if you have had skin cancer or if you get an unforeseen skin change during treatment. Treatment with hydrochlorothiazide, especially long-term use with high doses, may increase the risk of certain types of skin and lip cancer (non-melanoma skin cancer). Protect your skin from exposure to sunlight and UV rays while taking CoAprovel<\/li><\/ul>\n\n\n\nYour doctor may need to check your kidney function, blood pressure, and the number of electrolytes (eg potassium ) in your blood at regular intervals.
See also the information under the heading “Do not take CoAprovel”.
If you think you may be pregnant or become pregnant during treatment, consult your doctor. CoAprovel is not recommended during early pregnancy and should not be used during the last 6 months of pregnancy as it may cause birth defects, see section Pregnancy, breast-feeding and fertility.
You should also tell your doctor:<\/strong><\/p>\n\n\n\nif you are on a low salt diet<\/strong><\/li>if you have symptoms such as abnormal thirst, dry mouth, general weakness, drowsiness, muscle aches or cramps, nausea, vomiting<\/strong>, or an abnormally fast heart rate<\/strong> which may indicate an excessive effect of hydrochlorothiazide(found in CoAprovel)<\/li>if you notice increased sun sensitivity of the skin<\/strong>, which burns (with redness, itching, swelling, blistering) faster than usual<\/li>if you are going to have surgery<\/strong> or get anesthesia<\/strong><\/li>if you experience impaired vision or pain in one or both of your eyes<\/strong> while taking CoAprovel. This may be a sign of choroidal effusion or increased pressure in your eyes ( glaucoma ) and may occur within hours or up to a week after taking CoAprovel. This can lead to permanent vision loss if left untreated. If you have previously had an allergy to penicillin or sulfonamides, you may be at higher risk of developing this. You should then end treatment with CoAprovel and see a doctor immediately.<\/li><\/ul>\n\n\n\nHydrochlorothiazide contained in this medicine may give a positive result in doping tests.<\/p>\n\n\n\n
Children and young people<\/h2>\n\n\n\n CoAprovel should not be given to children or adolescents (under 18 years of age).<\/p>\n\n\n\n
Other medicines and CoAprovel<\/h2>\n\n\n\n Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.
Diuretics such as hydrochlorothiazide in CoAprovel may affect other medicines. Medicines containing lithium should not be taken with CoAprovel without the careful supervision of your doctor.
Your doctor may need to change your dose and\/or take other precautions:<\/p>\n\n\n\n
If you are taking an ACE inhibitor or aliskiren (see also the information under the headings “Do not take CoAprovel” and “Warnings and precautions”).
You may need to have blood tests done if you are taking:<\/strong><\/p>\n\n\n\npotassium supplement<\/li> salt substitute containing potassium<\/li> potassium-sparing medicines or other diuretic drugs<\/li> certain laxatives<\/li> drugs for the treatment of gout<\/li> therapeutic vitamin D supplementation<\/li> drugs to control heart rhythm<\/li> drugs for diabetes (tablets or insulin )<\/li> carbamazepine (a medicine used to treat epilepsy )<\/li><\/ul>\n\n\n\nIt is also important to tell your doctor if you are taking other medicines to lower blood pressure, steroids, medicines to treat cancer, painkillers, anti-inflammatory drugs or cholestyramine, and colestipol resins to lower cholesterol levels in the blood.<\/p>\n\n\n\n
CoAprovel with food and drink<\/h2>\n\n\n\n CoAprovel can be taken with or without food.
Due to the hydrochlorothiazide content of CoAprovel, if you drink alcohol during treatment with this medicine, you may have an increased feeling of dizziness when standing up, especially when standing up from a sitting position.<\/p>\n\n\n\n
Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n Pregnancy<\/strong> Breast-feeding<\/strong> Driving and using machines<\/h2>\n\n\n\n CoAprovel is unlikely to affect your ability to drive or use machines. Occasionally, however, dizziness or fatigue may occur during the treatment of high blood pressure. If you experience this, talk to your doctor before driving or using machines.<\/p>\n\n\n\n
CoAprovel contains lactose<\/h2>\n\n\n\n If you have been told by your doctor that you have an intolerance to some sugars (eg lactose ), contact your doctor before taking this medicine.
3. How to take CoAprovel<\/h2>\n\n\n\n Always take this medicine exactly as your doctor has told you. Ask your doctor or pharmacist if you are unsure.
Posology The<\/strong> Intake<\/strong> is used orally<\/strong>. Swallow the tablets with a sufficient amount of liquid (eg a glass of water). You can take CoAprovel with or without food. You should try to take the daily dose at about the same time each day. It is important that you continue to take CoAprovel until your doctor tells you otherwise.Maximum reduction in blood pressure should be achieved 6-8 weeks after starting treatment.<\/p>\n\n\n\n
If you take more CoAprovel then you should<\/h2>\n\n\n\n If you accidentally take too many tablets, contact your doctor immediately.
