{"id":7019,"date":"2021-02-10T13:20:46","date_gmt":"2021-02-10T13:20:46","guid":{"rendered":"https:\/\/zeepedia.com\/?p=7019"},"modified":"2021-06-02T08:22:31","modified_gmt":"2021-06-02T08:22:31","slug":"cometriq","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/cometriq\/","title":{"rendered":"Cometriq &#8211; Cabozantinib uses, dose and side effects"},"content":{"rendered":"\n<p> 20 mg, 80 mg&nbsp;hard capsules&nbsp;<br>cabozantinib<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What COMETRIQ is and what it is used for<\/h2>\n\n\n\n<p>What COMETRIQ is<br><\/p>\n\n\n\n<p>COMETRIQ is a cancer drug containing the active substance cabozantinib.&nbsp;It is a drug used to treat medullary thyroid cancer, an unusual thyroid cancer that cannot be removed with&nbsp;surgery&nbsp;or that has spread to other parts of the body.<br><\/p>\n\n\n\n<p>How COMETRIQ works<br><\/p>\n\n\n\n<p>COMETRIQ blocks the effect of&nbsp;proteins&nbsp;called receptor tyrosine kinases (RTKs), which are involved in the growth of cells and the development of new blood vessels that supply the cells.&nbsp;These&nbsp;proteins&nbsp;can be found in large amounts in cancer cells.&nbsp;By blocking their effect, COMETRIQ can slow the growth rate of the tumor and help cut off the blood supply that the cancer cells need.&nbsp;COMETRIQ can slow or stop the medullary thyroid cancer from growing.&nbsp;The drug can also help shrink&nbsp;tumors associated with this type of cancer.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before taking COMETRIQ<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take COMETRIQ<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to cabozantinib or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking COMETRIQ if you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>have high&nbsp;blood pressure<\/li><li>have or have had an&nbsp;aneurysm&nbsp;(enlargement and weakening of a vessel wall) or a rupture in a vessel wall<\/li><li>have diarrhea<\/li><li>have recently coughed up blood or had major bleeding<\/li><li>have had surgery in the last month (or if you have&nbsp;surgery&nbsp;planned), including dental surgery<\/li><li>has received radiation treatment in the last 3 months<\/li><li>have&nbsp;inflammation&nbsp;of the intestine (for example,&nbsp;Crohn&#8217;s disease,&nbsp;ulcerative colitis,&nbsp;or&nbsp;diverticulitis&nbsp;)<\/li><li>have received information that your cancer has spread to the airways or esophagus<\/li><li>recently had a blood clot in the leg,&nbsp;stroke,&nbsp;or heart attack<\/li><li>taking medications to control your heart rhythm, have a slow heart rhythm, have heart problems or problems with your calcium, potassium, or magnesium levels<\/li><li>have severe liver or kidney disease.<\/li><\/ul>\n\n\n\n<p><strong>Talk to your doctor if any of these apply to you<\/strong>.&nbsp;You may need to be treated for it, or your doctor may change your&nbsp;dose&nbsp;of COMETRIQ or stop treatment altogether.&nbsp;See also section 4,&nbsp;\u201cPossible side effects\u201d.<br><\/p>\n\n\n\n<p>Tell your dentist that you are taking COMETRIQ.&nbsp;It is important that you take care of proper oral hygiene when you are treated with COMETRIQ.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>COMETRIQ is not recommended for children or adolescents.&nbsp;It is not known what effects COMETRIQ has on people under 18 years of age.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and COMETRIQ<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription, herbal medicines, or other herbal medicines.&nbsp;This is because COMETRIQ may affect the way some other medicines work or change their effects.&nbsp;In addition, some other medicines may affect the way COMETRIQ works.&nbsp;This may require your doctor to change the dose (s) you are taking.