\n\n20 mg film-coated tablets
cobimetinib<\/p>\n\n\n\n
What <\/strong>Cotellic is<\/strong> What Cotellic is used for<\/strong><\/p>\n\n\n\n Cotellic is used to treat adult patients with a type of skin cancer called melanoma, which has spread to other parts of the body or cannot be removed by surgery.<\/p>\n\n\n\n How Cotellic works<\/strong> If you are not sure, talk to your doctor, pharmacist, or nurse before taking Cotellic. Talk to your doctor, pharmacist, or nurse before taking Cotellic if you have: Cotellic can cause severe bleeding, especially in the brain or stomach ( see also Severe bleeding in section 4<\/em> ). Contact your doctor immediately if you have any unusual bleeding or any of these symptoms; headache, dizziness, feeling weak, blood in the stool or black stools, and bloody vomiting. Cotellic can cause eye problems ( see also ” Eye problems “<\/strong> in section 4<\/em> ). Contact your doctor immediately if you experience the following symptoms: blurred vision, distorted vision, loss of vision, or other vision changes during treatment. Your doctor should examine your eyes if you experience any new or worsening problems with your vision while taking Cotellic. Cotellic may reduce the amount of blood pumped by your heart ( see also ” Heart problems “<\/strong> in section 4<\/em> ). Your doctor should perform tests before and during treatment with Cotellic to check how well your heart can pump blood. Contact your doctor immediately if you have a feeling that your heart is beating, rushing, or beating irregularly, or if you experience dizziness, shortness of breath, fatigue, or swelling in your legs. Cotellic may increase the level of certain liver enzymes in your blood during treatment. Your doctor will take blood samples to check these levels and how well your liver is working. Cotellic can cause elevated levels of creatine phosphokinase, which is an enzyme found primarily in muscle, heart, and brain. This may be a sign of muscle damage ( rhabdomyolysis ) (see also Muscle problems in section 4). Your doctor will take blood samples to check this. Contact your doctor immediately if you get any of these symptoms; muscle pain, muscle spasm, weakness, or dark or red urine. Contact your doctor immediately if you get diarrhea. Severe diarrhea can cause loss of body fluid ( dehydration ). Follow your doctor’s instructions for what to do to prevent or treat diarrhea.<\/p>\n\n\n\n Cotellic is not recommended for children and adolescents. The effects of Cotellic in people under 18 years of age are not known.<\/p>\n\n\n\n Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines. This is because Cotellic may affect the way some other medicines work. Other medicines can also affect the way Cotellic works. Avoid taking Cotellic with grapefruit juice. The reason is that it could increase the amount of Cotellic in the blood. If you are pregnant or breast-feeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n Contraceptives<\/strong> Cotellic may affect your ability to drive and use machines. Avoid driving and using machines if you feel that your vision is affected or other problems that may affect your ability, e.g. if you feel dizzy or tired. Contact your doctor if you are unsure.<\/p>\n\n\n\n The tablets contain lactose (a type of sugar). If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine. This medicine contains less than 1 mmol (23 mg) sodium per tablet, ie it is essentially ‘sodium-free’. Always take this medicine exactly as your doctor or pharmacist has told you. Ask your doctor or pharmacist if you are unsure. How many tablets to take<\/strong><\/p>\n\n\n\n The recommended dose is 3 tablets once daily (total 60 mg)<\/p>\n\n\n\n How to take your tablets<\/strong><\/p>\n\n\n\n If you vomit<\/strong> If you take more Cotellic than you should, contact a doctor immediately. Bring the medicine pack and this leaflet. It is important that you continue to take Cotellic for as long as your doctor prescribes it.<\/p>\n\n\n\n If you have any further questions on the use of this product, ask your doctor, pharmacist, or nurse. Like all medicines, this medicine can cause side effects, although not everybody gets them. If you experience side effects, your doctor may decide to lower your dose, temporarily or permanently discontinue treatment. Serious side effects are<\/strong><\/p>\n\n\n\n Contact your doctor immediately if you experience any of the side effects listed below or if they get worse during treatment. Severe bleeding<\/strong> (common: may affect up to 1 in 10 people)<\/p>\n\n\n\n Cotellic can cause severe bleeding, especially in the brain or stomach. Depending on the bleeding site, symptoms may include:<\/p>\n\n\n\n Eye (vision) problems<\/strong> (very common: may affect more than 1 user in 10)<\/p>\n\n\n\n Cotellic can cause eye problems. Some of these eye problems can occur due to something called “serous retinopathy” (an accumulation of fluid under the retina of the eye). Symptoms of serious retinopathy include:<\/p>\n\n\n\n Heart problems<\/strong> (common: may affect up to 1 in 10 people)<\/p>\n\n\n\n Cotellic can reduce the amount of blood pumped by your heart. Symptoms of this may include:<\/p>\n\n\n\n Muscle problems<\/strong> ( uncommon<\/strong>: may