{"id":7015,"date":"2021-02-10T13:17:22","date_gmt":"2021-02-10T13:17:22","guid":{"rendered":"https:\/\/zeepedia.com\/?p=7015"},"modified":"2021-06-02T10:06:20","modified_gmt":"2021-06-02T10:06:20","slug":"combivent","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/combivent\/","title":{"rendered":"Combivent &#8211; Ipratropium Bromide and Salbutamol uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n0.5 mg \/ 2.5 mg&nbsp;solution&nbsp;nebulizer&nbsp;<br>ipratropium bromide \/ salbutamol<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Combivent is and what it is used for<\/h2>\n\n\n\n<p>Combivent dilates the trachea.&nbsp;Combivent is used as maintenance treatment for treatable airway contraction.<br><\/p>\n\n\n\n<p>Ipratropium bromide and salbutamol contained in Combivent may also be approved for the treatment of other conditions not mentioned in this product information.&nbsp;Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before using Combivent<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Combivent<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to ipratropium bromide,&nbsp;salbutamol, substances related to atropine, or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you have certain types of heart muscle disease or heart rhythm disorders.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Stop taking Combivent and contact a doctor immediately<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you get a&nbsp;hypersensitivity reaction&nbsp;(swelling in or around the mouth and airways, difficulty breathing, skin rash,&nbsp;hives&nbsp;).<\/li><li>after&nbsp;inhalation&nbsp;of the drug you get sudden,&nbsp;acute&nbsp;wheezing or shortness of breath.<\/li><\/ul>\n\n\n\n<p>Contact a doctor immediately if you experience&nbsp;acute&nbsp;or rapidly increasing shortness of breath.<br><\/p>\n\n\n\n<p>If you have any of the following conditions, you should consult a doctor before starting treatment with Combivent:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>recent heart attack<\/li><li>heart disease or angina<\/li><li>another serious cardiovascular disease<\/li><li>hyperfunction of the thyroid gland<\/li><li>very high&nbsp;blood pressure&nbsp;due to overproduction of&nbsp;adrenaline&nbsp;and&nbsp;norepinephrine<\/li><li>predisposition for&nbsp;glaucoma&nbsp;with narrow&nbsp;ventricular angle<\/li><li>difficulty urinating<\/li><li>diabetes<\/li><li>cystic fibrosis<\/li><li>hepatic impairment<\/li><li>renal impairment<\/li><\/ul>\n\n\n\n<p>It is important to avoid getting Combivent in your eyes.&nbsp;This is especially true for people who suffer from&nbsp;glaucoma.&nbsp;In rare cases, eye problems (pupillary enlargement, the pressure increase in the eye,&nbsp;glaucoma&nbsp;with a narrow&nbsp;ventricular angle, eye pain) have been reported when Combivent comes into contact with the eyes.&nbsp;Seek an ophthalmologist immediately if eye irritation and pain, visual phenomena and red, irritated eyes occur, as this may be a sign of&nbsp;acute&nbsp;glaucoma&nbsp;with a narrow&nbsp;ventricular angle.<br><\/p>\n\n\n\n<p>It is important to take good care of your oral hygiene as Combivent can cause&nbsp;dry mouth, which increases the risk of&nbsp;caries.<br><\/p>\n\n\n\n<p>Combivent can give a positive result in doping tests.<br><\/p>\n\n\n\n<p>A condition called lactic acidosis (increased acidity (&nbsp;lactic acid&nbsp;) in the blood) has been reported with high&nbsp;doses&nbsp;of&nbsp;salbutamol&nbsp;, especially in patients being treated for&nbsp;acute&nbsp;bronchospasm&nbsp;(spasm of the trachea) (see sections 3 and 4).&nbsp;An increase in lactate levels (lactic acid level) can lead to difficulty breathing and hyperventilation (rapid and shallow breathing) even if other symptoms such as wheezing improve.&nbsp;If you experience that your medicine does not work as well as usual and you need to use the nebulizer more than your doctor has prescribed, talk to a doctor immediately.<br><\/p>\n\n\n\n<p><em>If the effect of Combivent worsens, contact a doctor immediately for further instruction.