{"id":7087,"date":"2021-02-13T08:36:52","date_gmt":"2021-02-13T08:36:52","guid":{"rendered":"https:\/\/zeepedia.com\/?p=7087"},"modified":"2023-03-02T10:11:52","modified_gmt":"2023-03-02T10:11:52","slug":"cosopt-sine","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/cosopt-sine\/","title":{"rendered":"Cosopt Sine &#8211; Dorzolamide &#8211; Timolol Uses, Dose And Side Effects"},"content":{"rendered":"\n<p>Cosopt Sine 20 mg \/ ml + 5 mg \/ ml&nbsp;eye drops&nbsp;, solution&nbsp;(dorzolamide \/ timolol)<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Is Cosopt Sine, And What Is It Used For?<\/h2>\n\n\n\n<p>Cosopt sine contains two drug substances: dorzolamide and&nbsp;timolol.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Dorzolamide belongs to a group of medicines called&nbsp;carbohydrase inhibitors.<\/li><li>Timolol&nbsp;belongs to a group of medicines called&nbsp;beta-blockers.<\/li><\/ul>\n\n\n\n<p>These drugs lower the pressure in the eye in different ways. <strong>Cosopt sine eye drops are used to lower an elevated pressure in the eye in\u00a0glaucoma\u00a0(\u00a0glaucoma\u00a0) when treatment with\u00a0eye drops\u00a0containing only\u00a0beta-blocker\u00a0is insufficient.<\/strong><br>Cosopt sine is a\u00a0sterile\u00a0solution that does not contain\u00a0preservatives. Dorzolamide and\u00a0timolol contained\u00a0in Cosopt sine may also be approved for the treatment of other conditions not mentioned in this product information.<\/p>\n\n\n\n<p>Ask your doctor, pharmacist, or other healthcare professionals if you have further questions, and always follow their instructions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What You Need To Know Before Using Cosopt Sine?<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do Not Use Cosopt Sine:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are allergic to dorzolamide hydrochloride, timolol maleate, or any of the other ingredients of this medicine (listed in section 6)<\/li><li>If you have now or previously had respiratory problems such as\u00a0asthma\u00a0or severe\u00a0chronic\u00a0obstructive\u00a0bronchitis\u00a0(severe lung disease that can cause wheezing, difficulty breathing, and\/or prolonged cough)<\/li><li>If you have a low\u00a0heart rate,\u00a0heart failure,\u00a0or heart rhythm disturbances (irregular heartbeat)<\/li><li>If you have severe kidney disease or severe kidney problems or\u00a0kidney stones<\/li><li>If the acidity of your blood is elevated due to elevated chloride levels in the blood (hyperchloraemic\u00a0acidosis\u00a0).<\/li><\/ul>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings And Cautions:<\/h2>\n\n\n\n<p>Talk to your doctor before using Cosopt sine if you have or have had:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Coronary heart disease (symptoms may include chest pain or pressure over the chest, shortness of breath, or suffocation),\u00a0heart failure, low\u00a0blood pressure<\/li><li>Heart rhythm disorders such as low\u00a0heart rate<\/li><li>Respiratory distress,\u00a0asthma,\u00a0or\u00a0chronic obstructive pulmonary disease\u00a0(COPD)<\/li><li>A disease that involves poor blood circulation (such as\u00a0Raynaud&#8217;s disease\u00a0or Raynaud&#8217;s syndrome)<\/li><li>Diabetes, because\u00a0timolol\u00a0can mask the signs and symptoms of low blood sugar<\/li><li>The overactive\u00a0thyroid gland, as\u00a0timolol\u00a0can obscure the signs and symptoms of this<\/li><li>Any\u00a0allergies\u00a0or anaphylactic reactions<\/li><li>Muscle weakness or you have been diagnosed with\u00a0myasthenia gravis\u00a0(muscle disease)<\/li><li>If you wear soft contact lenses.\u00a0Cosopt sine has not been studied in patients using contact lenses.<\/li><\/ul>\n\n\n\n<p>If you have a contact <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/insect-allergy\/\">allergy<\/a> to silver, do not use this medicine, as the drops may contain traces of silver from the cork of the container.<\/p>\n\n\n\n<p>Tell your doctor before an operation that you are taking Cosopt sine, as\u00a0timolol\u00a0may alter the effect of certain medicines used under anaesthesia. <strong>Cosopt sine eye drops can affect the whole body.