{"id":7154,"date":"2021-02-18T09:22:17","date_gmt":"2021-02-18T09:22:17","guid":{"rendered":"https:\/\/zeepedia.com\/?p=7154"},"modified":"2021-05-29T09:04:13","modified_gmt":"2021-05-29T09:04:13","slug":"cyanokit","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/cyanokit\/","title":{"rendered":"Cyanokit &#8211; Hydroxocobalamin uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n2.5 g&nbsp;powder for&nbsp;infusion&nbsp;solution&nbsp;<br>hydroxocobalamin<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Cyanokit is and what it is used for<\/h2>\n\n\n\n<p>Cyanokit contains the active substance hydroxocobalamin.<\/p>\n\n\n\n<p>Cyanokit is an antidote for the treatment of known or suspected cyanide poisoning in all age groups.<\/p>\n\n\n\n<p>Cyanokit should be used in conjunction with appropriate decontamination and support measures.<br><\/p>\n\n\n\n<p>Cyanide is a very toxic chemical substance.&nbsp;Cyanide poisoning can be caused by exposure to smoke from residential and industrial fires, inhalation or ingestion of cyanide, or skin contact with cyanide.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before using Cyanokit<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Tell a doctor or other healthcare professional<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to hydroxocobalamin or&nbsp;vitamin&nbsp;B12.&nbsp;They must take this into account before you are treated with Cyanokit.<\/li><li>that you have been treated with Cyanokit if you need to do the following:<ul><li>some blood or urine tests.&nbsp;Cyanokit may affect the results of these tests.<\/li><li>assessment of burns.&nbsp;Cyanokite can affect the assessment because it stains the skin red.<\/li><li>hemodialysis.&nbsp;Cyanokit may cause the hemodialysis machine to stop working until it has been eliminated from the bloodstream (at least 5.5 to 6.5 days).<\/li><li>monitoring of renal function.&nbsp;Cyanokite can cause&nbsp;kidney failure&nbsp;and crystals in the urine.<\/li><\/ul><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Cyanokit<\/h2>\n\n\n\n<p>Tell your doctor or another healthcare professional if you are taking, have recently taken, or might take any other medicines.<br><\/p>\n\n\n\n<p>Detailed information for physicians or other healthcare professionals regarding concomitant&nbsp;administration&nbsp;of Cyanokit and other medicinal products can be found at the end of this leaflet (see \u201cHandling instructions\u201d).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>This medicine is for emergency treatment.&nbsp;It can be given during pregnancy and lactation.<\/p>\n\n\n\n<p>Tell your doctor as soon as possible if you were pregnant or think you may have been pregnant during treatment with Cyanokit.<\/p>\n\n\n\n<p>Your doctor will recommend that you stop breastfeeding after treatment with Cyanokit.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Cyanokit<\/h2>\n\n\n\n<p>Your doctor or healthcare professional will give you Cyanokit by&nbsp;infusion(administration) into a vein.&nbsp;You may need one or two&nbsp;infusions.<br><\/p>\n\n\n\n<p>You will receive the first&nbsp;infusion of Cyanokit in 15 minutes.&nbsp;For adults, the initial&nbsp;dose is&nbsp;5 g. For children, it is 7mg\/kg body weight up to a maximum of 5 g. If you need a second&nbsp;infusion, you will receive it for 15 minutes to 2 hours.&nbsp;It depends on the severity of the poisoning.<\/p>\n\n\n\n<p>The highest recommended total dose is 10 g for adults and 14mg\/kg body weight for children up to a maximum of 10 g.<br><\/p>\n\n\n\n<p>Detailed instructions for physicians or other healthcare professionals on how&nbsp;to prepare&nbsp;an infusion&nbsp;of Cyanokit and how to determine a&nbsp;dose&nbsp;can be found at the end of this leaflet (see &#8220;Handling instructions&#8221;).<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.&nbsp;The following&nbsp;side effects&nbsp;can be expected (frequency can not be calculated from the available data):<br><\/p>\n\n\n\n<p><strong>Allergy&nbsp;(hypersensitivity)<\/strong><\/p>\n\n\n\n<p>Tell&nbsp;your doctor&nbsp;<strong>immediately<\/strong>&nbsp;if you get the following symptoms during or after this treatment:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>swelling around the eyes, lips, tongue, throat, at or hands<\/li><li>difficulty breathing, hoarseness, ss or speech difficulties<\/li><li>redness,&nbsp;hives&nbsp;(&nbsp;urticaria,&nbsp;) or&nbsp;itching.<\/li><\/ul>\n\n\n\n<p><strong>Such&nbsp;side effects&nbsp;can be serious and require immediate care.<\/strong><br><\/p>\n\n\n\n<p><strong>Heart and blood pressure problems<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>symptoms such as headache or dizziness, as they may be due to high&nbsp;blood pressure.&nbsp;This high&nbsp;blood pressure&nbsp;occurs especially at the end of treatment and usually drops again within a few hours.<\/li><li>irregular heartbeats<\/li><li>flushing (hot flashes).<\/li><\/ul>\n\n\n\n<p>Lowered&nbsp;blood pressure&nbsp;and faster heart rate have also been observed in patients with cyanide poisoning.<br><\/p>\n\n\n\n<p><strong>Breathing and chest problems<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>fluid in the chest (pleural effusion)<\/li><li>breathing difficulties<\/li><li>a feeling of tightness in the throat<\/li><li>throat dryness<\/li><li>pressure over the chest.