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Medicines for fungal infections, such as itraconazole,&nbsp;ketoconazole, and posaconazole<\/li><li>Medications used to treat bacterial&nbsp;infections&nbsp;(&nbsp;antibiotics&nbsp;) such as erythromycin, clarithromycin, and rifampicin<\/li><li>Allergy medications such as fexofenadine<\/li><li>Medicines for&nbsp;angina pectoris&nbsp;(chest pain due to insufficient blood flow to the heart), e.g.&nbsp;ranolazine<\/li><li>Steroids&nbsp;used to reduce&nbsp;inflammation&nbsp;or treat several different diseases of the immune system<\/li><li>Medications used for&nbsp;epilepsy&nbsp;and seizures such as&nbsp;phenytoin, carbamazepine, and phenobarbital<\/li><li>Herbal remedies that contain&nbsp;St. John&#8217;s wort&nbsp;(Hypericum perforatum), which are sometimes used to treat depression or depression-like conditions such as.&nbsp;anxiety<\/li><li>Medications used to thin the blood, e.g.&nbsp;warfarin&nbsp;and dabigatran etexilate<\/li><li>Medications used to treat high&nbsp;blood pressure&nbsp;or other heart conditions, e.g.&nbsp;aliskiren, ambrisentan,&nbsp;digoxin, talinolol, and tolvaptan<\/li><li>Medications used to treat&nbsp;diabetes, e.g.&nbsp;saxagliptin and sitagliptin<\/li><li>Medications used to treat&nbsp;gout, e.g.&nbsp;kolkicin<\/li><li>Medicines for&nbsp;HIV&nbsp;or&nbsp;AIDS&nbsp;, e.g.&nbsp;ritonavir, maravirok and emtricitabine<\/li><li>Medicines for viral infections, e.g.&nbsp;efavirenz<\/li><li>Medications used to prevent&nbsp;graft rejection&nbsp;(cyclosporine) and cyclosporine-based treatments for&nbsp;rheumatoid arthritis&nbsp;and&nbsp;psoriasis<\/li><\/ul>\n\n\n\n<p>Oral contraceptives (taken by mouth, swallowed)<\/p>\n\n\n\n<p>If you take COMETRIQ while taking oral contraceptives, these contraceptives may be ineffective.&nbsp;You should therefore also use a&nbsp;barrier method&nbsp;(eg condoms or&nbsp;diapers&nbsp;) while you are taking COMETRIQ and for at least 4 months after stopping treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">COMETRIQ with food<\/h2>\n\n\n\n<p>Avoid eating anything that contains grapefruit while using this medicine, as it may increase the levels of COMETRIQ in your blood.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p><strong>Avoid getting pregnant while taking COMETRIQ<\/strong>.&nbsp;If you or your partner may become pregnant, use appropriate contraception during treatment and for at least 4 months after stopping treatment.&nbsp;Ask your doctor about which contraceptive methods are appropriate when taking COMETRIQ.&nbsp;See section 2.<br><\/p>\n\n\n\n<p>Tell your doctor if you or your partner become pregnant or are planning to become pregnant while you are being treated with COMETRIQ.<br><\/p>\n\n\n\n<p><strong>Talk to your doctor BEFORE you take COMETRIQ<\/strong>&nbsp;if you or your partner are considering or planning to have a baby after treatment.&nbsp;There is a risk that your fertility (possibility of becoming pregnant) will be affected by treatment with COMETRIQ.<br><\/p>\n\n\n\n<p>Women taking COMETRIQ should not breast-feed during treatment and not until at least 4 months after stopping treatment, as cabozantinib and\/or its&nbsp;metabolites&nbsp;may be excreted in human milk and may be harmful to your baby.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Be careful when driving or using machines.&nbsp;Keep in mind that COMETRIQ can make you feel tired and weak.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take COMETRIQ<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor or pharmacist has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<br><\/p>\n\n\n\n<p>You should continue to take this medicine until your doctor decides to stop treatment.&nbsp;If you experience serious&nbsp;side effects, your doctor may decide to change the&nbsp;dose&nbsp;or discontinue treatment earlier than planned.