<\/strong><\/p>\n\n\n\n<p>Talk to your doctor if you are taking Cosopt sine:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Feels irritation of any kind in the eye or has other eye problems, such as red or swollen eyelids.<\/li><li>Suspects that Cosopt sine causes an\u00a0allergic reaction\u00a0or hypersensitivity (eg skin rash, severe skin reaction, or\u00a0redness\u00a0and\u00a0itching\u00a0of the eye).\u00a0Discontinue treatment and contact a doctor as soon as possible.<\/li><li>Develops an\u00a0eye infection, gets an eye injury, undergoes eye surgery, or develops a reaction with symptoms that worsen or that you have not experienced before.<\/li><\/ul>\n\n\n\n<p><span style=\"text-decoration: underline;\"><strong>Use in children<\/strong>:<\/span><\/p>\n\n\n\n<p>Experience in the treatment of infants and children with Cosopt (containing\u00a0preservatives\u00a0) is limited.<\/p>\n\n\n\n<p><strong><span style=\"text-decoration: underline;\">Use in the elderly<\/span><\/strong><\/p>\n\n\n\n<p>The effect was comparable in studies with Cosopt (containing preservatives ) in elderly and younger patients.<\/p>\n\n\n\n<p><strong><span style=\"text-decoration: underline;\">Use in patients with hepatic impairment<\/span><\/strong>:<\/p>\n\n\n\n<p>Tell your doctor if you have or have had any liver problems in the past.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other Medicines And Cosopt Sine:<\/h2>\n\n\n\n<p>Cosopt sine can affect or be affected by other medicines you use, including other\u00a0eye drops\u00a0for the treatment of\u00a0glaucoma.\u00a0Tell your doctor if you are taking or plan to take medicines that lower your\u00a0blood pressure, heart medicine, or medicines used to\u00a0treat diabetes.<\/p>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take other medicines.\u00a0This is especially important if you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Use medicines that lower\u00a0blood pressure\u00a0or to treat heart disease (such as\u00a0calcium channel\u00a0blockers,\u00a0beta-blockers,\u00a0or\u00a0digoxin\u00a0)<\/li><li>Use drugs to treat irregular heartbeats such as\u00a0calcium channel\u00a0blockers,\u00a0beta-blockers,\u00a0or\u00a0digoxin<\/li><li>Use other\u00a0eye drops\u00a0that contain a\u00a0beta-blocker<\/li><li>Uses another\u00a0carbohydrate inhibitor\u00a0such as acetazolamide<\/li><li>Uses\u00a0monoamine oxidase inhibitors\u00a0(\u00a0MAOIs\u00a0)<\/li><li>Use medicines you have been given for, for example, vomiting problems (parasympathomimetics).\u00a0Parasympathomimetics are a drug sometimes used to restore regular bowel movements.<\/li><li>Use certain strong painkillers such as morphine<\/li><li>Use drugs to treat\u00a0diabetes<\/li><li>Use antidepressant drugs called\u00a0fluoxetine\u00a0and\u00a0paroxetine<\/li><li>Use medicines containing a sulfonamide<\/li><li>Uses\u00a0quinidine\u00a0(used to treat heart conditions and certain types of\u00a0malaria\u00a0).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy And Breastfeeding:<\/h2>\n\n\n\n<p>Ask your doctor or pharmacist for advice before taking any medicine.<\/p>\n\n\n\n<p><strong><em><span style=\"text-decoration: underline;\">Pregnancy<\/span><\/em><\/strong><\/p>\n\n\n\n<p>Do not use Cosopt sine if you are pregnant unless your doctor considers it necessary.<\/p>\n\n\n\n<p><strong><em><span style=\"text-decoration: underline;\">Breast-feeding<\/span><\/em><\/strong><\/p>\n\n\n\n<p>Do not use Cosopt if you are breastfeeding.\u00a0Timolol\u00a0can be excreted in your breast milk.\u00a0Ask your doctor for advice before taking any medicine while you are breastfeeding.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving And Using Machines:<\/h2>\n\n\n\n<p>No studies on the effects on the ability to drive and use machines have been performed.\u00a0Cosopt sine can cause\u00a0side effects\u00a0such as blurred vision, affecting your ability to drive or use machines.<\/p>\n\n\n\n<p>Wait to drive or use machines until you feel good or your vision is clear. You are responsible for assessing whether you can drive a motor vehicle or perform work requiring increased attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.<\/p>\n\n\n\n<p>Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If unsure, talk to your doctor, nurse, or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How To Use Cosopt Sine?