<p><strong>New or worsening kidney problems, including&nbsp;kidney failure<\/strong><\/p>\n\n\n\n<p>This may happen to some people taking Delstrigo.&nbsp;Your doctor will take blood samples to check your kidney function before and during treatment with Delstrigo.<br><\/p>\n\n\n\n<p><strong>Skeletal problem<\/strong><\/p>\n\n\n\n<p>This may happen to some people taking Delstrigo.&nbsp;Skeletal problems include skeletal pain, softer or thinner skeletons (which can lead to bone fractures).&nbsp;Joint or muscle pain or muscle weakness may also occur.&nbsp;Your doctor may need to take more samples to check your skeleton.<br><\/p>\n\n\n\n<p><strong>Immune reactivation syndrome<\/strong><\/p>\n\n\n\n<p>This is something that can happen when you start taking HIV&nbsp;medicine, including Delstrigo.&nbsp;Your immune system can become stronger and start fighting&nbsp;infections that have been hidden in your body for a long time.&nbsp;Tell your doctor immediately if you get any new symptoms once you have started your&nbsp;HIV&nbsp;treatment.<br><\/p>\n\n\n\n<p>Autoimmune disorders (a condition in which the immune system attacks healthy body tissue) may also occur after you start taking medicines to treat your&nbsp;HIV&nbsp;&#8211;&nbsp;infection.&nbsp;Autoimmune disorders can occur several months after starting treatment.&nbsp;If you notice any symptoms of&nbsp;infection&nbsp;or other symptoms such as muscle weakness, a weakness that starts in the hands or feet and moves to the torso, palpitations, tremors, or hyperactivity, inform your doctor immediately for the necessary treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p><strong>Do not give this medicine to anyone under 18 years of age.&nbsp;<\/strong>The use of Delstrigo in people under 18 years of age has not yet been studied.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Delstrigo<\/h2>\n\n\n\n<p>Tell your doctor, pharmacist, or nurse if you are taking, have recently taken, or might take any other medicines.&nbsp;This is because other medicines may affect the way Delstrigo works and Delstrigo may affect the way some other medicines work.<br><\/p>\n\n\n\n<p>There are certain medicines that you must not take Delstrigo with.&nbsp;See the list under the section &#8220;Do not take Delstrigo&#8221;.<br><\/p>\n\n\n\n<p>Talk to your doctor before taking the following medicines at the same time as Delstrigo as your doctor may need to change the&nbsp;dose of&nbsp;one of your medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>bosentan&nbsp;(a medicine used to treat lung diseases)<\/li><li>dabrafenib (medicine for skin cancer)<\/li><li>lesinurad (medicine for&nbsp;gout&nbsp;)<\/li><li>modafinil (a medicine used to treat excessive sleep)<\/li><li>nafcillin (medicine for certain bacterial infections)<\/li><li>rifabutin (medicines for certain bacterial infections, such as&nbsp;tuberculosis&nbsp;)<\/li><li>telotristatetyl (antiarrhythmic drug in people with carcinoid syndrome)<\/li><li>thioridazine (a medicine used to treat mental disorders such as schizophrenia).<\/li><\/ul>\n\n\n\n<p>If your doctor decides that you should take these medicines with Delstrigo, your doctor will prescribe a 100 mg tablet of Moravian to be taken daily approximately 12 hours after your&nbsp;dose of&nbsp;Delstrigo.