&nbsp;Your doctor will decide if your&nbsp;dose&nbsp;needs to be changed, especially during the first eight weeks of treatment with COMETRIQ.<br><\/p>\n\n\n\n<p>COMETRIQ should be taken once a day.&nbsp;Depending on the&nbsp;dose&nbsp;your doctor has given you, you should take as many capsules as possible:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>140 mg (1 orange 80 mg capsule and 3 gray 20 mg capsules)<\/li><li>100 mg (1 orange 80 mg capsule and 1 gray 20 mg capsule)<\/li><li>60 mg (3 gray 20 mg capsules)<\/li><\/ul>\n\n\n\n<p>Your doctor will decide which&nbsp;dose&nbsp;is right for you.<br><\/p>\n\n\n\n<p>The capsules are in a blister card sorted according to the prescribed&nbsp;dose.&nbsp;Each blister card has enough capsules to last for seven days (one week).&nbsp;The capsules are also available as a 28-day pack containing enough capsules for 28 days, in 4 blister cards with enough capsules to last for seven days for each blister card.<br><\/p>\n\n\n\n<p>Every day, take all the capsules in a row.&nbsp;Section 6 provides more information about the blister cards, including how many capsules to take and how many capsules there are in total in each blister card.&nbsp;Make a note of the date you took your first&nbsp;dose&nbsp;in the space next to the capsules to keep track of your&nbsp;dose.&nbsp;To remove the capsules from the blister card:<br><\/p>\n\n\n\n<p>1. Press the tab.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20121214000038#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/res\/RootMedia\/Swedish20Orphan20Biovitrum\/Media\/Cometriq\/PIL\/cometriq20bild201.jpg\" alt=\"Cometriq picture 1\"\/><\/a><\/figure>\n\n\n\n<p>2. Pull off the paper strip.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20121214000038#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/res\/RootMedia\/Swedish20Orphan20Biovitrum\/Media\/Cometriq\/PIL\/cometriq20bild202.jpg\" alt=\"Cometriq picture 2\"\/><\/a><\/figure>\n\n\n\n<p>3. Push the capsule out through the foil.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20121214000038#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/res\/RootMedia\/Swedish20Orphan20Biovitrum\/Media\/Cometriq\/PIL\/cometriq20bild203.jpg\" alt=\"Cometric image 3\"\/><\/a><\/figure>\n\n\n\n<p>COMETRIQ should&nbsp;<strong>not<\/strong>&nbsp;be taken with food.&nbsp;You should not eat anything at least 2 hours before taking COMETRIQ and at least 1 hour after taking the medicine.&nbsp;Swallow the capsules one at a time with water.&nbsp;Do not open them.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more COMETRIQ than you should<\/h2>\n\n\n\n<p>If you have taken more COMETRIQ than you were prescribed, contact a doctor immediately or go to the hospital with the capsules and this leaflet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take COMETRIQ<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If it is still 12 hours or more until the next dose, take a&nbsp;dose&nbsp;you forgot as soon as you remember.&nbsp;Take the next&nbsp;dose&nbsp;at the usual time.<\/li><li>If it is less than 12 hours until the next dose, do not take a&nbsp;dose&nbsp;you forgot.&nbsp;Take the next&nbsp;dose&nbsp;at the usual time.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.&nbsp;If you experience&nbsp;side effects, your doctor may ask you to take a lower&nbsp;dose&nbsp;of COMETRIQ.&nbsp;Your doctor may also prescribe other medicines to help you control the&nbsp;side effects.<br><\/p>\n\n\n\n<p><strong>Contact your doctor immediately if you notice any of the following&nbsp;side effects- you may need&nbsp;urgent&nbsp;medical attention<\/strong>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Symptoms such as abdominal pain, nausea, vomiting, constipation, or fever.&nbsp;They can be signs of gastrointestinal&nbsp;perforation, a growing hole in the stomach or intestines that can be life-threatening.