caffeine<\/a> habits can also change the effect of Clozapine Sandoz.<\/p>\n\n\n\nPregnancy and breastfeeding<\/h2>\n\n\n\n
If you are pregnant or breast-feeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before using this medicine. Your doctor will discuss the benefits and possible risks for you of using this medicine during pregnancy. Tell your doctor immediately if you become pregnant during treatment with Clozapine Sandoz.<\/p>\n\n\n\n
<\/p>\n\n\n\n
The following symptoms may occur in newborns of mothers who used Clozapine Sandoz during the last trimester (last three months of pregnancy): tremors, muscle stiffness and\/or weakness, drowsiness, anxiety, difficulty breathing, and difficulty eating. If your child has any of these symptoms, you may need to consult a doctor.
<\/p>\n\n\n\n
Some women who take medication to treat mental illness have irregular periods or none at all. If you have been affected in this way, your periods may return when you are treated with Clozapine Sandoz. This means that you must use an effective method of contraception.
<\/p>\n\n\n\n
Do not breast-feed during treatment with Clozapine Sandoz. Clozapine, the active substance in Clozapine Sandoz, may pass into your breast milk and affect your baby.<\/p>\n\n\n\n
Driving and using machines<\/h2>\n\n\n\n
Clozapine Sandoz can cause fatigue, drowsiness, and cramps, especially at the beginning of treatment. Do not drive or use any tools or machines while you have these symptoms.<\/p>\n\n\n\n
You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention. One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or side effects. Descriptions of these effects and side effects can be found in other sections. Read all the information in this leaflet for guidance. If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n
Clozapine Sandoz contains lactose<\/h2>\n\n\n\n
If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.
<\/p>\n\n\n\n
Clozapine Sandoz contains sodium<\/strong><\/p>\n\n\n\nThis medicine contains less than 1 mmol (23 mg) sodium per tablet, ie it is essentially ‘sodium-free’.
<\/p>\n\n\n\n
3. How to take Clozapine Sandoz<\/h2>\n\n\n\n
To reduce the risk of low blood pressure, seizures, and drowsiness, it is necessary for your doctor to increase the dose gradually. Always use this medicine exactly as your doctor has told you. Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n
It is important that you do not change your dose or stop taking Clozapine Sandoz without consulting your doctor first. Keep taking the tablets for as long as your doctor tells you to. If you are 60 years of age or older, your doctor may start with a lower dose and gradually increase it as you are at greater risk of developing any side effects(see section 2 \u201cWhat you need to know before you take Clozapine Sandoz\u201d).
<\/p>\n\n\n\n
Treatment of schizophrenia<\/strong><\/p>\n\n\n\nThe usual starting dose is 12.5 mg (half a 25 mg tablet) once or twice on the first day followed by 25 mg once or twice daily on the second day. If you tolerate this well, your doctor will gradually increase the dose one by one in steps of 25-50 mg over the next 2-3 weeks until a dose of 300 mg per day is reached. Thereafter, if necessary, the daily dose may be increased in steps of 50-100 mg twice a week or preferably at weekly intervals.
<\/p>\n\n\n\n
The effective daily dose is usually between 200 mg and 450 mg, divided into several single doses per day. Some patients may need a higher dose. A daily dose of up to 900 mg is allowed. Increased side effects (especially seizures) may occur with daily doses above 450 mg. Always take the lowest dose that is effective for you. Most people take part of their dose in the morning and the other part in the evening. Your doctor will tell you exactly how to distribute the daily dose. About your daily dose only 200 mg, you can take it as a single dose in the evening. Once you have taken Clozapine Sandoz with good results for some period, your doctor may try a lower dose. You need to take Clozapine Sandoz for at least 6 months.
<\/p>\n\n\n\n
Treatment of severe thought disorders in patients with Parkinson’s disease<\/strong><\/p>\n\n\n\nThe usual starting dose is 12.5 mg (half a 25 mg tablet) in the evening. The doctor will then gradually increase the dose one in steps of 12.5 mg, not faster than 2 steps in a week, all the way to a maximum dose of 50 mg at the end of the second week. Increases in dosage one should be discontinued or postponed if you feel dizzy, dizzy, or confused. To avoid such symptoms, your blood pressure will be measured during the first few weeks of treatment.