Children should not take CoAprovel<\/strong> If you forget to take CoAprovel<\/h2>\n\n\n\n If you accidentally skip a daily dose, just take the next dose normally. Do not take a double dose to make up for a forgotten dose.
If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n
4. Possible side effects<\/h2>\n\n\n\n Like all medicines, this medicine can cause side effects, although not everybody gets them.
Rare cases of allergic skin reactions (skin rash, hives ) as well as local swelling of the face, lips, and\/or tongue have been reported in patients treated with irbesartan. If you get any of the above symptoms or become short of breath,<\/strong> stop taking CoAprovel and contact your doctor immediately.The frequency of side effects listed below is defined according to the following convention:
Adverse reactions reported in clinical trials in patients treated with CoAprovel were:
Common side effects are<\/strong> (may affect up to 1 in 10)<\/p>\n\n\n\nnausea\/vomiting<\/li> altered urination<\/li> fatigue<\/li> dizziness (also when getting up from a lying or sitting position)<\/li> Blood tests may show elevated levels of an enzyme that measures muscle and heart function (creatine kinase) or elevated levels of substances that measure kidney function (s- urea, creatinine ).<\/li><\/ul>\n\n\n\nIf any of these side effects get you down,<\/strong> talk to your doctor.Less common side effects are<\/strong> (may affect up to 1 in 100 patients)<\/p>\n\n\n\ndiarrhea<\/li> low blood pressure<\/li> fainting sensation<\/li> palpitation<\/li> redness<\/li> swelling<\/li> impaired sexual ability<\/li> Blood tests may show decreased levels of potassium and sodium in the blood<\/li><\/ul>\n\n\n\nIf any of these side effects get you down,<\/strong> talk to your doctor.Side effects are reported after CoAprovel has entered the market<\/strong><\/p>\n\n\n\nSome side effects have been reported since CoAprovel hit the market. Side effects without known frequency are: headache, ringing in the ears, cough, taste changes, indigestion, joint and muscle pain, impaired liver function and impaired kidney function, increased levels of potassium in the blood, and allergic reactions such as skin rash, hives, swelling of the face, lips, mouth, tongue or throat. Jaundice (yellowing of the skin and\/or whites of the eyes) has, as a less common side effect, also been reported.
As with all combinations of two active substances, side effects associated with each individual active substance cannot be ruled out.<\/p>\n\n\n\n
Side effects are associated with irbesartan alone<\/strong><\/p>\n\n\n\nIn addition to the side effects described above, chest pain, severe allergic reactions (anaphylactic shock ) and decreased platelet count (a blood cell needed for the blood to coagulate) have also been reported.<\/p>\n\n\n\n
Side effects associated with hydrochlorothiazide<\/strong> No known frequency<\/strong> (frequency can not be calculated from the available data): skin and lip cancer (non-melanoma skin cancer), decreased vision or pain in the eyes due to high pressure (possible signs of choroidal effusion or acute narrow-angle glaucoma ).It is known that side effects associated with hydrochlorothiazide may increase with higher doses.
Reporting of side effects<\/em><\/p>\n\n\n\nIf you get any side effects, talk to your doctor, pharmacist, or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly to the Medical Products Agency, www.lakemedelsverket.se. By reporting side effects, you can help increase drug safety information. Postal address<\/p>\n\n\n\n
5. How to store CoAprovel<\/h2>\n\n\n\n Keep this medicine out of the sight and reach of children.
Do not use this medicine after the expiry date which is stated on the carton and on the blister after EXP. The expiration date is the last day of the specified month.
Do not store above 30 \u00b0 C.
Store in the original package. Moisture sensitive.
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.<\/p>\n\n\n\n
6. Contents of the packaging and other information<\/h2>\n\n\n\nContent declaration<\/h2>\n\n\n\nThe active substances are irbesartan and hydrochlorothiazide . Each CoAprovel 150 mg \/ 12.5 mg film-coated tablet contains 150 mg irbesartan and 12.5 mg hydrochlorothiazide .<\/li> The other ingredients are lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, hypromellose, silica, magnesium stearate, titanium dioxide, macrogol 3000, red and yellow iron oxide, carnauba wax. See section 2 \u201cCoAprovel contains lactose\u201d.<\/li><\/ul>\n\n\n\nWhat the medicine looks like and the contents of the pack<\/h2>\n\n\n\n CoAprovel 150 mg \/ 12.5 mg film-coated tablet is peach-colored, biconvex, oval, with a heart embossed on one side and number 2875 engraved on the other side.