<\/li><\/ul>\n\n\n\n<p><strong>Kidney and urine problems<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>kidney damage such as&nbsp;acute&nbsp;renal impairment and crystals in the urine<\/li><li>red urine<\/li><\/ul>\n\n\n\n<p>All patients will show fairly clear dark red urine during the first three days following treatment.&nbsp;Urine staining may persist for up to 35 days after treatment with Cyanokit.&nbsp;This red coloring has no other effect on your body.<br><\/p>\n\n\n\n<p><strong>Gastrointestinal problems<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>discomfort in the stomach<\/li><li>indigestion<\/li><li>diarrhea<\/li><li>nausea<\/li><li>vomiting<\/li><li>difficulty swallowing.<\/li><\/ul>\n\n\n\n<p><strong>Eye problems<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>swelling, irritation, redness.<\/li><\/ul>\n\n\n\n<p><strong>Skin reactions<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Most patients will experience a transient redness of the skin and mucous membranes that may persist for up to 15 days after treatment with Cyanokit.<\/li><li>blister-like changes in the skin (blisters).&nbsp;These can persist for several weeks and mainly affect the face and neck.<\/li><li>inflammation&nbsp;in the part of the body where the drug was administered.<\/li><\/ul>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;ar<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>restlessness<\/li><li>memory problem<\/li><li>dizziness<\/li><li>headache<\/li><li>swollen ankles<\/li><li>altered results on blood samples of certain&nbsp;white blood cells&nbsp;(&nbsp;lymphocytes&nbsp;)<\/li><li>colored&nbsp;place, which may cause an unnatural increase or decrease in the levels of certain laboratory parameters.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Cyanokit<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the vial, cart, on, and carton after EXP.<br><\/p>\n\n\n\n<p>Do not store above 25 \u00b0 C.<br><\/p>\n\n\n\n<p>During outpatient use, Cyanokit may be exposed for a short period of time to temperature variations that occur at<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>normal transport (15 days at temperatures varying between 5 \u00b0 C and 40 \u00b0 C)<\/li><li>desert transport (4 days at temperatures varying between 5 \u00b0 C and 60 \u00b0 C) and<\/li><li>freezing or thawing cycles (15 days at temperatures varying between -20 \u00b0 C and 40 \u00b0 C).<\/li><\/ul>\n\n\n\n<p>For storage instructions for the reconstituted product, see &#8220;Handling instructions&#8221; at the end of this leaflet.<br><\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is hydroxocobalamin.&nbsp;Each&nbsp;vial&nbsp;contains 2.5 g of hydroxocobalamin.&nbsp;After&nbsp;reconstitution&nbsp;with 100 ml of&nbsp;dilute each ml of reconstituted solution contains 25 mg of hydroxocobalamin.<\/li><li>The other ingredient is&nbsp;hydrochloric acid&nbsp;(for&nbsp;pH&nbsp;adjustment).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the d contents of the pack<\/h2>\n\n\n\n<p>Cyanokit powder for&nbsp;solution&nbsp;for&nbsp;infusion&nbsp;is a dark red, crystalline powder that is supplied in a&nbsp;glass&nbsp;vial&nbsp;with a bromobutyl rubber stopper and an aluminum cap with a plastic closure.<br><\/p>\n\n\n\n<p>Each pack contains two vials (each&nbsp;vial&nbsp;is packaged in a carton), two sterile transfer needles, a sterile infusion set for&nbsp;intravenous&nbsp;use, and a short&nbsp;sterile&nbsp;catheter&nbsp;for&nbsp;administration&nbsp;to children.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>SERB SA<\/p>\n\n\n\n<p>Avenue Louise 480<\/p>\n\n\n\n<p>1050 Brussels<\/p>\n\n\n\n<p>Belgium<br><\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Merck Sant\u00e9 sas \/ SEMOY<\/p>\n\n\n\n<p>2, rue du Pressoir Vert<\/p>\n\n\n\n<p>45400 Semoy<\/p>\n\n\n\n<p>France<br><\/p>\n\n\n\n<p>Or<br><\/p>\n\n\n\n<p>SERB SA<\/p>\n\n\n\n<p>Avenue Louise 480<\/p>\n\n\n\n<p>1050 Brussels<\/p>\n\n\n\n<p>Belgium<br><\/p>\n\n\n\n<p>Or<br><\/p>\n\n\n\n<p>SERBIAN<\/p>\n\n\n\n<p>40 Avenue George V<\/p>\n\n\n\n<p>75008 Paris<\/p>\n\n\n\n<p>France<br><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cyanokit contains the active substance hydroxocobalamin. Cyanokit is an antidote for the treatment of known or suspected cyanide poisoning in all age groups.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2203,2200],"tags":[6360,6363,6362,6355,6357,6359,6364,6358,6361,6356],"class_list":["post-7154","post","type-post","status-publish","format-standard","hentry","category-c","category-medicines","tag-cyanokit","tag-cyanokit-powder","tag-cyanokit-side-effects","tag-hydroxocobalamin","tag-hydroxocobalamin-powder","tag-hydroxocobalamin-side-effects","tag-side-effects-of-cyanokit","tag-side-effects-of-hydroxocobalamin","tag-what-is-cyanokit","tag-what-is-hydroxocobalamin"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7154","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=7154"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7154\/revisions"}],"predecessor-version":[{"id":11210,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7154\/revisions\/11210"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=7154"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=7154"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=7154"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}