<br><\/p>\n\n\n\n<p>Your doctor may check your blood levels or monitor for&nbsp;side effects&nbsp;if you are taking the following medicines with Delstrigo:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>ledipasvir\/sofosbuvir (medicines for&nbsp;hepatitis&nbsp;C&nbsp;infection&nbsp;)<\/li><li>sirolimus (a medicine used to control your body&#8217;s&nbsp;immune response&nbsp;after a transplant)<\/li><li>sofosbuvir \/ velpatasvir (medicines for&nbsp;hepatitis&nbsp;C&nbsp;infection&nbsp;)<\/li><li>tacrolimus (a medicine used to control your body&#8217;s&nbsp;immune response&nbsp;after a transplant)<\/li><li>medicines (often liquid) containing sorbitol or other sugar alcohols (such as xylitol, mannitol, lactitol, or maltitol), if taken regularly<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice on the risks and benefits of taking Delstrigo.&nbsp;It is preferable to avoid the use of Delstrigo during pregnancy.&nbsp;This is because it has not been studied during pregnancy and it is not known if Delstrigo will harm your baby when you are pregnant.<br><\/p>\n\n\n\n<p>Women with&nbsp;HIV&nbsp;should not breast-feed because&nbsp;HIV&nbsp;can be transmitted to the baby through breast milk.&nbsp;Talk to your doctor about the best way to feed your child.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Caution should be exercised if you drive, cycle or use machines if you feel tired, dizzy, or sleepy after taking this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Substrigo contains lactose<\/h2>\n\n\n\n<p>If you have been told&nbsp;by your doctor that you have lactose intolerance, talk to your doctor before taking this medicine.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to take Delstrigo<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor, pharmacist or nurse has told you.&nbsp;If you are not sure, talk to your doctor, pharmacist, or nurse.&nbsp;Delstrigo is a complete combination treatment administered as one tablet for the treatment of&nbsp;HIV&nbsp;&#8211;&nbsp;infection.<br><\/p>\n\n\n\n<p><strong>How much to take<\/strong><\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;is one tablet once a day.&nbsp;If you are taking certain medicines, your doctor may need to change the&nbsp;dose of&nbsp;a Moravian you are taking.&nbsp;See section &#8220;Other medicines and Delstrigo&#8221; for a list of medicines.<br><\/p>\n\n\n\n<p><strong>How to take this medicine<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Swallow the tablet whole (it must not be crushed or chewed).<\/li><li>This medicine can be taken with food or between meals.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Delstrigo than you should<\/h2>\n\n\n\n<p>Do not take more than the recommended&nbsp;dose.&nbsp;If you happen to take more, contact your doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Delstrigo<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>You mustn&#8217;t miss or skip a&nbsp;dose&nbsp;of Delstrigo.<\/li><li>If you forget to take a&nbsp;dose, take it as soon as you remember.&nbsp;But if it is time for your next&nbsp;dose&nbsp;within 12 hours, you should instead skip the missed&nbsp;dose&nbsp;and take the next&nbsp;dose&nbsp;at the usual time.&nbsp;Then continue with the treatment as before.<\/li><li>Do not take two&nbsp;doses of&nbsp;Delstrigo at the same time to compensate for a missed&nbsp;dose.<\/li><li>Contact your doctor or pharmacist if you are not sure what to do.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Delstrigo<\/h2>\n\n\n\n<p>Make sure you do not run out of Delstrigo.&nbsp;Renew your prescription or talk to your doctor before all Delstrigo is over.<br><\/p>\n\n\n\n<p>If you stop taking Delstrigo doctor must check your health and often take blood samples at intervals of several months to check your&nbsp;HIV&nbsp;&#8211;&nbsp;infection.&nbsp;If you have&nbsp;HIV&nbsp;&#8211;&nbsp;infection&nbsp;and&nbsp;hepatitis&nbsp;B&nbsp;infection, it is especially important not to stop taking Delstrigo without first talking to your doctor.