{"id":7025,"date":"2021-02-10T13:24:36","date_gmt":"2021-02-10T13:24:36","guid":{"rendered":"https:\/\/zeepedia.com\/?p=7025"},"modified":"2021-06-02T08:12:38","modified_gmt":"2021-06-02T08:12:38","slug":"competact","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/competact\/","title":{"rendered":"Competact &#8211; Pioglitazone and Metformin uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n15 mg \/ 850 mg&nbsp;film-coated tablets&nbsp;<br>pioglitazone \/ metformin hydrochloride<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Competact is and what it is used for<\/h2>\n\n\n\n<p>Competact contains pioglitazone and&nbsp;metformin.&nbsp;It is a treatment for&nbsp;diabetes&nbsp;used in adults to treat type 2 (non-insulin-dependent)&nbsp;diabetes mellitus&nbsp;when treatment with&nbsp;metformin&nbsp;is not sufficient.&nbsp;This type 2&nbsp;diabetes&nbsp;usually develops in adulthood, especially in obese people who cannot produce enough&nbsp;insulin&nbsp;(a&nbsp;hormone&nbsp;that controls blood sugar levels) or cannot use the&nbsp;insulin&nbsp;that is produced.&nbsp;3 to 6 months after starting treatment, your doctor will check if Competact works for you.<br><\/p>\n\n\n\n<p>Competact helps keep blood sugar levels under control in type 2&nbsp;diabetes&nbsp;so that the body can make better use of the&nbsp;insulin&nbsp;that is formed.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before taking Compatect<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Competact<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to pioglitazone,&nbsp;metformin,&nbsp;or any&nbsp;of the other&nbsp;ingredients of this medicine (listed in section 6).<\/li><li>if you have or have had&nbsp;heart failure in the&nbsp;past.<\/li><li>if you have recently had a heart attack, have severe circulatory problems including&nbsp;shock, or difficulty breathing.<\/li><li>if you have any liver disease.<\/li><li>if you have a high alcohol intake (either every day or only occasionally).<\/li><li>if you have uncontrolled&nbsp;diabetes&nbsp;with, for example, severe&nbsp;hyperglycemia&nbsp;(high blood sugar), nausea, vomiting, diarrhea, rapid weight loss,&nbsp;lactic acidosis&nbsp;(see section &#8220;Risk of lactic acidosis&#8221;), or&nbsp;ketoacidosis.&nbsp;Ketoacidosis&nbsp;is a condition in which substances called&nbsp;ketone bodies&nbsp;to accumulate in the blood, which can lead to diabetic precoma.&nbsp;Symptoms include stomach pain, rapid and deep breathing, drowsiness, or that your breath gets a different, fruity odor.<\/li><li>if you have or have ever had bladder cancer.<\/li><li>if you have blood in your urine that your doctor has not examined further.<\/li><li>if you have severe renal impairment.<\/li><li>if you have a serious&nbsp;infection&nbsp;or are dehydrated.<\/li><li>if you are going to have a certain type of x-ray with an injectable contrast agent, talk to your doctor as you will have to stop taking Competact for a while before and after the examination.<\/li><li>if you are breast-feeding.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Competact (see also section 4).<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have heart problems.&nbsp;Some patients who have had type 2&nbsp;diabetes&nbsp;for many years and heart disease or have had&nbsp;strokes&nbsp;treated with pioglitazone and&nbsp;insulin&nbsp;at the same time have suffered from&nbsp;heart failure.&nbsp;Tell your doctor as soon as possible if you get signs of&nbsp;heart failure&nbsp;such as sudden shortness of breath, rapid weight gain, or local swelling (&nbsp;edema&nbsp;).<\/li><li>if you are accumulating water (&nbsp;fluid retention&nbsp;) or have problems with&nbsp;heart failure, especially if you are over 75 years old.&nbsp;Tell your doctor if you are taking anti-inflammatory medications that may cause you to accumulate fluid and swell.<\/li><li>if you have macular edema, a specific diabetic eye disease (swelling in the back of the eye), talk to your doctor if you notice any change in vision.<\/li><li>if you have ovarian cysts (&nbsp;polycystic ovary syndrome&nbsp;).&nbsp;This can lead to an increased chance of getting pregnant because you may ovulate again when you take Competact.&nbsp;If this affects you, use appropriate contraception to avoid unplanned pregnancy.<\/li><li>if you have liver problems.&nbsp;Before you start using Competact, you will be given blood tests to check your liver function.&nbsp;This check may be repeated at intervals.