{"id":6893,"date":"2021-02-01T08:22:16","date_gmt":"2021-02-01T08:22:16","guid":{"rendered":"https:\/\/zeepedia.com\/?p=6893"},"modified":"2023-02-20T16:17:48","modified_gmt":"2023-02-20T16:17:48","slug":"cliovelle","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/cliovelle\/","title":{"rendered":"Cliovelle &#8211; Estradiol Noretisterone Uses, Dose And Side Effects"},"content":{"rendered":"\n<p><strong>cliovelle 1mg\/0.5 mg<\/strong> <strong>Estradiol\/Norethisterone Acetate\u00a0Tablets\u00a0<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Cliovelle Is And What Cliovelle Used For?<\/h2>\n\n\n\n<p>Cliovelle is a preparation used for hormonal\u00a0substitution therapy\u00a0(\u00a0Hormone Replacement\u00a0Therapy,\u00a0HRT\u00a0).\u00a0It contains two female sex hormones;\u00a0estrogen\u00a0and a\u00a0progestogen.<\/p>\n\n\n\n<p><strong>Cliovelle used for women whose menstruation has stopped (\u00a0menopause\u00a0) at least one year after their last natural menstruation.<\/strong><\/p>\n\n\n\n<p><span style=\"text-decoration: underline;\"><strong>Cliovelle is used to:<\/strong><\/span> <strong>Relieve symptoms during and after menopause.<\/strong><\/p>\n\n\n\n<p>When menstruation ceases (\u00a0menopause\u00a0), a woman&#8217;s\u00a0estrogen\u00a0drops.\u00a0It can cause problems such as sweating and hot flashes.\u00a0Cliovelle relieves these symptoms after\u00a0menopause.\u00a0Cliovelle should only be used if the problems cause problems in daily life.<\/p>\n\n\n\n<p><span style=\"text-decoration: underline;\"><strong>Prevent osteoporosis<\/strong>:<\/span><\/p>\n\n\n\n<p>After\u00a0menopause,\u00a0some women suffer from osteoporosis.\u00a0Discuss all possible options with your doctor. If you have an increased risk of\u00a0fractures\u00a0(broken bones) and other medicines that are not suitable for you, you can use Cliovelle to prevent osteoporosis after\u00a0menopause.<\/p>\n\n\n\n<p>Estradiol and norethisterone acetate in Cliovelle may also be approved for treating other conditions not mentioned in this product information.<\/p>\n\n\n\n<p>Ask your doctor, pharmacist, or other healthcare professional if you have further questions and always follow their instructions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What You Need To Know Before You Take Cliovelle?<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do Not Use Cliovelle:<\/h2>\n\n\n\n<p><strong><span style=\"text-decoration: underline;\">Medical background and regular check-ups<\/span><\/strong><\/p>\n\n\n\n<p>The use of\u00a0HRT\u00a0involves risks that must be considered when deciding to start or continue an ongoing treatment.<br>Experience is limited for treating women whose menstruation has stopped prematurely (when the ovaries have stopped working or the uterus has been removed).\u00a0If you belong to that group, the risks of\u00a0HRT\u00a0may be different.\u00a0Talk to your doctor.<br>Before starting treatment (or resuming treatment), your doctor will ask about your and your family&#8217;s medical background.\u00a0Your doctor may do a general medical and gynecological examination, including an examination of your breasts.<\/p>\n\n\n\n<p>Once you have started treatment, you should go for regular medical check-ups at least once a year.\u00a0During these check-ups, you should discuss the benefits and risks of continued treatment with your doctor. Perform regular breast examinations according to your doctor&#8217;s recommendations.<\/p>\n\n\n\n<p><strong><span style=\"text-decoration: underline;\">Do not take Cliovelle:<\/span><\/strong><\/p>\n\n\n\n<p>If any of the following apply to you.\u00a0If you are not sure,\u00a0<strong>talk to your doctor<\/strong>\u00a0before taking Cliovelle.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you have or have had\u00a0breast <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/getting-a-cancer-message\/\">cancer<\/a>\u00a0or if there is a suspicion that you may have it.