Do not use Colineb<\/h2>\n\n\n\n- if you are allergic<\/strong> (hypersensitive) to colistimethate sodium, colistin, or other polymyxins.<\/li><\/ul>\n\n\n\n
Warnings and cautions<\/h2>\n\n\n\n
Warnings and cautions<\/strong><\/p>\n\n\n\nTalk to your doctor, pharmacist, or nurse before using Colineb<\/p>\n\n\n\n
- if you have or have had kidney problems<\/li>
- if you suffer from myasthenia gravis<\/li>
- if you suffer from porphyria<\/li>
- if you suffer from asthma.<\/li><\/ul>\n\n\n\n
Children<\/h2>\n\n\n\n
In premature and newborns, special care should be taken when using Colineb as the kidneys are not fully developed.
<\/p>\n\n\n\n
Other drugs and Colineb<\/h2>\n\n\n\n
Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n
The following medicines may interfere with the effect of Colineb:<\/p>\n\n\n\n
- drugs that can affect your kidney function. If you take Colineb at the same time as these medicines, the risk of kidney damage may increase.<\/li>
- drugs that can affect the nervous system. If you take Colineb at the same time as these medicines, the risk of side effects in the nervous system may increase.<\/li>
- drugs called muscle relaxants, which are often used under anesthesia. Colineb may increase the effect of these medicines. If you are going to be anesthetized, tell your anesthetist that you have taken Colineb.<\/li><\/ul>\n\n\n\n
If you suffer from myasthenia gravis and also use other antibiotics called macrolides(such as azithromycin, clarithromycin, or erythromycin) or antibiotics called fluoroquinolones (such as ofloxacin, norfloxacin, and ciprofloxacin ), while taking Colineb increases the risk of muscle weakness.
<\/p>\n\n\n\n
Taking colistimethate sodium as an infusion while inhaling Colineb may increase the risk of side effects.
<\/p>\n\n\n\n
Pregnancy and breastfeeding<\/h2>\n\n\n\n
If you are pregnant or breast-feeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. Colineb should only be given during pregnancy or breast-feeding when really needed.
<\/p>\n\n\n\n
Driving and using machines<\/h2>\n\n\n\n
Colin can cause dizziness, confusion and visual disturbances, e.g. dimsyn.<\/p>\n\n\n\n
If you get these side effects, do not drive or use any tools or machines. Talk to a doctor or pharmacist.<\/p>\n\n\n\n
You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention. One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or side effects. Descriptions of these effects and side effects can be found in other sections. Read all the information in this leaflet for guidance. If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n
Colineb contains sodium<\/h2>\n\n\n\n
This medicine contains less than 1 mmol (23 mg) sodium per bottle, ie essentially ‘sodium-free’.
<\/p>\n\n\n\n
3. How to use Colineb<\/h2>\n\n\n\n
Always use this medicine exactly as your doctor or pharmacist has told you. Ask your doctor or pharmacist if you are unsure.
<\/p>\n\n\n\n
Your doctor may decide to adjust the dose depending on your circumstances. If you are also taking other inhaled medicines, your doctor will tell you the order in which you should take them.
<\/p>\n\n\n\n
The recommended dose is: <\/strong>Show larger<\/p>\n\n\n\n
<\/td>Recommended dose<\/strong><\/td>Maximum dose one per day<\/strong><\/td><\/tr>Adults<\/strong><\/td>1 to 2 million international units (MIE) two to three times a day<\/td> 6 MIE per day<\/td><\/tr> Children<\/strong>(2 years to 11 years)and young people<\/strong>(12 years to 17 years)<\/td>1 to 2 million international units (MIE)two to three times a day<\/td> 6 MIE per day<\/td><\/tr> Children younger than 2 years<\/strong><\/td>0.5 to 1 million international units (MIE)twice a day<\/td> 2 MIE per day<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\nYou should take the first dose of Colineb in the presence of a doctor or nurse.
<\/p>\n\n\n\n
Take Colineb after breathing exercises (if you go to breathing exercises).
<\/p>\n\n\n\n
Length of treatment<\/em><\/p>\n\n\n\nYour doctor will tell you how long you should be treated with Colineb. Do not stop treatment prematurely. When treating the bacterial infection, it is important to complete the entire course of treatment to reduce the risk of developing resistance.
<\/p>\n\n\n\n
Method of administration<\/em><\/p>\n\n\n\nColineb should be inhaled with a suitable nebulizer after the powder has dissolved.
<\/p>\n\n\n\n
Prepare inhalation treatment<\/strong><\/p>\n\n\n\nIf you are treating yourself at home, your doctor or nurse will show you how to use Colineb in the nebulizer when you first start treatment.
<\/p>\n\n\n\n
Before Colineb can be used, it must be dissolved in isotonic saline<\/strong> (saline). Show larger<\/p>\n\n\n\nTo start treatment, you need the following:<\/strong>
a clear glass bottle with Colineb<\/strong>liquid to dissolve the powder (3 ml isotonic saline solution if you are to take Colineb 1 million IU, or 4 ml saline solution if you are going to take Colineb 2 million IU)<\/strong>a nebulizer, which is suitable for inhalation of Colineb (eg .<\/em> PARI LC PLUS, PARI LC SPRINT or eFlow rapid)<\/strong><\/th><\/tr><\/tbody><\/table><\/figure>\n\n\n\nIt is important that the nebulizer system works properly before you start treatment with Colineb. Carefully read the nebulizer operating instructions for further information on handling the nebulizer system.<\/strong>
<\/p>\n\n\n\nLay the parts of the nebulizer on a clean, level surface and follow the manufacturer’s instructions.