&nbsp;Tell your doctor as soon as possible if you get signs of liver disease (such as unexplained nausea, vomiting, stomach pain, fatigue, loss of appetite, and\/or dark urine) as your liver function should be checked.<\/li><\/ul>\n\n\n\n<p>You may also experience a decrease in the number of&nbsp;blood cells&nbsp;(&nbsp;anemia&nbsp;).<br><\/p>\n\n\n\n<p><strong>Risk of&nbsp;lactic acidosis<\/strong><\/p>\n\n\n\n<p>Competact can cause the very rare, but very serious&nbsp;side effect&nbsp;of&nbsp;lactic acidosis, particularly if your kidneys are not working properly.&nbsp;The risk of developing&nbsp;lactic acidosis&nbsp;is also increased in uncontrolled&nbsp;diabetes, severe&nbsp;infections, long-term fasting or alcohol consumption, dehydration (see more information below), liver problems, and conditions where part of the body has reduced oxygen supply (including&nbsp;acute&nbsp;severe heart disease).<\/p>\n\n\n\n<p>If any of the above apply to you, talk to your doctor for further information.<br><\/p>\n\n\n\n<p><strong>Stop taking Competact for a short time if you have a condition that may be associated with dehydration,<\/strong>&nbsp;such as severe vomiting, diarrhea, fever, exposure to heat, or if you drink less fluid than normal.&nbsp;Talk to a doctor for further instructions.<br><\/p>\n\n\n\n<p><strong>Stop taking Competact and contact a doctor or nearest hospital immediately if you experience any of the symptoms of&nbsp;lactic acidosis&nbsp;as the condition may lead to&nbsp;coma<\/strong>.<\/p>\n\n\n\n<p>Symptoms of&nbsp;lactic acidosis&nbsp;include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>vomiting<\/li><li>abdominal pain (stomach pain)<\/li><li>muscle cramps<\/li><li>a general feeling of not feeling well and pronounced fatigue<\/li><li>hard to breathe<\/li><li>lowered body temperature and&nbsp;heart rate.<\/li><\/ul>\n\n\n\n<p>Lactic acidosis&nbsp;is an&nbsp;acute&nbsp;medical condition that must be treated in a hospital.<br><\/p>\n\n\n\n<p>During treatment with Competact, your doctor will check your kidney function at least once a year or more often if you are older and\/or if your kidney function is deteriorating.<br><\/p>\n\n\n\n<p>If you are going to undergo a major operation, you must stop taking Competact during the operation and a certain time after it.&nbsp;Your doctor will decide when to stop taking Competact and when to start taking it again.<br><\/p>\n\n\n\n<p>Hypoglycemia<\/p>\n\n\n\n<p>If you use Competact with other diabetes medicines, it is likely that your blood sugar may drop below normal levels (hypoglycemia).&nbsp;If you experience symptoms of&nbsp;hypoglycemia&nbsp;such as weakness, dizziness, increased sweating, rapid&nbsp;heartbeat, visual disturbances, or difficulty concentrating, you should eat something sweet to raise your blood sugar level again.&nbsp;If you are not sure how to recognize&nbsp;hypoglycemia&nbsp;talk to your doctor or pharmacist for more information.&nbsp;It is recommended that you bring sugar cubes, sweets, biscuits, or fruit drinks that contain sugar.<br><\/p>\n\n\n\n<p>Fracture<\/p>\n\n\n\n<p>A higher incidence of bone fractures has been observed in patients, especially in women taking pioglitazone.&nbsp;Your doctor will take this into account when treating your&nbsp;diabetes.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Use in children and adolescents under 18 years of age is not recommended.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Competact<\/h2>\n\n\n\n<p>If you need to get an&nbsp;injection&nbsp;in the blood with contrast media that contain iodine, for example in connection with X-rays or&nbsp;computed tomography, you must stop taking Competact before or at the time of&nbsp;injection.&nbsp;Your doctor will decide when to stop taking Competact and when to start taking it again.<br><\/p>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking or have recently taken or might take any other medicines.&nbsp;You may need to do more blood sugar and kidney function tests, or&nbsp;your&nbsp;doctor may need to adjust the&nbsp;dose&nbsp;of Competact.