&nbsp;In some patients, blood tests or symptoms have shown that&nbsp;hepatitis&nbsp;one has worsened when they stop taking or tenofovir disoproxil (two of the three active substances in Delstrigo).&nbsp;If you stop taking Delstrigo, your doctor may recommend that you resume treatment for&nbsp;hepatitis B. You may need blood tests to check how your liver is working for 4 months after stopping treatment.&nbsp;For some patients with advanced liver disease or&nbsp;liver cirrhosis&nbsp;(cirrhosis of the&nbsp;liver&nbsp;), it is not recommended to stop treatment as it may make&nbsp;hepatitis&nbsp;worse, which can be life-threatening.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.&nbsp;Do not stop taking this medicine without talking to your doctor first.<br><\/p>\n\n\n\n<p><strong>Common<\/strong>: may affect up to 1 in 10 people:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>abnormal dreams, difficulty sleeping (&nbsp;insomnia&nbsp;)<\/li><li>headache, dizziness, drowsiness<\/li><li>cough, nasal symptoms<\/li><li>nausea, diarrhea, abdominal pain, vomiting, gas (&nbsp;flatulence&nbsp;)<\/li><li>hair loss, rash<\/li><li>muscle symptoms (pain, stiffness)<\/li><li>fatigue, fever<\/li><\/ul>\n\n\n\n<p>Blood tests may also show:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>elevated levels of liver enzymes (&nbsp;ALT&nbsp;)<\/li><\/ul>\n\n\n\n<p><strong>Uncommon:<\/strong>&nbsp;may affect up to 1 in 100 people:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>nightmares, depression, anxiety, irritability, confusion, suicidal thoughts<\/li><li>difficulty concentrating, impaired memory, tingling in hands and feet, stiff muscles, poor sleep quality<\/li><li>high&nbsp;blood pressure<\/li><li>constipation, abdominal discomfort, swollen or bloated stomach, indigestion, loose stools, stomach cramps, frequent bowel movements,&nbsp;inflammation&nbsp;of the pancreas (&nbsp;pancreatitis&nbsp;) (causes abdominal pain, vomiting)<\/li><li>itching<\/li><li>joint pain, degradation of muscle tissue, muscle weakness<\/li><li>the feeling of weakness, a general feeling of illness<\/li><\/ul>\n\n\n\n<p>Blood tests may also show:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>decreased number of&nbsp;white blood cells&nbsp;in the blood (&nbsp;neutropenia&nbsp;)<\/li><li>decreased number of&nbsp;red blood cells&nbsp;in the blood (&nbsp;anemia&nbsp;)<\/li><li>decreased levels of&nbsp;platelets&nbsp;in the blood (you can bleed more easily)<\/li><li>decreased levels of&nbsp;phosphate<\/li><li>decreased levels of&nbsp;potassium&nbsp;in the blood<\/li><li>elevated levels of&nbsp;creatinine&nbsp;in the blood<\/li><li>elevated levels of liver enzymes (&nbsp;ASAT&nbsp;)<\/li><li>elevated levels of&nbsp;lipase<\/li><li>elevated levels of amylase<\/li><li>decreased levels of&nbsp;hemoglobin<\/li><\/ul>\n\n\n\n<p>Muscle pain, muscle weakness, and decreased amount of&nbsp;potassium&nbsp;or&nbsp;phosphate&nbsp;in the blood can be due to damage to the small channels in the kidneys.<br><\/p>\n\n\n\n<p><strong>Rare:<\/strong>&nbsp;may affect up to 1 in 1,000 people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>aggression, hallucinations, difficulty adapting to changes, mood swings, sleepwalking<\/li><li>difficulty breathing, enlarged tonsils<\/li><li>the feeling of incomplete bowel movements<\/li><li>enlarged liver or&nbsp;fatty liver, yellowing of the skin or eyes, abdominal pain caused by&nbsp;inflammation&nbsp;of the liver<\/li><li>inflammation&nbsp;of the skin due to&nbsp;allergies,&nbsp;redness&nbsp;of the cheeks, nose, chin, or forehead, lumps or pimples on the face, swelling of the face, lips, tongue, or throat<\/li><li>muscle weakness, weakening of the skeleton (with skeletal pain and sometimes resulting in bone fractures)<\/li><li>kidney