{"id":7051,"date":"2021-02-11T10:19:15","date_gmt":"2021-02-11T10:19:15","guid":{"rendered":"https:\/\/zeepedia.com\/?p=7051"},"modified":"2023-01-21T11:02:51","modified_gmt":"2023-01-21T11:02:51","slug":"constella","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/constella\/","title":{"rendered":"Constella &#8211; Linaclotide Uses, Dose, And Side Effects"},"content":{"rendered":"\n<p><strong> Constella<\/strong> <strong>290 microgram <strong>Linaclotide<\/strong><\/strong> <strong>Hard Capsules<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Constella Is And What It Is Used For<\/h2>\n\n\n\n<p><strong>What Constella is used for?<br><\/strong>Constella contains the active substance linaclotide and is used to treat the symptoms of moderate to severe\u00a0irritable\u00a0bowel syndrome (often called <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/ibs-sensitive-bowel\/\">IBS<\/a>) with <a href=\"https:\/\/zeepedia.com\/diseases\/constipation\/\">constipation<\/a> in adult patients.<\/p>\n\n\n\n<p>IBS is a common intestinal disease.&nbsp;The main symptoms of <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/constipation\/\">constipation<\/a> IBS include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Abdominal or abdominal <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/brain-and-nerves\/pain\/\">pain<\/a><\/li><li>Feeling of bloating<\/li><li>Irregular, hard, small, or pellet-like stools.<\/li><\/ul>\n\n\n\n<p>These symptoms may vary from person to person.<\/p>\n\n\n\n<p><strong>How Constella works<\/strong>&nbsp;<br>Constella acts locally in the intestine to relieve pain and swelling and to restore normal bowel function.&nbsp;It is not absorbed into the body but attaches to a&nbsp;receptor on the surface of the intestine called guanylate cyclase C. By attaching to this&nbsp;receptor, the drug blocks the sensation of pain and allows fluid from the body to enter the intestine to thereby relieve constipation by dissolving the contents of the intestines. and increase bowel movements.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><a href=\"https:\/\/amzn.to\/3J3sC8C\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" width=\"187\" height=\"300\" src=\"https:\/\/zeepedia.com\/wp-content\/uploads\/2021\/02\/Constella.png\" alt=\"Constella\" class=\"wp-image-45714\"\/><\/a><\/figure><\/div>\n\n\n<h2 class=\"wp-block-heading\">2. What You Need To Know Before Using Constella<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do Not Use Constella<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are allergic to linaclotide or any of the other ingredients of this medicine (listed in section 6)<\/li><li>If you or your doctor know that you have a blockage in your stomach or intestines.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings And Cautions<\/h2>\n\n\n\n<p>Your doctor has given you <em>Constella medication<\/em> after ruling out other diseases, especially in the intestines, and has determined that you are suffering from IBS with constipation.&nbsp;Other diseases can have the same symptoms as IBS and it is important that you quickly report changes or irregularities in symptoms to your doctor.<\/p>\n\n\n\n<p>If you experience severe or prolonged <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/diarrhea-in-children\/\">diarrhea<\/a> (frequent, watery bowel movements for 7 days or longer), stop taking Constella and contact your doctor (see section 4).&nbsp;Make sure you drink plenty of fluids to replace the water and&nbsp;electrolytes, e.g.&nbsp;potassium, which is lost through diarrhea.<\/p>\n\n\n\n<p>Tell your doctor if you experience bleeding from the gastrointestinal tract or rectum.<\/p>\n\n\n\n<p>Take special care <strong>constella medication<\/strong> if you are older than 65 years as you are at higher risk of developing diarrhea.<\/p>\n\n\n\n<p>Also take special care if you have severe or prolonged diarrhea and another illness, e.g.&nbsp;high&nbsp;blood pressure, previous illness involving the heart and blood vessels (eg previous heart attacks), or&nbsp;diabetes.