<\/p>\n\n\n\n
The effective dose is usually between 25 mg and 37.5 mg, which is taken as an evening dose. Doses of 50 mg per day should only be exceeded in exceptional cases. The maximum daily dose is 100 mg. Always take the lowest dose that is effective for you.
<\/p>\n\n\n\n
Method of administration<\/strong><\/p>\n\n\n\nClozapine Sandoz is taken by mouth. Swallow the tablet with water. Clozapine Sandoz can be taken before, during, or after a meal. The tablet can be divided into equal parts.<\/p>\n\n\n\n
If you take more Clozapine Sandoz then you should<\/h2>\n\n\n\n
The symptoms of overdose are:<\/p>\n\n\n\n
Drowsiness, fatigue, lack of energy, unconsciousness, coma, confusion, hallucinations, agitation, incoherent speech, stiff joints, trembling hands, convulsions (seizures), increased production of saliva, dilation of pupil one, blurred vision, low blood pressure, collapse, rapid or irregular heartbeat, shallow breathing or heavy breathing.<\/p>\n\n\n\n
If you forget to take Clozapine Sandoz<\/h2>\n\n\n\n
If you forget to take a dose, take it as soon as you remember. If it is almost time for your next dose, do not take the forgotten tablets but take the next dose at the right time. Do not take a double dose to make up for a forgotten dose. Contact your doctor as soon as possible if you have not taken Clozapine Sandoz for more than 48 hours.<\/p>\n\n\n\n
If you stop taking Clozapine Sandoz<\/h2>\n\n\n\n
Do not stop taking Clozapine Sandoz without consulting your doctor, as you may experience withdrawal reactions. These reactions include sweating, headache, nausea, vomiting, and diarrhea. If you get any of these reactions, contact your doctor immediately. These reactions can be followed by more serious side effects if you are not treated immediately. Your basic symptoms may return. A gradual reduction of one dose in steps of 12.5 mg over a period of one to two weeks is recommended if you need to stop treatment. Your doctor will advise you on how to reduce your daily dose<\/strong>. If you need to stop treatment with Clozapine Sandoz quickly, you will need to be checked by a doctor.
<\/p>\n\n\n\nIf your doctor decides that you should start treatment with Clozapine Sandoz again and it has been over 48 hours since your last dose of Clozapine Sandoz, the starting dose should be 12.5 mg.
<\/p>\n\n\n\n
If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/strong><\/p>\n\n\n\n4. Possible side effects<\/h2>\n\n\n\n
Like all medicines, this medicine can cause side effects, although not everybody gets them.<\/p>\n\n\n\n
Some side effects can be serious and require immediate medical attention. Tell your doctor immediately before taking the next Clozapine Sandoz tablet if you experience any of the following:<\/strong>
<\/p>\n\n\n\nVery common <\/strong>( <\/em>may affect more than 1 user in 10):<\/em><\/p>\n\n\n\n- severe constipation. <\/strong>Your doctor will need to treat this to avoid further complications.<\/li>
- fast heartbeat.<\/li><\/ul>\n\n\n\n
Common <\/strong> (may affect up to 1 in 10 people):<\/em><\/p>\n\n\n\n- signs of cold, fever, flu-like symptoms<\/strong>, sore throat, or any other infection. You will quickly need to take a blood test to check if your symptoms are related to your medicine.<\/li>
- seizures.<\/li>
- suddenly faints or loses consciousness at the same time as you become muscle weak ( syncope ).<\/li><\/ul>\n\n\n\n
Uncommon <\/strong> (may affect up to 1 in 100 people):<\/em><\/p>\n\n\n\n- a sudden rapid increase in body temperature, stiff muscles, which can lead to unconsciousness (malignant neuroleptic syndrome) as this can be a serious side effect that requires immediate treatment.<\/li>
- dizzy, dizzy, or dizzy when standing up from a sitting or lying position as these may increase the risk of falling.<\/li><\/ul>\n\n\n\n
Rare <\/strong> (may affect up to 1 in 1,000 people):<\/em><\/p>\n\n\n\n- signs of respiratory infection or pneumonia such as fever, cough, difficulty breathing, or wheezing.<\/li>
- severe, burning pain in the upper abdomen extending to the back as well as nausea and vomiting (due to inflammation of the pancreas).<\/li>
- faints or becomes muscle weak due to a sharp drop in blood pressure.<\/li>
- difficulty swallowing (which may cause you to put food in the trachea).<\/li>
- nausea, vomiting, and\/or loss of appetite. Then your doctor needs to check your liver.<\/li>
- signs of becoming overweight or increasing obesity.<\/li>
- respiratory arrest with or without snoring during sleep.<\/li><\/ul>\n\n\n\n