<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Always use this medicine exactly as your doctor has told you.\u00a0Ask your doctor or pharmacist if you are unsure.\u00a0Your doctor determines the appropriate dose and duration of treatment.<\/li><li><strong>The recommended\u00a0dose<\/strong>\u00a0is a drop morning and evening in the eye (s) to be treated.<\/li><li>If Cosopt sine is used with other\u00a0eye drops, the eye\u00a0drops\u00a0should be taken at least 10 minutes apart.<\/li><li>Do not\u00a0change the dosage\u00a0without consulting a doctor.<\/li><li>If you have difficulty taking your\u00a0eye drops, ask for help from a family member or caregiver.<\/li><li>Ensure that the tip of the multi-dose container does not touch the eye or the area around the eye.\u00a0It can hurt your eye.\u00a0It can also lead to contamination with bacteria, which can cause\u00a0an eye infection.\u00a0Such an\u00a0infection\u00a0can lead to serious eye damage, including loss of vision.\u00a0To avoid contamination of the multi-dose container, wash your hands before using this medicine, and the tip of the multi-dose container should not touch other surfaces.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><strong><em>Instructions For Use<\/em><\/strong>:<\/h2>\n\n\n\n<p><strong>Before using eye drops:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Wash your hands before opening the bottle.<\/li><li>Do not use this medicine if the seal on the neck of the bottle is broken before using it for the first time.<\/li><li>When using the bottle for the first time and before dropping a drop in the eye, practice using the bottle.&nbsp;Gently press the bottle so that a drop appears.&nbsp;Aim the bottle away from the eye.<\/li><li>When you are sure that you can drip one drop at a time, choose the position that feels most comfortable for you to drip the drops (you can sit, lie down on your back, or stand in front of a mirror).<\/li><li>Each time you open a new bottle, drip a drop away from the eye to activate the bottle.<\/li><\/ul>\n\n\n\n<p><strong>Do this:<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\"><li>Hold the bottle just below the cap and turn the cap to open the bottle.\u00a0Do not touch the bottle tip to prevent contamination of the solution.<a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20170329000013#\" rel=\"noopener\"><\/a><\/li><li>Tilt your head back and hold the bottle above your eye.<\/li><li>Pull down the lower eyelid and look up.\u00a0Press lightly in the middle of the bottle and let a drop fall into the eye.\u00a0Note that it may take a few seconds for the drop to come out after you press the bottle.\u00a0Do not press too hard.<a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20170329000013#\" rel=\"noopener\"><\/a><\/li><li>Close the eye and press with a finger in the inner corner of the eye for about two minutes.\u00a0This way you avoid the solution getting into the rest of the body.<a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20170329000013#\" rel=\"noopener\"><\/a><\/li><li>Repeat steps 2-4 to drip a drop into the other eye, even if your doctor has told you to.\u00a0Sometimes only one eye needs to be treated, and the doctor will tell you if this applies to you and which eye should be treated.<\/li><li>After each use and before screwing on the cap, shake the bottle down once without touching the drip tip to remove any liquid that may have remained on the tip.\u00a0This is necessary for the following drops to be able to be dropped.\u00a0<a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20170329000013#\" rel=\"noopener\"><\/a><\/li><li>Wipe off any solution that may have ended up on the skin around the eye.<\/li><li>After the shelf life has expired after 2 months, some Cosopt sine will be left in the bottle.\u00a0Do not try to use the amount left in the bottle after completing the treatment.\u00a0Do not use the eye drops more than 2 months after the first opening of the bottle.<\/li><\/ol>\n\n\n\n<p>If you are unsure how to use this medicine, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If You Take More Cosopt Sine Than You Should:<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if, for example, a child has accidentally ingested the medicine, contact a doctor, hospital, or the Poison Information Center for risk assessment and advice.