damage,&nbsp;kidney stones,&nbsp;kidney failure, damage to the small ducts in the kidneys, kidney damage, copious amounts of urine, and thirst<\/li><li>chest pain, chills, pain, thirst<\/li><\/ul>\n\n\n\n<p>Blood tests may also show:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>decreased levels of&nbsp;magnesium<\/li><li>lactic acidosis (excess&nbsp;lactic acid&nbsp;in the blood)<\/li><li>elevated levels of creatine phosphokinase<\/li><\/ul>\n\n\n\n<p><strong>Very rare:<\/strong>&nbsp;may affect up to 1 in 10,000 people<\/p>\n\n\n\n<p>Blood tests may also show:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>the inability of&nbsp;bone marrow&nbsp;to produce new&nbsp;red blood cells&nbsp;(lack of&nbsp;red blood cells alone&nbsp;)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Delstrigo<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Keep this medicine out of the sight and reach of children.<\/li><li>Do not use this medicine after the expiry date which is stated on the can after EXP.<\/li><li>The jar contains a desiccant that protects the tablets from moisture.&nbsp;There may be more than one in a jar.&nbsp;Leave the desiccant in the jar and do not throw it away until you have taken all the tablets.<\/li><li>Close the jar tightly.&nbsp;Moisture sensitive.<\/li><li>No special temperature instructions.<\/li><li>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substances are 100 mg doravirin, 300 mg lamivudine and 245 mg tenofovir disoproxil (as fumarate)<\/li><li>The other ingredients are croscarmellose sodium E468, hypromellose acetate succinate, magnesium stearate E470b, microcrystalline cellulose E460,&nbsp;colloidal anhydrous silica E551, and sodium stearyl fumarate.&nbsp;The tablets have a film coating consisting of the following ingredients: carnauba wax E903, hypromellose E464, yellow iron oxide E172,&nbsp;lactose monohydrate, titanium dioxide E171, and triacetin E1518.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Delstrigo is a yellow, oval, film-coated tablet, marked with the company logo and &#8220;776&#8221; on one side and smooth on the other.<br><\/p>\n\n\n\n<p>The following pack sizes are available:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>1 jar of 30 film-coated tablets<\/li><li>90 film-coated tablets (3 cans of 30 film-coated tablets)<\/li><\/ul>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Merck Sharp &amp; Dohme BV<\/p>\n\n\n\n<p>Waarderweg 39<\/p>\n\n\n\n<p>2031 BN Haarlem<\/p>\n\n\n\n<p>Netherlands<br><\/p>\n\n\n\n<p>Contact the representative of the marketing authorization holder to find out more about this medicine:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgium \/ Belgique \/ Belgien<\/strong>MSD Belgium BVBA \/ SPRLTel: +32 (0) 27766211dpoc_belux@merck.com<\/td><td><strong>Lithuania<\/strong>UAB Merck Sharp &amp; DohmeTel.&nbsp;+ 370 5 278 02 47msd_lietuva@merck.com<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Mark Harp and Doom Bulgaria BulgariaTel: +359 2 819 3737info-msdbg@merck.com<\/td><td><strong>Luxembourg \/ Luxemburg<\/strong>MSD Belgium BVBA \/ SPRLTel: +32 (0) 27766211dpoc_belux@merck.com<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Merck Sharp &amp; Dohme sroTel: +420 233 010 111dpoc_czechslovak@merck.com<\/td><td><strong>Hungary<\/strong>MSD Pharma Hungary Kft.Tel .: +36 1 888 5300hungary_msd@merck.com<\/td><\/tr><tr><td><strong>Denmark<\/strong>MSD Danmark ApSTel: + 45 4482 4000dkmail@merck.com<\/td><td><strong>Malta<\/strong>Merck Sharp &amp; Dohme Cyprus LimitedTel: 8007 4433 (+356 99917558)malta_info@merck.com<\/td><\/tr><tr><td><strong>Germany<\/strong>MSD SHARP &amp; DOHME GMBHTel: 0800 673 673 673 (+49 (0) 89 4561 2612)e-mail@msd.de<\/td><td><strong>The Netherlands<\/strong>Merck Sharp &amp; Dohme BVTel: 0800 9999000(+31 23 5153153)medicalinfo.nl@merck.com<\/td><\/tr><tr><td><strong>Eesti<\/strong>Merck Sharp &amp; Dohme O\u00dcTel .: +372 6144 200msdeesti@merck.com<\/td><td><strong>Norway<\/strong>MSD (Norway) ASTel: +47 32 20 73 00msdnorge@msd.no<\/td><\/tr><tr><td><strong>Greece<\/strong>MSD \u0391.