<\/p>\n\n\n\n<p>Tell your doctor if you suffer from intestinal inflammation such as&nbsp;Crohn&#8217;s disease&nbsp;or&nbsp;ulcerative colitis, as Constella is not recommended for these patients.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children And Young People<\/h2>\n\n\n\n<p>Do not give this medicine to children and adolescents under 18 years of age, as the safety and efficacy of Constella for this age group have not been established.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other Drugs And Constella<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Some medicines may work less effectively if you have severe or prolonged diarrhea:<ul><li>Contraceptives in tablet form &#8211; if you have very severe diarrhea,&nbsp;birth control pills&nbsp;may not work&nbsp;as they should and the use of another method of contraception is recommended.&nbsp;See the instructions in the package leaflet for the&nbsp;contraceptive pill&nbsp;you are using.<\/li><li>Drugs that require careful and accurate&nbsp;dosing, e.g.&nbsp;levothyroxine (a&nbsp;hormone used to treat hypothyroidism).<\/li><\/ul><\/li><li>Some medicines may increase the risk of diarrhea when taken with Constella:<ul><li>Drugs called proton pump inhibitors are used to treat&nbsp;stomach ulcers&nbsp;or excess stomach acid<\/li><li>Drugs called non-steroidal anti-inflammatory drugs (&nbsp;NSAIDs&nbsp;) used to treat pain and&nbsp;inflammation<\/li><li>Laxatives.<\/li><\/ul><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Constella With Food<\/h2>\n\n\n\n<p>Constella causes more frequent bowel movements and diarrhea (loose stools) when taken with food compared to when taken on an empty stomach (see section 3).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy And Breastfeeding<\/h2>\n\n\n\n<p>There is only limited information on the effects of Constella on pregnant and lactating women.<\/p>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking <strong>constella medication<\/strong>.<br><\/p>\n\n\n\n<p>In a breast-only breast-feeding study involving seven breastfeeding women who had already been treated with linaclotide, neither linaclotide nor its active&nbsp;metabolite&nbsp;was detected&nbsp;in breast milk.&nbsp;Therefore, breastfeeding is not expected to cause the baby to be exposed to linaclotide and Constella can be used during breastfeeding.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving And Using Machines<\/h2>\n\n\n\n<p>Constella does not affect your ability to drive or use machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How To Use Constella<\/h2>\n\n\n\n<p>Always use this medicine exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>The recommended&nbsp;<strong>constella dose<\/strong>&nbsp;is one capsule (ie 290 micrograms of linaclotide) taken orally once daily.&nbsp;The capsule should be taken at least 30 minutes before a meal.<\/p>\n\n\n\n<p>If you do not experience any improvement in your symptoms&nbsp;<strong>after 4 weeks of treatment<\/strong>, you should contact your doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If You Use More Constella Then You Should<\/h2>\n\n\n\n<p>The most likely effect of taking too much Constella is diarrhea.&nbsp;Contact your doctor or pharmacist if you have used too much of <strong>constella medication<\/strong>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If You Forget To Use Constella<\/h2>\n\n\n\n<p>Do not take a double&nbsp;dose&nbsp;to make up for a forgotten&nbsp;dose.&nbsp;Take the next <em>Constella dose<\/em>&nbsp;at the usual time and continue as usual.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If You Stop Using Constella<\/h2>\n\n\n\n<p>Preferably discuss with a doctor before ending treatment.&nbsp;However, treatment with Constella can be safely discontinued at any time.<\/p>\n\n\n\n<p>If you have any further questions about the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible Constella Side Effects<\/h2>\n\n\n\n<p>Like all medicines, <span style=\"text-decoration: underline;\">constella medication<\/span> can cause&nbsp;side effects, although not everybody gets them.