<\/p>\n\n\n\n<p>If you have dropped too many drops in the eye or have swallowed some of the contents of the container, you can, e.g.\u00a0become:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Dizzy<\/li><li>Difficulty breathing<\/li><li>Feeling your heart beating slower<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If You Forget To Take Cosopt Sine:<\/h2>\n\n\n\n<p>It is essential to take Cosopt sine according to your doctor&#8217;s instructions. If you forget to take a\u00a0dose, take it as soon as possible.\u00a0However, if it is time to take the next\u00a0dose,\u00a0skip the missed\u00a0dose\u00a0and then follow your usual dosing schedule. Do not take a double\u00a0dose\u00a0to make up for a forgotten\u00a0dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If You Stop Using Cosopt Sine:<\/h2>\n\n\n\n<p>If you want to stop treatment with the medicine, first consult your doctor. If you have any further questions on the use of this product, ask your doctor or pharmacist<strong>.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible Side Effects:<\/h2>\n\n\n\n<p>This medicine can cause side effects like all medicines,\u00a0although not everybody gets them.<\/p>\n\n\n\n<p><strong><em>Serious side effects:<\/em><\/strong><\/p>\n\n\n\n<p>If you get any of the following&nbsp;side effects&nbsp;stop using this medicine and seek medical attention immediately as these may be signs of a drug reaction.<\/p>\n\n\n\n<p><strong>Rare (may affect up to 1 in 1,000 people):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Chest pain<\/li><li>Oedema\u00a0(fluid retention)<\/li><li>Changes in rhythm or rate of the heartbeat<\/li><li>Heart failure\u00a0(heart disease with shortness of breath<\/li><li>Swelling of the feet and legs due to fluid retention)<\/li><li>Heart attack<\/li><li>Heart block<\/li><li>Low\u00a0blood pressure,<\/li><li>Cerebral\u00a0ischemia\u00a0(reduced blood supply to the brain)<\/li><li>Stroke<\/li><li>Shortness of breath<\/li><li>Impaired breathing<\/li><li>Airway constriction<\/li><li>Signs and symptoms of systemic allergic reactions, such as:<ul><li>Angioedema<ul><li>Swelling of the lips, eyelids, face, tongue, and throat<\/li><\/ul><\/li><li>Hives<\/li><li>Itching<\/li><li>Rash<\/li><li>Anaphylactic reaction\u00a0(severe\u00a0allergic reaction\u00a0).<\/li><\/ul><\/li><li>Severe skin reactions, including swelling under the skin.<\/li><\/ul>\n\n\n\n<p><strong><em>Other side effects:<\/em><\/strong><\/p>\n\n\n\n<p>You can usually continue to use the drops unless the\u00a0side effects\u00a0are severe.\u00a0If you have any further questions, ask your doctor or pharmacist.\u00a0Do not stop using Cosopt sine without talking to a doctor.<\/p>\n\n\n\n<p>The following\u00a0side effects\u00a0have been reported with Cosopt sine or any of its ingredients, either in\u00a0clinical trials\u00a0or after the drug has started to be sold:<\/p>\n\n\n\n<p><strong>Very common (may affect more than 1 user in 10):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Burning and stinging sensation in the eyes<\/li><li>Taste changes<\/li><\/ul>\n\n\n\n<p><strong>Common (may affect up to 1 in 10 people):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Effects in the eye:\u00a0redness\u00a0in and around the eye\/eyes, increased tear flow or\u00a0itching\u00a0in the eye\/eyes, damage to the cornea (damage to the outer layer of the eye)<\/li><li>Swelling and irritation in or around the eye\/eyes feeling of having received something in the eye<\/li><li>Decreased sensitivity of the cornea (do not notice that anything has entered the eye), eye pain<\/li><li>Eye dryness<\/li><li>Blurred vision<\/li><li>General side effects:<ul><li>Headache<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/sinusitis\/\">Sinusitis<\/a> (it presses or feels full in the nose)<\/li><li>Nausea<\/li><li>Weakness\/fatigue<\/li><\/ul><\/li><\/ul>\n\n\n\n<p><strong>Uncommon (may affect up to 1 in 100 people):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Effects on the eye:<ul><li>Inflammation\u00a0of the iris<\/li><li>Visual disturbances, including <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/refractive-errors\/\">refractive errors<\/a> (sometimes due to discontinuation of