<\/li><li>If you have or have had\u00a0estrogen-dependent cancer, such as cancer of the lining of the uterus (endometrium), or if there is a suspicion of such cancer.<\/li><li>If you have\u00a0unexpected genital bleeding\u00a0that a doctor has not investigated.<\/li><li>If you have\u00a0endometrial hyperplasia\u00a0(severe thickening of the uterine lining) and are not being treated for it.<\/li><li>If you have or have had a\u00a0blood clot in a vein\u00a0(venous\u00a0thromboembolism\u00a0), in your legs (deep\u00a0vein thrombosis\u00a0), or your lungs (\u00a0pulmonary embolism\u00a0).<\/li><li>If you have a\u00a0coagulation disorder, a condition with an increased risk of blood clots (lack of\u00a0protein\u00a0C,\u00a0protein\u00a0S, or antithrombin).<\/li><li>If you have or have had a disease caused by blood clots in the\u00a0arteries,\u00a0are as\u00a0heart attack,\u00a0stroke\u00a0(stroke), or\u00a0angina.<\/li><li>If you have or have had any\u00a0liver disease\u00a0and still have abnormal liver values.<\/li><li>If you have\u00a0porphyria, a rare inherited blood disorder.<\/li><li>If you are\u00a0allergic\u00a0to estradiol valerate, norethisterone acetate, or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<p>If any of the above affects you the first time you use Cliovelle, stop taking Cliovelle and contact your doctor immediately.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings And Cautions:<\/h2>\n\n\n\n<p>Talk to your doctor if you have or have had any of the following problems before starting treatment.\u00a0They may recur or worsen during treatment with Cliovelle.\u00a0Should this occur, have more frequent check-ups with a doctor.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you have any disease affecting the uterus lining, muscle knots (\u00a0fibroids\u00a0),\u00a0endometriosis,\u00a0or endometrial hyperplasia\u00a0(severe uterine lining thickening).<\/li><li>If you have an increased risk of getting a blood clot (see below &#8220;Blood clots in a vein (\u00a0thrombosis\u00a0)&#8221;)<\/li><li>If a close relative has had breast cancer or other estrogen-dependent cancer.<\/li><li>High\u00a0blood pressure<\/li><li>Liver disease eg liver adenoma (benign\u00a0tumor\u00a0)<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/diabetes-type-1\/\">Diabetes<\/a><\/li><li>Gallstone disease<\/li><li>If you get a\u00a0migraine\u00a0or severe headache<\/li><li>If you have <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/sle\/\">systemic lupus erythematosus<\/a> (\u00a0SLE\u00a0) &#8211; an\u00a0autoimmune\u00a0disease that affects many organs in the body<\/li><li>Epilepsy<\/li><li>Asthma<\/li><li>Otosclerosis (ossification of the middle ear leading to a hearing loss)<\/li><li>Hypertriglyceridemia\u00a0(elevated blood lipids)<\/li><li>Fluid retention due to heart or kidney disease<\/li><\/ul>\n\n\n\n<p><strong>You should contact a doctor immediately and discontinue treatment if any of the following occur:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Any of the things mentioned in the section &#8216;Do not take Cliovelle.&#8217;<\/li><li>If skin or whites of the eyes turn yellow (jaundice);\u00a0it may be a symptom of liver disease.<\/li><li>If your\u00a0blood pressure\u00a0rises sharply (symptoms may be headache, fatigue, or dizziness)<\/li><li>If you are experiencing migraine-like headaches for the first time<\/li><li>If you become pregnant<\/li><li>If you get symptoms of a blood clot, such as:<ul><li>Painful swelling and redness of the legs<\/li><li>Sudden chest <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/brain-and-nerves\/pain\/\">pain<\/a><\/li><li>Breathing difficulties<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>For further information, see &#8220;Blood clots in a vein (\u00a0thrombosis\u00a0).&#8221;<\/p>\n\n\n\n<p><strong>Note:<\/strong>\u00a0Cliovelle is not a contraceptive.\u00a0If it is less than 12 months since your last period, or if you are under 50, you may still need to use contraception to avoid pregnancy.\u00a0Consult your doctor.