<\/li><li>Swelling, pain in hands or feet, or difficulty breathing.<\/li><li>A wound that does not heal.<\/li><li>Vomiting or blood cough, which may be bright red or look like ground coffee.<\/li><li>Pain in the mouth, teeth, and\/or jaw, swelling or sores inside the mouth, numbness or feeling of heaviness in the jaw, or a loose tooth.&nbsp;These symptoms may indicate bone damage in the jaw (&nbsp;osteonecrosis&nbsp;).<\/li><li>Seizures, headaches, confusion, or difficulty concentrating.&nbsp;These may be signs of a condition called posterior reversible encephalopathy syndrome (PRES).&nbsp;PRES is unusual (affects less than 1 in 100 people).<\/li><li>Severe diarrhea that does not seem to go away.<\/li><\/ul>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;are:<\/strong><br><\/p>\n\n\n\n<p><strong>Very common<\/strong>&nbsp;(may affect more than 1 user in 10)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Stomach problems such as&nbsp;diarrhea, nausea, vomiting, constipation, indigestion, and stomach pain<\/li><li>Difficulty swallowing<\/li><li>Blisters, pain in hands or soles of the feet, rash or redness of the skin, dry skin<\/li><li>Decreased appetite, weight loss, altered sense of taste<\/li><li>Fatigue, weakness, headache, dizziness<\/li><li>Changed hair color (lighter), hair loss<\/li><li>Hypertension&nbsp;(high&nbsp;blood pressure&nbsp;)<\/li><li>Redness, swelling or pain in the mouth or throat, difficulty speaking, hoarseness<\/li><li>Changes in blood samples taken for a general health check and liver values, low electrolyte levels (eg&nbsp;magnesium,&nbsp;calcium,&nbsp;or&nbsp;potassium&nbsp;)<\/li><li>Low levels of&nbsp;platelets<\/li><li>Joint pain, muscle cramps<\/li><li>Swollen&nbsp;lymph nodes<\/li><li>Pain in arms, hands, legs, or feet<\/li><\/ul>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Anxiety, depression, confusion<\/li><li>General pain, chest or muscle pain, sore ears, ringing in the ears<\/li><li>Weakness or decreased sensation or tingling in arms and legs<\/li><li>Chills, tremors<\/li><li>Dehydration\/dehydration<\/li><li>Inflammation&nbsp;of the abdomen or pancreas<\/li><li>Inflammation&nbsp;of the lips and mouth pores<\/li><li>Inflammation&nbsp;of the hair roots, pimples, blisters (on body parts other than the hands or feet)<\/li><li>Swelling of the face and other parts of the body<\/li><li>Loss of or altered taste<\/li><li>Hypotension&nbsp;(decreased&nbsp;blood pressure&nbsp;)<\/li><li>Atrial fibrillation&nbsp;(a fast and irregular heartbeat)<\/li><li>Bleaching of the skin, flaky skin, unusually pale skin<\/li><li>Abnormal hair growth<\/li><li>Hemorrhoids<\/li><li>Pneumonia<\/li><li>Pain in the mouth, teeth, and\/or jaw, swelling or sores inside the mouth, numbness or feeling of heaviness in the jaw, or a loose tooth<\/li><li>Decreased thyroid activity, with symptoms such as&nbsp;fatigue, weight gain, constipation, the feeling of cold and dry skin<\/li><li>Low levels of&nbsp;white blood cells<\/li><li>Decreased level of&nbsp;phosphate&nbsp;in the blood<\/li><li>Crack, hole or bleeding in the abdomen or intestines,&nbsp;inflammation&nbsp;or crack in the anus, bleeding in the lungs or trachea<\/li><li>An abnormal connection in&nbsp;tissue&nbsp;one in the digestive system.&nbsp;Symptoms may include severe or persistent stomach pain<\/li><li>Abnormal connections of&nbsp;tissue&nbsp;in the trachea, esophagus, or lungs<\/li><li>An abscess&nbsp;(abscess with an accumulation of goods, with swelling and&nbsp;inflammation&nbsp;) in the abdomen, around the groin, or in the teeth\/gums<\/li><li>Blood clots in blood vessels and lungs<\/li><li>Stroke<\/li><li>Fungal infection in e.g.