&nbsp;It is especially important that you mention the following:<br><\/p>\n\n\n\n<p>The following medicines are very likely to affect the amount of sugar in your blood:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>gemfibrozil (cholesterol-lowering)<\/li><li>rifampicin (used to treat&nbsp;tuberculosis&nbsp;and other&nbsp;infections&nbsp;)<\/li><li>cimetidine (used to reduce stomach acid)<\/li><li>glucocorticosteroids (used to treat&nbsp;inflammation&nbsp;)<\/li><li>beta-2&nbsp;agonists&nbsp;(for the treatment of&nbsp;asthma&nbsp;)drugs that increase urine production (&nbsp;diuretics&nbsp;)<\/li><li>drugs used to treat pain and&nbsp;inflammation&nbsp;(&nbsp;NSAIDs&nbsp;and COX 2 inhibitors, such as&nbsp;ibuprofen&nbsp;and celecoxib)<\/li><li>certain medicines for the treatment of high&nbsp;blood pressure&nbsp;(angiotensin converters (&nbsp;ACEs&nbsp;) and&nbsp;angiotensin&nbsp;II receptor antagonists).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Competact with alcohol<\/h2>\n\n\n\n<p>Avoid high alcohol intake while taking Competact as alcohol may increase the risk of&nbsp;lactic acidosis&nbsp;(see section &#8220;Risk of lactic acidosis&#8221;).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are pregnant, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine.&nbsp;Competact is not recommended during pregnancy.&nbsp;If you want to get pregnant, your doctor will advise you to stop taking this medicine.<\/li><li>Do not use Competact if you are breast-feeding or planning to breast-feed your baby (see section &#8220;Do not take Competact&#8221;).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>This medicine does not affect your ability to drive or use machines, but use caution if you experience visual disturbances.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to take Competact<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor or pharmacist has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<br><\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;is one tablet twice daily.&nbsp;If necessary, your doctor may ask you to take another&nbsp;dose.&nbsp;If you have impaired kidney function, your doctor may prescribe a lower&nbsp;dose, which may need to be given as separate tablets of pioglitazone and&nbsp;metformin.<br><\/p>\n\n\n\n<p>The tablets should be swallowed together with a glass of water.&nbsp;You should take the tablets with or just after food to reduce the risk of stomach upset.<br><\/p>\n\n\n\n<p>If you are recommended a special diet for&nbsp;diabetes, you should continue with this while taking Competact.<br><\/p>\n\n\n\n<p>Check your weight regularly and tell your doctor if the weight increases.<br><\/p>\n\n\n\n<p>Your doctor will take blood samples regularly during treatment with Competact.&nbsp;This is done to check that the liver is functioning normally.&nbsp;At least once a year (more often if you are elderly or have kidney problems), your doctor will check that your kidneys are functioning normally.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Competact than you should<\/h2>\n\n\n\n<p>If you accidentally take too many tablets, or if someone else or a child takes your medicine, talk to a doctor or&nbsp;pharmacist&nbsp;immediately.&nbsp;Your blood sugar can fall below normal levels and can be increased by consuming sugar.&nbsp;It is a recommendation to carry sugar cubes, sweets, biscuits, or sugary fruit drinks.<br><\/p>\n\n\n\n<p>If you take more Competact than you should you may have lactic acidosis (see section &#8220;Risk of lactic acidosis&#8221;).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Competact<\/h2>\n\n\n\n<p>Try to take Competact daily as prescribed.&nbsp;However, if you miss a&nbsp;dose, skip the missed&nbsp;dose&nbsp;and just continue with the next&nbsp;dose&nbsp;as usual.&nbsp;Do not take a double&nbsp;dose to make up for a forgotten tablet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Competact<\/h2>\n\n\n\n<p>Competact should be used daily to achieve the desired effect.&nbsp;If you stop taking Competact, your blood sugar level may increase.&nbsp;Talk to your doctor before stopping this treatment.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<br><\/p>\n\n\n\n<p>Competact can cause the very rare (may affect up to 1 in 10,000), but very serious&nbsp;side effects<strong>&nbsp;a&nbsp;lactic acidosis&nbsp;(see section &#8220;Risk of lactic acidosis&#8221;).&nbsp;If this happens to you,&nbsp;stop taking Competact and contact your doctor or nearest hospital immediately&nbsp;as&nbsp;lactic acidosis&nbsp;may lead to&nbsp;a coma<\/strong>.<br><\/p>\n\n\n\n<p>Bladder cancer has been detected in some patients (may affect up to 1 in 100 people) taking Competact.&nbsp;Signs and symptoms of this can be blood in the urine, pain when urinating, or urinary incontinence (sudden need to urinate).