<br><\/p>\n\n\n\n<p>Very common&nbsp;<em>side effects of constella<\/em>&nbsp;(may affect more than 1 in 10 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Diarrhea<\/li><\/ul>\n\n\n\n<p>Diarrhea is usually short-lived.&nbsp;If you experience severe or prolonged diarrhea (frequent or watery stools for 7 days or longer) and feel dizzy or weak, stop taking Constella and consult a doctor.<br><\/p>\n\n\n\n<p>Common&nbsp;constella side effects&nbsp;(may affect up to 1 in 10 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Stomach or abdominal pain<\/li><li>Feeling of bloating<\/li><li>Gases<\/li><li>Stomach flu (viral&nbsp;gastroenteritis&nbsp;)<\/li><li>Dizziness<\/li><\/ul>\n\n\n\n<p>Uncommon&nbsp;<em>side effects of constella<\/em>&nbsp;(may affect up to 1 in 100 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Accidental bowel movements (&nbsp;fecal&nbsp;incontinence&nbsp;)<\/li><li>Urgent need to empty the bowel<\/li><li>Fainting when you get up quickly<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/dehydration\/\">Dehydration<\/a><\/li><li>Low levels of&nbsp;potassium&nbsp;in the blood<\/li><li>Decreased appetite<\/li><li>Bleeding from the rectum<\/li><li>Bleeding from the gastrointestinal tract or rectum including bleeding from&nbsp;hemorrhoids<\/li><li>Nausea<\/li><li>Vomiting<\/li><li>Hives&nbsp;(&nbsp;urticaria&nbsp;)<\/li><\/ul>\n\n\n\n<p>Rare&nbsp;side effects&nbsp;(may affect up to 1 in 1,000 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Decreased level of&nbsp;bicarbonate&nbsp;in the blood<\/li><\/ul>\n\n\n\n<p>Adverse reactions&nbsp;without known frequency (frequency can not be calculated from the available data)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Rash<\/li><\/ul>\n\n\n\n<p><em>Reporting of <\/em><strong>side effects of constella<\/strong><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.&nbsp;Postal address<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How To Store Constella<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Keep this medicine out of the sight and reach of children.<\/li><li>Do not use this medicine after the expiry date which is stated on the carton and jar after \u201cEXP\u201d.&nbsp;The expiration date is the last day of the specified month.&nbsp;Once opened, the capsules should be used within 18 weeks.<\/li><li>Do not store above 30 \u00b0 C.&nbsp;Close the jar tightly, the contents are moisture sensitive. Show larger<\/li><\/ul>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Warning: The<\/strong>&nbsp;jar contains one or more sealed pads with silica gel to keep the capsules dry.&nbsp;Store the pillows in the jar.&nbsp;Do not swallow.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<ul class=\"wp-block-list\"><li>Do not use this medicine if you notice signs of damage to the jar or any change in the appearance of the capsules.<\/li><\/ul>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents Of The Packaging And Other Information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content Declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is linaclotide.&nbsp;Each capsule contains 290 micrograms of linaclotide.<br><\/li><li>Other ingredients are:<ul><li><strong>Capsule contents:<\/strong>&nbsp;microcrystalline cellulose, hypromellose, calcium chloride dihydrate, and leucine<\/li><li><strong>Capsule housing:<\/strong>&nbsp;red iron oxide (E172), titanium dioxide (E171), yellow iron oxide (E172), and gelatin<\/li><li><strong>Ink<\/strong>:&nbsp;shellac, propylene glycol, concentrated ammonia solution, potassium hydroxide, titanium dioxide (E171), and black iron oxide (E172)<\/li><\/ul><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What The Medicine Looks Like And The Contents Of The Pack<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The capsules are white to off-white-orange, opaque and hard, marked with \u201c290\u201d in gray ink.<\/li><li>They are packaged in a white high-density polyethylene (HDPE) jar, with a guarantee seal and a childproof screw cap, along with one or more desiccant pads with silica gel.<\/li><li>Constella is available in packs containing 10, 28, or 90 capsules and in a multi-pack of 112 capsules divided into 4 cartons with 28 capsules in each.