{"id":7029,"date":"2021-02-10T13:29:00","date_gmt":"2021-02-10T13:29:00","guid":{"rendered":"https:\/\/zeepedia.com\/?p=7029"},"modified":"2021-06-02T08:04:29","modified_gmt":"2021-06-02T08:04:29","slug":"conbriza","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/conbriza\/","title":{"rendered":"Conbriza &#8211; Bazedoxifene uses, dose and side effects"},"content":{"rendered":"\n<p> 20 mg\u00a0film-coated tablets\u00a0<br>Bazedoxifene<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What CONBRIZA is and what it is used for<\/h2>\n\n\n\n<p>CONBRIZA contains the active substance bazedoxifene and is a medicine that belongs to a group of non-hormonal medicines called selective estrogen receptor modulators (SERMs).&nbsp;It is used to treat&nbsp;osteoporosis&nbsp;in women who have reached&nbsp;menopause and who therefore have an increased risk of&nbsp;fractures.&nbsp;The drug works by slowing down or stopping the thinning of bones in these women.&nbsp;This medicine should not be used to treat&nbsp;osteoporosis&nbsp;in men<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before using CONBRIZA<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use CONBRIZA<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic (hypersensitive) to bazedoxifene or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you have or have had a blood clot (for example in a blood vessel in your legs, lungs, or eyes).<\/li><li>if you are pregnant or may become pregnant.&nbsp;This medicine can harm the fetus if taken during pregnancy.<\/li><li>if you have unexplained vaginal bleeding.&nbsp;This must be examined by a doctor.<\/li><li>if you have uterine cancer.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking CONBRIZA<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>as the medicine may increase the risk of you getting a blood clot.&nbsp;Blood clots occur very rarely but can cause serious health problems, disability, or death.&nbsp;Talk to your doctor to determine if you have an increased risk of blood clots.<\/li><li>if you have difficulty moving for a long period of time, for example, if you are in a wheelchair, have to sit down most of the time or lie in bed while you recover from an operation or illness.&nbsp;If you are traveling long distances, get up and move or move your legs and feet regularly.&nbsp;If you sit still in the same position for a long time, the blood circulation can be affected and the risk of blood clots increases.&nbsp;If you have to stay still for a long time, for example, to have surgery soon, it is important that you talk to your doctor about how you can reduce the risk of blood clots.<\/li><li>if you have not yet reached&nbsp;menopause.&nbsp;CONBRIZA has only been studied in women who have reached&nbsp;menopause, and can therefore not be recommended to others.<\/li><li>if you have previously had elevated levels of&nbsp;triglycerides&nbsp;(a type of fat found in the blood).<\/li><li>if you have liver problems or severe kidney problems.<\/li><li>if you bleed from your vagina while taking CONBRIZA, talk to your doctor.<\/li><li>if you have breast cancer because there is not enough experience with the use of this medicine among women with this disease.<\/li><\/ul>\n\n\n\n<p>Due to, among other things, the conditions described above, this medicine may not be suitable for you.&nbsp;If you have any of the problems described, talk to your doctor before taking the medicine.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and CONBRIZA<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking or have recently taken any other medicines.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>CONBRIZA is intended for use only among men who have reached&nbsp;menopause.&nbsp;It must not be taken by women who are pregnant or who may still be pregnant.&nbsp;Do not take this medicine if you are breast-feeding, as it is unclear whether the medicine can pass into breast milk.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>If you feel drowsy after taking this medicine, do not drive or use machines.&nbsp;<br><\/p>\n\n\n\n<p>You may have some vision problems, such as blurred vision, such as blurred vision while taking this medicine.&nbsp;If this happens, do not drive or use machines until your doctor tells you it&#8217;s safe to do so.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">CONBRIZA contains lactose and sodium<\/h2>\n\n\n\n<p>This medicine contains&nbsp;lactose&nbsp;(a type of sugar).&nbsp;If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.&nbsp;This medicine contains less than 1 mmol&nbsp;sodium&nbsp;(23 mg) per tablet, ie essentially &#8216;sodium-free&#8217;.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use CONBRIZA<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor or pharmacist has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.&nbsp;You should continue to take this medicine for as long as your doctor tells you to.