{"id":7059,"date":"2021-02-11T10:26:29","date_gmt":"2021-02-11T10:26:29","guid":{"rendered":"https:\/\/zeepedia.com\/?p=7059"},"modified":"2021-06-01T09:58:01","modified_gmt":"2021-06-01T09:58:01","slug":"corotrop","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/corotrop\/","title":{"rendered":"Corotrop &#8211; Milrinone uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n1 mg \/ ml&nbsp;injection&nbsp;solution&nbsp;<br>milrinone<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Corotrop is and what it is used for<\/h2>\n\n\n\n<p>Corotropic is a drug used to increase&nbsp;cardiac output&nbsp;(the work of the heart).&nbsp;The active substance is called milrinone.&nbsp;It is a substance with properties that increase the power of the heart to contract and dilate the blood vessels.<br><\/p>\n\n\n\n<p>Corotrop can be used in adults for:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>short-term treatment of pronounced left heart failure (when the heart can not pump enough blood to the rest of the body) when other drugs do not help.<\/li><\/ul>\n\n\n\n<p>Corotrop can be used in children for:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>short-term treatment (up to 35 hours) of severe&nbsp;heart failure&nbsp;(when the heart can not pump enough blood to the rest of the body) when other drugs do not help.<\/li><li>short-term treatment (up to 35 hours) of&nbsp;acute&nbsp;heart failure&nbsp;after heart surgery (when your heart temporarily has difficulty pumping blood into the body).<\/li><\/ul>\n\n\n\n<p>When Corotrop is used, constant monitoring of heart function and&nbsp;blood pressure&nbsp;is required.<br><\/p>\n\n\n\n<p>Milrinone contained in Corotrop may also be approved for the treatment of other conditions not mentioned in this product information.&nbsp;Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before you use Corotrop<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Corotrop<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to milrinone or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you have severe narrowing of the heart valves (obstructive&nbsp;aortic&nbsp;or&nbsp;pulmonary valve disease)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before using Corotrop:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have or are expected to be diagnosed with, certain types of heart rhythm disturbances (such as&nbsp;atrial flutter,&nbsp;atrial fibrillation,&nbsp;or certain other types of heart rhythm disturbances emanating from the lower chamber (ventricle) of the heart), as Corotrop may promote certain heart rhythm disturbances.&nbsp;Low levels of&nbsp;potassium&nbsp;in the blood and\/or high levels of the cardiac drug&nbsp;digitalis&nbsp;further increases the risk of heart rhythm disorders.&nbsp;Your doctor will therefore check if further treatment is necessary or if dose adjustment or&nbsp;ECG&nbsp;monitoring is required.<\/li><li>if it is suspected that your heart has too low a filling pressure (eg due to previous treatment with diuretics).&nbsp;Your doctor will check your filling pressure before treatment and correct it if necessary.<\/li><li>if you have kidney disease or low&nbsp;blood pressure.&nbsp;Your doctor will make appropriate checks before and during your treatment and take these checks into account during treatment and when determining the&nbsp;dose of&nbsp;a Corotrop and other medicines.<\/li><li>if you have a decreased&nbsp;platelet count&nbsp;(&nbsp;platelets&nbsp;) or&nbsp;red blood cells&nbsp;(&nbsp;erythrocytes) or a low hemoglobin value, Corotrop can only be used under close monitoring of&nbsp;platelet count&nbsp;as treatment may further reduce&nbsp;blood counts.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>In addition to what is mentioned under Warnings and precautions for adults, the following should be considered: Before giving Corotrop&nbsp;injection,&nbsp;your&nbsp;doctor will check several parameters such as&nbsp;heart rate and&nbsp;blood pressure.&nbsp;He\/she will also&nbsp;prescribe&nbsp;blood sampling.<\/p>\n\n\n\n<p>Injection&nbsp;one should not be started if your child&#8217;s heart rate or&nbsp;blood pressure is&nbsp;not stable.<br><\/p>\n\n\n\n<p>Tell your doctor about:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>your child has kidney problems<\/li><li>your baby is born prematurely or had a low birth weight.<\/li><li>your child has a special heart problem called the open&nbsp;ductus arteriosus&nbsp;(a connection between two large blood vessels (the carotid artery and the pulmonary artery) that remains even though it should be closed).<\/li><\/ul>\n\n\n\n<p><strong>Elderly patients<\/strong><\/p>\n\n\n\n<p>There are no special dosing recommendations for the elderly.&nbsp;Controlled pharmacokinetic studies to date have not shown any age-dependent effect on the distribution and\/or secretion of milrinone, the active substance in Corotrop.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Corotrop<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>When Corotrop is given at the same time as heart-strengthening medicines (ie which increase the power of the heart&#8217;s contractions, eg&nbsp;dobutamine&nbsp;), Corotrop can increase heart-strengthening (positive inotropic) effect of these medicines and vice versa.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>There are no clinical data on the use of milrinone in pregnant women.&nbsp;Animal studies do not indicate direct or indirect harmful effects with respect to pregnancy, prenatal development (ie before birth), childbirth, or&nbsp;postnatal&nbsp;development (ie after birth).<\/p>\n\n\n\n<p>Use during pregnancy should be done with caution.<br><\/p>\n\n\n\n<p>As it is unknown whether milrinone is excreted in human milk, breast-feeding must be discontinued during treatment.<br><\/p>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>There is no experience available regarding adverse effects on the ability to drive or use machines.