<\/p>\n\n\n\n<p><span style=\"text-decoration: underline;\"><strong>HRT\u00a0and cancer<\/strong>:<\/span><\/p>\n\n\n\n<p><strong>Severe thickening of the uterine lining (\u00a0endometrial hyperplasia\u00a0) and cancer of the uterine lining (endometrial cancer)<\/strong> Using\u00a0HRT\u00a0with\u00a0estrogen\u00a0alone\u00a0increases the risk of severe thickening of the uterine lining and cancer of the uterine lining. The\u00a0progestogen in Cliovelle protects you against this extra risk.<\/p>\n\n\n\n<p><span style=\"text-decoration: underline;\"><strong>Irregular bleeding<\/strong>:<\/span><\/p>\n\n\n\n<p>Irregular spotting or spotting may occur during the first 3 &#8211; 6 months of taking Cliovelle. But about the bleeding<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Lasts longer than 6 months<\/li><li>Begins after taking Cliovelle for 6 months<\/li><li>Continues after you stop taking Cliovelle<\/li><\/ul>\n\n\n\n<p><strong>you should see a doctor as soon as possible.<\/strong><br><strong><span style=\"text-decoration: underline;\">Breast cancer:<\/span><\/strong><\/p>\n\n\n\n<p>Data show that hormone replacement therapy (\u00a0HRT\u00a0) with a combination of\u00a0estrogen-progestogen\u00a0or with\u00a0estrogen\u00a0alone\u00a0increases the risk of breast cancer.\u00a0The increased risk depends on how long you use\u00a0HRT.\u00a0The increased risk is seen within 3 years.\u00a0When treatment is stopped, the increased risk decreases over time, but it can persist for 10 years or more if you have used\u00a0HRT\u00a0for more than 5 years.<\/p>\n\n\n\n<p><em><strong>Comparison<\/strong><\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Of 1,000 women aged 50-54 who do not take\u00a0HRT, an average of 13-17 will be diagnosed with breast cancer over 5 years.<\/li><li>In women who are 50 years old and start taking\u00a0HRT\u00a0with\u00a0estrogen\u00a0alone\u00a0for 5 years, 16-17 cases per 1,000 users (ie 0-3 extra cases) will occur.<\/li><li>In women who are 50 years old and start taking\u00a0HRT\u00a0with\u00a0estrogen-progestogen\u00a0for 5 years, there will be 21 cases per 1,000 users (ie 4-8 extra cases).<\/li><li>Among women aged 50\u201359 who do not use\u00a0HRT, an average of 27 out of 1,000 will be diagnosed with breast cancer over 10 years.<\/li><li>In women who are 50 years old and start taking\u00a0HRT\u00a0with\u00a0estrogen\u00a0alone\u00a0for 10 years, 34 cases per 1,000 users (ie 7 extra cases) will occur.<\/li><li>In women who are 50 years old and start taking\u00a0HRT\u00a0with\u00a0estrogen-progestogen\u00a0for 10 years, 48 \u200b\u200bcases per 1,000 users (ie 21 extra cases) will occur.<\/li><\/ul>\n\n\n\n<p><strong>Check your breasts regularly.&nbsp;Contact a doctor if you notice changes such as:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Indentations or pits<\/li><li>Changes of the nipple<\/li><li>Nodules you can see or feel<\/li><\/ul>\n\n\n\n<p>In addition, it is recommended that you participate in a mammography examination when offered.\u00a0At the mammogram, you must tell the nurse\/healthcare professional examining that you are using\u00a0HRT, as this medicine may increase the density of the breasts and it may affect the results of the mammogram.\u00a0An increased breast density can make detecting lumps on the mammography images more difficult.<\/p>\n\n\n\n<p><strong><span style=\"text-decoration: underline;\">Ovarian cancer<\/span><\/strong>:<\/p>\n\n\n\n<p>Ovarian cancer is rare &#8211; much more rare than breast cancer.&nbsp;Use of&nbsp;HRT&nbsp;with&nbsp;estrogen&nbsp;alone&nbsp;or combined&nbsp;estrogen-progestogen&nbsp;has been associated with a slightly increased risk of ovarian cancer.<\/p>\n\n\n\n<p>The risk of ovarian cancer varies with age.\u00a0For example, ovarian cancer diagnosis will be made on about 2 women out of 2,000 between the ages of 50 and 54 who do not take\u00a0HRT\u00a0for a 5-year period.\u00a0For women who have taken\u00a0HRT\u00a0for 5 years, there will be about 3 cases per 2,000 users (ie about 1 extra case).