treatment with pupil astringent)<\/li><\/ul><\/li><li>Common side effects:<ul><li>Dizziness<\/li><li>Depression<\/li><li>Low\u00a0heart rate<\/li><li>Fainting<\/li><li>Shortness of breath<\/li><li>Indigestion<\/li><li>Kidney stones<\/li><\/ul><\/li><\/ul>\n\n\n\n<p><strong>Rare (may affect up to 1 in 1,000 people):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Effects on the eye:<\/strong><ul><li>Temporary myopia that may disappear when treatment is stopped<\/li><li>Loosening of the blood vessel-containing membrane under the retina after filtration surgery which may cause visual disturbances<\/li><li>Drooping eyelids (causing the eye to be half-closed)<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/distinction-and-double-vision-in-adults\/\">Double vision<\/a><\/li><li>Crusting on the eyelids<\/li><li>Swelling in the cornea (with symptoms of visual disturbance)<\/li><li>Low pressure in the eye<\/li><\/ul><\/li><li><strong>Common side effects:<\/strong><ul><li>Severe heartbeat, which may be fast or irregular (palpitations); Raynaud&#8217;s phenomenon (swelling or cold hands and feet and decreased blood circulation in the arms and legs)<\/li><li>Leg cramps and pain in the legs when walking (claudication)<\/li><li>Dry mouth<\/li><li>Cough, throat irritation<\/li><li>Dry mouth, difficulty\u00a0falling asleep<\/li><li>Nightmares<\/li><li>Memory loss<\/li><li>Tingling or numbness in the hands or feet<\/li><li>Aggravated signs and symptoms of\u00a0myasthenia gravis\u00a0(muscle disease), decreased sexual desire<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/sle\/\">Systemic lupus erythematosus<\/a> (\u00a0SLE, an immune disease that can cause\u00a0inflammation\u00a0of internal organs)<\/li><li>Earrings<\/li><li>Runny or stuffy nose<\/li><li>Nosebleeds, diarrhoea<\/li><li>Contact dermatitis(skin inflammation)<\/li><li>Hair loss<\/li><li>A rash with a silvery appearance (psoriasis-like rash)<\/li><li>Peyronie&#8217;s disease (which can cause a bend of the penis)<\/li><li>Reactions of an allergic-type such as:<ul><li>Skin rash<\/li><li>Hives<\/li><li>Itching, in rare cases<\/li><li>Possibly swelling of the lips, eyes, and mouth<\/li><li>Hissing breathing.<\/li><\/ul><\/li><\/ul><\/li><\/ul>\n\n\n\n<p>Like other medicines given to your eyes,\u00a0timolol is\u00a0absorbed into\u00a0your\u00a0bloodstream.\u00a0This can cause similar\u00a0side effects\u00a0as those seen with\u00a0oral beta-blockers.\u00a0The incidence of\u00a0side effects\u00a0when giving medicines locally in the eye is lower than when medicines are taken orally or injected, for example.<\/p>\n\n\n\n<p>Additional noted\u00a0side effects\u00a0are reactions observed for the class of\u00a0beta-blockers\u00a0in the treatment of eye diseases.<\/p>\n\n\n\n<p><strong>Has been reported (occurs in an unknown number of users):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Low blood sugar levels<\/li><li>Abdominal pain<\/li><li>Vomiting<\/li><li>Muscle pain not caused by exercise<\/li><li>Sexual dysfunction<\/li><li>Hallucination<\/li><li>The feeling of debris in the eye<\/li><\/ul>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse if you get any side effects.\u00a0This includes any possible side effects not listed in this leaflet.\u00a0You can also report side effects directly to the Medical Products Agency,\u00a0<a href=\"http:\/\/www.lakemedelsverket.se\/\" target=\"_blank\" rel=\"noreferrer noopener\">www.lakemedelsverket.se<\/a>.\u00a0By reporting side effects, you can help increase drug safety information.<a href=\"javascript:void(0);\">\u00a0Postal address<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How To Store Cosopt Sine?<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Keep this medicine out of the sight and reach of children.<\/li><li>Do not use this medicine after the expiry date stated on the carton and bottle after EXP.\u00a0The expiration date is the last day of the specified month.<\/li><li>Do not store above 25 \u00b0 C.<\/li><li>The solution is a sturdy\u00a0<strong>2 Month\u00a0rafter<\/strong> first opening of the bottle.\u00a0Close the bottle tightly.<\/li><li>Do not use this medicine if you notice that the sealing ring around the neck of the bottle is broken when you use the bottle for the first time.