&nbsp;the skin, mouth, or genitals<\/li><li>Hard-to-heal wounds<\/li><li>Protein&nbsp;or blood in the urine,&nbsp;gallstones, pain when urinating<\/li><li>Dimsyn<\/li><li>Increase in the amount of&nbsp;bilirubin&nbsp;in the blood (which can lead to jaundice \/ yellowish skin or eyes)<\/li><li>The decrease in protein levels in the blood (albumin)<\/li><\/ul>\n\n\n\n<p><strong>Uncommon<\/strong>&nbsp;(may affect up to 1 in 100 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Inflammation&nbsp;of the esophagus.&nbsp;Symptoms may include heartburn, chest pain, nausea, taste change, bloating, belching, and indigestion.<\/li><li>Infection&nbsp;and&nbsp;inflammation&nbsp;of the lungs, lung collapse<\/li><li>Skin sores, cysts, red spots\/spots on the face or thighs<\/li><li>Facial pain<\/li><li>Changes in test results that measure the blood&#8217;s coagulation capacity or blood cells<\/li><li>Loss of coordination in the muscles, damage to the skeletal muscles<\/li><li>Lack of attention, unconsciousness, speech changes,&nbsp;delirium, abnormal dreams<\/li><li>Chest pain due to blockage of the&nbsp;arteries&nbsp;are, palpitations<\/li><li>Liver damage,&nbsp;kidney failure<\/li><li>Impaired hearing<\/li><li>Inflammation&nbsp;of the eyes,&nbsp;cataract&nbsp;(cataract)<\/li><li>Menstrual interruption,&nbsp;vaginal&nbsp;bleeding<\/li><li>A condition called posterior reversible encephalopathy syndrome (PRES), with symptoms such as seizures, headaches, confusion, or difficulty concentrating<\/li><\/ul>\n\n\n\n<p><strong>Has been reported<\/strong>&nbsp;(occurs in an unknown number of users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Myocardial infarction<\/li><li>An enlargement and weakening of a vessel wall or a rupture in a vessel wall (&nbsp;aneurysms&nbsp;and arterial dissections)<\/li><\/ul>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.&nbsp;Postal address<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store COMETRIQ<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the blister after EXP.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>Do not store above 25 \u00b0 C.&nbsp;Store in the original package in order to protect from moisture.<br><\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>The active substance is cabozantinib (&nbsp;<em>S<\/em>&nbsp;) -malate.<br><\/p>\n\n\n\n<p>COMETRIQ 20 mg capsules contain kabozantinib (&nbsp;<em>S<\/em>&nbsp;) -malate equivalent to 20 mg kabozantinib.<\/p>\n\n\n\n<p>COMETRIQ 80 mg capsules contain kabozantinib (&nbsp;<em>S<\/em>&nbsp;) -malate equivalent to 80 mg kabozantinib.<br><\/p>\n\n\n\n<p>Other ingredients are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Capsule contents<\/strong>: microcrystalline cellulose, croscarmellose sodium, sodium starch glycolate,&nbsp;colloidal&nbsp;anhydrous silica, and stearic acid<\/li><li>Capsule housing: gelatin and titanium dioxide (E171)<ul><li>The 20 mg capsules also contain black iron oxide (E172)<\/li><li>The 80 mg capsules also contain red iron oxide (E172)<\/li><\/ul><\/li><li>Ink: shellac glaze, black iron oxide (E172), and propylene glycol<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>COMETRIQ 20 mg hard capsules are gray with the text \u201cXL184 20mg\u201d printed on one side.<\/p>\n\n\n\n<p>COMETRIQ 80 mg hard capsules are orange with the text \u201cXL184 80mg\u201d printed on one side.<br><\/p>\n\n\n\n<p>COMETRIQ hard capsules are packaged in blister cards that are arranged according to the&nbsp;dose&nbsp;your doctor decides&nbsp;you need.&nbsp;Each blister contains a 7-day&nbsp;dose&nbsp;of the medicine.&nbsp;Each line in the blister map contains a daily dose.<br><\/p>\n\n\n\n<p>The blister chart for 60 mg daily&nbsp;dose&nbsp;contains 21 capsules of 20 mg, which corresponds to a total of 7 daily doses.&nbsp;Each daily dose is in one row and contains 3 capsules of 20 mg:<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20121214000038#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/res\/RootMedia\/Swedish20Orphan20Biovitrum\/Media\/Cometriq\/PIL\/cometriq206020mg.jpg\" alt=\"Cometriq 60 mg\"\/><\/a><\/figure>\n\n\n\n<p>The blister chart for the 100 mg daily&nbsp;dose&nbsp;contains 7 capsules of 80 mg and 7 capsules of 20 mg, which corresponds to a total of 7 daily doses.