<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><span style=\"text-decoration: underline;\"><strong>How\u00a0HRT\u00a0affects the heart and blood circulation<\/strong>?<\/span><\/li><li><strong>Blood clots in a vein (\u00a0thrombosis\u00a0)<\/strong><\/li><li>The risk of\u00a0<strong>blood clots in the veins<\/strong>\u00a0is 1.3\u20133 times higher for women who take\u00a0HRT than those who do not, especially during the first year of treatment.<\/li><li>Blood clots can be serious.\u00a0If a blood clot ends up in the lungs, it can cause chest pain, shortness of breath, collapse, or even lead to death.<\/li><li>You are more likely to get a blood clot in a vein if the following apply to you.\u00a0Tell your doctor if any of the following apply to you:<ul><li>You have not been able to walk or stand for a long time due to a major operation, injury or illness (see also section 3, \u201cIf you need surgery\u201d)<\/li><li>You are severely overweight (\u00a0BMI\u00a0over 30 kg \/ m\u00a0<sup>2<\/sup>\u00a0)<\/li><li>You have a coagulation disorder that requires long-term treatment with drugs that prevent blood clots.<\/li><li>If a close relative has had a blood clot in the bone, lung, or another organ<\/li><li>You have\u00a0SLE\u00a0(systemic lupus erythematosus)<\/li><li>You have cancer<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>The symptoms of a blood clot are described in the section &#8220;You should contact a doctor immediately and stop the treatment&#8221;.<br><em><strong>Comparison<\/strong><\/em>: <\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>For women in their 50s who do not take\u00a0HRT, an average of 4 &#8211; 7 out of 1,000 people are expected to have a blood clot in a vein over 5 years.<\/li><li>For women in their 50s who have taken\u00a0HRT\u00a0with\u00a0estrogen-progestogen\u00a0for more than 5 years, 9 &#8211; 12 out of 1,000 users are expected to get a blood clot in a vein (ie 5 extra cases)<\/li><\/ul>\n\n\n\n<p><strong><span style=\"text-decoration: underline;\">Heart disease (heart attack)<\/span><\/strong>:<\/p>\n\n\n\n<p>There is no evidence that\u00a0HRT\u00a0prevents heart attacks. For women over 60 who take\u00a0HRT\u00a0with\u00a0estrogen-progestin, the risk of developing heart disease is slightly higher than those who do not.<\/p>\n\n\n\n<p><strong><span style=\"text-decoration: underline;\">Stroke\u00a0(apoplexy)<\/span><\/strong><\/p>\n\n\n\n<p>The risk of\u00a0stroke\u00a0is about 1.5 times higher for those who take\u00a0HRT\u00a0than those who do not.\u00a0The risk of\u00a0stroke\u00a0is age-dependent; therefore, the number of stroke cases\u00a0increases\u00a0due to the use of\u00a0HRT\u00a0with increasing age.<\/p>\n\n\n\n<p><em><strong><span style=\"text-decoration: underline;\">Comparison<\/span><\/strong><\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>For women in their 50s who do not take\u00a0HRT, an average of 8 out of 1,000 people is expected to have a\u00a0stroke\u00a0over 5 years.<\/li><li>For women in their 50s who have taken\u00a0HRT\u00a0for more than 5 years, 11 out of 1,000 users are expected to have a\u00a0stroke\u00a0(ie 3 extra cases)<\/li><\/ul>\n\n\n\n<p><strong>Other conditions<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Using\u00a0HRT\u00a0does not prevent memory loss.\u00a0The risk of memory loss may be slightly higher in women who start using\u00a0HRT\u00a0after age 65.\u00a0Consult your doctor.<\/li><li>In women with hereditary\u00a0angioedema,\u00a0HRT\u00a0may increase or worsen the symptoms.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Other Medicines And Cliovelle:<\/h2>\n\n\n\n<p>Some medicines may affect how Cliovelle works, leading to irregular bleeding.