<\/p>\n\n\n\n
Prepare Colineb for inhalation<\/strong><\/p>\n\n\n\nColineb must be used immediately after reconstitution. Do not dissolve Colineb until you are ready to inhale a dose (see also section 5).
<\/p>\n\n\n\n
Step 1<\/strong>: Take out a bottle of Colineb and tap the glass bottle gently so that the powder sinks to the bottom. This way you can check that you are getting the right dose of medicine. Open the medicine bottle by lifting the plastic cap (figure 1).
<\/p>\n\n\n\n
Warnings and cautions<\/h2>\n\n\n\n
Warnings and cautions<\/strong><\/p>\n\n\n\n Talk to your doctor, pharmacist, or nurse before using Colineb<\/p>\n\n\n\n In premature and newborns, special care should be taken when using Colineb as the kidneys are not fully developed. Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n The following medicines may interfere with the effect of Colineb:<\/p>\n\n\n\n If you suffer from myasthenia gravis and also use other antibiotics called macrolides(such as azithromycin, clarithromycin, or erythromycin) or antibiotics called fluoroquinolones (such as ofloxacin, norfloxacin, and ciprofloxacin ), while taking Colineb increases the risk of muscle weakness. Taking colistimethate sodium as an infusion while inhaling Colineb may increase the risk of side effects. If you are pregnant or breast-feeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. Colineb should only be given during pregnancy or breast-feeding when really needed. Colin can cause dizziness, confusion and visual disturbances, e.g. dimsyn.<\/p>\n\n\n\n If you get these side effects, do not drive or use any tools or machines. Talk to a doctor or pharmacist.<\/p>\n\n\n\n You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention. One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or side effects. Descriptions of these effects and side effects can be found in other sections. Read all the information in this leaflet for guidance. If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n This medicine contains less than 1 mmol (23 mg) sodium per bottle, ie essentially ‘sodium-free’. Always use this medicine exactly as your doctor or pharmacist has told you. Ask your doctor or pharmacist if you are unsure. Your doctor may decide to adjust the dose depending on your circumstances. If you are also taking other inhaled medicines, your doctor will tell you the order in which you should take them. The recommended dose is: <\/strong>Show larger<\/p>\n\n\n\n You should take the first dose of Colineb in the presence of a doctor or nurse. Take Colineb after breathing exercises (if you go to breathing exercises). Length of treatment<\/em><\/p>\n\n\n\n Your doctor will tell you how long you should be treated with Colineb. Do not stop treatment prematurely. When treating the bacterial infection, it is important to complete the entire course of treatment to reduce the risk of developing resistance. Method of administration<\/em><\/p>\n\n\n\n Colineb should be inhaled with a suitable nebulizer after the powder has dissolved. Prepare inhalation treatment<\/strong><\/p>\n\n\n\n If you are treating yourself at home, your doctor or nurse will show you how to use Colineb in the nebulizer when you first start treatment. Before Colineb can be used, it must be dissolved in isotonic saline<\/strong> (saline). Show larger<\/p>\n\n\n\n It is important that the nebulizer system works properly before you start treatment with Colineb. Carefully read the nebulizer operating instructions for further information on handling the nebulizer system.<\/strong> Lay the parts of the nebulizer on a clean, level surface and follow the manufacturer’s instructions. Prepare Colineb for inhalation<\/strong><\/p>\n\n\n\n Colineb must be used immediately after reconstitution. Do not dissolve Colineb until you are ready to inhale a dose (see also section 5). Step 1<\/strong>: Take out a bottle of Colineb and tap the glass bottle gently so that the powder sinks to the bottom. This way you can check that you are getting the right dose of medicine. Open the medicine bottle by lifting the plastic cap (figure 1).Children<\/h2>\n\n\n\n
<\/p>\n\n\n\nOther drugs and Colineb<\/h2>\n\n\n\n
<\/p>\n\n\n\n
<\/p>\n\n\n\nPregnancy and breastfeeding<\/h2>\n\n\n\n
<\/p>\n\n\n\nDriving and using machines<\/h2>\n\n\n\n
Colineb contains sodium<\/h2>\n\n\n\n
<\/p>\n\n\n\n3. How to use Colineb<\/h2>\n\n\n\n
<\/p>\n\n\n\n
<\/p>\n\n\n\n
<\/td>Recommended dose<\/strong><\/td> Maximum dose one per day<\/strong><\/td><\/tr> Adults<\/strong><\/td> 1 to 2 million international units (MIE) two to three times a day<\/td> 6 MIE per day<\/td><\/tr> Children<\/strong>(2 years to 11 years)and young people<\/strong>(12 years to 17 years)<\/td> 1 to 2 million international units (MIE)two to three times a day<\/td> 6 MIE per day<\/td><\/tr> Children younger than 2 years<\/strong><\/td> 0.5 to 1 million international units (MIE)twice a day<\/td> 2 MIE per day<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n
<\/p>\n\n\n\n
<\/p>\n\n\n\n
<\/p>\n\n\n\n
<\/p>\n\n\n\n
<\/p>\n\n\n\nTo start treatment, you need the following:<\/strong>
a clear glass bottle with Colineb<\/strong>liquid to dissolve the powder (3 ml isotonic saline solution if you are to take Colineb 1 million IU, or 4 ml saline solution if you are going to take Colineb 2 million IU)<\/strong>a nebulizer, which is suitable for inhalation of Colineb (eg .<\/em> PARI LC PLUS, PARI LC SPRINT or eFlow rapid)<\/strong><\/th><\/tr><\/tbody><\/table><\/figure>\n\n\n\n
<\/p>\n\n\n\n
<\/p>\n\n\n\n
<\/p>\n\n\n\n
<\/p>\n\n\n\n