&nbsp;You must take this medicine every day for the treatment to work.<br><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The recommended&nbsp;dose&nbsp;is one tablet (orally) daily.&nbsp;More than one tablet a day does not give an increased effect and it can be associated with an increased risk.<\/li><li>You can take the tablet at any time of the day with or without food.<\/li><li>This medicine should be taken with enough&nbsp;calcium&nbsp;and&nbsp;vitamin&nbsp;D. Talk to your doctor to find out if your&nbsp;calcium&nbsp;and&nbsp;vitamin&nbsp;D&nbsp;intake is&nbsp;already sufficient or if you need&nbsp;calcium&nbsp;and\/or&nbsp;vitamin D&nbsp;supplements. You can take the supplements at the same time as the medicine.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more CONBRIZA than you should &nbsp;<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist if you have accidentally taken too much CONBRIZA.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use CONBRIZA<\/h2>\n\n\n\n<p>If you forget to take a tablet at the usual time, take it as soon as you remember.&nbsp;If it is almost time for your next&nbsp;dose&nbsp;of this medicine, skip the&nbsp;dose&nbsp;you missed and take your next&nbsp;dose&nbsp;at the usual time.&nbsp;Do not take a double&nbsp;dose&nbsp;to make up for a forgotten tablet.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using CONBRIZA<\/h2>\n\n\n\n<p>If you decide to stop taking this medicine before the end of the prescribed treatment period, talk to your doctor first.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, or on stopping the use of this medicine, contact your doctor or pharmacist<strong>.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<br><\/p>\n\n\n\n<p><strong>Serious&nbsp;side effects&nbsp;are&nbsp;<\/strong><strong>&#8211; Stop taking CONBRIZA and see a doctor immediately<\/strong><br><\/p>\n\n\n\n<p><strong>Uncommon<\/strong>&nbsp;(may affect up to 1 in 100 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you get signs of blood clots in your legs or lungs, such as painful swelling or&nbsp;redness&nbsp;on your legs, sudden chest pain, or difficulty breathing.<\/li><li>If you have signs of a blood clot in your eye (&nbsp;retinal&nbsp;vein), such as unilateral vision disorder, impaired vision, blurred vision, or loss of vision in one eye.<\/li><li>If you get any of the problems listed in the&nbsp;<strong>&#8220;Do not take CONBRIZA&#8221; section<\/strong><\/li><\/ul>\n\n\n\n<p><strong>No known frequency<\/strong>&nbsp;(occurs in an unknown number of users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you experience other&nbsp;side effects&nbsp;that affect the eye and\/or vision (see sparks or flashes of light, get narrowing&nbsp;fields of vision,&nbsp;and swelling of the eye or eyelids).&nbsp;<\/li><\/ul>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;ar<\/strong><\/p>\n\n\n\n<p>Some patients have experienced the following&nbsp;side effects&nbsp;while taking CONBRIZA:<br><\/p>\n\n\n\n<p><strong>Very common<\/strong>&nbsp;(may affect more than 1 user in 10):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Muscle cramps (including leg cramps)<\/li><li>Hot flashes<\/li><li>Swelling of hands, feet, and legs (peripheral&nbsp;edema&nbsp;)<\/li><\/ul>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Allergisk reaktion&nbsp;(inklusive \u00f6verk\u00e4nslighet och&nbsp;urtikaria)<\/li><li>Utslag,&nbsp;kl\u00e5da<\/li><li>Muntorrhet<\/li><li>\u00d6kad m\u00e4ngd&nbsp;triglycerider i blodet (fett som finns i blodet)<\/li><li>F\u00f6rh\u00f6jt antal leverenzymer<\/li><li>S\u00f6mnighet<\/li><\/ul>\n\n\n\n<p><strong>Ingen k\u00e4nd frekvens&nbsp;<\/strong>(f\u00f6rekommer hos ett ok\u00e4nt antal anv\u00e4ndare):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Hj\u00e4rtklappning<\/li><li>Torra \u00f6gon, \u00f6gonsm\u00e4rta, minskad&nbsp;synsk\u00e4rpa, nedsatt syn,&nbsp;blefarospasm(onormala oavsiktliga blinkningar eller \u00f6gonlocksspasmer).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">5. Hur CONBRIZA &nbsp;ska f\u00f6rvaras<\/h2>\n\n\n\n<p>F\u00f6rvara detta l\u00e4kemedel utom syn- och r\u00e4ckh\u00e5ll f\u00f6r barn.<br><\/p>\n\n\n\n<p>Anv\u00e4nds f\u00f6re utg\u00e5ngsdatum som anges p\u00e5 kartongen och blistret efter EXP.<br><\/p>\n\n\n\n<p>The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>Do not store above 25 \u00b0 C.<br><\/p>\n\n\n\n<p>The medicine should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is bazedoxifene.&nbsp;One film-coated tablet contains bazedoxifene acetate equivalent to 20 mg bazedoxifene.<\/li><li>The other ingredients are&nbsp;lactose monohydrate, microcrystalline cellulose, pregelatinized&nbsp;starch&nbsp;(corn), sodium, sodium,&nbsp;colloidal&nbsp;anhydrous silica,&nbsp;ascorbic acid, hypromellose, titanium dioxide (E171), and macrogol 400 (see section 2 &#8220;CONBRIZA contains&nbsp;lactose&nbsp;and sodium&#8221;).