\u00a0The following applies:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Drugs for&nbsp;<strong>epilepsy<\/strong>&nbsp;(eg phenobarbital,&nbsp;phenytoin,&nbsp;and carbamazepine)<\/li><li>Medicines for&nbsp;<strong>tuberculosis<\/strong>&nbsp;(eg rifampicin, rifabutin)<\/li><li>Drugs for&nbsp;<strong>HIV&nbsp;&#8211;&nbsp;infection&nbsp;(for example, nevirapine, efavirenz, ritonavir, and nelfinavir telaprevir)<\/strong><\/li><li><strong>An herbal<\/strong> medicine containing&nbsp;<strong>St. John&#8217;s wort<\/strong>&nbsp;(&nbsp;<em>Hypericum perforatum<\/em>&nbsp;)<\/li><\/ul>\n\n\n\n<p><strong>Cliovelle may increase or decrease the effect of other medicines:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The effect of ciclosporin (used, for example, to prevent\u00a0transplant rejection, treatment of\u00a0rheumatoid arthritis\u00a0or\u00a0psoriasis\u00a0) may increase.<\/li><li>The effect of lamotrigine (an epilepsy medicine) may be reduced, and the\u00a0dose of lamotrigine may need to be adjusted to control the risk of seizures.<\/li><\/ul>\n\n\n\n<p>Medicines containing\u00a0ketoconazole\u00a0(\u00a0antifungal\u00a0) can increase the effect of Cliovelle. Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines, including medicines obtained without a prescription and herbal remedies.<\/p>\n\n\n\n<p><strong><span style=\"text-decoration: underline;\">Results from blood test analyze<\/span><\/strong><\/p>\n\n\n\n<p>If you need to take a blood sample, tell your doctor, or the person taking the blood sample, that you are taking Cliovelle, as it may affect the results of some tests.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy And Breastfeeding:<\/h2>\n\n\n\n<p>Cliovelle is for women whose menstruation has stopped.&nbsp;If you become pregnant, stop taking Cliovelle and consult a doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving And Using Machines:<\/h2>\n\n\n\n<p>No effects on the ability to drive and use machines have been observed. You are responsible for assessing whether you can drive a motor vehicle or perform work requiring sharpened attention.<\/p>\n\n\n\n<p>One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\u00a0side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.<\/p>\n\n\n\n<p>Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Cliovelle Contains Lactose Monohydrate:<\/h2>\n\n\n\n<p>If your doctor has told you that you are intolerant to some sugars, contact your doctor before taking this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How To Take Cliovelle?<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Always take this medicine exactly as your doctor has told you.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/li><li>Take one tablet daily without pausing between tablets (blisters).<\/li><li>When you start taking Cliovelle, take the first tablet where the day of the week is indicated on the tablet map (eg &#8220;M&#8221; for Monday).\u00a0Then follow the direction of the arrows from the first tablet and take one tablet every day until the tablet map is finished.\u00a0The next day you start with a new tablet map.<\/li><li>The tablets should be swallowed with sufficient water, preferably at the same time each day.<\/li><li>Your doctor will strive to\u00a0give you\u00a0the lowest\u00a0dose, which will give you symptom relief, and that you should use Cliovelle for the shortest possible time.\u00a0Talk to your doctor if you do not get any relief from the symptoms or feel that the\u00a0dose\u00a0is too high.<\/li><\/ul>\n\n\n\n<p><strong>After an overdose, you may feel soreness in your breasts, feel sick or vomit, have irregular bleeding, feel down, feel tired, develop\u00a0acne,\u00a0or experience increased hair growth on your body or face.<\/strong> If you accidentally take an extra\u00a0dose, the usual\u00a0dose\u00a0should be taken the next day.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If You Forget To Take Cliovelle:<\/h2>\n\n\n\n<p>If you forget to take a tablet, you can take it within 12 hours from the usual time; otherwise, discard the forgotten tablet and take the next tablet, as usual, the next day. Do not take a double\u00a0dose\u00a0to make up for a forgotten tablet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If You Need Surgery:<\/h2>\n\n\n\n<p>If you have surgery, tell your surgeon that you are taking Cliovelle.