{"id":7247,"date":"2021-02-20T06:07:07","date_gmt":"2021-02-20T06:07:07","guid":{"rendered":"https:\/\/zeepedia.com\/?p=7247"},"modified":"2021-05-28T10:33:27","modified_gmt":"2021-05-28T10:33:27","slug":"daonil","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/daonil\/","title":{"rendered":"Daonil &#8211; Glibenclamide uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n3.5 mg&nbsp;Tablets&nbsp;<br>Glibenclamide<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Daonil is and what it is used for<\/h2>\n\n\n\n<p>Daniel seems to lower blood sugar, partly by increasing insulin production and possibly partly by making the body&#8217;s own&nbsp;insulin&nbsp;et more efficiently.<br><\/p>\n\n\n\n<p>Daonil is used for&nbsp;type 2&nbsp;diabetes mellitus&nbsp;(adult diabetes), like diet, exercise, and weight reduction alone do not have a sufficient effect.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before using Daonil<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Daonil<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic (hypersensitive) to glibenclamide or any of the other ingredients of Daonil.<\/li><li>if you have&nbsp;type 1&nbsp;diabetes mellitus&nbsp;(insulin-dependent&nbsp;diabetes&nbsp;).<\/li><li>in diabetic coma and case of the too high content of acidic substances in the body (&nbsp;ketoacidosis&nbsp;).<\/li><li>in case of malnutrition.<\/li><li>in severe renal or hepatic impairment.<\/li><li>in acute conditions that complicate diabetes, such as&nbsp;infection&nbsp;or cold sores.<\/li><li>when co-administered with medicines containing&nbsp;bosentan&nbsp;(used to treat high&nbsp;blood pressure&nbsp;in the blood vessels of the lungs).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Take special care with Daonil:<\/h2>\n\n\n\n<p>Blood sugar should be checked regularly.<\/p>\n\n\n\n<p>The risk of low blood sugar (hypoglycemia) is increased during the first weeks of treatment.<br><\/p>\n\n\n\n<p>Elderly patients may be more sensitive to low blood sugar, so your doctor will adjust the&nbsp;dose&nbsp;to as low a&nbsp;dose&nbsp;as possible.<\/p>\n\n\n\n<p>With impaired renal or hepatic function and after prolonged fasting, the blood sugar lowering effect may become too strong.<br><\/p>\n\n\n\n<p><em>Hypoglycemia<\/em>&nbsp;(hypoglycemia<em>)<\/em><\/p>\n\n\n\n<p>Hypoglycemia&nbsp;(hypoglycemia), a so-called &#8220;feeling&#8221;, can occur with the concomitant use of other drugs, overdose, irregular meals, decreased food or fluid intake, stress, and increased physical activity.<br><\/p>\n\n\n\n<p>Mild symptoms of low blood sugar can range from hunger, lethargy, drowsiness, visual disturbances, irritability, emotional disturbances, confusion, sweating, anxiety, tremors, coordination problems, pallor, and headaches.&nbsp;In most cases, the symptoms disappear fairly quickly after consuming sugar.&nbsp;You should therefore always carry some form of sugar with you, such as grape sugar, chocolate, or the like.&nbsp;Note that sweeteners do not affect.&nbsp;If sugar intake does not help or if symptoms return, contact your doctor or hospital.&nbsp;More serious symptoms of low blood sugar can be seizures and if the blood sugar does not rise, unconsciousness can occur.&nbsp;Doctors should be contacted immediately in case of more severe symptoms.<br><\/p>\n\n\n\n<p>In case of severe overdose, there is a risk of affecting the brain, heart, blood, liver, and respiration.<br><\/p>\n\n\n\n<p><em>Elevated blood sugar (hyperglycemia)<\/em><\/p>\n\n\n\n<p>Signs of high blood sugar (hyperglycemia) may include thirst, frequent urination,&nbsp;dry mouth,&nbsp;and dry skin.&nbsp;In such cases, a doctor should be consulted.&nbsp;In connection with accidents, operations, and febrile conditions, it may be necessary to switch to insulin treatment.<br><\/p>\n\n\n\n<p>Talk to your doctor before taking Daonil if you have heart disease, as it may increase the risk of serious heart problems.<br><\/p>\n\n\n\n<p>People who are hypersensitive to other medicines in the same group (sulphonylureas and&nbsp;sulphonamides&nbsp;) may also develop allergic reactions to Daonil.<br><\/p>\n\n\n\n<p>Daonil can in rare cases affect the white&nbsp;blood cells&nbsp;so that the&nbsp;defense against&nbsp;infection deteriorates.&nbsp;If you get an&nbsp;infection&nbsp;with symptoms such as fever with severe general deterioration or fever with local infection symptoms such as sore throat\/pharynx \/ mouth or urination problems, you should see a doctor as soon as possible so that a lack of&nbsp;white blood cells&nbsp;(&nbsp;agranulocytosis&nbsp;)&nbsp;can be ruled out via blood tests.