\u03a6.\u0392.\u0395.\u0395.:\u0397\u03bb: +30 210 98 97 300dpoc_greece@merck.com<\/td><td><strong>Austria<\/strong>Merck Sharp &amp; Dohme Ges.mbHTel: +43 (0) 1 26 044msd-medizin@merck.com<\/td><\/tr><tr><td><strong>Spain<\/strong>Merck Sharp &amp; Dohme de Espa\u00f1a, SATel: +34 91 321 06 00msd_info@merck.com<\/td><td><strong>Poland<\/strong>MSD Polska Sp.&nbsp;z ooTel: +48 22 549 51 00msdpolska@merck.com<\/td><\/tr><tr><td><strong>France<\/strong>MSD FranceTel: + 33 (0) 1 80 46 40 40<\/td><td><strong>Portugal<\/strong>Merck Sharp &amp; Dohme, LdaTel: +351 21 4465700inform_pt@merck.com<\/td><\/tr><tr><td><strong>Croatia:<\/strong>Merck Sharp &amp; Dohme dooTel: + 385 1 6611 333croatia_info@merck.com<\/td><td><strong>Romania<\/strong>Merck Sharp &amp; Dohme Romania SRLTel: +40 21 529 29 00msdromania@merck.com<\/td><\/tr><tr><td><strong>Ireland<\/strong>Merck Sharp &amp; Dohme Ireland (&nbsp;Human&nbsp;Health) LimitedTel: +353 (0) 1 2998700medinfo_ireland@merck.com<\/td><td><strong>Slovenia<\/strong>Merck Sharp &amp; Dohme, an innovative freelance dooTel: +386 1 5204 201msd.slovenia@merck.com<\/td><\/tr><tr><td><strong>Iceland<\/strong>Vistor hf.Phone: + 354 535 7000<\/td><td><strong>Slovak Republic<\/strong>Merck Sharp &amp; Dohme, sroTel: +421 2 58282010dpoc_czechslovak@merck.com<\/td><\/tr><tr><td><strong>Italy<\/strong>MSD Italia SrlTel: +39 06 361911medicalinformation.it@merck.com<\/td><td><strong>Finland \/ Finland<\/strong>MSD Finland OyPuh \/ Tel: +358 (0) 9 804 650info@msd.fi<\/td><\/tr><tr><td><strong>Latvia<\/strong>SIA Merck Sharp &amp; Dohme LatvijaTel: + 371 67364224msd_lv@merck.com<\/td><td><strong>United Kingdom<\/strong>Merck Sharp &amp; Dohme LimitedTel: +44 (0) 1992 467272medicalinformationuk@merck.com<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Substring is used to treat HIV (&#8220;human immunodeficiency virus&#8221;) infection. It belongs to a group of medicines called &#8220;antiretroviral medicines&#8221;.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2204,2200],"tags":[5981,5985,5983,5986,5988,5989,4015,5225,5984,5990,5991,5992,2211,3389,4331,4332,5982,5987,4016,4330],"class_list":["post-7315","post","type-post","status-publish","format-standard","hentry","category-d","category-medicines","tag-delstrigo","tag-delstrigo-side-effects","tag-delstrigo-tablet","tag-doravirin","tag-doravirin-side-effects","tag-doravirin-tablet","tag-lamivudine","tag-lamivudine-tablet","tag-side-effects-of-delstrigo","tag-side-effects-of-doravirin","tag-side-effects-of-lamivudine","tag-side-effects-of-tenofovir-disoproxil","tag-tablets","tag-tenofovir-disoproxil","tag-tenofovir-disoproxil-side-effects","tag-tenofovir-disoproxil-tablet","tag-what-is-delstrigo","tag-what-is-doravirin","tag-what-is-lamivudine","tag-what-is-tenofovir-disoproxil"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7315","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=7315"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7315\/revisions"}],"predecessor-version":[{"id":11118,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7315\/revisions\/11118"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=7315"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=7315"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=7315"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}