affect up to 1 in 100 people)<\/p>\n\n\n\n Cotellic may result in the degradation of muscle tissue ( rhabdomyolysis ). Symptoms of this may include:<\/p>\n\n\n\n Diarrhea<\/strong> (very common: may affect more than 1 user in 10)<\/p>\n\n\n\n Contact your doctor immediately if you get diarrhea. Follow your doctor’s instructions for what to do to prevent or treat diarrhea. Other side effects are<\/strong> Very common<\/strong>: may affect more than 1 user in 10<\/p>\n\n\n\n Common<\/strong>: may affect up to 1 in 10 users<\/p>\n\n\n\n Reporting of side effects<\/em><\/p>\n\n\n\n If you get any side effects, talk to your doctor, pharmacist, or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly to the Medical Products Agency. By reporting side effects, you can help increase drug safety information.<\/p>\n\n\n\n Cotellic film-coated tablets are white and round with \u201cCOB\u201d engraved on one side. There is one available pack size: 63 tablets (3 blisters with 21 tablets each).<\/p>\n\n\n\n Roche Registration GmbH<\/p>\n\n\n\n Emil-Barell-Strasse 1<\/p>\n\n\n\n 79639 Grenzach-Wyhlen<\/p>\n\n\n\n Germany Manufacturer<\/strong><\/p>\n\n\n\n Roche Pharma AG<\/p>\n\n\n\n Emil-Barell-Strasse 1<\/p>\n\n\n\n 79639<\/p>\n\n\n\n Grenzach-Wyhlen<\/p>\n\n\n\n Germany Contact the representative of the marketing authorization holder to find out more about this medicine:<\/p>\n\n\n\n Cotellic is a cancer medicine that contains the active substance cobimetinib. Cotellic is used to treat adult patients with a type of skin cancer called melanoma, which has spread to other parts of the body or cannot be removed by surgery.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2203,2200],"tags":[6526,6528,6529,6531,6533,6534,6530,6535,2210,6527,6532],"class_list":["post-7090","post","type-post","status-publish","format-standard","hentry","category-c","category-medicines","tag-cobimetinib","tag-cobimetinib-side-effects","tag-cobimetinib-tablet","tag-cotellic","tag-cotellic-side-effects","tag-cotellic-tablet","tag-side-effects-of-cobimetinib","tag-side-effects-of-cotellic","tag-tablet","tag-waht-is-cobimetinib","tag-what-is-cotellic"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7090","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=7090"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7090\/revisions"}],"predecessor-version":[{"id":11250,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7090\/revisions\/11250"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=7090"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=7090"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=7090"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Cotellic is a cancer medicine that contains the active substance cobimetinib.
<\/p>\n\n\n\n
Cotellic affects a protein called “MEK”, which is important for the growth of cancer cells. When Cotellic is used in combination with vemurafenib (which affects the altered “BRAF” protein ), it further slows down or stops, the growth of your cancer.
<\/p>\n\n\n\nWhat you need to know before taking Cotellic<\/h2>\n\n\n\n
Do not take Cotellic:<\/h2>\n\n\n\n
<\/p>\n\n\n\nWarnings and cautions<\/h2>\n\n\n\n
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<\/p>\n\n\n\nChildren and young people<\/h2>\n\n\n\n
Other medicines and Cotellic<\/h2>\n\n\n\n
<\/p>\n\n\n\n
<\/p>\n\n\n\nDrug<\/strong><\/th> Purpose of the drug<\/strong><\/th><\/tr> itraconazole, clarithromycin, erythromycin, telithromycin, voriconazole, rifampicin, posaconazole, fluconazole, miconazole<\/td> against certain fungal and bacterial infections<\/td><\/tr> ritonavir, cobicistat, lopinavir, delavirdine, amprenavir, fosamprenavir<\/td> against HIV – infection<\/td><\/tr> telaprevir<\/td> against hepatitis C<\/td><\/tr> nefazodone<\/td> against depression<\/td><\/tr> amiaridon<\/td> against irregular heartbeats<\/td><\/tr> diltiazem , verapamil<\/td> against high blood pressure<\/td><\/tr> imatinib<\/td> against cancer<\/td><\/tr> carbamazepine, phenytoin<\/td> against seizures<\/td><\/tr> St. John’s wort<\/td> herbal medicine used to treat mild depression<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n Cotellic with food and drink<\/h2>\n\n\n\n
<\/p>\n\n\n\nPregnancy and breastfeeding<\/h2>\n\n\n\n
Women of childbearing potential should use two effective methods of contraception, e.g. condom or another barrier method (with spermicide, if available) during treatment and for at least 3 months after treatment has ended. Ask your doctor about the best contraceptive methods for you.<\/p>\n\n\n\nDriving and using machines<\/h2>\n\n\n\n
Cotellic contains lactose and sodium<\/h2>\n\n\n\n
<\/p>\n\n\n\n
<\/p>\n\n\n\nHow to take Cotellic<\/h2>\n\n\n\n
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If you vomit after taking Cotellic, do not take an extra dose of Cotellic that day. Continue to take Cotellic, as usual, the next day.<\/p>\n\n\n\nIf you take more Cotellic then you should<\/h2>\n\n\n\n
<\/p>\n\n\n\nIf you forget to take Cotellic<\/h2>\n\n\n\n
If you stop taking Cotellic<\/h2>\n\n\n\n
<\/p>\n\n\n\n4. Possible side effects<\/h2>\n\n\n\n
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Also read the package leaflet for vemurafenib, which is used in combination with Cotellic.