\u00a0<br><br>Medicines should not be disposed of via wastewater or household waste.\u00a0Ask your pharmacist how to dispose of medicines no longer required.\u00a0These measures will help to protect the environment.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents Of The Packaging And Other Information:<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content Declaration:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substances are dorzolamide and&nbsp;timolol&nbsp;.&nbsp;One ml contains 20 mg dorzolamide (as 22.26 mg dorzolamide hydrochloride) and 5 mg&nbsp;timolol&nbsp;(as 6.83 mg timolol maleate).<\/li><li>The other ingredients are hydroxyethylcellulose, mannitol, sodium citrate, sodium hydroxide, and water for&nbsp;injection.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What Does The Medicine Look Like And The Contents Of The Pack?<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Cosopt sine is a clear, colourless, almost colourless, slightly viscous solution that is essentially free of visible particles.\u00a0It is supplied in a white plastic bottle with a white Novelia drip applicator and a white plastic screw cap with a sealing ring.<\/li><li>Pack sizes: 1, 2, or 3 bottles in a carton.<\/li><li>Not all pack sizes may be available.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder And Manufacturer<\/h2>\n\n\n\n<p><em>Marketing Authorization Holder:<\/em><\/p>\n\n\n\n<p>Santen Oy<\/p>\n\n\n\n<p>Niittyhaankatu 20<\/p>\n\n\n\n<p>33720 Tampere<\/p>\n\n\n\n<p>Finland<\/p>\n\n\n\n<p><em>Manufacturer:<\/em><\/p>\n\n\n\n<p>Tubilux Pharma<\/p>\n\n\n\n<p>Via Costarica 20<\/p>\n\n\n\n<p>00071 Pomezia (Rome)<\/p>\n\n\n\n<p>Italy or Santen Oy<\/p>\n\n\n\n<p>Kelloportinkatu 1<\/p>\n\n\n\n<p>33100 Tampere<\/p>\n\n\n\n<p>Finland<\/p>\n\n\n\n<p><strong>This medicinal product is authorized under the European Economic Area under the name: <\/strong><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20170329000013#\" rel=\"noopener\">Show larger<\/a>.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>Austria, Bulgaria, Croatia, Cyprus, Greece, Portugal, Spain<\/td><td>COST multi<\/td><\/tr><tr><td>Belgium, Luxembourg<\/td><td>COSOPT Sine Conservans<\/td><\/tr><tr><td>Czech Republic<\/td><td>COST Multi-Dose without preservative<\/td><\/tr><tr><td>Denmark<\/td><td>COST its unpreserved<\/td><\/tr><tr><td>Estonia, Finland, France, Germany, Iceland, Norway<\/td><td>COST sine<\/td><\/tr><tr><td>Hungary<\/td><td>COST Multi<\/td><\/tr><tr><td>Ireland, United Kingdom<\/td><td>COST Multi Preservative Free<\/td><\/tr><tr><td>Italy<\/td><td>COST<\/td><\/tr><tr><td>Latvia Lithuania<\/td><td>COST PF<\/td><\/tr><tr><td>Poland<\/td><td>COST PF Multi<\/td><\/tr><tr><td>Romania<\/td><td>COSOPT fara conservant<\/td><\/tr><tr><td>Slovakia<\/td><td>COST Multi-Dose Free<\/td><\/tr><tr><td>Slovenia<\/td><td>COSOPT brez konzervansa<\/td><\/tr><tr><td>Netherlands<\/td><td>COST Multidose preservative-free<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>cosopt sine treats glaucoma by lowering intraocular pressure when beta-blocker eyedrops alone are insufficient.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2203,2200],"tags":[6537,6540,6539,5032,5035,5034,4501,6541,6536,5029,5248,6538,5033,5030],"class_list":["post-7087","post","type-post","status-publish","format-standard","hentry","category-c","category-medicines","tag-cosopt-sine","tag-cosopt-sine-eye-drops","tag-cosopt-sine-side-effects","tag-dorzolamide","tag-dorzolamide-eye-drops","tag-dorzolamide-side-effects","tag-eye-drops","tag-side-effects-of-cosopt-sine","tag-side-effects-of-dorzolamide","tag-timolol","tag-timolol-eye-drops","tag-what-is-cosopt-sine","tag-what-is-dorzolamide","tag-what-is-timolol"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7087","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=7087"}],"version-history":[{"count":77,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7087\/revisions"}],"predecessor-version":[{"id":53107,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7087\/revisions\/53107"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=7087"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=7087"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=7087"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}