&nbsp;.&nbsp;It is important that you then information about your medication.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Use of other medicines:<\/h2>\n\n\n\n<p>The following combination with glibenclamide should not be used:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Medicines for the treatment of high&nbsp;blood pressure&nbsp;in the lungs (&nbsp;bosentan&nbsp;)<\/li><\/ul>\n\n\n\n<p>The following medicines may increase the blood-glucose-lowering effect of Daonil which may lead to an increased risk of&nbsp;hypoglycemia&nbsp;(low blood sugar):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Other medicines used to treat diabetes (such as&nbsp;insulin, or&nbsp;metformin&nbsp;)<\/li><li>Medicines for the treatment of pain and&nbsp;inflammation&nbsp;(phenylbutazone, azapropazone, and oxyphenbutazone)<\/li><li>Drugs that promote muscle building (anabolic&nbsp;steroids&nbsp;)<\/li><li>Drugs used in the replacement of male sex hormone<\/li><li>Drugs used to treat depression (&nbsp;fluoxetine,&nbsp;MAO inhibitors&nbsp;)<\/li><li>Drugs used to treat&nbsp;tuberculosis&nbsp;(para-aminosalicylic acid)<\/li><li>Drugs primarily used in the treatment of&nbsp;infection&nbsp;your urinary tract and&nbsp;prostate(+ sulfamethoxazole-trimethoprim)<\/li><li>Medicines that lower high&nbsp;blood pressure&nbsp;or are used in the treatment of certain heart diseases (&nbsp;ACE inhibitors&nbsp;)<\/li><li>Drugs that lower high cholesterol levels (fibrates)<\/li><li>Drugs used to treat cancer (cyclophosphamide and ifosfamide)<\/li><li>Medicines for the treatment of&nbsp;gout&nbsp;(probenecid and sulfinpyrazone)<\/li><li>Medicines for the treatment of nasal&nbsp;allergies&nbsp;such as hay fever (tritoqualin)<\/li><li>Drugs that increase blood circulation when given in high&nbsp;doses&nbsp;by&nbsp;intravenous infusion&nbsp;(pentoxifylline)<\/li><li>Medicines used for weight loss (fenfluramine)<\/li><li>Drugs called sympatholytic drugs such as&nbsp;beta-blockers&nbsp;and guanethidine used to treat high&nbsp;blood pressure,&nbsp;heart failure,&nbsp;or prostate symptoms<\/li><li>Medicines for the treatment of cardiac arrhythmias (&nbsp;amiodarone&nbsp;)<\/li><li>Medicines used to treat&nbsp;bacterial&nbsp;and fungal infections (&nbsp;tetracyclines, chloramphenicol,&nbsp;fluconazole,&nbsp;miconazole, quinolone antibiotics, clarithromycin)<\/li><li>Salicylic acid derivatives (used to remove dry and scaly skin, eg in&nbsp;psoriasis&nbsp;)<\/li><\/ul>\n\n\n\n<p>The following medicines may lower the blood sugar lowering effect of Daonil.&nbsp;This may lead to an increased risk of&nbsp;hyperglycemia&nbsp;(high blood sugar):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Medicines containing female sex hormones (&nbsp;estrogens, progestogens)<\/li><li>Medicines for the treatment of increased pressure in the eye (acetazolamide)<\/li><li>Medicines for the treatment of anxiety and sleep problems (&nbsp;barbiturates&nbsp;)<\/li><li>Drugs that act as&nbsp;diuretics&nbsp;(&nbsp;diuretics&nbsp;)<\/li><li>Drugs that stimulate the thyroid gland (such as levothyroxine)<\/li><li>Medicines for the treatment of seizures (&nbsp;phenytoin&nbsp;)<\/li><li>Medicines for the treatment of&nbsp;allergies&nbsp;and&nbsp;inflammation&nbsp;(&nbsp;glucocorticoids&nbsp;)<\/li><li>Medicines for the treatment of severe mental disorders (phenazine derivatives)<\/li><li>Medicines for the treatment of high cholesterol levels (&nbsp;nicotinic acid&nbsp;)<\/li><li>Medicines for long-term treatment of constipation (&nbsp;laxatives&nbsp;)<\/li><li>Medicines for the treatment of high&nbsp;blood pressure&nbsp;or the treatment of low blood sugar (diazoxide)<\/li><li>Medicines for the treatment of severe low blood sugar (glucagon)<\/li><li>Medicines used in life-threatening situations (&nbsp;sympathomimetic&nbsp;)<\/li><li>Drugs used to treat&nbsp;infections,&nbsp;tuberculosis&nbsp;(rifampicin)<\/li><\/ul>\n\n\n\n<p>The following medicines may either enhance or weaken Daonil&#8217;s blood sugar lowering effect:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Medicines for the treatment of&nbsp;stomach ulcers&nbsp;(so-called H2&nbsp;antagonists&nbsp;)<\/li><li>Medicines for the treatment of high&nbsp;blood pressure&nbsp;or&nbsp;heart failures&nbsp;such as&nbsp;beta-blockers,&nbsp;clonidine,&nbsp;and reserpine.