Rare <\/strong> (may affect up to 1 in 1,000 people)<\/em> or very rare <\/strong> (may affect up to 1 in 10,000 users):<\/em><\/p>\n\n\n\n- rapid and irregular heartbeat<\/strong> even at rest, palpitations, difficulty breathing, chest pain, or unexplained fatigue<\/strong>. Your doctor will need to examine your heart and, if necessary, refer you immediately to a cardiologist.<\/li><\/ul>\n\n\n\n
Very rare <\/strong> (may affect up to 1 in 10,000 people):<\/em><\/p>\n\n\n\n- persistent painful erection of the penis, if you are a man. This is called priapism. If you have an erection that lasts for more than 4 hours, immediate medical treatment may be necessary to avoid further complications.<\/li>
- spontaneous bleeding or bruising, which may be a sign of decreased platelet count.<\/li>
- symptoms due to uncontrolled blood sugar levels (such as nausea or vomiting, stomach pain, increased thirst, urination abnormally, and often, confusion).<\/li>
- stomach pain, cramps, bloating, vomiting, constipation, and problems with gas in the gastrointestinal tract, which may be signs and symptoms of intestinal obstruction (intestinal obstruction).<\/li>
- poor appetite, swollen stomach, stomach pain, yellow skin, severe weakness, and malaise. These symptoms may be a sign that you have started to develop a liver disease that can lead to cell death in the liver ( fulminant liver necrosis). <\/li>
- nausea, vomiting, fatigue, weight loss that may be symptoms of inflammation of the kidneys.<\/li><\/ul>\n\n\n\n
Has been reported <\/strong> (occurs in an unknown number of users):<\/em><\/p>\n\n\n\n- oppressive chest pain, feeling of tightness in the chest (chest pain may radiate to the left arm, jaw, neck, and upper abdomen), difficulty breathing, sweating, weakness, dizziness, nausea, vomiting, and palpitations (signs of heart attack). Seek emergency medical treatment immediately.<\/li>
- pressure over the chest, heaviness, tightness, burning or suffocating sensation (signs of insufficient blood flow and oxygen to the heart muscle). Your doctor will need to check your heart.<\/li>
- periodically “throbbing”, “throbbing” or “fluttering” feeling in the chest (palpitations).<\/li>
- rapid and irregular heartbeat ( atrial fibrillation ). It can cause symptoms such as temporary palpitations, fainting, shortness of breath, or chest pain. Your doctor will need to control your heart.<\/li>
- symptoms of low blood pressure such as dizziness, dizziness, fainting, blurred vision, unusual tiredness, cold and damp\/sticky skin, or nausea.<\/li>
- signs of blood clots in the veins, especially in the legs (symptoms are swelling, pain, and redness of the legs), which can be transported via the blood vessels to the lungs and cause chest pain and difficulty breathing.<\/li>
- diagnosed or suspected infection together with fever or low body temperature, abnormally fast breathing, fast heart rate, altered alertness, and consciousness, drop in blood pressure (symptoms of sepsis ).<\/li>
- heavy sweating, headache, nausea, vomiting, and diarrhea (symptoms of cholinergic syndrome).<\/li>
- severely decreased urine production (signs of renal failure ).<\/li>
- allergic reaction (swelling mainly of the face, mouth, and throat, as well as the tongue, which may be itchy or painful).<\/li>
- poor appetite, swollen stomach, stomach pain, yellow skin, severe weakness, and malaise. It can be a sign of a kind of liver disease which means that normal liver tissue is replaced with scar tissue. This leads to reduced liver function, including liver effects that have life-threatening consequences such as liver failure (which can lead to death), liver damage (damage to liver cells, bile duct in the liver, or both), and liver transplantation.<\/li>
- constipation, abdominal pain, abdominal tenderness, fever, bloating, bloody diarrhea. This may indicate possible megacolon (enlargement of the intestines) or blood clot in the intestinal blood vessels (intestinal infarction\/ischemia). Your doctor will need to examine you.<\/li>
- sharp chest pain with shortness of breath with or without cough.<\/li>
- increased or new muscle weakness, muscle spasms, muscle pain. This may indicate possible muscle disease ( rhabdomyolysis ). Your doctor will need to examine you.<\/li>
- sharp chest or abdominal pain with shortness of breath and with or without cough or fever.<\/li><\/ul>\n\n\n\n
If you get any of these side effects, talk to your doctor immediately before taking the next Clozapine Sandoz tablet.