&nbsp;Not all pack sizes may be marketed.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Allergan Pharmaceuticals International Limited<\/p>\n\n\n\n<p>Clonshaugh Business &amp; Technology Park<\/p>\n\n\n\n<p>Dublin 17, D17 E400<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong>&nbsp;<br>Allergan Pharmaceuticals International Limited<\/p>\n\n\n\n<p>Clonshaugh Business &amp; Technology Park<\/p>\n\n\n\n<p>Dublin 17, D17 E400<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p>Contact the representative of the marketing authorization holder to find out more about this medicine: Show a larger<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgium \/ Belgium \/ Belgium \/ Luxembourg \/ Luxembourg \/ Netherlands<\/strong>Allergan nvTel: +32 (0) 2 351 2424<\/td><td><br><\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Allergan Bulgaria \u0415\u041e\u041e\u0414Tel: +359 (0) 800 20 280<\/td><td><br><\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Allergan CZ sroTel: +420 800 188 818<\/td><td><strong>Hungary<\/strong>Allergan Hungary Kft.Tel .: +36 80 100 101<\/td><\/tr><tr><td><strong>Germany<\/strong>Pharm-Allergan GmbHTel: + 49 69 92038-1050<\/td><td><br><\/td><\/tr><tr><td><strong>\/&nbsp;<\/strong><strong>\u039b\u03bb\u03ac\u03b4\u03b1&nbsp;<\/strong><strong>\/&nbsp;<\/strong><strong>\u039a\u03cd\u03c0\u03c1\u03bf\u03c2<\/strong>Allergan Hellas Pharmaceuticals SA&nbsp;<br>\u03a4\u03b7\u03bb: +30 210 74 73 300<br><\/td><td><strong>Austria<\/strong>Pharm-Allergan GmbHTel: +43 1 99460 6355<\/td><\/tr><tr><td><strong>Spain<\/strong>Allergan SATel: + 34 91 807 6130<\/td><td><strong>Poland<\/strong>Allergan Sp.&nbsp;z ooTel: +48 22 256 37 00<\/td><\/tr><tr><td><strong>France<\/strong>Allergan France SASTel: +33 (0) 1 49 07 83 00<\/td><td><strong>Portugal<\/strong>Profarin Lda.Tel: + 351 21 425 3242<\/td><\/tr><tr><td><strong>Croatia<\/strong>Ewopharma dooTel: +385 1 6646 563<\/td><td><strong>Romania<\/strong>Allergan SRLTel: +40 21 301 53 02<\/td><\/tr><tr><td><br><\/td><td><strong>Slovenia<\/strong>Ewopharma dooTel: + 386 (0) 590 848 40<\/td><\/tr><tr><td><strong>Iceland<\/strong>Actavis Pharmaceuticals Iceland ehf.Phone: +354 550 3300<\/td><td><strong>Slovak Republic<\/strong>Allergan SK sroTel: +421 2 593 961 00<\/td><\/tr><tr><td><strong>Italy<\/strong>Allergan SpATel: + 39 06 509 562 90<\/td><td><br><\/td><\/tr><tr><td><strong>Latvia&nbsp;<\/strong><strong>\/&nbsp;<\/strong><strong>Lithuania \/ Estonia<\/strong>Allergan Baltics UABTel: + 371 676 60 831 (LT);&nbsp;+ 37 052 \u200b\u200b072 777 (LV);&nbsp;+ 37 2634 6109 (ET)<br><\/td><td><strong>United Kingdom<\/strong>Allergan LtdTel: + 44 (0) 1628 494026<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Constella has the active matter linaclotide. It is used to delight the signs of sensible to severe short-tempered bowel disease with constipation in grownup patients. IBS is a mutual gut disorder.<\/p>\n","protected":false},"author":2,"featured_media":45714,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2203,2200],"tags":[2239,6647,6650,6649,6642,6645,6644,6651,6646,6648,6643],"class_list":["post-7051","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-c","category-medicines","tag-capsule","tag-constella","tag-constella-capsule","tag-constella-side-effects","tag-linaclotide","tag-linaclotide-capsule","tag-linaclotide-side-effects","tag-side-effects-of-constella","tag-side-effects-of-linaclotide","tag-what-is-constella","tag-what-is-linaclotide"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7051","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=7051"}],"version-history":[{"count":47,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7051\/revisions"}],"predecessor-version":[{"id":45715,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7051\/revisions\/45715"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media\/45714"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=7051"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=7051"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=7051"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}