\u00a0You may need to stop taking Cliovelle for 4 to 6 weeks before surgery to avoid the risk of blood clots (see section 2, \u201cBlood clots in a vein (\u00a0thrombosis\u00a0)\u201d).\u00a0Ask your doctor when it is appropriate to start taking Cliovelle again. Ask your doctor or pharmacist if you have any further questions about using this product.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible Cliovelle Side Effects:<\/h2>\n\n\n\n<p>This medicine can cause side effects like all medicines,\u00a0although not everybody gets them.\u00a0Most\u00a0side effects\u00a0are mild to moderate and do not usually mean that women must stop taking their tablets. The following diseases are more common in women who take\u00a0HRT\u00a0than those who do not:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Breast cancer<\/li><li>Severe thickening of the uterine lining (\u00a0endometrial hyperplasia\u00a0) or cancer of the uterine lining (endometrial cancer)<\/li><li>Ovarian cancer (\u00a0ovarian cancer\u00a0)<\/li><li>Blood clots in veins in bones or lungs (venous\u00a0thromboembolism\u00a0)<\/li><li>Heart disease<\/li><li>Stroke\u00a0(stroke)<\/li><li>Probable memory loss, if treatment with\u00a0HRT is\u00a0started after the age of 65<\/li><\/ul>\n\n\n\n<p>See section 2 for more information on these\u00a0side effects. The following\u00a0side effects\u00a0may occur during treatment with Cliovelle:<br><em><strong>Very common (affects more than 1 user in 10)<\/strong><\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Vaginal bleeding<\/li><li>Pain or tenderness in the breasts<\/li><\/ul>\n\n\n\n<p><em><strong>Common (affects up to 1 in 10 people)<\/strong><\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Fungal infection of the abdomen or\u00a0inflammation\u00a0of the vagina<\/li><li>Accumulation of fluid in the body<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/depression\/\">Depression<\/a> or worsening of ongoing depression<\/li><li>Migraine\u00a0or worsening of ongoing\u00a0migraine<\/li><li>Headache<\/li><li>Nausea<\/li><li>Back pain<\/li><li>Breast edema or breast enlargement<\/li><li>Uterine nodules (\u00a0fibroids\u00a0) or impaired or recurrent uterine nodules<\/li><li>Peripheral\u00a0edema\u00a0(swollen arms or legs)<\/li><li>Weight gain<\/li><\/ul>\n\n\n\n<p><em><strong>Uncommon (affects up to 1 in 100 people)<\/strong><\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Hypersensitivity (\u00a0allergic reaction\u00a0)<\/li><li>Nervousness<\/li><li>Superficial venous inflammation associated with the blood clots<\/li><li>Pain, tension, or discomfort in the abdomen<\/li><li>Gases<\/li><li>Bloating<\/li><li>Morbidly strong hair (increased hair growth on body and face)<\/li><li>Acne<\/li><li>Hair loss<\/li><li>Itching<\/li><li>Hives<\/li><li>Leg cramps<\/li><\/ul>\n\n\n\n<p><em><strong>Rare (affects up to 1 in 1,000 people)<\/strong><\/em><\/p>\n\n\n\n<p>A blood clot in the lung (See section 2, &#8220;What you need to know before taking Cliovelle&#8221;).<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Deep vein inflammation associated with blood clots.<\/li><\/ul>\n\n\n\n<p><em><strong>Very rare (affects 1 in 10,000 people)<\/strong><\/em><\/p>\n\n\n\n<p>Anaphylactic reactions (sudden, severe, potentially life-threatening allergic reactions). The following\u00a0side effects\u00a0have been reported with other HRTs:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The disease of the gallbladder<\/li><li>Various skin diseases:<ul><li>Dark skin spots, especially on the face and neck, so-called &#8220;pregnancy spots&#8221; (chloasma)<\/li><li>Painful reddish-purple bumps on the skin (erythema nodosum)<\/li><li>Annular redness or sore rash (erythema multiforme)<\/li><\/ul><\/li><li>Dry eyes<\/li><li>Change in the composition of the tear fluid<\/li><\/ul>\n\n\n\n<p><em><strong>Reporting of side effects<\/strong><\/em><\/p>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse if you get any side effects.