&nbsp;These medicines can also hide the signs of&nbsp;hypoglycemia, so special precautions should be taken when using them.<\/li><\/ul>\n\n\n\n<p>The following medicines may be affected by Daonil:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Cimetidine (used to treat&nbsp;stomach ulcers&nbsp;)<\/li><\/ul>\n\n\n\n<p>Daonil may either potentiate or weaken the effect of the following medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Drugs that inhibit blood coagulation (coumarin derivatives such as&nbsp;warfarin&nbsp;)<\/li><li>Ciclosporin (used to block the body&#8217;s natural immune system)<\/li><\/ul>\n\n\n\n<p>Daniel should be taken at least 4 hours before medicines containing colesevelam (medicines used to treat high cholesterol levels).<br><\/p>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.<br><\/p>\n\n\n\n<p>The effect of Daonil may be affected if Daonil and alcohol are taken at the same time.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Intake of Daonil with food and drink<\/h2>\n\n\n\n<p>The tablets should always be taken just before or at mealtime.&nbsp;At&nbsp;doses&nbsp;above 7 mg, take 7 mg in the morning for breakfast and the rest in connection with the evening meal.<br><\/p>\n\n\n\n<p>Alcohol may enhance or weaken the blood sugar unpredictably lowering the effect of Daonil.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p><em>Pregnancy<\/em><\/p>\n\n\n\n<p>There is a risk that the fetus is affected.&nbsp;Daonil should therefore not be used during pregnancy but should be replaced by&nbsp;insulin.&nbsp;If you are planning to become pregnant, tell your doctor.<br><\/p>\n\n\n\n<p><em>Breast-feeding<\/em><\/p>\n\n\n\n<p>It is not known if Daonil passes into breast milk but other medicines in the same group (sulphonylureas) do.&nbsp;Daonil should therefore not be used during breast-feeding.&nbsp;Consult a doctor as it may be necessary to switch to&nbsp;insulin.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>During the first weeks of treatment, care should be taken when driving and handling machines.&nbsp;Too low or too high blood sugar can impair reactivity and visual acuity.<br><\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased vigilance.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Important information about some of the ingredients of Daonil<\/h2>\n\n\n\n<p>Daonil contains&nbsp;lactose.&nbsp;If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use Daonil<\/h2>\n\n\n\n<p>Dose&nbsp;one is determined by the doctor who adapts it for you.&nbsp;Always use Daonil exactly as your doctor has told you.&nbsp;If you are not sure, talk to your doctor or pharmacist.&nbsp;The usual&nbsp;dose&nbsp;for adults varies between 1.75 mg and 10.5 mg daily depending on your blood sugar level.&nbsp;The tablets should always be taken just before or at mealtime.<\/p>\n\n\n\n<p>The tablets have a score line and can be divided into two equal parts.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Daonil than you should:<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if, for example, a child has ingested the medicine by mistake, always contact a doctor, hospital, or the Poisons Information Center immediately for assessment of the risk and advice.<\/p>\n\n\n\n<p>If you take more&nbsp;doses of&nbsp;Daonil may be symptoms associated with low blood sugar may occur.<\/p>\n\n\n\n<p>If overdose is suspected, sugar, fruit juice, or the like should be taken immediately.&nbsp;See also section &#8220;Take special care with Daonil&#8221;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Daonil:<\/h2>\n\n\n\n<p>DO NOT take a double&nbsp;dose&nbsp;to make up for a&nbsp;forgotten&nbsp;dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Daonil:<\/h2>\n\n\n\n<p>Modification or termination of treatment should only be done in consultation with a physician.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, Daonil can cause&nbsp;side effects,&nbsp;although not everybody gets them.<br><\/p>\n\n\n\n<p>Daonil can in rare cases affect the white&nbsp;blood cells&nbsp;so that the&nbsp;defense against&nbsp;infection deteriorates.&nbsp;If you get an&nbsp;infection&nbsp;with symptoms such as fever with severe deterioration in general condition or fever with local infection symptoms such as sore throat\/throat \/ mouth or difficulty urinating, you should see a doctor as soon as possible so that blood tests can rule out a lack of&nbsp;white blood cells&nbsp;(&nbsp;agranulocytosis&nbsp;).&nbsp;It is important that you then information about your medication.