&nbsp;Contact your doctor as soon as possible if you experience any of these symptoms.<br><\/p>\n\n\n\n<p>It has been common (may affect up to 1 in 10 users) that female patients taking Competact have reported bone fractures.&nbsp;Bone fractures have also been reported in male patients taking Competact (occurs in an unknown number of users).&nbsp;Contact your doctor as soon as possible if you experience this&nbsp;side effect.<br><\/p>\n\n\n\n<p>Visual disturbances associated with swelling (or fluid) in the posterior part of the eye (macular edema) have been reported (no known frequency, can not be calculated from the available data).&nbsp;Talk to your doctor as soon as possible if you experience these symptoms for the first time.&nbsp;If you already have visual disturbances and the symptoms worsen, talk to your doctor immediately even then.<br><\/p>\n\n\n\n<p>Allergic reactions have been reported with no known frequency (cannot be calculated from the available data) in patients taking Competact.&nbsp;If you get a severe&nbsp;allergic reaction&nbsp;such as hives or swelling of your face, lips, tongue, or throat, which may cause difficulty breathing or swallowing, stop taking this medicine and contact your doctor immediately.<br><\/p>\n\n\n\n<p>Some patients have experienced the following&nbsp;side effects&nbsp;from Competact<br><\/p>\n\n\n\n<p>Very common (may affect more than 1 user in 10)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>magont<\/li><li>the feeling of nausea (nausea)<\/li><li>vomiting<\/li><li>diarrhea<\/li><li>loss of appetite<\/li><\/ul>\n\n\n\n<p>Common (may affect up to 1 in 10 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>limited swelling (&nbsp;edema&nbsp;)<\/li><li>weight gain<\/li><li>headache<\/li><li>respiratory tract infection<\/li><li>visual impairment<\/li><li>joint pain<\/li><li>impotence<\/li><li>blood in the urine<\/li><li>reduction of&nbsp;red blood cells&nbsp;(&nbsp;anemia&nbsp;)<\/li><li>loss of sensation<\/li><li>taste disorders<\/li><\/ul>\n\n\n\n<p>Uncommon (may affect up to 1 in 100 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>sinusitis (&nbsp;sinusitis&nbsp;)<\/li><li>weather voltage<\/li><li>insomnia (&nbsp;insomnia&nbsp;)<\/li><\/ul>\n\n\n\n<p>Very rare (may affect up to 1 user in 10,000):<br><\/p>\n\n\n\n<p>reduction of&nbsp;vitamin&nbsp;B12 in the blood<\/p>\n\n\n\n<p>reddening of the skin<\/p>\n\n\n\n<p>itching<\/p>\n\n\n\n<p>hives (raised itchy rash)<br><\/p>\n\n\n\n<p>No known frequency (cannot be calculated from the available data)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>liver inflammation (&nbsp;hepatitis&nbsp;)<\/li><li>impaired liver function (altered levels of liver enzymes)<\/li><\/ul>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.&nbsp;Postal address<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Competact<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton and blister after EXP.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>No special storage instructions are required for this medicine.<br><\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substances are pioglitazone and metformin hydrochloride.&nbsp;Each tablet contains 15 mg of pioglitazone (as hydrochloride) and 850 mg of metformin hydrochloride.<\/li><li>The other ingredients are microcrystalline cellulose, povidone (K 30), sodium croscarmellose, magnesium stearate, hypromellose, magrocol 8000, talc, and titanium dioxide (E171).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>The film-coated tablets (tablets) are white to off-white, oblong, cupped, film-coated tablets (tablet) and marked &#8220;15\/850&#8221; on one side and &#8220;4833M&#8221; on the other.&nbsp;They come in aluminum \/ aluminum blisters in packs of 14, 28, 30, 50, 56, 60, 90, 98, 112, 180, multiple packs of 196 (2 packs of 98) tablets or in perforated single-dose blisters of aluminum \/ aluminum in packs of 60 x 1 tablets.<br><\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Takeda Pharma A \/ S<\/p>\n\n\n\n<p>Dybendal Alle 10<\/p>\n\n\n\n<p>2630 Taastrup<\/p>\n\n\n\n<p>Denmark<br><\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Takeda Ireland Limited, Bray Business Park, Kilruddery, County Wicklow, Ireland.<\/p>\n\n\n\n<p>Delpharm Novara Srl, Via Crosa, 86, I-28065 Cerano (NO), Italy.<\/p>\n\n\n\n<p>Lilly SA, Avda.&nbsp;de la Industria 30, 28108 Alcobendas, Madrid, Spain.