&nbsp;Repeated&nbsp;inhalation&nbsp;without effect means that another treatment is required.<\/em><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Combivent<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<br><\/p>\n\n\n\n<p>The effect of Combivent can be enhanced by other medicines for respiratory diseases, certain antidepressants, and certain anesthetics.&nbsp;A certain type of blood pressure medication, so-called&nbsp;beta&nbsp;&#8211;&nbsp;receptor blockers, can counteract the effects of Combivent.&nbsp;Treatment with Combivent can lead to low blood potassium levels.&nbsp;Some other medicines, especially diuretics, may aggravate this effect.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p>Limited experience of use during pregnancy.&nbsp;Therefore, always consult a doctor if more than temporary use of Combivent during pregnancy.<\/p>\n\n\n\n<p>It is not known whether the ingredients in Combivent pass into breast milk.&nbsp;Therefore, consult a physician before regular use during breast-feeding.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Dizziness is a less common side effect of Combivent.&nbsp;Also, Combivent may in rare cases cause visual disturbances.&nbsp;You should keep this in mind when driving or using machines.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use Combivent<\/h2>\n\n\n\n<p>Always use this medicine exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><em>The recommended&nbsp;dose&nbsp;for adults and children over 12 years<\/em>&nbsp;is 1&nbsp;single-dose container&nbsp;3-4 times daily.<br><\/p>\n\n\n\n<p><strong><em>Instructions for use<\/em><\/strong>&nbsp;<\/p>\n\n\n\n<p>Read the operating instructions carefully and follow the instructions.<br>Show larger<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=19980220000012#\" rel=\"noopener\"><\/a>1.&nbsp;<a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=19980220000012#\" rel=\"noopener\"><\/a>2.&nbsp;<a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=19980220000012#\" rel=\"noopener\"><\/a>3.&nbsp;<\/td><td>1. Tear off a container.<br>2. Open the container by turning off the top.<br>Squeeze out the contents of the nebulizer. Inhale calmly evenly through the nozzle\/nebulizer mask.<br><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>The inhalation liquid is ready to use, it should not be diluted.&nbsp;The liquid is inhaled with the help of a so-called&nbsp;nebulizer.&nbsp;The liquid is not intended to be drunk or supplied to the body using a&nbsp;syringe.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Combivent than you should&nbsp;<\/h2>\n\n\n\n<p>If you take too large&nbsp;a dose&nbsp;of Combivent you can for example get chest pains and palpitations.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Combivent<\/h2>\n\n\n\n<p>Do not take a double&nbsp;dose&nbsp;to make up for a forgotten&nbsp;dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Combivent<\/h2>\n\n\n\n<p>Contact your doctor to get another medicine for your airways.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist<strong>.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects,&nbsp;although not everybody gets them.<br><\/p>\n\n\n\n<p>Stop taking Combivent and contact your doctor immediately if you get any of the following symptoms (&nbsp;angioedema&nbsp;):<\/p>\n\n\n\n<p>swelling of the face, tongue, or throat, difficulty swallowing,&nbsp;hives,&nbsp;and difficulty breathing.&nbsp;This may in rare cases occur with the use of Combivent.<br><\/p>\n\n\n\n<p>Stop taking Combivent and contact your doctor immediately if you&nbsp;experience sudden,&nbsp;acute&nbsp;wheezing or shortness of breath&nbsp;after&nbsp;inhaling the&nbsp;medicine.&nbsp;This may in rare cases occur after the use of inhaled medicines such as Combivent.<br><\/p>\n\n\n\n<p>In very rare cases, some people may develop chest pain (as a sign of angina) when using Combivent.&nbsp;If this happens, talk to your doctor as soon as possible.&nbsp;However, do not interrupt the treatment on your own.