<br><\/p>\n\n\n\n<p>Mild forms of&nbsp;hives&nbsp;have in some cases developed into more serious and even life-threatening conditions with respiratory arrest and drop in blood pressure.&nbsp;Therefore, contact a doctor immediately if you get&nbsp;hives.<br><\/p>\n\n\n\n<p>Other&nbsp;side effects&nbsp;that may occur are:<br><\/p>\n\n\n\n<p><em>Common (affects less than 1 user in 10)<\/em><\/p>\n\n\n\n<p>Nausea, vomiting<br><\/p>\n\n\n\n<p><em>Uncommon (affects less than 1 user in 100)<\/em><\/p>\n\n\n\n<p>Low blood sugar (hypoglycemia) is sometimes prolonged and even life-threatening.&nbsp;Rash.<br><\/p>\n\n\n\n<p><em>Rare (affects less than 1 user in 1,000):<\/em><\/p>\n\n\n\n<p>Elevated liver values, impaired liver function, or jaundice.&nbsp;Increased sensitivity to sunlight.&nbsp;Allergic vasculitis can be life-threatening.&nbsp;Hematological changes such as thrombocytopenia (lack of&nbsp;platelets&nbsp;).<br><\/p>\n\n\n\n<p><em>No known frequency (cannot be calculated from the available data)<\/em><\/p>\n\n\n\n<p>Hypersensitivity reaction, allergic reactions, for example in the form of skin rash.<\/p>\n\n\n\n<p>Skin reactions, even severe with eg blisters and skin detachment<\/p>\n\n\n\n<p>Weight gain<\/p>\n\n\n\n<p>Decreased&nbsp;sodium&nbsp;content&nbsp;in blood serum<\/p>\n\n\n\n<p>The feeling of pressure or satiety, abdominal pain, and diarrhea<\/p>\n\n\n\n<p>Liver effects<\/p>\n\n\n\n<p>Transient visual disturbances<br><\/p>\n\n\n\n<p>Isolated cases of pressure or satiety, abdominal pain, and diarrhea have been reported.&nbsp;These symptoms often subside with continued use, which rarely makes it necessary to discontinue treatment.<br><\/p>\n\n\n\n<p>Hepatic impairment has been reported in isolated patients treated with Daonil.&nbsp;Conditions that can lead to life-threatening liver failure may return when treatment with Daonil is stopped.<br><\/p>\n\n\n\n<p>Transient visual disturbances may occur especially at the beginning of treatment due to changes in blood sugar levels.<br><\/p>\n\n\n\n<p>If any of the&nbsp;side effects&nbsp;gets serious, or if you notice any&nbsp;side effects&nbsp;not listed in this leaflet, please tell your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Daonil<\/h2>\n\n\n\n<p>Keep out of sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>Do not store above 25 \u00b0 C.<br><\/p>\n\n\n\n<p>The medicine should not be disposed of via wastewater or household waste.&nbsp;Ask at the pharmacy how to deal with medicines that are no longer used.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is glibenclamide.&nbsp;One Daonil film-coated tablet contains 3.5 mg glibenclamide.<br><\/li><li>The other ingredients are&nbsp;lactose monohydrate&nbsp;123.2 mg, magnesium stearate, microcrystalline cellulose, macrogol stearate, crospovidone, povidone.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p><strong>Appearance<\/strong><\/p>\n\n\n\n<p>The tablets are white, round (8.0 mm * 8.0 mm), scored, and marked with LAF.<br><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>3.5 mg:<\/td><td>Blister 100 tablets.<\/td><\/tr><tr><td>&nbsp;<\/td><td>Glass jar 100 and 500 (for hospital use) tablets.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Sanofi AB, Box 30052, 104 25 Stockholm<br><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Daniel seems to lower blood sugar, partly by increasing insulin production and possibly partly by making the body&#8217;s own insulin et more efficiently.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2204,2200],"tags":[6145,6147,6148,6140,6142,6143,6149,6144,6146,6141],"class_list":["post-7247","post","type-post","status-publish","format-standard","hentry","category-d","category-medicines","tag-daonil","tag-daonil-side-effects","tag-daonil-tablet","tag-glibenclamide","tag-glibenclamide-side-effects","tag-glibenclamide-tablet","tag-side-effects-of-daonil","tag-side-effects-of-glibenclamide","tag-what-is-daonil","tag-what-is-glibenclamide"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7247","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=7247"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7247\/revisions"}],"predecessor-version":[{"id":11158,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7247\/revisions\/11158"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=7247"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=7247"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=7247"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}