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased vigilance.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use Corotrop<\/h2>\n\n\n\n<p>Corotropic&nbsp;injection&nbsp;is used in hospitals as an&nbsp;intravenous&nbsp;injection\/infusion.&nbsp;Dosage one is determined and adjusted individually by the doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Corotrop than you should&nbsp;<\/h2>\n\n\n\n<p>Drops in blood pressure and rapid heartbeat can occur.<\/p>\n\n\n\n<p>In case of overdose, your doctor will stop the&nbsp;infusion&nbsp;or reduce the infusion rate and possibly start other appropriate treatments.&nbsp;There is no known specific&nbsp;antidote.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Corotrop<\/h2>\n\n\n\n<p>Your doctor or nurse has instructions on when to get your medicine.&nbsp;It is unlikely that you will not receive the medicine listed.&nbsp;However, if you think you have missed a&nbsp;dose, tell your doctor or nurse.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<br><\/p>\n\n\n\n<p><em>Common (may affect up to 1 in 10 people):<\/em>&nbsp;Headache, fainting (&nbsp;syncope&nbsp;).&nbsp;Palpitations, arrhythmias, low&nbsp;blood pressure&nbsp;(&nbsp;hypotension&nbsp;),&nbsp;heart failure.<br><\/p>\n\n\n\n<p><em>Uncommon (may affect up to 1 in 100 people):<\/em>&nbsp;Decreased&nbsp;platelet count.&nbsp;Low potassium levels.&nbsp;Tremors.&nbsp;Heart fibrillation.&nbsp;Severe chest pain, often with tightness over the chest and difficulty breathing.&nbsp;Nausea, vomiting.&nbsp;Impaired liver values \u200b\u200bas a result of impaired liver function.<br><\/p>\n\n\n\n<p><em>Very rare (may affect up to 1 in 10,000 people):<\/em>&nbsp;Allergic (anaphylactic)&nbsp;shock.&nbsp;A particularly dangerous form of palpitations (&nbsp;torsade de points&nbsp;).&nbsp;Spasmodic contractions in the trachea.&nbsp;Rash.<br><\/p>\n\n\n\n<p><em>Has been reported (occurs in an unknown number of users):<\/em>&nbsp;&nbsp;Reduction of&nbsp;red blood cells&nbsp;and\/or hemoglobin concentration (blood pigment).&nbsp;Bleeding in fluid-filled areas (ventricles) surrounded by the brain (&nbsp;intraventricular&nbsp;hemorrhage).&nbsp;Renal failure&nbsp;at simultaneously low&nbsp;blood pressure&nbsp;(&nbsp;hypotension&nbsp;).&nbsp;Reactions at the infusion site.<br><\/p>\n\n\n\n<p>Life-threatening cardiac arrhythmias have occurred in patients with previously irregular heartbeat and\/or metabolic disorders (low potassium levels) and\/or high levels of&nbsp;digitalis&nbsp;(a heart drug).<br><\/p>\n\n\n\n<p><strong>Additional&nbsp;side effects&nbsp;are in children<\/strong><\/p>\n\n\n\n<p>In addition to the&nbsp;side effects&nbsp;reported in adults, the following have been reported in children:<\/p>\n\n\n\n<p><em>Has been reported<\/em>&nbsp;(&nbsp;<em>occurs in an unknown number of users<\/em>&nbsp;): A heart problem called open ductus arteriosus: a connection between two large blood vessels (the carotid artery and the pulmonary artery) that remain but should be closed.&nbsp;This can cause excess fluid in the lungs, bleeding, destruction of the intestine or parts of the intestine and can be fatal.<br><\/p>\n\n\n\n<p>In addition to adults, a decrease in the number of&nbsp;platelets&nbsp;in the blood&nbsp;seems to&nbsp;occur more often in children, and the risk of this&nbsp;side effect&nbsp;increases with the infusion time.<\/p>\n\n\n\n<p>Cardiac arrhythmias appear to occur less frequently in children than in adults.<br><\/p>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.&nbsp;Postal address<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Corotrop<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton after EXP.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>Do not store above 30 \u00b0 C.&nbsp;Store in a cold place.<br><\/p>\n\n\n\n<p>After dilution, the solution should be used within 12 hours.<br><\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is milrinone.&nbsp;<br>Each ml of&nbsp;solution for injection&nbsp;contains 1 mg milrinone.&nbsp;Each&nbsp;ampoule&nbsp;of 10 ml&nbsp;solution for injection&nbsp;contains 10 mg milrinone.<\/li><li>The other ingredients are&nbsp;glucose,&nbsp;lactic acid, sodium hydroxide, water for injections.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Clear, pale yellow solution.<br><\/p>\n\n\n\n<p>Corotrop is available in the following pack sizes:<\/p>\n\n\n\n<p>The ampoule&nbsp;is 10&#215;10 ml.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Sanofi AB<\/p>\n\n\n\n<p>Box 30052<\/p>\n\n\n\n<p>104 25 Stockholm<br><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Corotropic is a drug used to increase cardiac output (the work of the heart). The active substance is called milrinone. It is a substance with properties that increase the power of the heart to contract and dilate the blood vessels.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2203,2200],"tags":[6597,6600,6599,2215,6592,6595,6594,6601,6596,6598,6593],"class_list":["post-7059","post","type-post","status-publish","format-standard","hentry","category-c","category-medicines","tag-corotrop","tag-corotrop-injection","tag-corotrop-side-effects","tag-injection","tag-milrinone","tag-milrinone-injection","tag-milrinone-side-effects","tag-side-effects-of-corotrop","tag-side-effects-of-milrinone","tag-what-is-corotrop","tag-what-is-milrinone"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7059","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=7059"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7059\/revisions"}],"predecessor-version":[{"id":11266,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7059\/revisions\/11266"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=7059"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=7059"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=7059"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}