&nbsp;Each daily dose is in one row and contains 1 capsule of 80 mg and 1 capsule of 20 mg:<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20121214000038#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/res\/RootMedia\/Swedish20Orphan20Biovitrum\/Media\/Cometriq\/PIL\/cometriq2010020mg.jpg\" alt=\"Cometriq 100 mg\"\/><\/a><\/figure>\n\n\n\n<p>The blister card with 140 mg daily&nbsp;dose&nbsp;contains 7 capsules of 80 mg and 21 capsules of 20 mg, which corresponds to a total of 7&nbsp;doses.&nbsp;Each daily dose is in one row and contains 1 capsule of 80 mg and 3 capsules of 20 mg:<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20121214000038#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/res\/RootMedia\/Swedish20Orphan20Biovitrum\/Media\/Cometriq\/PIL\/cometriq2014020mg.jpg\" alt=\"Cometriq 140 mg\"\/><\/a><\/figure>\n\n\n\n<p>COMETRIQ hard capsules are also available in 28-day packs:<\/p>\n\n\n\n<p>84 capsules (4 blister cards with 21 x 20 mg) (60 mg daily&nbsp;dose&nbsp;)<\/p>\n\n\n\n<p>56 capsules (4 blister cards with: 7 x 20 mg and 7 x 80 mg) (100 mg daily&nbsp;dose&nbsp;)<\/p>\n\n\n\n<p>112 capsules (4 blister cards with: 21 x 20 mg and 7 x 80 mg) (140 mg daily&nbsp;dose&nbsp;)<br><\/p>\n\n\n\n<p>Each 28-day pack contains enough medicine for 28 days.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><br><\/p>\n\n\n\n<p>Ipsen Pharma&nbsp;<br>65 quai Georges Gorse&nbsp;<br>92100 Boulogne-Billancourt&nbsp;<br>France<br><\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><br><\/p>\n\n\n\n<p>Catalent UK Packaging Limited<\/p>\n\n\n\n<p>Lancaster Way<\/p>\n\n\n\n<p>Wingates Industrial Park<\/p>\n\n\n\n<p>Westhoughton<\/p>\n\n\n\n<p>Bolton<\/p>\n\n\n\n<p>Lancashire<\/p>\n\n\n\n<p>BL5 3XX<\/p>\n\n\n\n<p>UK<br><\/p>\n\n\n\n<p>Or<br><\/p>\n\n\n\n<p>Catalent Germany Schorndorf GmbH<\/p>\n\n\n\n<p>Steinbeisstr.&nbsp;1 and 2<\/p>\n\n\n\n<p>73614 Schorndorf<\/p>\n\n\n\n<p>Germany<br><\/p>\n\n\n\n<p>Contact the representative of the marketing authorization holder to find out more about this medicine:<br><\/p>\n\n\n\n<p>Institute of Synthesis Products (IPSEN) AB<\/p>\n\n\n\n<p>Kista Science Tower<\/p>\n\n\n\n<p>F\u00e4r\u00f6gatan 33<\/p>\n\n\n\n<p>SE- 164 51 Kista<\/p>\n\n\n\n<p>Sverige \/ Ruotsi \/ Sverige<\/p>\n\n\n\n<p>Phone \/ Puh \/ Tel \/ Phone: +46 8 451 60 00<br><\/p>\n","protected":false},"excerpt":{"rendered":"<p>COMETRIQ is a cancer drug containing the active substance cabozantinib. It is a drug used to treat medullary thyroid cancer, an unusual thyroid cancer that cannot be removed with surgery or that has spread to other parts of the body.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2203,2200],"tags":[6713,6716,6715,2239,6718,6721,6720,6717,6722,6714,6719],"class_list":["post-7019","post","type-post","status-publish","format-standard","hentry","category-c","category-medicines","tag-cabozantinib","tag-cabozantinib-capsule","tag-cabozantinib-side-effects","tag-capsule","tag-cometriq","tag-cometriq-capsule","tag-cometriq-side-effects","tag-side-effects-of-cabozantinib","tag-side-effects-of-cometriq","tag-what-is-cabozantinib","tag-what-is-cometriq"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7019","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=7019"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7019\/revisions"}],"predecessor-version":[{"id":11296,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7019\/revisions\/11296"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=7019"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=7019"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=7019"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}