<\/p>\n\n\n\n
Other side effects:<\/strong><\/p>\n\n\n\nVery common <\/strong>( <\/em>may affect more than 1 user in 10):<\/em><\/p>\n\n\n\nDrowsiness, dizziness, increased saliva flow.
<\/p>\n\n\n\n
Common <\/strong>(may affect up to 1 in 10 people):<\/em><\/p>\n\n\n\nIncreased white blood cell count ( leukocytosis ), increased white blood cell count ( eosinophilia ), weight gain, blurred vision, headache, tremors, stiffness, restlessness, seizures, muscle twitching, abnormal movements, inability to initiate movement, inability to remain changes in ECG, high blood pressure, fainting when getting up quickly, nausea, vomiting, loss of appetite, dry mouth, slightly elevated values \u200b\u200bin liver tests, urinary incontinence, difficulty urinating, fatigue, fever, increased sweating, increased body temperature, speech difficulties (e.g. slurred speech).
<\/p>\n\n\n\n
Uncommon <\/strong> (may affect up to 1 in 100 people) <\/em>:<\/em><\/p>\n\n\n\nA pronounced decrease in white blood cell count ( agranulocytosis ), speech difficulties (eg stuttering).
<\/p>\n\n\n\n
Rare <\/strong> (may affect up to 1 in 1,000 people) <\/em>:<\/em><\/p>\n\n\n\nDecreased number of red blood cells ( anemia ), restlessness, agitation, confusion, delirium, irregular heartbeat, inflammation of the heart muscle ( myocarditis ) or membranes surrounding the heart muscle (pericarditis), fluid accumulation around the pericardium (pericardial effusion), high blood sugar Mellitus, high blood sugar, blood clots in the lungs ( thromboembolism ), inflammation of the liver ( hepatitis ), a liver disease that causes yellowing of the skin \/ dark urine\/itching, elevated levels of an enzyme called creatinine phosphokinase in the blood.
<\/p>\n\n\n\n
Very rare <\/strong> (may affect up to 1 in 10,000 people) <\/em>:<\/em><\/p>\n\n\n\nIncreased platelet count with the risk of blood clots, involuntary twitching of mouth\/tongue, legs, and arms, obsessions and obsessive-compulsive behaviors (signs of obsessive-compulsive disorder), skin reactions, swelling in front of the ear (enlargement of the parotid glands), difficulty breathing, very high levels of triglycerides or cholesterol in the blood, heart muscle disease ( cardiomyopathy ), cardiac arrest, sudden unexplained death.
<\/p>\n\n\n\n
Has been reported <\/strong> (occurs in an unknown number of users) <\/em>:<\/em><\/p>\n\n\n\nChanges in brain activity (seen on electroencephalogram \/ EEC), diarrhea, stomach pain, heartburn, stomach pain after a meal, muscle weakness, muscle cramps, muscle aches, nasal congestion, nocturnal bedwetting, sudden, uncontrollable increase in blood pressure (pseudopheochromocytoma) (pleurothotonus), disturbed ejaculation in men which means that semen enters the bladder instead of ejaculation through the penis (dry orgasm or retrograde ejaculation), rash, purplish-red spots, fever or itching due to inflammation of blood vessels, inflammation in the large intestine causing diarrhea, abdominal pain, fever, changes in skin color, flushing, joint pain, muscle aches, fever and fatigue (lupus erythematosus), restless legs syndrome (compulsive need to move your legs or arms. This is usually accompanied by unpleasant sensations during emotional times of rest, especially in the evening or at night, and temporarily relieved by movement).