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>CONBRIZA is delivered as white to off-white, capsule-shaped, film-coated tablets marked \u201cWY20\u201d.&nbsp;The tablet is approximately 1.5 cm long.&nbsp;They are packaged in PVC \/ Aclar blisters and are supplied in packs of 7, 28, 30, 84, and 90 tablets.<br><\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder:<\/strong><\/p>\n\n\n\n<p>Pfizer Europe MA EEIG, Boulevard de la Plaine 17, 1050 Brussels, Belgium.<br><\/p>\n\n\n\n<p><strong>Manufacturer:<\/strong><\/p>\n\n\n\n<p>Pfizer Ireland Pharmaceuticals, Little Connell, Newbridge, County Kildare, Ireland.<br><\/p>\n\n\n\n<p>Contact the representative of the marketing authorization holder to find out more about this medicine: Show larger<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgium \/ Belgique \/ Belgien&nbsp;<br>Luxembourg \/ Luxemburg<\/strong>Pfizer SA \/ NVTel: +32 (0) 2 554 62 11<\/td><td><strong>Latvia<\/strong>Pfizer Luxembourg SARL subsidiary Latvij\u0101Tel .: + 371 670 35 775<\/td><\/tr><tr><td><strong>Bulgaria<\/strong> Pfizer of Luxembourg, Clone of BulgariaTel: +359 2 970 4333<\/td><td><strong>Lithuania<\/strong>Pfizer Luxembourg SARL branches in LithuaniaTel.&nbsp;+ 370 52 51 4000<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Pfizer sroTel: + 420-283-004-111<\/td><td><strong>Hungary<\/strong>Pfizer Kft&nbsp;<br>Tel: +36 1 488 3700<\/td><\/tr><tr><td><strong>Denmark<\/strong>Pfizer ApSTel: +45 44 201 100<\/td><td><strong>Malta<\/strong>Vivian Corporation Ltd.Tel: +35621 344610<\/td><\/tr><tr><td><strong>Germany<\/strong>Pfizer Pharma PFE GmbHTel: +49 (0) 800 8535555<\/td><td><strong>The Netherlands<\/strong>Pfizer BVTel: +31 (0) 10 406 43 01<\/td><\/tr><tr><td><strong>Eesti<\/strong>&nbsp;<br>Pfizer Luxembourg SARL Eesti subsidiaryTel .: +372 666 7500<\/td><td><strong>Norway<\/strong>Pfizer ASTel: +47 67 526 100<\/td><\/tr><tr><td><strong>Greece<\/strong>Pfizer Hellas AE&nbsp;<br>\u03a4\u03b7\u03bb .: +30 210 6785 800<\/td><td><strong>Austria<\/strong>Pfizer Corporation Austria Ges.mbHTel: +43 (0) 1 521 15-0<\/td><\/tr><tr><td><strong>Spain<\/strong>Pfizer, SLTel: +34 91 490 99 00<\/td><td><strong>Poland<\/strong>Pfizer Polska Sp.&nbsp;z ooTel: +48 22 335 61 00<\/td><\/tr><tr><td><strong>France<\/strong>Pfizer PFE France&nbsp;Tel: +33 (0) 1 58 07 34 40<\/td><td><strong>Portugal<\/strong>Pfizer Biopharmaceuticals, Sociedade Unipessoal LdaTel: +351 21 423 5500<\/td><\/tr><tr><td><strong>Croatia<\/strong>Pfizer Croatia dooTel: + 385 1 3908 777<\/td><td><strong>Romania<\/strong>Pfizer Romania SRLTel: +40 (0) 21 207 28 00<\/td><\/tr><tr><td><strong>Ireland<\/strong>Pfizer Healthcare IrelandTel: 1800 633 363 (toll free)+44 (0) 1304 616161<\/td><td><strong>Slovenia<\/strong>Pfizer Luxembourg SARLPfizer, underwriting and dryingpharmacevtske dejavnosti, LjubljanaTel .: + 386 (0) 1 52 11 400<\/td><\/tr><tr><td><strong>Iceland<\/strong>Icepharma hfPhone: +354 540 8000<\/td><td><strong>Slovak Republic<\/strong>Pfizer Luxembourg SARL,organizing serviceTel: + 421 2 3355 5500<\/td><\/tr><tr><td><strong>Italy<\/strong>Pfizer Italia SrlTel: +39 06 33 18 21<\/td><td><strong>Finland \/ Finland<\/strong>Pfizer OyPuh \/ Tel: +358 (0) 9 430 040<\/td><\/tr><tr><td><br><\/td><td><strong>United Kingdom<\/strong>Pfizer Limited,Tel: +44 (0) 1304 616161<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>CONBRIZA contains the active substance bazedoxifene and is a medicine that belongs to a group of non-hormonal medicines called selective estrogen receptor modulators (SERMs). It is used to treat osteoporosis in women who have reached menopause and who therefore have an increased risk of fractures. The drug works by slowing down or stopping the thinning of bones in these women. This medicine should not be used to treat osteoporosis in men<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2203,2200],"tags":[5109,5111,6669,6671,6673,6674,6670,6675,6672],"class_list":["post-7029","post","type-post","status-publish","format-standard","hentry","category-c","category-medicines","tag-bazedoxifene","tag-bazedoxifene-side-effects","tag-bazedoxifene-tablet","tag-conbriza","tag-conbriza-side-effects","tag-conbriza-tablet","tag-side-effects-of-bazedoxifene","tag-side-effects-of-conbriza","tag-what-is-conbriza"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7029","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=7029"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7029\/revisions"}],"predecessor-version":[{"id":11285,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7029\/revisions\/11285"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=7029"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=7029"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=7029"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}