<br><\/p>\n\n\n\n<p><strong>Other possible side effects:<\/strong><br><\/p>\n\n\n\n<p><em>Uncommon (may affect up to 1 in 100 people):<\/em>&nbsp;Nervousness, dizziness, headache, tremors, palpitations, fast heart rate, cough, hearing loss, nausea,&nbsp;dry mouth, throat irritation, weakness, skin reactions (such as skin rash,&nbsp;itching,&nbsp;and&nbsp;hives&nbsp;), increase in blood pressure.<br><\/p>\n\n\n\n<p><em>Rare (may affect up to 1 in 1,000 people):<\/em>&nbsp;Severe&nbsp;allergic reaction, hypersensitivity, decreased&nbsp;potassium&nbsp;in the blood, psychological effects (eg anxiety, memory disorders, anxiety, depression), effects on the eyes (eg&nbsp;glaucoma, visual disturbances, eye pain), fits in the larynx, dry throat, diarrhea, constipation, disorders of bowel function, vomiting,&nbsp;inflammation&nbsp;or swelling of the mouth, sweating,&nbsp;hives, muscle cramp, muscle weakness, muscle, blood pressure, bladder emptying problems, cardiac arrhythmias,&nbsp;cardiac fibrillation.<br><\/p>\n\n\n\n<p><em>The following&nbsp;side effects&nbsp;have also been reported and occur in an unknown number of users:<\/em><\/p>\n\n\n\n<p>A condition called lactic acidosis (increased acidity (&nbsp;lactic acid&nbsp;)) can cause<\/p>\n\n\n\n<p>abdominal pain, hyperventilation (rapid and shallow breathing), difficulty breathing (although other symptoms such as wheezing improve), cold hands and feet, irregular heartbeat, or thirst.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.&nbsp;Postal address<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Combivent<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton after \u201cEXP\u201d.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>Store in the outer carton.&nbsp;Sensitive to light.<\/p>\n\n\n\n<p>Do not store above 25 \u00b0 C.&nbsp;Do not freeze.<br><\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>The active substances are ipratropium bromide monohydrate corresponding to 0.5 mg anhydrous ipratropium bromide and salbutamol sulfate corresponding to 2.5 mg&nbsp;salbutamol.<br><\/p>\n\n\n\n<p>The other ingredients are: sodium chloride, dilute&nbsp;hydrochloric acid&nbsp;(for&nbsp;adjustment), purified water.<br><\/p>\n\n\n\n<p>A&nbsp;single-dose&nbsp;container contains 2.5 ml of inhalation fluid.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Unstained inhalation liquid.<\/p>\n\n\n\n<p>Package with&nbsp;a single-dose container&nbsp;of polyethylene 60 pcs x 2.5 ml.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Boehringer Ingelheim International GmbH, Binger Strasse 173, 55216 Ingelheim, Germany.<br><\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Laboratory UNITHER, Espace Industriel Nord, 151 rue Andr\u00e9 Durouchez &#8211; CS 28028, 80084 Amiens Cedex 2, France.<br><\/p>\n\n\n\n<p><em>Information is provided by<\/em><\/p>\n\n\n\n<p>Email: info.sto@boehringer-ingelheim.com<\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Combivent dilates the trachea. Combivent is used as maintenance treatment for treatable airway contraction.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2203,2200],"tags":[6738,6741,6740,6729,6728,6732,6731,6733,6734,6736,6737,6739,6730,6735],"class_list":["post-7015","post","type-post","status-publish","format-standard","hentry","category-c","category-medicines","tag-combivent","tag-combivent-nebulizer","tag-combivent-side-effects","tag-ipratropium-bromide","tag-ipratropium-bromide-and-salbutamol","tag-ipratropium-bromide-nebulizer","tag-ipratropium-bromide-side-effects","tag-nebulizer","tag-salbutamol","tag-salbutamol-nebulizer","tag-side-effects-of-salbutamol","tag-what-is-combivent","tag-what-is-ipratropium-bromide","tag-what-is-salbutamol"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7015","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=7015"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7015\/revisions"}],"predecessor-version":[{"id":11300,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/7015\/revisions\/11300"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=7015"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=7015"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=7015"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}