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, tell your doctor, pharmacist, or nurse if you notice any of the following side effects:
<\/p>\n\n\n\n5. How to store Cotellic<\/h2>\n\n\n\n
6. Contents of the packaging and other information<\/h2>\n\n\n\n
Content declaration<\/h2>\n\n\n\n
What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n
Marketing Authorisation Holder<\/h2>\n\n\n\n
<\/p>\n\n\n\n
<\/p>\n\n\n\nBelgium \/ Belgique \/ Belgien<\/strong>NV Roche SATel: +32 (0) 2 525 82 11<\/td> Lithuania<\/strong>UAB \u201cRoche Lietuva\u201dTel: +370 5 2546799<\/td><\/tr> Bulgaria<\/strong>Rosh BULGARIA LOODETel: +359 2 818 44 44<\/td> Luxembourg \/ Luxemburg<\/strong>(See \/ See Belgium \/ Belgium)<\/td><\/tr> Czech Republic<\/strong>Roche sroTel: +420 – 2 20382111<\/td> Magyarorsz <\/strong>\u00e1g<\/strong>Roche (Hungary) Kft.Tel: +36 – 23 446 800<\/td><\/tr> Denmark<\/strong>Roche a \/ sTel: +45 – 36 39 99 99<\/td> Malta<\/strong>(See Ireland)<\/td><\/tr> Germany<\/strong>Roche Pharma AGTel: +49 (0) 7624 140<\/td> The Netherlands<\/strong>Roche Nederland BVTel: +31 (0) 348 438050<\/td><\/tr> Eesti<\/strong>Roche Eesti O\u00dcTel: + 372 – 6 177 380<\/td> Norway<\/strong>Roche Norge ASTel: +47 – 22 78 90 00<\/td><\/tr> Greece<\/strong>Roche (Hellas) AE:\u0397\u03bb: +30 210 61 66 100<\/td> Austria<\/strong>Roche Austria GmbHTel: +43 (0) 1 27739<\/td><\/tr> Spain<\/strong>Roche Farma SATel: +34 – 91 324 81 00<\/td> Poland<\/strong>Roche Polska Sp.z ooTel: +48 – 22 345 18 88<\/td><\/tr> France<\/strong>RocheTel: +33 (0) 1 47 61 40 00<\/td> Portugal<\/strong>Roche Pharmac\u00eautica Chemica, LdaTel: +351 – 21 425 70 00<\/td><\/tr> Croatia<\/strong>Roche dooTel: + 385 1 47 22 333<\/td> Romania<\/strong>Roche Rom\u00e2nia SRLTel: +40 21 206 47 01<\/td><\/tr> Ireland<\/strong>Roche Products (Ireland) Ltd.Tel: +353 (0) 1 469 0700<\/td> Slovenia<\/strong>Roche pharmacevtska dru\u017eba dooTel: +386 – 1 360 26 00<\/td><\/tr> Iceland<\/strong>Roche a \/ sc \/ o Icepharma hfPhone: +354 540 8000<\/td> Slovak Republic<\/strong>Roche Slovensko, sroTel: +421 – 2 52638201<\/td><\/tr> Italy<\/strong>Roche SpATel: +39 – 039 2471<\/td> Finland \/ Finland<\/strong>Roche Oy Puh \/ Tel: +358 (0) 10 554 500<\/td><\/tr> K <\/strong>\u03cd\u03c0\u03c1\u03bf\u03c2<\/strong> \u0393.\u0391.\u03a3\u03c4\u03b1\u03bc\u03ac\u03c4\u03b7\u03c2 & \u03a3\u03b9\u03b1 \u039b\u03c4\u03b4.:\u0397\u03bb: +357 – 22 76 62 76<\/td> Roche ABTel: +46 (0) 8 726 1200<\/td><\/tr> Latvia<\/strong>Roche Latvija SIATel: +371 – 6 7039831<\/td> United Kingdom<\/strong>Roche Products Ltd.Tel: +44 (0) 1707 366000<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"