<\/p>\n\n\n\n
In the elderly with dementia, a small increase in the number of deaths has been reported for patients who have been treated with antipsychotics compared with those who have not been treated.
<\/p>\n\n\n\n
Reporting of side effects<\/em><\/p>\n\n\n\nIf you get any side effects, talk to your doctor, pharmacist, or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly to the Medical Products Agency, www.lakemedelsverket.se. By reporting side effects, you can help increase drug safety information. Postal address<\/p>\n\n\n\n
5. How to store Clozapine Sandoz<\/h2>\n\n\n\n
Keep this medicine out of the sight and reach of children.
<\/p>\n\n\n\n
Do not use this medicine after the expiry date which is stated on the carton after EXP. or EXP. The expiration date is the last day of the specified month.
<\/p>\n\n\n\n
No special storage instructions.
<\/p>\n\n\n\n
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.<\/p>\n\n\n\n
6. Contents of the packaging and other information<\/h2>\n\n\n\nContent declaration<\/h2>\n\n\n\n
The active substance is clozapine.<\/p>\n\n\n\n
Each tablet contains 25 mg of clozapine.<\/p>\n\n\n\n
Each tablet contains 100 mg of clozapine.<\/p>\n\n\n\n
The other ingredients are lactose monohydrate, maize starch, colloidal anhydrous silica, sodium lauryl sulfate, povidone (K25), microcrystalline cellulose, sodium starch glycolate (type A), and magnesium stearate.<\/p>\n\n\n\n
What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n
25 mg tablets are round, light yellow, scored and marked with \u201cC 25\u201d.<\/p>\n\n\n\n
100 mg tablets are round and light yellow. They have a cloverleaf arrangement.
<\/p>\n\n\n\n
The tablets are packaged in blister cards or plastic jars with screw caps.<\/p>\n\n\n\n
Pack sizes:<\/p>\n\n\n\n
Blisters: 20, 28, 30, 40, 50, 60 (100 mg only), 84, 98, 100, 10 x 50 and 100 x 50.<\/p>\n\n\n\n
10 x 50 and 100 x 50 tablets are for hospital use and dose dispensing only.<\/p>\n\n\n\n
Jars (hospital use and dose dispensing):<\/p>\n\n\n\n
100, 250, and 500.
<\/p>\n\n\n\n
Not all pack sizes may be marketed.<\/p>\n\n\n\n
Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n
Marketing Authorisation Holder:<\/em><\/p>\n\n\n\nSandoz A \/ S, Edvard Thomsens Vej 14, 2300 Copenhagen S, Denmark
<\/p>\n\n\n\n
Manufacturer<\/em><\/p>\n\n\n\nSalutas Pharma GmbH, Otto-Von-Guericke-Allee 1, 39179 Barleben, Germany<\/p>\n\n\n\n
or<\/p>\n\n\n\n
Lek SA, Ul. Domaniewska 50C, 02-672 Warsaw, Poland<\/p>\n\n\n\n
or<\/p>\n\n\n\n
Lek Pharmaceuticals dd, Verov\u0161kova 57, 1526 Ljubljana, Slovenia
<\/p>\n","protected":false},"excerpt":{"rendered":"
The active substance in Clozapine Sandoz is clozapine which belongs to a group of medicines called antipsychotic medicines. These are drugs used to treat specific mental illnesses such as psychosis.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2203,2200],"tags":[2304,6866,6868,6869,2430,6864,6865,6870,6863,6867],"class_list":["post-6947","post","type-post","status-publish","format-standard","hentry","category-c","category-medicines","tag-clozapine","tag-clozapine-sandoz","tag-clozapine-sandoz-side-effects","tag-clozapine-sandoz-tablet","tag-clozapine-side-effects","tag-clozapine-tablet","tag-side-effects-of-clozapine","tag-side-effects-of-clozapine-sandoz","tag-what-is-clozapine","tag-what-is-clozapine-sandoz"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6947","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=6947"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6947\/revisions"}],"predecessor-version":[{"id":11330,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6947\/revisions\/11330"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=6947"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=6947"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=6947"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}