<br><\/p>\n\n\n\n<p>For any information about this medicine, please contact the local representative of the Marketing Authorization Holder:Show larger<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgium \/ Belgique \/ Belgien<\/strong>Takeda BelgiumTel: +32 2 464 06 11takeda-belgium@takeda.com<\/td><td><strong>Lithuania<\/strong>Eli Lilly Holdings Limited sharesTel.&nbsp;+370 (5) 2649600<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Takade BulgariaTel .: + 359 2 958 27 36;+ 359 2 958 15 29<\/td><td><strong>Luxembourg \/ Luxemburg<\/strong>Takeda BelgiumTel: +32 2 464 06 11takeda-belgium@takeda.com<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>ELI LILLY \u010cR, sroTel: + 420 234 664 111<\/td><td><strong>Hungary<\/strong>Lilly Hungary Kft.Tel: + 36 1 328 5100<\/td><\/tr><tr><td><strong>Denmark<\/strong>Takeda Pharma A \/ STel: +45 46 77 11 11<\/td><td><strong>Malta<\/strong>Takeda Italia SpATel: +39 06 502601<\/td><\/tr><tr><td><strong>Germany<\/strong>Takeda GmbHTel: 0800 825 3325medinfo@takeda.de<\/td><td><strong>The Netherlands<\/strong>Eli Lilly Netherlands BVTel: +31 (0) 30 60 25 800<\/td><\/tr><tr><td><strong>Eesti<\/strong>Takeda Pharma ASTel: +372 617 7669<\/td><td><strong>Norway<\/strong>Takeda ASTel: +47 6676 3030infonorge@takeda.com<\/td><\/tr><tr><td><strong>Greece<\/strong>\u03a6\u0391\u03a1\u039c\u0391\u03a3\u0395\u03a1\u0392-\u039b\u0399\u039b\u039b\u03a5 \u0391.\u0395.\u0392.\u0395.:\u0397\u03bb: +30 210 629 4600<\/td><td><strong>Austria<\/strong>Takeda Pharma Ges.mbHTel: +43 (0) 800 20 80 50<\/td><\/tr><tr><td><strong>Spain<\/strong>Lilly SATel: + 34 (91) 663 50 00<\/td><td><strong>Poland<\/strong>Takeda Polska Sp.&nbsp;z ooTel .: + 48 22 608 13 00<\/td><\/tr><tr><td><strong>France<\/strong>Takeda France SASTel: +33 1 46 25 16 16<\/td><td><strong>Portugal<\/strong>Lilly Portugal &#8211; Pharmaceutical Products, LdaTel: + 351 21 412 6600<\/td><\/tr><tr><td><strong>Croatia<\/strong>Takeda Pharmaceuticals Croatia dooTel: +385 1 377 88 96<\/td><td><strong>Romania<\/strong>Eli Lilly Rom\u00e2nia SRLTel: +40 21 4023000<\/td><\/tr><tr><td><strong>Ireland<\/strong>Takeda Products Ireland LimitedTel: +353 (0) 1 6420021<\/td><td><strong>Slovenia<\/strong>Takeda GmbH, Podru\u017enica SlovenijaPhone + 386 (0) 59 082 480<\/td><\/tr><tr><td><strong>Iceland<\/strong>Vistor hf.Phone: +354 535 7000vistor@vistor.is<\/td><td><strong>Slovak Republic<\/strong>Takeda Pharmaceuticals Slovakia sroTel: +421 (2) 20 602 600<\/td><\/tr><tr><td><strong>Italy<\/strong>Takeda Italia SpATel: +39 06 502601<\/td><td><strong>Finland \/ Finland<\/strong>Oy Eli Lilly Finland AbPuh \/ Tel: +358 (0) 9 8545250<\/td><\/tr><tr><td><strong>Latvia<\/strong>Eli Lilly Holdings Limited is a Latvian companyTel: +371 6 7 364 000<\/td><td><strong>United Kingdom<\/strong>Takeda UK LtdTel: +44 (0) 1628 537 900<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Competact contains pioglitazone and metformin. It is a treatment for diabetes used in adults to treat type 2 (non-insulin-dependent) diabetes mellitus when treatment with metformin is not sufficient. This type 2 diabetes usually develops in adulthood, especially in obese people who cannot produce enough insulin (a hormone that controls blood sugar levels) or cannot use the insulin that is produced. 3 to 6 months after starting treatment, your doctor will check if Competact works for you.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2203,2200],"tags":[6687,6689,6683,6685,6691,6693,6694,6690,6686,6695,6688,6684,6692],"class_list":["post-7025","post","type-post","status-publish","format-standard","hentry","category-c","category-medicines","tag-competact","tag-competact-tablet","tag-metformin","tag-metformin-tablet","tag-pioglitazone","tag-pioglitazone-side-effects","tag-pioglitazone-tablet","tag-side-effects-of-competact","tag-side-effects-of-metformin","tag-side-effects-of-pioglitazone","tag-what-is-competact","tag-what-is-metformin","tag-what-is-pioglitazone"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7025","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=7025"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7025\/revisions"}],"predecessor-version":[{"id":11290,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7025\/revisions\/11290"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=7025"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=7025"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=7025"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}