\u00a0This includes any possible side effects not listed in this leaflet.\u00a0You can also report side effects directly to the Medical Products Agency,\u00a0www.lakemedelsverket.se.\u00a0By reporting side effects, you can help increase drug safety information.\u00a0<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How To Store Cliovelle?<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Keep this medicine out of sight and reach of children.<\/li><li>Do not use this medicine after the expiry date stated on the blister and carton after EXP.\u00a0The expiration date is the last day of the specified month.<\/li><li>The medicine should not be disposed of via wastewater or household waste.\u00a0Ask your pharmacist how to dispose of medicines that are no longer required.\u00a0These measures will help to protect the environment.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents Of The Packaging And Other Information:<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content Declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substances are estradiol 1 mg (as estradiol valerate) and norethisterone acetate 0.5 mg.<\/li><li>Crospovidone, lactose monohydrate , magnesium stearate, and corn starch are other ingredients.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What Looks Like And The Contents Of The Pack:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>White, round, biconvex tablets, 6 mm in diameter.<\/li><li>Calendar blister packs of 28 and 84 tablets.<\/li><li>Blister packs of 30 and 90 tablets.<\/li><li>Not all pack sizes may be marketed.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder And Manufacturer<\/h2>\n\n\n\n<p>DR.&nbsp;KADE Pharmazeutische Fabrik GmbH<\/p>\n\n\n\n<p>Ringstrasse 2<\/p>\n\n\n\n<p>D &#8211; 12277 Berlin<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p><strong>For further information about Cliovelle, contact your local representative\/agent:<\/strong><\/p>\n\n\n\n<p>CampusPharma AB<\/p>\n\n\n\n<p>Karl Gustavsgatan 1A<\/p>\n\n\n\n<p>SE &#8211; 411 25 Gothenburg<\/p>\n\n\n\n<p>e-mail: info@campuspharma.se<\/p>\n\n\n\n<p>Tel: +46 31 20 50 20<br><strong>This medicinal product is authorized under the European Economic Area under the names:<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>Denmark:<\/td><td>Cliovelle<\/td><\/tr><tr><td>Finland:<\/td><td>Cliovelle 1 mg \/ 0.5 mg tablets<\/td><\/tr><tr><td>Norway:<\/td><td>Cliovelle 1 mg \/ 0.5 mg tablets<\/td><\/tr><tr><td>Poland:<\/td><td>Cliovelle 1 mg \/ 0.5 mg tablets<\/td><\/tr><tr><td>:<\/td><td><\/td><\/tr><tr><td>Germany:<\/td><td>Cliovelle 1 mg \/ 0.5 mg tablets<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Cliovelle is prescribed for postmenopausal women who have had at least one year since their last natural menstruation. The amount of oestrogen generated by a woman&#8217;s body decreases throughout menopause.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2203,2200],"tags":[6970,6972,6973,6966,6968,6969,2212,2210,6967,6971],"class_list":["post-6893","post","type-post","status-publish","format-standard","hentry","category-c","category-medicines","tag-cliovelle","tag-cliovelle-side-effects","tag-cliovelle-tablet","tag-estradiol-noretisterone","tag-estradiol-noretisterone-side-effects","tag-estradiol-noretisterone-tablet","tag-medicine","tag-tablet","tag-waht-is-estradiol-noretisterone","tag-what-is-cliovelle"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6893","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=6893"}],"version-history":[{"count":70,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6893\/revisions"}],"predecessor-version":[{"id":50112,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6893\/revisions\/50112"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=6893"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=6893"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=6893"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}