CoAprovel 150 mg \/ 12.5 mg film-coated tablets are supplied in blister packs of 14, 28, 30, 56, 84, 90 and 98 tablets. Single-dose packs (pressure packs) of 56 \u00d7 1 tablets are also available for hospital use.
Not all pack sizes may be marketed.<\/p>\n\n\n\n
Marketing Authorisation Holder<\/h2>\n\n\n\n sanofi-aventis groupe
Manufacturer<\/strong> CHINON PRIVATE CO. LTD.
SANOFI WINTHROP INDUSTRY
Sanofi-Aventis, SA<\/p>\n\n\n\n
Ctra. C-35 (La Batlloria-Hostalric), km. 63.09<\/p>\n\n\n\n
17404 Riells and Viabrea (Girona)<\/p>\n\n\n\n
Spain
Further information on this medicine can be obtained from the representative of the marketing authorization holder: Show larger<\/p>\n\n\n\nBelgium \/ Belgique \/ Belgien<\/strong>Sanofi BelgiumTel: +32 (0) 2 710 54 00Lithuania<\/strong>UAB sanofi-aventis LietuvaTel: +370 5 2755224Bulgaria<\/strong>Sanofi Bulgaria EOODTel: +359 (0) 2 970 53 00Luxembourg \/ Luxemburg<\/strong>Sanofi BelgiumPhone: +32 (0) 2 710 54 00 (Belgium \/ Belgium)Czech Republic<\/strong>sanofi-aventis, sroTel: +420 233 086 111Hungary<\/strong>sanofi-aventis zrt., Magyarorsz\u00e1gTel .: +36 1 505 0050Denmark<\/strong>Sanofi A \/ STel: +45 45 16 70 00Malta<\/strong>Sanofi SpATel: +39 02 39394275Germany<\/strong>Sanofi-Aventis Deutschland GmbHTel: 0800 52 52 010Tel. from abroad: +49 69 305 21 131The Netherlands<\/strong>sanofi-aventis Netherlands BVTel: +31 20 245 4000Eesti<\/strong>sanofi-aventis Estonia O\u00dcTel: +372 627 34 88Norway<\/strong>sanofi-aventis Norge ASTel: +47 67 10 71 00Greece<\/strong>sanofi-aventis \u0391\u0395BE:\u0397\u03bb: +30 210 900 16 00Austria<\/strong>sanofi-aventis GmbHTel: +43 1 80 185 – 0Spain<\/strong>sanofi-aventis, SATel: +34 93 485 94 00Poland<\/strong>sanofi-aventis Sp. z ooTel .: +48 22 280 00 00France<\/strong>sanofi-aventis FranceTel: 0 800 222 555Call from abroad: +33 1 57 63 23 23Portugal<\/strong>Sanofi – Pharmaceutical Products, LdaTel: +351 21 35 89 400Croatia<\/strong>sanofi-aventis Croatia dooTel: +385 1 600 34 00Romania<\/strong>Sanofi Romania SRLTel: +40 (0) 21 317 31 36Ireland<\/strong>sanofi-aventis Ireland Ltd. T \/ A SANOFITel: +353 (0) 1 403 56 00Slovenia<\/strong>sanofi-aventis dooTel: +386 1 560 48 00Iceland<\/strong>Vistor hf.Phone: +354 535 7000Slovak Republic<\/strong>sanofi-aventis Pharma Slovakia sroTel: +421 2 33 100 100Italy<\/strong>Sanofi SpATel: 800.536389Finland \/ Finland<\/strong>Sanofi OyPuh \/ Tel: +358 (0) 201 200 300Latvia<\/strong>sanofi-aventis Latvia SIATel .: +371 67 33 24 51CoAprovel is a combination of two active substances, irbesartan, and hydrochlorothiazide. <\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2203,2200],"tags":[6846,6848,3664,3666,4301,6850,6852,2212,6847,4300,6853],"class_list":["post-6951","post","type-post","status-publish","format-standard","hentry","category-c","category-medicines","tag-coaprovel","tag-coaprovel-side-effects","tag-hydrochlorothiazide","tag-hydrochlorothiazide-side-effects","tag-hydrochlorothiazide-tablet","tag-irbesartan","tag-irbesartan-side-effects","tag-medicine","tag-what-is-coaprovel","tag-what-is-hydrochlorothiazide","tag-what-is-irbesartan"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6951","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=6951"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6951\/revisions"}],"predecessor-version":[{"id":11325,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6951\/revisions\/11325"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=6951"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=6951"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=6951"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}